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4081
Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application
Published 2017-01-01“…So far, ultra-early thrombolytic therapy is the most effective treatment. However, most patients still live with varying degrees of neurological dysfunction due to its narrow therapeutic time window. …”
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4082
Peculiarities of micronutrient metabolism in obese pregnant women (literature review)
Published 2021-06-01“…It is important to consider a woman's body mass index to prescribe the minimum effective dose of the necessary drugs. Timely preventive personalized correction of the micronutrient state can reduce the risks of such major obstetric syndromes as preeclampsia, premature birth, fetal growth retardation, miscarriage, and placental dysfunction.…”
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4083
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation
Published 2025-06-01“…Succinate dehydrogenase (SDH) is central to mitochondrial metabolism and targeting SDH with dimethyl malonate (DMM) has been shown to be effective in treating renal ischemia-reperfusion (IR) injury in the murine model. …”
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4084
“Super Responder” of Percutaneous Bicaval Valve Implantation for Severe Tricuspid Regurgitation: A Case Report
Published 2025-01-01“…This case underscores the potential utility of the TricValve system in providing an effective, lower-risk treatment option for patients not suited for traditional surgical intervention.…”
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4085
Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities
Published 2025-09-01“…By consolidating recent research, this review highlights the profound significance of ROS in PCOS, aiming to inspire innovative pathogenesis research, improve clinical management, and establish a robust theoretical foundation for more effective PCOS treatment strategies.…”
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4086
Comparative gastrointestinal organoid models across species: A Zoobiquity approach for precision medicine
Published 2025-03-01“…These models have revolutionized the study of autoimmune disorders, homeostatic dysfunction, and pathogen infections, such as norovirus and Salmonella, which affect millions of humans and animals globally. …”
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4087
Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice
Published 2024-12-01“…This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. …”
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4088
PO72 | Fondaparinux in patient with active tuberculosis
Published 2025-08-01“…Conclusions: the anticoagulation with fondaparinux can be a valid alternative for the treatment of venous thromboembolism in patients on quadruple therapy (isoniazide, ethambutol, rifampin, pyrazinamide) for Mycobacterium tuberculosis infection proving to be safe and effective. …”
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4089
Autoantibodies and the Immune Hypothesis in Psychotic Brain Diseases: Challenges and Perspectives
Published 2013-01-01“…There is a growing body of evidence that points to dysfunction of the immune system in a subgroup of patients with psychosis. …”
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4090
Rehabilitation patients of cerebral stroke
Published 2024-10-01“…Assessment of RP is necessary to develop an effective rehabilitation program and predict the degree of restoration of impaired functions.Objective. …”
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4091
Transcranial Doppler Ultrasonography of the Basilar Artery in Cerebral Small Vessel Disease
Published 2025-04-01“…Although it cannot directly visualize small vessels due to limited spatial resolution, it can detect indirect indicators of microvascular dysfunction—most notably elevated pulsatility index (PI) and reduced end-diastolic velocity (EDV), both of which suggest increased distal resistance and impaired perfusion. …”
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4092
Design and experimentation of the nested pneumatic soft actuator for hand exoskeleton
Published 2025-08-01“…While rigid hand exoskeleton robots are effective, they are often heavy and may cause secondary injuries. …”
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4093
Mitochondrial fusion protein: a new therapeutic target for lung injury diseases
Published 2025-03-01“…Regulating mitochondrial fusion, maintaining mitochondrial dynamics, and improving mitochondrial function are effective strategies for mitigating lung tissue and cellular damage. …”
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4094
Probiotics Containing Collagen Peptides for Weight Loss and Improvement of Brain Disorders Caused by Obesity in a Mouse Model
Published 2025-01-01“…However, the effects of CPP and ORL in female mice were slightly different. …”
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4095
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Published 2025-01-01“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, driven by the accumulation of amyloid-beta plaques and neurofibrillary tangles. It involves the dysfunction of key enzymes such as Acetylcholinesterase (AChE) and β-secretase (BACE1), making them critical targets for therapeutic intervention. …”
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4096
Probable Anti-Glutamate Decarboxylase 65 (Gad65) Antibody-Associated Cerebellar Ataxia. Clinical Case Report and Literature Review
Published 2023-11-01“…As more information about cerebellar ataxia induced by anti- GAD65 antibodies is accumulated, cerebellar dysfunction is increasingly associated with autoimmune causes. …”
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4097
Molecular mechanisms underlying hyperoxia-induced lung fibrosis
Published 2022-03-01“…Many infants with lung fibrosis develop significant respiratory morbidities including reactive airways dysfunction and obstructive lung disease during childhood. …”
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4098
Genetics of familial amyotrophic lateral sclerosis
Published 2021-10-01“…Information about the genes associated with ALS and understanding of particular pathogenetic mechanisms of the disease play a key role in the development of effective therapeutic strategies.…”
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4099
Extracellular Vesicles with Possible Roles in Gut Intestinal Tract Homeostasis and IBD
Published 2020-01-01“…Various studies have found that the dysfunction of intestinal homeostasis contributes to the pathogenesis of inflammatory bowel disease (IBD). …”
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4100
Unraveling Vitiligo: From Immune Mechanisms to Promising Therapeutic Strategies
Published 2024-12-01“…Oxidative stress and mitochondrial dysfunction in melanocytes cause vitiligo, while immune privilege protects hair follicle melanocytes, allowing for possible repigmentation. …”
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