Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cells by Zhao-Qing Shen, Wen-Tai Chiu, Cheng-Heng Kao, Yu-Chen Chen, Li-Hsien Chen, Tsai-Wen Teng, Shao-Yu Hsiung, Tsai-Yu Tzeng, Chien-Yi Tung, Chi-Chang Juan, Ting-Fen Tsai

“…Nevertheless, the mechanism underlying β-cell dysfunction in WFS2 remains elusive. Here we delineate the essential role of CISD2 in β-cells. …”
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THE INFLAMMASOME DRIVES MICROVASCULAR IMPAIRMENT IN MOUSE MODELS OF INTRAVASCULAR HEMOLYSIS by PL Brito, EMFG Azevedo, LFS Gushiken, FC Leonardo, FF Costa, N Conran

“…These results confirm that these mouse models effectively mimic acute and chronic hemolytic stress. …”
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Non-hematopoietic roles of erythropoietin in inflammation and metabolic disorders by Satoru Sugimoto, Takeshi Goda

“…Obesity-induced chronic inflammation underlies insulin resistance, a key driver of metabolic disorders such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatohepatitis (MASH). Recent evidence shows EPO exerts anti-inflammatory effects in insulin-sensitive tissues, thereby improving insulin sensitivity in the context of obesity. …”
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Elucidation of blink reflex characteristics in Parkinson's disease subtypes through prepulse inhibition by Zhen Zhang, Ling Zhang, Xiaofeng Huang, Xinqing Hao, Tao Li, Yayin Luo, Xiaoxue Yin, Chunli Song, Zhanhua Liang

“…Compared to controls, PD patients exhibited impaired PPI across various stimulation intervals, with a more pronounced effect in the PD-PIGD subgroup. Interestingly, no significant differences in PPI were observed between the left and right sides, suggesting a bilateral effect. …”
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Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis by Andreas Margraf, Jianmin Chen, Marilena Christoforou, Pol Claria-Ribas, Ayda Henriques Schneider, Chiara Cecconello, Weifeng Bu, Paul R C Imbert, Thomas D Wright, Stefan Russo, Isobel A Blacksell, Duco S Koenis, Jesmond Dalli, John A Lupisella, Nicholas R Wurtz, Ricardo A Garcia, Dianne Cooper, Lucy V Norling, Mauro Perretti

“…Abstract Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. …”
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High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway by RuiYang Hong, Su Min, Jia Huang, Mou Zou, DongYu Zhou, Yun Liang

“…Abstract Background Mitochondrial dysfunction is closely associated with cancer development. …”
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Therapeutic efficacy and mechanisms of Xuebijing in Acinetobacter baumannii infection based on meta-analysis and integrated pharmacology approaches by Jiaqi Li, Yihan Sun, Hao Wen, Boying Xiao, Jianming Wang, Ziqi Li, Lei Wang, Meiyu Yu

“…Meta-analysis demonstrated that XBJ significantly improved clinical outcomes, with a higher overall effective rate (RR = 1.20, 95% CI: 1.13–1.27, P < 0.01) and enhanced bacterial clearance (RR = 1.44, 95% CI: 1.23–1.68, P < 0.01) compared to conventional treatment alone. …”
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Executive functions and associated brain volumetry in children with persistent stunting and catch-up growth by Beena Koshy, Vedha Viyas Thilagarajan, Roshan S. Livingstone, Manikandan Srinivasan, Venkata Raghava Mohan, Rachel Beulah, Anitha Jasper, Sushil John, Gagandeep Kang

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Central venous stenosis and methods of its treatment in hemodialysis patients by Z. B. Kardanakhishvili, A. B. Zulkarnaev

“…However, stenting is undoubtedly effective in the case of rapid occurrence of recurrent stenosis or rigid stenosis and recoil immediately after surgery. …”
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In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…This mutation causes muHTT to oligomerize and aggregate in the brain, particularly in the striatum and cortex, causing alterations in intracellular trafficking, caspase activation, and ganglioside metabolism, ultimately leading to neuronal damage and death and causing signs and symptoms such as chorea and cognitive dysfunction. Currently, there is no available cure for HD patients; hence, there is a strong need to look for effective therapies. …”
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Saliva versus plasma cytokines as possible predictors of autism severity by Yu. Yu. Filippova, A. S. Alekseeva, E. V. Devyatova, K. A. Rusakova, A. L. Burmistrova

“…There are no available and effective biomarkers for them. Immune dysfunction is seen as an important risk factor contributing to the neurodevelopmental deficit in ASD, and is signified, among other things, by an imbalance of cytokines in the brain and on the periphery. …”
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Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α pathway by Liang Huang, Wei Gao, Xuri He, Tong Yuan, Huaqi Zhang, Xiufen Zhang, Wenxuan Zheng, Qilin Wu, Ju Liu, Wence Wang, Lin Yang, Yongwen Zhu

