Severe myocarditis as a cause of the formation of cardiorenal syndrome in a patient with refractory rheumatoid arthritis by Z. Yu. Mutovina, A. V. Gordeev, I. V. Rozanova, E. A. Galushko

“…Complete regression of myocarditis and cattle occurred precisely against the background of effective treatment of refractory rheumatoid arthritis (RA) with basic antirheumatic drugs and the successful use of biological therapy.…”
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Clinical case of liver transplantation in a kidney transplant recipient with hepatocellular cancer and сoronary artery disease by A. V. Shabunin, Z. A. Bagatelia, P. A. Drozdov, A. G. Komarova, S. A. Bliznyuk, G. S. Michailyants, E. Yu. Astapovich, S. A. Astapovich, V. A. Tsurkan, Yu. I. Mitchenko, P. E. Pazenko

“…Our treatment experience has shown the effectiveness and necessity of a multidisciplinary approach, early diagnosis, therapy modification during transplantation and further treatment of patients with end-stage multiple organ dysfunction.…”
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Longitudinal Extensive Transverse Myelitis due to Varicella-Zoster Virus Infection in an Undiagnosed HIV-Positive Patient by Elahe Yaghmaei, Ahmad Najafi, Reza Daneshvar Kakhki

“…When a patient presents with skin shingles along with myelopathy, varicella-zoster myelitis should be considered, and the patient should be evaluated in terms of immune system dysfunction. Treatment with acyclovir has been shown to be effective in reducing clinical symptoms in such cases.…”
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Development of a machine learning model for predicting renal damage in children with closed spinal dysraphism by Yu He, Wan-liang Guo, Ming-chang Zhang

“…This study aims to develop an effective machine learning model to predict renal damage in children with CSD. …”
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A Review: Can Cytokines Induce Vascular Inflammation as a Sequela of Viral Infections? by Shahana Akhter Deena, Samia Aziz Tonima, Sakif Ahamed Khan, Mohammad Shahangir Biswas, Syed Masudur Rahman Dewan

“…In this piece, we looked at one of these effects that influence the venous system of the body, vasculitis, an inflammation of the blood vessels. …”
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Potential of valsartan+sacubitril therapy in hypertensive heart disease by A. G. Ovchinnikov, A. D. Gvozdeva, A. V. Potekhina, M. V. Vitsenya, F. T. Ageev

“…Since no effective treatment has yet been found for HFpEF, the main way for HHD treatment should be to prevent the diastolic dysfunction progression, which justifies valsartan+sacubitril therapy starting from the early/ asymptomatic stages.…”
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Modulator-refractory cystic fibrosis: Defining the scope and challenges of an emerging at-risk population by Lindsay Somerville, Larry Borish, Imre Noth, Dana Albon

“…Cystic fibrosis (CF) causes life-shortening respiratory and systemic disease due to dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. …”
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Salivary Alpha-Amylase Activity Levels in Catatonic Schizophrenia Decrease after Electroconvulsive Therapy by Misako Kanayama, Tsuyoshi Miyaoka, Tomoko Araki, Maiko Hayashida, Sadayuki Hashioka, Jun Horiguchi

“…Background. Dysfunction of the autonomic nervous system (ANS) in schizophrenia has been detected by electrophysiological methods, but the underlying mechanisms remain unknown. …”
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KDM2B regulates stroke injury by modulating OGT-mediated 0-GlcNAcylation of SLC7A11 by Yi Li, Liangbo Niu, Dai Zheng, Xinxing Zhang, Lu Feng, Jing Fu

“…Currently, recanalization of blood flow through surgery or medication is the only effective means to control ischemia-reperfusion injury. …”
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Advances in Targeted Autophagy Modulation Strategies to Treat Cancer and Associated Treatment-Induced Cardiotoxicity by Lauren A. Ling, Asma Boukhalfa, Andrew H. Kung, Vicky K. Yang, Howard H. Chen

“…Autophagy, an evolutionarily conserved process, plays an important role in cellular homeostasis and human diseases. Cardiovascular dysfunction, which presents during cancer treatment or in cancer-free individuals years after treatment, is a growing clinical challenge. …”
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A study on reasons for replacement of hemodialysis tunneled cuffed catheter with polyester sheath and treatment of complications by BAI Ya-fei, CHEN Ru-man, XU Ming-zhi, AN Na, HE Ji-qing, WANG Chun-li, LI Hong

“…Objective To analyze the reasons, complications, treatment methods and treatment results of the replacement of tunneled cuffed catheter(TCC) in the single center in recent six years, and to provide a safe and effective evidence-based basis for TCC replacement. …”
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Oxidative cell death in the central nervous system: mechanisms and therapeutic strategies by Nan Liu, Nan Liu, Ya Liu, Yingzhao Wang, Chunsheng Feng, Meihua Piao, Ming Liu

