Results of a clinical trial of humeral neck osteosynthesis with carbon – carbon composite material by M. L. Golovakha, V. V. Chornyi

“…This effect was observed at the 3-month, 6-month, and 12-month evaluation points. …”
Get full text

Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

“…Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. …”
Get full text

Negative impact of insufficient sleep on the brain by Qiongfang Cao, Haiqi Xiang, Yuhan Wang, Fangfang Liu, Xiechuan Weng, Fan Xu

“…Long-term insufficient sleep is positively related to the prevalence of chronic and acute disease, such as reduced cognitive ability and increased negative emotions, such as anxiety.Methods Herein, we reviewed the mechanisms involving broken telomeres due to chaotic circadian rhythm, altered neuronal activity, nucleus dysfunction, and induced whole brain’s response speed.Results Insufficient sleep exerts significant negative effects on both physiological and psychological health. …”
Get full text

Pediatric heart failure: Current approach and treatment by Benjamin A. Olsen, Shelley D. Miyamoto

“…This review will focus on myocardial failure related to intrinsic cardiomyocyte, or cardiac muscle cell, dysfunction. While myocardial failure is a shared pathway in adult and pediatric HF, unique disease mechanisms are observed in pediatric patients, providing potential explanations for why existing HF treatment regimens are more effective in adults than children. …”
Get full text

The “Mother Load” and Return to Sport: A Case Report of Returning to Professional Netball Following Cesarean Section by Alexandra Diggles

“…Athletes have a higher risk of pelvic floor dysfunction (PFD) than non-athletes (54% versus 7%) and there is also an increased prevalence in post-partum women compared to nulliparous women (35% versus 2.8-7.9%). …”
Get full text

Fibrinogen and Neuroinflammation in the Neurovascular Unit in Stroke by Chen Y, Han L, Zhu DS, Guan YT

“…Recent evidence suggests that stroke pathophysiology extends beyond vascular dysfunction to include complex interactions within the neurovascular unit (NVU), particularly involving fibrinogen. …”
Get full text

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis by Yunan Gao, Hongxiao Yang, Yanbin Fan, Lin Li, Jiahui Fang, Wei Yang

“…Doxorubicin (DOX) remains the most effective anticancer agent which is widely used in several adult and pediatric cancers, but its application is limited for its cardiotoxicity and hepatotoxicity. …”
Get full text

Molecular Dynamics-Assisted Discovery of Novel Phosphodiesterase-5 Inhibitors Targeting a Unique Allosteric Pocket by Weihao Luo, Runduo Liu, Xinlin Cai, Qian Zhou, Chen Zhang

“…However, most of the reported PDE5 inhibitors lack specificity over PDE6, a holoenzyme in eleven PDE families, which may cause various adverse effects. Targeting a unique allosteric pocket has proved to be an effective approach to designing selective PDE5 inhibitors. …”
Get full text

Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility by Paulo César Gete Palacios, Alberto Moscona-Nissan, Renata Saucedo, Aldo Ferreira-Hermosillo

“…Bariatric surgery has been described as the most effective intervention for obesity, with improved fertility outcomes. …”
Get full text

Micromeria congesta Alleviates LPS‐Induced Inflammation, Apoptosis, Oxidative Stress and DNA Damage in Rat Heart and Kidneys by Muhammet Bahaeddin Dörtbudak, Muhammed Demircioğlu, Fuat Serkan Kapucuk

“…ABSTRACT Life‐threatening sepsis with high mortality and morbidity is an important cause of acute kidney injury and myocardial dysfunction. In this study, we investigated the protective effect of Micromeria congesta (MC) against kidney and heart damage caused by lipopolysaccharide (LPS) used as a sepsis model. …”
Get full text

Diabetic patients and postoperative complications in colorectal surgery by Ioana Paunica, Adrian Silaghi, Daniela Gabriela Bălan, Bogdan Socea, Cristian Balalau, Florin Silviu Groseanu, George Alexandru Popescu, Dragos Epistatu, Vlad Denis Constantin

