Thymic Self-Antigen Expression for the Design of a Negative/Tolerogenic Self-Vaccine against Type 1 Diabetes by Aziz Alami Chentoufi, Vincent Geenen

“…If this approach were found to be effective for reprogramming immunological tolerance in T1D, it could pave the way for the design of negative self-vaccines against autoimmune endocrine diseases, as well as other organ-specific autoimmune diseases.…”
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Social Exclusion and Hatred Towards Children from Alcoholic Families in Peer Environment. Peculiarities of Pedagogical Support by Anna Mączyńska

“…The article emphasizes that the family is the main environment of life. If it is a dysfunctional family, all its problems can have a negative impact on the development and upbringing of children. …”
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Neurological disorders after hysterectomy: from pathogenesis to clinical manifestations by A. G. Solopova, D. V. Blinov, E. Begovich, L. N. Sandzhieva, S. V. Demyanov, G. V. Demyanov

“…Hysterectomy currently occupies one of the leading places among obstetric and gynecological surgeries and is one of the highly effective and sometimes the only method of treating various diseases of the female genital organs.  …”
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Synaptic vesicle characterization of iPSC-derived dopaminergic neurons provides insight into distinct secretory vesicle pools by Kenshiro Fujise, Jaya Mishra, Martin Shaun Rosenfeld, Nisha Mohd Rafiq

“…Abstract The dysfunction of dopaminergic (DA) neurons is central to Parkinson’s disease. …”
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Rational Fabrication of Copper Nanoclusters and In Vitro Study of Antioxidant Property by Jiale Zhang, Xiao Liang, Mijia Yan, Qiuhong Zhang, Hangrong Chen

“…Herein, we report the fabrication of albumin-biomineralized copper nanoclusters (BCNCs) as a novel antioxidant platform and evaluate their effectiveness in combating oxidative stress. Our results show that BCNCs exhibit potent ROS scavenging abilities and protect cells from oxidative stress-induced damage, highlighting their potential as an effective therapeutic strategy for oxidative stress-related diseases.…”
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The integrated stress response in neurodegenerative diseases by Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee

“…Intriguingly, while acute ISR provide neuroprotection through the activation of cell survival mechanisms, prolonged ISR can promote neurodegeneration through protein misfolding, oxidative stress, and mitochondrial dysfunction. Understanding the molecular mechanisms and dynamics of the ISR in neurodegenerative diseases aids in the development of effective therapies. …”
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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues by Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li

“…Exercise, known for its antioxidant effects, can partly reverse pathological cardiac remodelling in the elderly by countering processes linked to age‐related chronic HF, such as mitochondrial dysfunction, inflammation, senescence and declining cardiomyocyte regeneration. …”
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Characteristics of heart changes in overweight and obese patients by S. V. Miklishanskaya, N. A. Mazur, V. V. Chigineva, E. A. Zolozova

“…In a smaller number of cases, the predominance of LV dilation over wall thickening contributes to the development of systolic dysfunction. In the presence of diastolic dysfunction, subclinically pronounced systolic dysfunction may also be present. …”
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Sexual function outcomes in prostate and cervical cancer patients treated with radiotherapy in sub-Saharan Africa: A cross-sectional study. by Joseph Daniels, Kofi Adesi Kyei, Prince Dela Frimpong-Boateng, Andrew Yaw Nyantakyi

“…Radiotherapy is indispensable for the successful treatment of many pelvic malignancies, but it is often associated with significant adverse effects on sexual function, including vaginal stenosis, decreased lubrication, erectile dysfunction, and loss of libido. …”
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Time-restricted eating for prevention of age-related vascular cognitive decline in older adults: A protocol for a single-arm open-label interventional trial. by Ana Clara da C Pinaffi-Langley, Zsofia Szarvas, Anna Peterfi, Zalan Kaposzta, Peter Mukli, Ali Shahriari, Mihaly Muranyi, Camila B Pinto, Cameron D Owens, Cheryl Adams, Brittany Karfonta, Michael Rohan, Stefano Tarantini, Andriy Yabluchanskiy

