Lupus-Associated Pulmonary Arterial Hypertension: Variable Course and Importance of Prompt Recognition by Kofi A. Mensah, Rajwardhan Yadav, Terence K. Trow, Cristina M. Brunet, Wassim H. Fares

“…We describe a critically ill young woman with systemic lupus erythematosus (SLE) presenting with circulatory shock, multiorgan dysfunction, and elevated right-sided heart pressures. …”
Get full text

A case of reversible hypoparathyroidism in a patient with Riedel's thyroiditis treated with glucocorticoids by Salma Salhi, Ibtissem Oueslati, Sabrina Ayari, Elyes Kamoun, Meriem Yazidi, Melika Chihaoui

“…Early administration of glucocorticoids may be effective in reducing the fibrosclerotic process and lead to the recovery of parathyroid dysfunction.…”
Get full text

Application of Light Therapy in Brain Function Modulation and Rehabilitation by TAO Qian, SO Kwok-Fai

“…This study systematically reviews the application of light therapy in the rehabilitation of mood disorders, cognitive dysfunction, sleep disorders, and pain. The results support that light therapy exerts a positive regulatory effect on various diseases related to brain function. …”
Get full text

Bioelectric Membrane Potential and Breast Cancer: Advances in Neuroreceptor Pharmacology for Targeted Therapeutic Strategies by Chitaranjan Mahapatra, Jineetkumar Gawad, Chandrakant Bonde, Mahesh B. Palkar

“…Advances in understanding these biological mechanisms could lead to more cost-effective and less invasive therapeutic strategies to treat tumors. …”
Get full text

Mechanisms of active components of Astragalus membranaceus in regulating the NLRP3 inflammasome to attenuate diabetic nephropathy by Qiao Lin, Gao Zhiqiang, Guo Zhaoan, Jin Yan

“…Diabetic nephropathy (DN) is one of the most prevalent microvascular complications of diabetes mellitus (DM), characterized by progressive renal dysfunction, ultimately leading to end-stage renal disease. …”
Get full text

A Multi-Pathology Ballistocardiogram Dataset for Cardiac Function Monitoring and Arrhythmia Assessment by Jing Zhan, Zhengying Li, Xiaoyan Wu, Chao Zhang, Tao Zhao, Kewei Chen, Zhibing Lu

“…Abstract Cardiac dysfunction plays a critical role in clinical diagnostics and treatment. …”
Get full text

Adrenal insufficiency induced by immune checkpoint inhibitors anticancer therapy by Paulina Ramaneckaite, Zuzanna Ratuszna, Julia Brymora, Ewa Zalewska, Renata Stodulska-Świątkowska

“…Therefore, diagnosing adrenal dysfunction requires careful monitoring of cortisol and adrenocorticotropichormone levels during ICIs therapy. …”
Get full text

Beta-adrenoЬlockers in patients with chronic heart failure and chronic obstructive pulmonary disease by M. E. Statsenko, D. A. Ivanova, O. E. Sporova, S. V. Belenkova

“…Comparing to metoprolol, bisoprolol more effectively increased left ventricular (LV) ejection fraction, decreased diastolic dysfunction severity, and reduced LV remodelling, did not affect LF and did not increase airway resistance.Conclusion. …”
Get full text

Redox Imbalance in Cystic Fibrosis: The Multifaceted Role of Oxidative Stress by Ilaria Artusi, Michela Rubin, Giorgio Cozza

“…It elucidates the nuanced connection between LPO and inflammatory processes driven by cellular stressors such as endoplasmic reticulum dysfunction, mitochondrial impairment and persistent bacterial infections. …”
Get full text

Temporal dynamics of Th17 responses to Candida albicans in rheumatoid arthritis: Implications for immunity and treatment by Sri Handayani, Mustofa Mustofa

“…Additionally, biologic therapies targeting the Th17/IL-17 pathway, while effective for RA symptom management, may exacerbate infection risks. …”
Get full text

Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson’s Disease by Ahmed Tanvir, Junghyun Jo, Sang Myun Park

“…These pathological features are exacerbated by mitochondrial dysfunction, oxidative stress, and neuroinflammation, all of which are influenced by glucose metabolism disruptions. …”
Get full text

