Oxidative Distress in Pathogenesis of Alcoholic Liver and Its Correction by S. P. Smolina, M. M. Petrova, V. I. Sharobaro, S. V. Nikolaev, I. G. Bobrinskaya

“…The aim of the study was to evaluate the effect of the succinatecontaining antioxidants Reamberin and Cytoflavin on (1) free radical oxidation of lipids and functioning of the antioxidant system in patient with alcoholic liver disease and hepatic encephalopathy and (2) severity of hepatocellular dysfunction.Material and methods. …”
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Incidence and risk factors of Post-intensive care syndrome (PICS) in surgical ICU survivors: a prospective Chinese cohort study by Ka Yin Lui, Gen Luo, Shuhe Li, Xiaodong Song, Xiayan Qian, Ruoxu Dou, Liqiong Li, Xiangdong Guan, Changjie Cai

“…PICS diagnosis was determined based on the presence of at least one of the following: physiological dysfunction (defined as PCS reductions greater than 10), psychological dysfunction (defined as MCS reductions greater than 10), or cognitive dysfunction (defined as SMQ reductions and scores less than 40 at six months). …”
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Restoration of Intestinal Propulsion in Patients with Severe Acute Pancreatitis in the Conditions of the Resuscitation and Intensive Care Unit by V. V. Kiselev, S. S. Petrikov, M. S. Zhigalova, S. V. Novikov, N. V. Shavrina, P. A. Yartsev

“…The intestine plays an important role in the processes of systemic inflammation, sepsis and multiple organ dysfunction, in the course of hemorrhagic shock, trauma, burns, pancreatitis, extensive abdominal surgery and in seriously ill patients in intensive care units (ICUs). …”
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Palliative management for malignant biliary obstruction and gastric outlet obstruction from pancreatic cancer by Pengfei Wu, Kai Chen, Jin He

“…While these procedures provide rapid symptom relief, they are associated with higher stent dysfunction rates and more frequent re‐intervention needs. …”
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“Super Responder” of Percutaneous Bicaval Valve Implantation for Severe Tricuspid Regurgitation: A Case Report by Ignatius Yansen, Bayushi Eka Putra, Muhammad Yamin, Simon Salim

“…This case underscores the potential utility of the TricValve system in providing an effective, lower-risk treatment option for patients not suited for traditional surgical intervention. …”
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Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF by Simon Sedej, Alina Stockner, Renate Schreiber, Abhinav Diwan, Rolf Breinbauer, Mahmoud Abdellatif

“…Atglistatin selectively inhibits ATGL in adipose tissue, but not in the heart, leading to superior reduction in adiposity and greater improvement in diastolic dysfunction compared to caloric restriction. These observations underscore the therapeutic potential of selectively targeting adipose tissue, independent of the effects of body weight loss. …”
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Dual regulation of Atf3 and Lonp1 as therapeutic targets in cerebral ischaemia-reperfusion injury by Bo Yu, Lin Zhou, Min Zhou, Weijian Fan, Jindong Tong, Jinyun Tan, Weihao Shi

“…Background Cerebral ischemia-reperfusion injury (CIRI) leads to cognitive dysfunction, neuronal death, and inflammation. Understanding the molecular mechanisms underlying CIRI is crucial for developing effective therapeutic strategies.Objective This study aims to investigate the roles of activating transcription factor 3 (Atf3) and lon protease homolog 1 (Lonp1) in CIRI, particularly focusing on how Atf3 regulates Lonp1 expression and its effects on mitochondrial function.Methods Single-cell transcriptomics and proteomic analyses were employed to explore Atf3's influence on Lonp1 and its subsequent impact on neuronal survival and apoptosis.Results The findings indicate that Atf3 plays a crucial role in modulating Lonp1 expression, which in turn affects mitochondrial function, neuronal survival, and apoptotic pathways.Conclusion This study provides new insights into the regulatory mechanisms of Atf3 and Lonp1 in CIRI, identifying potential therapeutic targets for managing ischemic brain injury and neurodegenerative diseases.…”
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Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology by Daniel Erskine, John-Paul Taylor

