In Vivo and In Vitro Evaluation of the Feasibility and Safety Profiles of Intraarticular Transplantation of Mitochondria for Future Use as a Therapy for Osteoarthritis by Carlos Vaamonde-Garcia, Tamara Hermida-Gómez, Sara Paniagua-Barro, Elena F. Burguera, Francisco J. Blanco, Mercedes Fernández-Moreno

“…No efficient treatment is currently available. Mitochondrial dysfunction in chondrocytes drives molecular dysregulation in OA pathogenesis. …”
Get full text

Research progress on influencing factors and risk prediction models of frailty in elderly stroke patients (老年脑卒中患者衰弱影响因素及风险预测模型的研究进展)... by YU Yue (余月)

“…Frailty, as a common multisystem dysfunction in the elderly, significantly increases the mortality rate and functional dependence of stroke patients. …”
Get full text

Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis by Lihui Liu, Lihui Liu, Yisong He, Yisong He, Gang Huang, Yangxi Zeng, Yangxi Zeng, Jiaan Lu, Ru He, Haiqing Chen, Yuheng Gu, Qingwen Hu, Bin Liao, Bin Liao, Juyi Wan, Juyi Wan

Get full text

OXIDATIVE STRESS AND POSSIBILITY TO CORRECT IT WITH ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN PATIENTS WITH MYOCARDIAL INFARCTION ASSOCIATED WITH DIABETES MELLITUS TYPE 2 by K. S. Lexina, N. Y. Timofeeva, V. S. Zadionchenko, G. G. Shehian, K. A. Aldushina

“…It is determined that oxidative stress is involved in the development of myocardial ischemia, reperfusion-syndrome, endothelial dysfunction and atherogenesis. There are data that angiotensin converting enzyme inhibitor, zofenopril, has both cardio- and vasoprotective activities as well as antioxidative effect. …”
Get full text

The ‘Mystery’ of Opioid-Induced Diarrhea by Silviu Bril, Yoav Shoham, Jeremy Marcus

“…Bowel dysfunction, mainly constipation, is a well-known and anticipated side effect of opioids. …”
Get full text

Immune regulation and organ damage link adiponectin to sepsis by Lili Zhang, Yuning Lin, Zhongying Zhang, Yuting Chen, Jinqing Zhong

“…It involves a disruption of immune homeostasis, marked by the release of Inflammatory factors and dysfunction of immune cells. Adiponectin is widely recognized as an anti-inflammatory mediator, playing a crucial role in regulating immune cell function and exerting protective effects on tissues and organs. …”
Get full text

Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…Fine particulate matter (PM2.5) is increasingly recognized for its detrimental effects on human health, with substantial evidence linking exposure to various forms of cell death and dysfunction across multiple organ systems. …”
Get full text

Metrnl protects intestinal barrier function by regulating tight junctions via the IKKβ/IκBα/NFκB/MLCK/MLC signaling pathway by Zhi-Yong Li, Heng-Yu Luo, Fei Xu, Yao Xu, Chun-Hui Ma, Sai-Long Zhang, Sheng Xu, Yuan-Yuan Ma, Nan Li, Chao-Yu Miao

“…The NFκB inhibitor PDTC reversed this effect both in vivo and in vitro. Macrophages played an essential role in Metrnl’s intestinal barrier protective effects during endotoxemia, but were not necessary in burn-induced barrier injury, suggesting potential differences in mechanism between these conditions. …”
Get full text

Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway by Yifan Lai, Jiawei Qiu, Kuang Zheng, Xiang Li, Yinuo Lin, Zhengzheng Li, Haiqiu Sun

“…Our results revealed that metformin effectively triggered mitophagy in HEI-OC1 cells. Moreover, metformin treatment showed the ability to prevent tert-butyl hydroperoxide (TBHP) induced mitochondrial dysfunction and intrinsic apoptotic pathways. …”
Get full text

Distinct sensorimotor cough features in a cohort of Progressive Supranuclear Palsy by Michela J. Mir, Justin Childers, Yuhan Mou, Bryn Taylor, Karen Wheeler-Hegland