“…We also discuss current advances and challenges in clinical trials, and suggest new directions for future research, including biomarker discovery, identification of potential drug targets, and exploration of new therapeutic techniques, with a view to providing more effective strategies for the treatment of CNS diseases.…”
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Lymphocyte subsets and the increased risk for opportunistic infections in severe restrictive anorexia nervosa by Petra Vidmar, Josje Altenburg, Ester M. van Leeuwen, Annemarie C. M. van Bellegem, Chantal Verhoef, Godelieve J. de Bree, Maarten R. Soeters

“…The paper aims to explain the underlying mechanisms of immune dysfunction. Proactive monitoring of immune status and incorporating such assays into clinical practice may benefit early detection, effective management, and ultimately, improved outcomes.…”
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Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats by Omar Ortiz-Avila, Mauricio Esquivel-Martínez, Berenice Eridani Olmos-Orizaba, Alfredo Saavedra-Molina, Alain R. Rodriguez-Orozco, Christian Cortés-Rojo

“…Diabetes is characterized by increased lipid peroxidation, altered glutathione redox status, exacerbated levels of ROS, and mitochondrial dysfunction. Although the pathophysiology of diabetic encephalopathy remains to be clarified, oxidative stress and mitochondrial dysfunction play a crucial role in the pathogenesis of chronic diabetic complications. …”
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TRC120038, a Novel Dual AT1/ETA Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats by Anookh Mohanan, Ram Gupta, Amita Dubey, Vikrant Jagtap, Appaji Mandhare, Ramesh C. Gupta, Vijay Chauthaiwale, Chaitanya Dutt

“…The primary objective of this study was to determine the effect of TRC120038, a novel dual AT1/ETA receptor blocker on BP, in obese Zucker spontaneously hypertensive fatty rats (ob-ZSF1), an animal model of moderate hypertension, diabetes with progressive renal and cardiac dysfunction. …”
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Macrophage differentiation in enhancing hematopoietic function of ribonucleic acid for injection II via multi-omics analysis by Yuan Li, Meng Teng, Siyu Li, Hongxin Yang, Yuebo Zhang, Meihua Cui, Lanzhou Li, Di Wang

“…However, the mechanism underlying the ameliorative effect on immunosuppressed hematopoietic dysfunction remains unclear. …”
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Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease by Yuhui Ma, Yan Han

“…Increasing evidence also suggests that dysfunction in glymphatic clearance is a key factor in the progression of cerebral small vessel disease. …”
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Dual-Network QSAZ@VPH hydrogel-mediated verapamil treatment improved recovery of diabetic ulcer through inhibiting mitochondrial oxidative stress and enhancing angiogenesis by Bin Chen, Hang Li, Yuliang Sun, Yuhua Li, Parisa Anvari, Ghazal Shokraneh, Menglin Cong, AmirMahdi Saeidi, Hecheng Ma, Tian Li, Gang Wang, Junhao Lin, Zhijian Wei

“…In vitro experiments evaluated its protective effects on HUVECs exposed to H2O2-induced mitochondrial dysfunction, including inflammatory marker expression, apoptosis inhibition, and angiogenesis promotion. …”
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Mitochondrial fission inhibitor Mdivi-1 alleviates lipopolysaccharide-induced parvalbumin interneurons dysregulation and cognitive impairments in a mouse model of sepsis-associated... by Lei Dai, Lei Dai, Shuxin Gu, Shuxin Gu, Yibao Zhang, Siqi Ma, Peishan Wang, Peishan Wang, Jingyun Zhang, Jingyun Zhang, Cai Wang, Cai Wang, Gaowei Su, Gaowei Su, Qun Fu, Wei Zhou, Yunxia Fan, Yunxia Fan

“…Introduction:Dysregulation of parvalbumin (PV) interneurons has been implicated in sepsis-associated encephalopathy (SAE), yet the underlying mechanisms remain poorly understood, and effective treatments are lacking. Given the high energy demands of PV interneurons and the emerging role of mitochondrial dynamics in SAE pathophysiology, this study aimed to investigate whether the mitochondrial fission inhibitor Mdivi-1 could alleviate PV interneuron dysfunction and cognitive impairments in a mouse model of SAE.Methods:C57BL/6 male mice were injected with lipopolysaccharide (LPS) to establish an animal model of SAE. …”
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A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases by Siyu Lou, Zhiwei Cui, Yingyong Ou, Junyou Chen, Linmei Zhou, Ruizhen Zhao, Chengyu Zhu, Li Wang, Zhu Wu, Fan Zou

“…Females are more likely to experience elevated blood prolactin and weight increase, whereas males are more prone to sexual dysfunction. Among the 1,065 ADE reports from the JADER database, we identified 51 positive signals, 35 of which overlapped with those found in FAERS, including schizophrenia, hyperprolactinemia, and erectile dysfunction. …”
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