Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis by Ze-Xi Jia, Meng-Tian Guo, Mei-Mei Li, Pan Liao, Bo Yan, Wei Zhang, Fang-Yuan Cheng, Ya-Ru Liu, Zi-Han Zhang, Cheng Wei, Jie Zhou, Fang-Lian Chen, Ping Lei, Xin-Tong Ge

“…Conclusions Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage. …”
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Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools by Xiao Zhang, Yuchang Di, Yu Zhang, Youwei Hu, Mingzhe Chi, Jian Kang, Yuqing Zheng, Hengyu Wang, Yu Wang, Jiazhen Chen, Xuelian Zhang

“…This study demonstrates that NrdE is integral to Mycobacterium survival and genomic stability and that its RNR dysfunction creates a mutagenic environment under selective pressure, indirectly contributes to the development of drug resistance, positioning NrdE as an effective target for therapeutic strategies and a valuable molecular marker for early detection of drug-resistant Mtb.…”
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Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis by Wenya Zhu, Jialing Ma, Tingting Zhang, Mengmeng Zhu, Yajun Duan, Xiaoxiao Yang, Yuanli Chen

“…IntroductionCluster of differentiation 36 (CD36) is highly expressed in the liver of patients with metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatohepatitis (MASH). …”
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Short-term impact of tirzepatide on metabolic hypogonadism and body composition in patients with obesity: a controlled pilot study by Sandro La Vignera, Rossella Cannarella, Vincenzo Garofalo, Andrea Crafa, Federica Barbagallo, Rosita A. Condorelli, Aldo E. Calogero

“…This condition exacerbates metabolic dysfunction and increases the risk of type 2 diabetes mellitus (DM). …”
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A novel cross-linked haemoglobin-based oxygen carrier is beneficial to sepsis in rats by Lei Kuang, Yu Zhu, Jie Zhang, Yue Wu, Kunlun Tian, Xiangyun Chen, Mingying Xue, Fei Chuen Tzang, Billi Lau, Bing Lou Wong, Liangming Liu, Tao Li

“…Pathological hypoxia-induced organ dysfunction contributes to the high mortality of sepsis. …”
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HIIT versus MICT in MASLD: mechanisms mediated by gut-liver axis crosstalk, mitochondrial dynamics remodeling, and adipokine signaling attenuation by Dongkun Deng, Lin Xu, Yufei Liu, Chang Li, Qingfeng Jiang, Jiaming Shi, Shuo Feng, Yunhua Lin

“…Abstract Objective Compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on metabolic dysfunction-associated steatotic liver disease (MASLD), focusing on the mechanisms by which these two exercise modalities influence gut microbiota structure, bile acid metabolism, and intestinal barrier function, as well as their regulatory roles in hepatic lipid synthesis and oxidative dynamics. …”
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Assessment of structural and functional changes in recipient's transplanted heart in the long-term postoperative period by M. Sh. Khubutiya, Kh. G. Alidzhanova, A. V. Dyatlov, A. A. Ivannikov, S. Yu. Shemakin, D. A. Kosolapov

“…Heart transplantation is an effective way of treating patients with end-stage heart failure. …”
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Clinical efficacy of gliclazide with modified release after myocardial infarction in patients with concomitant type 2 diabetes by N. S. Mykhailovska

“…Conclusions: gliclazide modified release long-term use in patients with myocardial infarction with type 2 diabetes mellitus has a positive effect on the clinical course of the disease, which is manifested in a decrease in frequency of development non-fatal myocardial infarction and mortality 2.29 times during the 12 months of observation, provides effective glucometabolic control and optimum portability.In patients with myocardial infarction with type 2 diabetes mellitus gliclazide modified release reduces the severity of hyperinsulinemia, hiperleptynemiyi and signs of endothelial dysfunction, prevents thrombus formation, reduces the concentration of proinflammatory cytokines during 12 months of therapy.…”
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Immediate and long-term results of the use of balloon angioplasty with stenting in the treatment of renal graft arterial stenosis by A. V. Shabunin, P. A. Drozdov, V. A. Tsurkan, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, S. A. Astapovich, I. A. Zyablikov

“…Stenosis was manifested by renal graft dysfunction with a progressive increase in urea and creatinine in 6 patients (75%), by arterial hypertension in 2 patients (25%). …”
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Histidine triad nucleotide‐binding protein 2 attenuates doxorubicin‐induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice by Hao Jiang, Jinyan Zhang, Daile Jia, Liwei Liu, Jinfeng Gao, Beijian Zhang, Zhen Dong, Xiaolei Sun, Wenlong Yang, Tiantong Ou, Suling Ding, Luna He, Yiqin Shi, Kai Hu, Aijun Sun, Junbo Ge

