The Prognostic and Functional Impact of Multimorbidity in Systemic Sclerosis by Jessica L. Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene‐Siew Ngian, Diane Apostolopoulos, Jennifer Walker, Lauren V. Host, Wendy Stevens, Mandana Nikpour, Laura Ross

“…Conclusion Multimorbidity occurred in 20% of patients in a large SSc cohort and was an important determinant of both prognosis and physical function. Effective treatment of non‐SSc morbidity may improve outcomes for patients with SSc.…”
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Intestinal Oxygenotherapy of Critical Conditions by V. A. Mazurok, A. S. Golovkin, I. I. Gorelov, A. E. Bautin, I. N. Menshugin, O. A. Slivin, D. S. Tarnovskaya, V. V. Ivanov, V. G. Nikiforov, K. A. Morozov, A. O. Marichev

“…The latent or mist diagnosed dysfunction of the small intestine is a common disorder in critically ill patients. …”
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Osteosarcopenia in Chronic Kidney Disease: An Overlooked Syndrome? by Lara Caldiroli, Paolo Molinari, Claudia D'Alessandro, Adamasco Cupisti, Carlo Alfieri, Giuseppe Castellano, Simone Vettoretti

“…Increased clinical awareness and research into effective therapies are crucial for improving the quality of life for individuals affected by CKD and osteosarcopenia.…”
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Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model by Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li

“…In addition, we demonstrated the significant cytotoxic effect of CD8+ T cell, which leads to apoptosis of neuron and neurological dysfunction of mice. …”
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Respiratory and Rehabilitation Expert Consensus on Full-Cycle Rehabilitation Assessment and Treatment for Elderly Patients with Chronic Obstructive Pulmonary Disease by CHEN Xin, JIA Jie, DING Yipeng, YE Xujun, DONG Anqin, HE Jing, LIAO Weijing, ZHENG Jiejiao, YU Binbin, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, FU Jianghong, WANG Siyuan, ZHANG Yangxian

“…This expert consensus identifies common functional impairments of elderly patients with COPD, including respiratory dysfunction, exercise tolerance impairment, psychological issues, swallowing dysfunction and cognitive impairment. …”
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The Role of Mental Stress in Ischaemia with No Obstructive Coronary Artery Disease and Coronary Vasomotor Disorders by Roos ET van der Meer, Angela HEM Maas

“…Additionally, psychological stress induces endothelial dysfunction more often in (young) women with INOCA than in men. …”
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Noninvasive biomarkers implicated in urea and TCA cycles for metabolic liver disease by Guiyan Yang, Yu-Jui Yvonne Wan

“…Abstract Bile acid (BA) and its receptor FXR play crucial roles in metabolism, and dysregulated BA synthesis regulated by hepatic and bacterial enzymes causes metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). …”
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Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge. by Clara Rimmer, Savas Hetelekides, Sophia I Eliseeva, Steve N Georas, Janelle M Veazey

“…Airway epithelial barrier dysfunction is increasingly recognized as a key feature of asthma and other lung diseases. …”
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Mitochondrial pathways of copper neurotoxicity: focus on mitochondrial dynamics and mitophagy by Michael Aschner, Anatoly V. Skalny, Anatoly V. Skalny, Anatoly V. Skalny, Rongzhu Lu, Airton C. Martins, Yousef Tizabi, Sergey V. Nekhoroshev, Abel Santamaria, Abel Santamaria, Anton I. Sinitskiy, Alexey A. Tinkov, Alexey A. Tinkov, Alexey A. Tinkov

“…Nonetheless, the role of alterations of mitochondrial dynamics in brain mitochondrial dysfunction induced by Cu exposure is still debatable. …”
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Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model by Liang Mi, Jiangyuan Yuan, Yuxing Jiang, Yuqian Hu, Chuanxiang Lv, Yongqiang Xu, Mingqi Liu, Tao Liu, Xuanhui Liu, Jinhao Huang, Rongcai Jiang, Wei Quan

“…It is essential to find an effective way to inhibit inflammation and repair BBB and glymphatic system after TBI; however, effective and lasting drug therapy remains challenging because BBB severely prevents drugs from being delivered to central nervous system. …”
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Thyroid impairment and male fertility: a narrative review of literature by Valentina Anelli, Elisa Gatta, Ilenia Pirola, Andrea Delbarba, Mario Rotondi, Carlo Cappelli