Get full text

CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells by Fang Wang, Linlin Zhao, Yingguang Shan, Ran Li, Guijun Qin

“…However, the role of CTRP3 in high glucose- (HG-) related endothelial dysfunction remains unclear. This study evaluates the effects of CTRP3 on HG-induced cell inflammation and apoptosis. …”
Get full text

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery by Bahareh Jafari, Mahmoud Gharbavi, Yasamin Baghdadchi, Hamidreza Kheiri Manjili, Javad Mahmoudi, Iraj Jafari-Anarkoli, Shayan Amiri, Mir-Jamal Hosseini

“…In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. …”
Get full text

Five-Year Follow-Up of a Cordotomy by Jan J Meeuse, Arnoud CM Vervest, Johannes H van der Hoeven, An KL Reyners

“…Five years after the procedure, a qualitative and quantitative evaluation of the long-term effects was performed. Sensory dysfunction was observed in the left side of the body, but no motor neuron or autonomic dysfunction was observed. …”
Get full text

Autophagy in alzheimer disease pathogenesis and its therapeutic values by Gabrielle Angst, Nuo Jia, Luis E. Tron Esqueda, Yanbo Fan, Qian Cai, Chenran Wang

“…AD is a heavy burden in an ageing society as there are no effective therapies in treating the causes or slowing down its progression. …”
Get full text

Management of Rotator Cuff Injuries: Surgical Repair vs. Conservative Treatment by Julia Szalajska, Filip Czyżewski, Iga Wiak, Klaudia Wojtach, Filip Banyś, Artur Łukawski, Konrad Bochen, Filip Jasiński, Anna Dziegciarczyk, Weronika Górska

“… Rotator cuff injuries are a common cause of shoulder pain and dysfunction, resulting from acute trauma or degenerative changes. …”
Get full text

An overview of benign prostatic hyperplasia and its appreciation in Greco-Arab (Unani) system of medicine by Shabir Ahmad Bhat, Shameem Ahmad Rather, Naquibul Islam

“…Objective: Conventional treatments for benign prostatic hyperplasia (BPH) like 5alpha-reductase inhibitors and invasive surgery are associated with some obvious side effects. Conversely, evidence, though limited, has shown that alternative medicines are safer and have potential to improve the lower urinary tract symptoms (LUTS) and quality of life in addition to improving sexual dysfunction in patients with BPH. …”
Get full text

Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment by Qin Wang, Xin Wang, Zhizhong Shang, Long Zhao

“…Abstract Spinal cord injury (SCI) involves a continuous and dynamic cascade of complex reactions, with mitochondrial damage and dysfunction-induced energy metabolism disorders playing a central role throughout the process. …”
Get full text

Disrupted microsaccade responses in late-life depression by Yao-Tung Lee, Ying-Hsuan Tai, Yi-Hsuan Chang, Cesar Barquero, Shu-Ping Chao, Chin-An Wang

“…Thus, it is imperative to develop objective and cost-effective methods for detecting LLD. Individuals with depression often exhibit disrupted levels of arousal, and microsaccades, as a type of fixational eye movement that can be measured non-invasively, are known to be modulated by arousal. …”
Get full text

Immunometabolic Interactions in Obesity: Implications for Therapeutic Strategies by Qin Fei, Jueru Huang, Yi He, Yufeng Zhang, Xiaojun Zhang, Jing Wang, Qiang Fu

“…This review examines the bidirectional relationship between obesity and immune dysfunction, focusing on how immune cell infiltration in adipose tissue drives inflammatory processes. …”
Get full text

Metabolic and Hormonal Changes in Pediatric Burn Patients: Mechanisms, Evidence, and Care Strategies by Gloria Pelizzo, Valeria Calcaterra, Michela Marinaro, Paola Baldassarre, Carlotta Paola Maria Canonica, Gianvincenzo Zuccotti

“…Timely nutritional support and individualized plans preserve muscle mass, promote wound healing, and reduce complications and organ dysfunction risk. Advances in pharmacological interventions, such as beta-blockers, anabolic agents, and hormonal treatment, offer promising pathways to improve recovery and mitigate long-term complications. …”
Get full text