Clinical features and mutational frequency of renal cell carcinoma from patients undergoing kidney transplant evaluation by Corbin J. Eule, Junxiao Hu, Kurtis D. Davies, Alkesh Jani, Alkesh Jani, Thomas Pshak, Elaine T. Lam

“…Despite increased understanding of genomic alterations in clear cell and papillary RCC, the most common subtypes, little is known about the effects of renal dysfunction on RCC pathogenesis.Materials and methodsThis retrospective study analyzed electronic medical records and pathology data from adult patients with renal cell carcinoma (RCC) who were evaluated for or received a kidney transplant at a single institution between 1995 and 2021. …”
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Stereotactic radiosurgery in pituitary metastases: a systematic review and meta-analysis by Bardia Hajikarimloo, Salem M. Tos, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Ibrahim Mohammadzadeh, Dorsa Najari, Mohammad Amin Habibi

“…Conclusion SRS is correlated with promising improvement in LC, OS, and CN dysfunction in patients with PM. On the other hand, SRS is accompanied by limited effectiveness in DI and improvement in anterior pituitary dysfunction due to irreversible damage to the pituitary cells by metastatic lesions.…”
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Mitochondrial DNA variants in the pathogenesis and metabolic alterations of diabetes mellitus by Praveen Kumar K.S., M.N. Jyothi, Akila Prashant

“…The main defect for MIDD is the m.3243 A > G variant, which comprises enhanced susceptibility to metabolic syndrome and type 2 diabetes, followed by mitochondrial dysfunction, insulin resistance, and beta-cell dysfunction. …”
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Vitamin C as a Cardioprotective Agent Against Doxorubicin‐Induced Cardiotoxicity by Hamdi Nsairat, Zainab Lafi, Bassam M. Abualsoud, Belal O. Al‐Najjar, Ali Al‐Samydai, Ghaleb Ali Oriquat, Walhan Alshaer, Abed Alqader Ibrahim, Anthony L. Dellinger

“…Further investigation is warranted to optimize dosing, timing, and delivery routes and better elucidate the exact molecular mechanisms of these protective effects. This review emphasizes key molecular mechanisms, such as oxidative and nitrosative stress, mitochondrial dysfunction, and inflammatory signaling, in the myocardium, and examines the role of vitamin C supplementation, alone or in combination with doxorubicin, on myocardial damage markers and cardiomyocyte viability.…”
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Botox’s Place in the Complex Treatment of Oculomotor System Pathology (the Optimal “Portrait” of the Patient for the Chemodenervation) by I. L. Plisov, V. V. Cherhykh, V. V. Atamanov, N. G. Antsiferova, V. B. Pushchina, T. K. Istomina

“…To summarize our fifteen-years clinical experience of using Botox in strabismology and determine the indications for the most effective use of chemodenervation in the complex treatment of oculomotor system pathology.Patients and methods. …”
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Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies by Nawfal Hasan Siam, Nayla Nuren Snigdha, Noushin Tabasumma, Irin Parvin

“…The pathophysiology of DM is complex, involving insulin resistance, β-cell dysfunction, and associated cardiovascular complications including diabetic cardiomyopathy (DCM) and cardiovascular autonomic neuropathy (CAN). …”
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Pre-hospital cooling in community-acquired heat stroke (CAHS): evidence, challenges, and strategies by Shu Cong, Guangxin Zheng, Xiaojuan Liang, Jianjun Gui, Hong Zhang, Jun Wang

“…Abstract Background Heat stroke (HS) is a critical medical emergency characterized by severe hyperthermia and central nervous system dysfunction, occurring predominantly in conditions of high ambient temperatures or through physical exertion. …”
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Anticancer properties of Dillenia suffruticosa (Griffith Ex. Hook. F. & Thomsom) Martelli by Ika Rahayu, Susana Elya Sudrajat, Kris Herawan Timotius

“…These extracts inhibit cancer cell growth, induce apoptosis, and target pathways like p53/p21, JNK, PI3K/AKT, and NFκB, with effects linked to mitochondrial dysfunction. Further research is needed to explore its roles in autophagy, cell differentiation, and the tumor microenvironment.…”
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Efficacy of Botulinum toxin type A in treatment of different forms of focal dystonias in the Serbian population: Experience of the Botulinum Toxin Outpatients Department by Tomić Aleksandra, Vujović Balša, Svetel Marina, Dragašević-Mišković Nataša, Petrović Igor, Pekmezović Tatjana, Kostić Vladimir S.