“…Result In ovo injected tert-butyl hydroperoxide (BHP) increases (P < 0.05) hepatic mitochondrial ROS, malondialdehyde (MDA) and 8-hydroxy-2-deoxyguanosine (8-OHdG), and decreases (P < 0.05) mitochondrial membrane potential (MMP), mitochondrial DNA (mtDNA) copy number and adenosine triphosphate (ATP) content, contributing to mitochondrial dysfunction. In vivo and in vitro studies revealed that Zn addition enhances (P < 0.05) ATP synthesis and metallothionein 4 (MT4) content and expression as well as alleviates (P < 0.05) the BHP-induced mitochondrial ROS generation, oxidative damage and dysfunction, exerting a protective effect on mitochondrial function by enhancing antioxidant capacity and upregulating the mRNA and protein expressions of Nrf2 and PGC-1α. …”
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The Gut-Brain Axis in IBD: An Investigator’s Perspective by Stephen M Collins, Harvey P Weingarten, Kevin McHugh

“…Studies in animal models of colitis and jejunitis have shown that mucosal injury and inflammation are associated with neuromuscular dysfunction and abnormal motility. Neuromuscular dysfunction often persists after the mucosa has healed. …”
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Identifying potential key metabolic pathways and biomarkers in glaucoma: a systematic review and meta-analysis by Maria Nilsson, Navid Golpour, Rune L Brautaset, Flora Hui, Jonas E Svensson, Pete A Williams, James R Tribble

“…Increasing evidence points to metabolic dysfunction, particularly mitochondrial dysfunction, as a contributing factor to glaucomatous neurodegeneration. …”
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COMPARATIVE EFFICACY AND TOLERABILITY OF AVOCADO / SOYBEAN UNSAPONIFIABLES AND THEIR COMBINATION WITH INTRA-ARTICULAR HYALURONIC ACID IN PATIENTS WITH KNEE AND HIP OSTEOARTHROSIS by Ye. I. Shmidt, I. V. Belozerova

“…There was a gradual reduction in joint pain, stiffness, and dysfunction (as shown by the visual analog scale) in both groups just one month posttherapy. …”
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Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders by Susmita Malwade, Carl M. Sellgren, Navneet A. Vasistha, Konstantin Khodosevich

“…Conclusions: Overall, we showed that although NDDs are only diagnosed during childhood or adolescence, the actual effect of genetic mutations on embryonic progenitor cells or early neurons may be strongest during fetal brain development, which could program the cascade for subsequent developmental changes and, together with further postnatal dysfunction, impair brain function.…”
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Inhaled Nitric Oxide for the Prevention of Impaired Arterial Oxygenation during Myocardial Revascularization with Extracorporeal Circulation by I. A. Kozlov, A. A. Romanov, E. V. Dzybinskaya, A. E. Balandyuk

“…The preventive effect of inhaled nitric oxide was steady-state: 6 hours following myocardial revascularization under EC, the patients intraoperatively receiving inhaled nitric oxide showed a 2.3-fold lower rate of lung oxygenating dysfunction (PaO2/FiO2 less than 300 mm Hg) than the controls. …”
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Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner by Wen Ge, Xiaohua Zhang, Jie Lin, Yangyang Wang, Xiao Zhang, Yu Duan, Xinchun Dai, Jiye Zhang, Yan Zhang, Mengyuan Jiang, Huanhuan Qiang, Zhijing Zhao, Xuebin Zhang, Dongdong Sun

“…Mechanically, the interaction between Rnd3 and Rho-associated kinase 1 (Rock1) may impede Rock1-induced Drp1 phosphorylation at Ser616, thus inhibiting mitochondrial fission and dysfunction. Interestingly, Rock1 knockdown nullified the effects of Rnd3 on cardiomyocytes PANoptosis, as well as Dox-induced cardiac remodeling and dysfunction elicited by Rnd3. …”
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POSSIBLE ROLE OF MITOCHONDRIAL GENOME MUTATIONS IN CORONARY HEART DISEASE by L. A. Egorova, M. V. Ezhov, G. M. Shiganova, A. Yu. Postnov

“…Mitochondrial dysfunction may be an important unifying mechanism that accounts for the atherogenic effect of major cardiovascular risk factors. …”
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Design Analysis and Experiment of Lower Limb Power Exoskeleton by Wei Ning, Gang Li, Zhendong Song, Wei Chen, Tong Wu

“…Abstract In order to effectively solve the motor dysfunction of lower limbs in the elderly caused by the degeneration of lower limb muscle function and stroke hemiplegia， the importance of rehabilitation exercise for the recovery of lower extremity dysfunction patients is analyzed from the perspective of rehabilitation medicine. …”
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