“…Postoperative ileus, characterized by gastrointestinal dysmotility, is common in diabetic patients due to neuropathic dysfunction and altered intestinal metabolism. In addition, diabetic patients are at increased risk of intestinal ischemia, requiring specific perioperative care. …”
Get full text

Otorhinolaryngological Problems in Mucopolysaccharidoses: A Review of Common Symptoms in a Rare Disease by Anna Waśniewska-Włodarczyk, Renata Pepaś, Oskar Rosiak, Wiesław Konopka

“…The earlier the diagnosis is made, the more effective treatment is. Ineffective or delayed treatment leads to premature death. …”
Get full text

Sonic Hedgehog signaling in spinal cord injury: mechanisms and therapeutic implications by Mingjuan Du, Xiaozhen Ji, Weiting Chen

“…Spinal cord injury is a serious neurological condition that results in severe dysfunction below the level of injury, often leading to long-term disability and impaired quality of life. …”
Get full text

From lab to real-life: A three-stage validation of wearable technology for stress monitoring by Basil A. Darwish, Shafiq Ul Rehman, Ibrahim Sadek, Nancy M. Salem, Ghada Kareem, Lamees N. Mahmoud

“…Stress negatively impacts health, contributing to hypertension, cardiovascular diseases, and immune dysfunction. While conventional diagnostic methods, such as self-reported questionnaires and basic physiological measurements, often lack the objectivity and precision needed for effective stress management, wearable devices present a promising avenue for early stress detection and management. …”
Get full text

Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Wit... by Franco Cavaleri, Sukalpa Chattopadhyay, Vrushalee Palsule, Pradip Kumar Kar, Ritam Chatterjee

“…Ashwagandha extracts play a significant role in traditional Indian medicine to help treat a wide range of disorders from amnesia, erectile dysfunction, neurodegenerative and cardiovascular diseases, cancer, stress, anxiety, and many more. …”
Get full text

Terahertz photons promote neuron growth and synapse formation through cAMP signaling pathway by Yuan Zhong, Yun Yu, Yangmei Li, Junkai Yin, Yuankun Sun, Rundong Jiang, Chao Chang

“…Overall, our results suggest THz photon stimulation as an effective and specific method for neuromodulation, promising for future applications in the treatment of cognitive dysfunction.…”
Get full text

Modern views on etiology and pathogenesis of Parkinson's disease by А.V. Kutsak, N. M. Buchakchyiska

“…Their identification will provide the basis for the effective preventive and predictive capabilities development. …”
Get full text

Cancer pain: molecular mechanisms and management by Wan-Li Wang, Yi-Hang Hao, Xin Pang, Ya-Ling Tang

“…Despite extensive research efforts and the existence of clinical guidelines, significant controversies persist regarding the molecular mechanisms underpinning cancer pain as well as the most effective management strategies. This review systematically delves into the neurobiological underpinnings of cancer pain, centering on the interplay of peripheral and central sensitization, cellular stress and dysfunction, as well as the crucial roles of various signaling pathways and epigenetic regulation in its pathogenesis. …”
Get full text

The Role of Regulatory T Cells and TH17 Cells in Multiple Myeloma by Walter M. T. Braga, Djordje Atanackovic, Gisele W. B. Colleoni

“…In MM patients, Tregs seem to contribute to myeloma-related immune dysfunction and targeting them could, therefore, help to restore and enhance vital immune responses. …”
Get full text

A New Approach for Brain Tumor Detection Using Machine Learning by Elsadek Hussien Ibrahim, Shaaban Ebrahim Abo-Youssef, Khaled El-Bahnasy, Khaled Ahmed Mohamed Fathy

“… Introduction: The abnormal brain cells consist of brain tumor which leads to severe organ dysfunction and potentially death. These tumors exhibit a wide range of sizes, textures, and locations. …”
Get full text