“…Most of the patients did not have therapy complications (81.4% and 72% in two applications). Side effects in the remaining patients (muscle weakness, dysphagia, ptosis, double vision, neck weakness and lacrimal dysfunction) lasted for 28.3 ± 18.6 days after the first treatment and 32.5 ± 36.2 days after the second one. …”
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Remarkable response to low dose of selpercatinib in a patient with RET-rearranged non-small cell lung cancer by Jun Sakakibara-Konishi, Hirofumi Takahashi, Kenichiro Ito, Tomoo Ikari, Yasuyuki Ikezawa, Hidenori Kitai, Megumi Furuta, Yuta Takashima, Tetsuaki Shoji, Masahide Fukudo, Satoshi Konno

“…Here, we describe a case who has response to 40 mg of selpercatinib every other day because the dose had to be adjusted owing to adverse events such as liver dysfunction. Dose modification of selpercatinib, according to adverse event incidences, may be considered, as selpercatinib may be effective in some cases even at very low concentrations.…”
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The Clinical Efficacy of Autologous Platelet-Rich Plasma Interventional Circulatory Perfusion Combined with Radiofrequency Ablation and Thermocoagulation in the Treatment of Discog... by Zhong-Liu Cao, Hu Xu, Jia-Qiang Wu, Jiang-Hua Dai, Si-Jian Lin, Ling-Feng Zou, Ling Yu, Hui-Chun Yang

“…After RFAT, interventional circulatory perfusion combined with autologous PRP intramedullary injection in the lumbar disc is a safe and effective treatment for DLBP, and it had superior long-term effects in improving the clinical symptoms and patient dysfunction than the RFAT and interventional circulatory perfusion.…”
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Paroxysmal Sympathetic Hyperactivity Syndrome (Review) by L. M. Tsentsiper, I. S. Terekhov, O. A. Shevelev, M. V. Petrova, A. N. Kondratiev

“…Its high incidence and severe sequelae including organ dysfunction, infectious complications, impaired blood supply to organs and tissues associate with increased disability and mortality. …”
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Tetrahydrobiopterin as a rheostat of cell resistance to oxidant injury by R. Steven Traeger, James Woodcock, Sidhartha Tan, Zhongjie Shi, Jeannette Vasquez-Vivar

“…We conclude that hydrogen peroxide is the least effective oxidant species at decreasing intracellular BH4 levels, while peroxynitrite is highly effective by targeting GTPCH-I and BH4 directly. …”
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Heart rate-lowering therapy in gout patients with stable coronary artery disease: focus on ivabradine by N. N. Kushnarenko, T. A. Medvedeva, M. Yu. Mishko, T. M. Karavaeva

“…Aim. To study the effect of ivabradine and bisoprolol on cardiac hemodynamics and diastolic remodeling in gout patients with coronary artery disease and hypertension and without left ventricular systolic dysfunction.Material and methods. …”
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Review on the Management of Female Urinary Incontinence and Anterior Vaginal Prolapse by Ronscardy F. Mondesir, Angelica Gousse, Daniel A. Boaretto, Daniel Ajabshir, Angelo Gousse

“…Surgical techniques such as using mid-urethral slings are highly effective but pose risks, including voiding dysfunction and lower urinary tract injury. …”
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P62 | FFAR4/GPR120 ACTIVATION COUNTERACTS FIBROGENIC PATHWAYS IN A CHOLESTATIC LIVER INJURY MODEL

“…Based on this evidence, the project aims to evaluate the effect of a selective GPR120 agonist (GprA) on liver fibrosis in a murine model of cholestasis induced surgically through bile duct ligation (BDL), and to compare its effects with those of obeticholic acid (OCA), a drug used in the treatment of primary biliary cirrhosis3. …”
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Endocrine consequences of childhood obesity: a narrative review by Maroun Badr, Ghazwa El-Rabaa, Marianne Freiha, Andrzej Kędzia, Elżbieta Niechciał

“…Understanding these complex interactions is crucial for developing effective public health policies to mitigate the impact of obesity on endocrine health in children. …”
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Air Pollution and Interstitial Lung Disease by Yong Suk Jo, Jin Woo Song

“…Despite these findings, effective interventions to mitigate effects of air pollution on ILD are not well established yet. …”
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Unconventional site of pacing for failed balloon valvotomy of prosthetic tricuspid valve: a case report by Aditi Newaskar, Radha Nandipati, Somasekhar Ganta, Dharma Teja Dhulipalla, John Satish, Krishna Prasad Nevali

“…Coronary sinus pacing offers an effective alternative to conventional RV pacing in such cases.…”
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Ultrasound-Guided Prolotherapy with Polydeoxyribonucleotide for Painful Rotator Cuff Tendinopathy by Kyoungho Ryu, Dongchan Ko, Goeun Lim, Eugene Kim, Sung Hyun Lee

“…Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. …”
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