“…Purpose To evaluate the effect of thyroid function on male fertility, focusing on hypo- and hyperthyroidism.Methods A PubMed/MEDLINE, Web of Science, and Scopus research was performed. …”
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New Biochemical Pathway May Control Erection by Thomas M. Mills

“…Thirty million men in the U.S. suffer from erectile dysfunction (ED) defined by their inability to achieve or maintain a penile erection sufficient for intercourse. …”
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Diastolic Left Ventricular Function in Relation to Urinary and Serum Collagen Biomarkers in a General Population. by Zhen-Yu Zhang, Susana Ravassa, Wen-Yi Yang, Thibault Petit, Martin Pejchinovski, Petra Zürbig, Begoña López, Fang-Fei Wei, Claudia Pontillo, Lutgarde Thijs, Lotte Jacobs, Arantxa González, Thomas Koeck, Christian Delles, Jens-Uwe Voigt, Peter Verhamme, Peter Verhamme, Tatiana Kuznetsova, Javier Díez, Harald Mischak, Jan A Staessen

“…Based on age-specific echocardiographic criteria, 182 participants (23.3%) had subclinical diastolic LV dysfunction. Partial least squares discriminant analysis contrasting normal vs. diastolic LV dysfunction confirmed the aforementioned associations with the uCI and uCIII fragments. …”
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Validity, Reliability and Optimal Cutoff Value of Persian Version of Arizona Sexual Experience Scale (ASEX) (male version) by Firoozeh Raisi, Hamide Sadat Sadrameli, Seyyed Tahs Yahyavi, Mohammalali Seddighi Gilani, Abbasali Nasehi, Azin Ahmadzadeh

“…Conclusion: This modified Persian version of the ASEX for male patients demonstrated adequate validity and reliability for screening sexual dysfunction in Iran. The revised Persian questionnaire shows greater effectiveness than the original questionnaire due to our culture and better understanding of sexual issues in Iranian society. …”
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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. by Matthew E Gegg, J Mark Cooper, Anthony H V Schapira, Jan-Willem Taanman

“…<h4>Background</h4>Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). …”
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Allopurinol attenuates development of Porphyromonas gingivalis LPS-induced cardiomyopathy in mice. by Akinaka Morii, Ichiro Matsuo, Kenji Suita, Yoshiki Ohnuki, Misao Ishikawa, Aiko Ito, Go Miyamoto, Mariko Abe, Takao Mitsubayashi, Yasumasa Mototani, Megumi Nariyama, Ren Matsubara, Yoshio Hayakawa, Yasuharu Amitani, Kazuhiro Gomi, Takatoshi Nagano, Satoshi Okumura

“…In this study, therefore, we examined the effects of the xanthine oxidase inhibitor allopurinol on cardiac dysfunction in mice treated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose (0.8 mg/kg/day) equivalent to the circulating level in patients with periodontal disease. …”
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Heat stroke with sepsis: A case report and review of the literature by Suyu Wei, Liang Sun

“…For eligible patients, hemodialysis should be initiated promptly to manage renal complications effectively.…”
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There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients by Mariana Nogueira Coutinho, Aluizio Barbosa Carvalho, Maria Aparecida Dalboni, Margaret Gori Mouro, Elisa Mieko Suemitsu Higa, Valéria Costa-Hong, Luiz Aparecido Bortolotto, Rejane Augusta de Oliveira Figueiredo, Maria Eugênia Fernandes Canziani

“…The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients. …”
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Par-4/NF-κB Mediates the Apoptosis of Islet β Cells Induced by Glucolipotoxicity by Wu QiNan, Gan XiaGuang, Lei XiaoTian, Deng WuQuan, Zhang Ling, Chen Bing

“…It also causes increased expression and activation of NF-κB, which induced NIT-1 cell apoptosis and dysfunction. Overexpression of Par-4 potentiates these effects, whereas downregulation of Par-4 attenuates them. …”
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Molecular insights into herbal medicines for the treatment of metabolic associated Steatohepatitis by Tamer A. Addissouky

“…Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH), previously known as non-alcoholic steatohepatitis (NASH), represents a severe form of metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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