Targeting Shp2 as a therapeutic strategy for neurodegenerative diseases by Jiao Pang, Changqian Cen, Yuan Tian, Xingrui Cao, Liang Hao, Xueshu Tao, Zhipeng Cao

“…However, most of the current governance strategies are palliative and lack effective therapeutic drugs. Therefore, elucidating the pathological mechanism of NDs is the key to the development of targeted drugs. …”
Get full text

Predictive Value of AIP and AGR for Non-alcoholic Fatty Liver Disease and Significant Liver Fibrosis by Zhang Simin, Zhou Changyu, Shi Xianquan, Huang Lizhen

“…Plasma atherogenic Index (AIP) is used to assess the risk of cardiovascular disease and metabolic dysfunction, and albumin to glutamyltransferase ratio (AGR) is often used to assess liver function, nutritional status, and immune system diseases. …”
Get full text

Intraoperative application of different imaging techniques in sacral neuromodulation: a systematic review and meta-analysis by Jialei Zhao, Haibin Tang, Rutong Xu, Gang Chen

“…Abstract Background Sacral neuromodulation (SNM) treats bladder dysfunction by implanting electrodes in the sacral foramen to regulate bladder reflexes. …”
Get full text

Sinapic Acid Ameliorates Doxorubicin-Induced Cardiotoxicity in H9c2 Cardiomyoblasts by Inhibiting Oxidative Stress Through Activation of the Nrf2 Signaling Pathway by Tsendsuren Tungalag, Hyung-Sub Kang, Dong Kwon Yang

“…SA effectively rescued the cells from Dox-induced cardiotoxicity. …”
Get full text

Alzheimer’s Disease in the Age of Precision Medicine: Advances in Pathophysiology, Clinical Management and Therapeutic Strategies by Michał Piotrowski, Piotr Serwicki, Szczepan Pośpiech, Jakub Prosowski, Jakub Początek, Jessika Schendzielorz

“…Overcoming current research limitations and healthcare accessibility issues will be critical to translating these innovations into effective clinical practice. …”
Get full text

Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial by Nafrialdi Nafrialdi, Johannes Hudyono, Frans D Suyatna, Arini Setiawati

“…Background: the use of statin to lower blood cholesterol is often associated with bothersome adverse effects such as myopathy and liver dysfunction. NC120 is herbal lipid lowering drug containing red yeast rice (RYR) extract, guggulipid, and chromium picolinate, and expected to have better safety profile. …”
Get full text

Improving cellular fitness of human stem cell-derived islets under hypoxia by Xi Wang, Shlomi Brielle, Jennifer Kenty-Ryu, Nataly Korover, Danny Bavli, Ramona Pop, Douglas A. Melton

“…Abstract Stem cell-derived islet cell therapy can effectively treat type 1 diabetes, but its efficacy is hindered by low oxygen supply post-transplantation, particularly in subcutaneous spaces and encapsulation devices, leading to cell dysfunction. …”
Get full text

The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury by Chih-Jen Liu, Lu-Kai Wang, Fu-Ming Tsai

“…These agents are expected to offer safer and more effective treatment options for cancer patients in clinical practice.…”
Get full text

Understanding risk factors and prognosis in diabetic foot ulcers by Wang Jixue, Yang Xirui, Zhou Tao, Ma Haitao, Yuan Xingxing, Yan Shuxun

“…Effective management of DFUs necessitates a comprehensive understanding of their risk factors and prognostic indicators. …”
Get full text

Recent advancements in the role of phytochemicals and Medicinal plants in prophylaxis and management of Alzheimer’s disease by Akanksha Mishra, Sairam Krishnamurthy