Exercise Preconditioning Ameliorates Cognitive Impairment in Mice with Ischemic Stroke by Alleviating Inflammation and Modulating Gut Microbiota by Heng Lv, Shasha Wang, Meihui Tian, Liya Wang, Jie Gao, Qitao Zhao, Zhaoyu Li, Xianjie Jia, Ying Yu

“…Several studies have demonstrated that exercise preconditioning is an effective means of alleviating poststroke cognitive impairment (PSCI). …”
Get full text

Interplay between MAPK signaling pathway and autophagy in skin aging: mechanistic insights and therapeutic implications by Xu Liu, Bo Chen, Xuefeng Liu, Xiaoqing Zhang, Jingdong Wu, Jingdong Wu

“…Autophagy, a lysosomal degradation mechanism essential for maintaining cellular homeostasis, demonstrates context-dependent duality in skin aging by mediating cytoprotective effects and stress-induced dysfunction. Emerging evidence highlights that the interplay between MAPK signaling and autophagy critically modulates skin aging progression. …”
Get full text

Rare Toxicities of CAR T-Cell Therapy: Cardiovascular, Hematopoietic and Other Infrequent Adverse Events by Antonia Müller

“…Chimeric antigen receptor (CAR) T-cell therapy has proven to be an effective treatment option for various hematological malignancies. …”
Get full text

Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management by Arya Tjipta Prananda, Princella Halim, Rony Abdi Syahputra

“…Unlocking this synergy could pave the way for more effective, personalized approaches to CVD management, addressing unmet needs in contemporary cardiovascular care.…”
Get full text

Dexmedetomidine Protects the Brain: Exploring the α2AR/FAK Pathway in Post-Stroke Intestinal Barrier Repair by Xinting Zhou, Yan Yang, Zixuan Su, Zhonghui Luo

“…Dexmedetomidine (Dex), an α2-adrenoceptor (α2AR) agonist, has proven anti-cerebral ischemic effects, yet its effects in post-stroke intestinal dysfunction remain unclear. …”
Get full text

A tale of two parasites: a glimpse into the RNA methylome of patient-derived Plasmodium falciparum and Plasmodium vivax isolates by Priyanka Roy, Sukriti Gujarati, Pallavi Gupta, Ishaan Gupta, Tanmaya Mahapatra, Dinesh Gupta, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Ashis Das

“…Abstract Background Understanding the molecular mechanisms of the malarial parasites in hosts is crucial for developing effective treatments. Epitranscriptomic research on pathogens has unveiled the significance of RNA methylation in gene regulation and pathogenesis. …”
Get full text

Interplay Between Insulin Resistance and Immune Dysregulation in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by Berbudi A, Khairani S, Tjahjadi AI

“…By understanding the dual role of insulin in regulating both metabolic and immune functions, this review underscores the importance of addressing immune dysfunction as part of comprehensive T2DM management. …”
Get full text

Mechanisms by which statins protect endothelial cells from radiation-induced injury in the carotid artery by Karima Ait-Aissa, Karima Ait-Aissa, Linette N. Leng, Nathanial R. Lindsey, Xutong Guo, Denise Juhr, Olha M. Koval, Isabella M. Grumbach, Isabella M. Grumbach, Isabella M. Grumbach

“…However, only pravastatin inhibited irradiation-induced production of mitochondrial superoxide; damage to the mitochondrial DNA; loss of electron transport chain activity; and expression of inflammatory markers.ConclusionsOur findings reveal some mechanistic underpinnings of the vasoprotective effects of statins after irradiation. Whereas both pravastatin and atorvastatin can shield from endothelial dysfunction after irradiation, pravastatin additionally suppresses mitochondrial injury and inflammatory responses involving mitochondria. …”
Get full text

Respiratory and Rehabilitation Expert Consensus on Full-cycle Rehabilitation Assessment and Treatment for Elderly Patients with Chronic Obstructive Pulmonary Disease by CHEN Xin, JIA Jie, DING Yipeng, YE Xujun, DONG Anqin, HE Jing, LIAO Weijing, ZHENG Jieqiao, YU Binbin, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, FU Jianghong, WANG Siyuan, ZHANG Yangxian

“…This consensus identifies common functional impairments in elderly COPD patients, including respiratory dysfunction, exercise tolerance impairment, psychological issues, swallowing dysfunction and cognitive impairment. …”
Get full text