“…There is emerging evidence suggesting a range of further pharmacological and non-pharmacological therapies may be effective in treating specific symptom domains of DLB, but further evidence is warranted to demonstrate their efficacy. …”
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The Pathogenesis and Treatment of Insomnia Combined with Depression by Chang Y, Liu L, Xu X, Zhang S

“…A more profound comprehension of the pathophysiological mechanisms and the development of comprehensive and effective treatment strategies for insomnia co-occurring with depression can enhance neuropsychiatrists’ ability to manage this comorbidity more effectively. …”
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Pneumococcal vaccine hyporesponsiveness in people living with HIV: A narrative review of immunological mechanisms and insights from minimally invasive lymph node sampling by Giovanni E. Loe-Sack-Sioe, Danny W. de Vos, Leo G. Visser, Simon P. Jochems, Anna H. E. Roukens

“…Despite highly effective antiretroviral therapy, people living with HIV (PLWH) remain at elevated risk for invasive pneumococcal disease. …”
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Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin by Eric M. George, Drew Colson, Jeremy Dixon, Ana C. Palei, Joey P. Granger

“…One of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and premature birth with no effective pharmacological intervention. While the underlying cause is unclear, it is believed that placental ischemia/hypoxia induces the release of factors into the maternal vasculature and lead to widespread maternal endothelial dysfunction. …”
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Scrub Typhus Induced Thrombotic Thrombocytopenia: A Rare Case Report by Maharshi Patel, Sourya Acharya, Samarth Shukla, Shubham Nimkar, Sunil Kumar

“…In scrub typhus patients, TTP and Multiple Organ Dysfunction Syndrome (MODS) can be avoided with early diagnosis and effective treatment. …”
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Surgical timing and approach for brainstem cavernous malformation warranting thorough preoperative evaluation by Xiao Qian, Weihai Ning, Deshan Liu, Yanming Qu, Hongwei Zhang

“…Abstract Hemorrhage from brainstem cavernous malformations (BSCMs) can cause severe neurological dysfunction. While surgery is effective, the optimal timing remains unclear. …”
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Particularities of the therapeutic procedures and success in treatment of combat-related lower extremities injuries by Šegrt Budimir

“…The aim of this observational study was to determine therapeutic procedures effective in a combat environment and to assess functional outcomes of definitive care. …”
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The clinical signifi cance of urethral sphincter hyperkinesis in the treatment of benign prosta???? c hyperplasia by I. I. Belousov

“…Exactly this fact, that these patients had urethral sphincter dysfunction in 14.5% of cases made for poor effect of surgical treatment of BPH. …”
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Improving retinal vascular endothelial cell tropism through rational rAAV capsid design. by Ramesh Periasamy, Dwani D Patel, Sanford L Boye, Shannon E Boye, Daniel M Lipinski

“…Vascular endothelial cells (VEC) are essential for retinal homeostasis and their dysfunction underlies pathogenesis in diabetic retinopathy (DR) and exudative age-related macular degeneration (AMD). …”
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Non allergic gastrointestinal manifestations of hereditary alpha-tryptasemia by Dylan Vainer, Kathryn Peterson

“…Mast cell mediated activation of protease-activated receptors may contribute to gut barrier dysfunction, exacerbating the gastrointestinal symptoms. …”
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Fuzzy Set and Soft Set Theories as Tools for Vocal Risk Diagnosis by José Sanabria, Marinela Álvarez, Osmin Ferrer

“…This is especially relevant in the field of health sciences, where these theories have great potential to design effective solutions that improve people’s quality of life. …”
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Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and futuredirections by Yajie Hao, Fahui Chen, Xiya Ren, Xiu Huang, Xiaoshuang Zhou

“…AKI suppresses MB, resulting in mitochondrial dysfunction, oxidative stress, and further renal damage. …”
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FCMCoach: Personalized Virtual Coaching Based on Fuzzy Cognitive Maps by Georgia Sovatzidi, Dimitris K. Iakovidis

“…Exercise should be personalized in order to be both effective and safe for the target individual, as excessive and high-intensity training may cause health problems, such as immune or respiratory system dysfunction. …”
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