“…Several mechanistic pathways are involved in AD including anticholinesterase activity, glutamate toxicity, free radicals generation, Amyloid β (Aβ) toxicity, inflammation, and mitochondrial dysfunction. Various phytochemicals such as paenol, andrographolide, isoquercitrin, flavonoids, and saponins obtained from different plant sources, various medicinal plants like Spirulina maxima, Salicornia europaea, Curcuma longa, Citrus Junos Tanaka, Cassiae semen, Centella asiatica as well as various traditional medicinal plants of China, Asia, Europe, Turkey, and Iran have been found effective against one or more of these targets. …”
Get full text

Assessment of mental health in adults of the northern part of the city of Kosovska Mitrovica by Mirković Momčilo, Simić Snežana, Trajković Goran

“…Mental health disorders lead to disorder of effective functioning of people and deterioration of quality of life. …”
Get full text

Dysosmia syndrome in COVID-19, сlinic, treatment and prevention by V. V. Skvortsov, V. B. Petrunicheva, D. I. Rodin

“…Therefore, it is necessary to develop an effective treatment plan for this complication of COVID-19 infection and conduct preventive education of the entire population.…”
Get full text

Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression by Lina Gliaudelytė, Steven P. Rushton, Rolando Berlinguer-Palmini, Alan J. Thomas, Christopher M. Morris

“…Dysfunction of dopaminergic neurotransmission contributing to anhedonia and loss of motivation has been described in MDD. …”
Get full text

Sleep-promoting non-pharmacological interventions to prevent delirium in the critically ill: scoping review by Catarina Barata, Marta Arsénio, Sérgio Deodato, Filipa Veludo

“… Introduction: Delirium is a syndrome characterised by an acute onset, with signs of acute brain dysfunction and fluctuations in the state of consciousness.  …”
Get full text

Emergency thyroidectomy for poorly controlled hyperthyroidism in the context of war in Ukraine by S. I. Savoliuk, A. Ye. Kovalenko, A. V. Zabronskyi

“…Urgent surgical intervention for hyperthyroidism can be safely performed when using effective protocols for accelerated preoperative preparation. …”
Get full text

In vitro electrophysiological characterization of Parkinson’s disease: challenges, advances, and future directions by Sara Grasselli, Andrea Andolfi, Donatella Di Lisa, Donatella Di Lisa, Laura Pastorino, Laura Pastorino

“…This review highlights the importance of employing electrophysiological techniques, such as patch-clamp recordings and microelectrode arrays, in providing critical insights into neuronal dysfunction, synaptic impairments, and network disruptions in Parkinson’s disease. …”
Get full text

Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures by Chengfeng Xing, Guili Liang, Xin Yu, Anxing Zhang, Xiang Luo, Yu Liu, Zengli Tang, Bian Wu, Zhengji Song, Danfeng Lan

“…Intestinal epithelial dysfunction is critical in the development of inflammatory bowel disease (IBD). …”
Get full text

Correlation between Chinese visceral adiposity index and serum uric acid levels in type 2 diabetes mellitus patients by Swailla Amina Araújo Intchasso Adotey, Qian Zhang, Mengxue Chen, Yang Jiao, Yin Zhang, Claudette Butoyi, Dong Wang, Ling Yang, Guoyue Yuan, Jue Jia

“…PurposeThe Chinese Visceral Adiposity Index (CVAI), a measure of visceral adiposity dysfunction, is used to assess visceral fat (VFA) malfunction. …”
Get full text

Ferroptosis-associated pathological injury mechanisms and therapeutic strategies after intracerebral hemorrhage by Yuhua Gong, Yuhua Gong, Fumei Yang, Ying Liu, Yuping Gong

“…However, there is no effective clinical treatment that can significantly improve the prognosis of ICH patients. …”
Get full text

Opportunities for Earlier Diagnosis and Treatment of Cardiac Amyloidosis by Trejeeve Martyn, Andres Carmona Rubio, Jerry D. Estep, Mazen Hanna

“…Therapeutics for transthyretin cardiomyopathy (ATTR-CM) are most effective when administered before significant symptoms of cardiac dysfunction manifest, making early identification of affected individuals of paramount importance. …”
Get full text