“…Abstract Doxorubicin (DOX) is an effective chemotherapy drug widely used against various cancers but is limited by severe cardiotoxicity. …”
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Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events by Michal Lotem, Limor Rubin, Aviv Talmon, Yaarit Ribak, David Lavie, Hovav Nechushtan, Nadia Caplan, Oded Shamriz, Irit Adini, Yuval Tal

“…There were no signals of negative impacts, such as tumor progression following IL5 axis inhibition.Eosinophilia secondary to ICI therapy can lead to organ dysfunction. Discontinuation of ICI might not be effective and symptoms may be refractory to steroid therapy hence targeted inhibition of the IL5 axis should be considered.…”
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Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands by Takashi I, Riho Kanai, Makoto Seki, Hideki Agata, Hideaki Kagami, Hiroshi Murata, Izumi Asahina, Simon D. Tran, Yoshinori Sumita

“…Introduction: We recently developed a new therapy using effective-mononuclear cells (E-MNCs) and demonstrated its efficacy in treating radiation-damaged salivary glands (SGs). …”
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Research progress on the relationship between gut microbiota and ferroptosis after ischemic stroke by PEI Xinyu, WU Minmin, ZHU Luwen

“…The occurrence of IS causes organ dysfunction. The effects on the gastrointestinal system lie mainly in the two-way communication between the intestine and the brain, involving the brain, gut microbiota and intestinal tissue, and it has been considered to be a key component of IS prognosis. …”
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Adaptation Robotics and Cognitive Load: Use of a Supernumerary Finger for Activities of Daily Living by Rateb Katmah, Mohammad I. Awad, Fatimah Al-Ani, Mohammed Khan, Feryal A. Alskafi, Irfan Hussain, Herbert F. Jelinek, Kinda Khalaf

“…The increasing global prevalence of stroke has heightened the need for effective rehabilitative solutions which address both motor and cognitive dysfunction simultaneously. …”
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A Senescence-Associated Gene Signature for Prognostic Prediction and Therapeutic Targeting in Adrenocortical Carcinoma by Hangya Peng, Qiujing Chen, Lei Ye, Weiqing Wang

“…Bioinformatics analysis identified potential chemotherapeutic agents, including BI-2536 and MIM1, as more effective treatment options for high-risk patients. …”
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The application of the biological treatment in atopic dermatitis: focus on dupilumab by Yu. S. Smolkin, S. S. Masalskiy, O. Y. Smolkina

“…Skin lesions, itching, and sleep dysfunction lead to impaired social adaptation and work performance.Systemic immunosuppressants are used for  the treatment of  severe AD.  …”
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Roles of extracellular vesicles from different origins in metabolic-associated fatty liver disease: progress and perspectives by Jing Wang, Shuoqiang Bao, Qi An, Caihong Li, Juan Feng

“…Also, the review explored microbial-derived EVs as novel therapeutic targets, particularly in relation to insulin resistance, liver inflammation, and dysfunction in MAFLD. Overall, by exploring the diverse roles of EVs from host, plant, and microbiota sources in MAFLD, this review offers valuable insights into their potential as non-invasive biomarkers and novel therapeutic strategies, which could pave the way for more effective diagnostic and treatment options for this increasingly prevalent liver disease. …”
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Review of respiratory syndromes in poultry: pathogens, prevention, and control measures by Huixin Liu, Sijia Pan, Chenchen Wang, Wenwen Yang, Xiaofang Wei, Yang He, Ting Xu, Kaichuang Shi, Hongbin Si

“…Abstract Respiratory syndromes (RS) include a variety of diseases that lead to respiratory dysfunction, resulting in significant economic losses for the poultry industry. …”
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Grape seed proanthocyanidins improve lymphatic drainage and blood perfusion in secondary lymphedema models by Hwayeong Cheon, Bumchul Kim, Jae Yong Jeon, Jae Yong Jeon

“…Considering the current lack of effective pharmacologic therapies for SLE, GSPE represents a promising candidate for future clinical applications. …”
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The impact of a heart failure management protocol based on a hospital-community pharmacist collaboration by Junichi Terashima, Takahiro Kambara, Eisei Hori, Masahiro Fukatsu, Yukina Ichiki, Eri Oki, Risako Koketsu, Rika Taguchi, Suzuka Mii, Ryoka Hiro, Teruhiro Sakaguchi, Hiroyuki Osanai, Tomoya Tachi, Tadashi Suzuki

“…Abstract Background Heart failure has a high readmission rate, but interventions by multiple professionals are effective. Although there is growing interest in the management of heart failure by community pharmacists in Japan, no effective method has been developed. …”
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