Identification of ligand and receptor interactions in CKD and MASH through the integration of single cell and spatial transcriptomics. by Jaime Moreno, Lise Lotte Gluud, Elisabeth D Galsgaard, Henning Hvid, Gianluca Mazzoni, Vivek Das

“…<h4>Background</h4>Chronic Kidney Disease (CKD) and Metabolic dysfunction-associated steatohepatitis (MASH) are metabolic fibroinflammatory diseases. …”
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A Mental Workload Evaluation Model Based on Improved Multibranch LSTM Network with Attention Mechanism by Hongning Zhang

“…Accurate assessment of mental workload is a method of effectively coping with physical and mental illness. …”
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Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury by Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao

“…Numerous immunomodulatory therapies have been suggested for the treatment of AKI, the current immunomodulatory treatment delivery systems are suboptimal and lack efficiency. Given the lack of effective treatment, AKI can result in multi‐organ dysfunction and even death, imposing a significant healthcare burden on both the family and society. …”
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Dual diagnosis of neurobrucellosis and Anti-LGI1 encephalitis: a rare case report by Chuyan Yang, Ying Liu, Yongzhong Lin, PeiYu Shi, Jing Tan

“…Abstract Background Anti-LGI1 encephalitis is a subtype of autoimmune encephalitis characterised by cognitive dysfunction, psychiatric disorders, faciobrachial dystonic seizures, and hyponatraemia. …”
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Probiotics in atopic dermatitis: Where do we stand? by Rashmi Agarwal, Abhijit Sushant Chakraborty, Abhijit Saha, Sandipan Dhar

“…Results: Classically, AD has been understood as a complex interplay between genetic susceptibility, barrier dysfunction, immune dysregulation, and exogenous factors. …”
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CLINICAL CASE OF SUCCESSFUL 10-YEAR AMBRIZENTAN TREATMENT OF THE PATIENT WITH IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION by T. V. Martynyuk, M. A. Saidova, N. M. Danilov, V. K. Lazutkina, I. Ye. Chazova

“…The key pathogenetic feature is the endothelial dysfunction, which leads to the development of vasoconstriction, thrombosis in situ, proliferative and inflammatory changes in the lung microvasculature. …”
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Update on Reye Syndrome by Sandeep Negi, Jitendra Kumar Sahu, Pratibha Singhi

“…This review provides an updated understanding of Reye syndrome, emphasizing the importance of early diagnosis and effective management.…”
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Random forest model analysis of influencing factors of chemotherapy-induced peripheral neuropathy in patients with nasopharyngeal carcinoma: a cross-sectional survey study by Yanxin Zhang, Xiaojun Huang, Guirong Yang, Wei Li, Limin Liang, Lina Wei, Jiamei Lu

“…The results of the random forest algorithm showed that age, chemotherapy cycle, tumor stage, chemotherapy regimen, concurrent chemoradiotherapy, BMI, hand and foot syndrome fatigue, and cognitive dysfunction were the main factors affecting CIPN in NPC patients (P&lt;0.05).ConclusionThere is an urgent need to accurately identify the risk factors for CIPN in patients with NPC and develop multidisciplinary collaborative prevention and intervention measures to achieve effective prevention and comprehensive management.…”
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CLINICAL CHARACTERISTICS OF RESPIRATORY INVOLVEMENT IN CHILDREN WITH CYSTIC FIBROSIS IN THE CHUVASH REPUBLIC by O. I. Golubtsova, S. A. Krasovskiy, S. L. Kozhevnikova, N. I. Kapranov

“…Cystic fibrosis is a common hereditary disease, characterized by multiple organ dysfunction, including early and severe involvement of respiratory system. …”
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Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies by Ademola S. Ojo, Simon A. Balogun, Oyeronke T. Williams, Olusegun S. Ojo

“…Pulmonary fibrosis is associated with permanent pulmonary architectural distortion and irreversible lung dysfunction. Available clinical, radiographic, and autopsy data has indicated that pulmonary fibrosis is central to severe acute respiratory distress syndrome (SARS) and MERS pathology, and current evidence suggests that pulmonary fibrosis could also complicate infection by SARS-CoV-2. …”
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Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications by Rubina Marzagalli, Soraya Scuderi, Filippo Drago, James A. Waschek, Alessandro Castorina

“…Finally, we will describe the main signalling routes activated by the peptide and propose possible future directions to focus on developing more effective peptide-based therapies to treat the major complications associated with longstanding diabetes.…”
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Clinical significance of calculating the plasma anion gap in metabolic acidosis in newborns with neonatal sepsis by O. K. Kirilochev

“…Plasma anion gap calculation is an inexpensive and effective tool that can help differentiate metabolic acidosis in newborns with neonatal sepsis for adequate intensive care.…”
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Hepatoses in highly productive cows, their treatment and prevention by Smolentsev Sergey, Onuchina Maria, Nikolaeva Zhanna, Goncharov Nikita, Gracheva Olga, Gasanov Alizade, Mukhutdinova Dina, Zukhrabova Zulfiyat, Karpova Natalia, Asrutdinova Rezilya

“…In order to find the most effective method of pharmacoprophylaxis and pharmacotherapy of hepatoses and fatty liver dystrophy in the first heifers, the drug “Hepatoject”, a hepatoprotective choleretic drug, was used on the farm. …”
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Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression by Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

“…Given the accessibility of the gut to both dietary and pharmacological interventions, targeting gut-localized α-synuclein represents a promising avenue for developing effective Parkinson’s disease therapies.…”
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Expert consensus recommendations on the evaluation and management of hypoglycemia in diabetes: DGENius Group Diabetes India by Amit Kumar Dey

“…Results: The consensus introduces the importance of effective hypoglycemia in people with diabetes management, addressing both type 1 and type 2 diabetes mellitus separately, with tailored recommendations. …”
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Relationship between depression and cardiovascular disease (review of literature) by E. V. Vinokurov, V. S. Sobennikov, L. V. Rychkova

“…Impaired adherence to health behaviors and adverse physiological effects of depression, including inflammation, endothelial dysfunction, platelet hyperactivity, and autonomic nervous system abnormalities, may link depression with adverse cardiac outcomes. …”
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Case Report: endoscopic microvascular decompression for trigeminal neuralgia in a centenarian: a landmark case with 5-year follow-up by Xuhao Fang, Feng Tang, Yao Deng, Yue Zhou, Weidong Gu, Renling Mao

“…BackgroundEndoscopic Microvascular Decompression (E-MVD) is a well-established effective treatment option for trigeminal neuralgia (TN). …”
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Advances in iron deficiency and iron-related arrhythmias and cardiovascular diseases by Sung Il Im

“…ID is easy to treat and effective in patients with HFrEF. These patients should be investigated for possible ID. …”
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Luteolin Alleviates the TNF-α-Induced Inflammatory Response of Human Microvascular Endothelial Cells via the Akt/MAPK/NF-κB Pathway by Qing-Yu Lu, Li Guo, Qi-Yun Zhang, Fu-Mei Yang, Shu-Ting Zhou, Qian-Yun Sun

“…Endothelial dysfunction and pathological alterations are pivotal in the pathogenesis of cardiovascular disease. …”
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Role of T Lymphocytes in Glioma Immune Microenvironment: Two Sides of a Coin by Laiba Noor, Arun Upadhyay, Vibhuti Joshi

“…Further, the expression of immune checkpoint inhibitors on the glioma cell surface leads to T cell anergy and dysfunction. Overall, this dynamic interplay between T lymphocytes and glioma is crucial for designing more effective immunotherapies. …”
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