“…Age-related cerebromicrovascular endothelial dysfunction underlies the initiation and progression of cognitive dysfunction and dementia, thus increasing the susceptibility of older adults to such conditions. …”
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Inhibition of Triacylglycerol Accumulation and Oxidized Hydroperoxides in Hepatocytes by <i>Allium cepa</i> (Bulb) by Dya Fita Dibwe, Saki Oba, Satomi Monde, Shu-Ping Hui

“…These findings suggest that such extracts may be beneficial in combating metabolic dysfunction-associated fatty liver disease (MAFLD) and its more advanced stage, metabolic dysfunction-associated steatohepatitis (MASH). …”
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SARS-COV-2 INFECTION AND THYROID DISEASES by Özlem Çelik

“…Physicians should be aware of possible relationships between thyroid dysfunction and COVID-19. This study aimed to review thyroid dysfunction in patients with COVID-19, and to overview thyroid diseases that are probably related to COVID-19.…”
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OVERACTIVE BLADDER SYNDROME IN CHILDREN by E.L. Vishnevskiy

“…If individual dosage is observed, which will enable preventing or significantly lowering possible side effects, oxybutinin will be still considered «the golden standard» for treating overactive bladder for years to come in cases when detrusor hypersensibility to acetylcholine is the key component of bladder dysfunction pathogenesis.Key words: overactive bladder, oxybutinin, urination disorder, children.…”
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Controversies in thyroid disease management in pregnancy by Pushpa Singh, Kristien Boelaert

“…A significant body of evidence has accumulated in recent years, including large systematic reviews and meta-analyses of observational studies determining effects of thyroid dysfunction on pregnancy and fetal outcomes. …”
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Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism by Arwa Ishaq Abdulmalik Khayyat, Altaf N. Alabdali, Mona Alonazi, Areej Ali Alzahrani, Eman Al-Shehri, Abir Ben Bacha

“…Thanks to its strong anti-inflammatory and antioxidant potencies, luteolin, has shown to be promising in alleviating these effects. This study investigated the therapeutic and protective effects of luteolin in a PPA-induced rodent model of ASD by assessing oxidative stress, intestinal permeability, and liver and kidney dysfunction biomarkers.MethodsFifty young male albino rats were divided into five groups: control, PPA-treated, luteolin-treated, therapeutic (PPA followed by luteolin), and protective (luteolin followed by PPA). …”
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Efficacy of Employment of Isotonic Sterofundin after Experimental Hemorrhagic Shock by A. Yu Yakovlev, V. V. Kichin, V. O Nikolsky, G. V. Kalentyev, D. V., Ryabikov, M. A. Ryabikova, D. M Protasov, T. A. Galanina, A. Yu. Smerkalov, O. S. Evdokimova

“…Objective: to perform an experimental study of the effect of isotonic sterofundin on the morphology of the myocardium, kidney, lung, pancreas, liver, and brain in the late period after hemorrhagic shock. …”
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Therapeutic potential of plant-derived small extracellular vesicles in sepsis: A network meta-analysis by Wen-Yi Lai, Ching-Wei Chuang, Yu-Chen Huang, Chun-Jen Huang

“…This study conducted a network meta-analysis to identify the most effective plant-derived sEVs for reducing sepsis-induced inflammation and oxidative stress. …”
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Thoraco-abdominal biomechanical model and dual-layer control method for soft robotic system with application to respiratory assistance by Wenzhuo Zhi, Wenzhuo Zhi, Wei Zhao, Wei Zhao, Yan Zhang, Enming Shi, Enming Shi, Yangfan Zhou, Yangfan Zhou, Bi Zhang

“…IntroductionRespiratory dysfunction remains a critical challenge for patients transitioning from intensive care. …”
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Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells by Yun-Ting Wang, Alexandra K. Moura, Rui Zuo, Zhengchao Wang, Kiana Roudbari, Jenny Z. Hu, Mi Wang, Pin-Lan Li, Yang Zhang, Xiang Li

“…Lipid droplets (LDs) have emerged as key regulators of fatty acid metabolism in endothelial cells (ECs), but their functional role in lipotoxicity-induced EC damage in the context of coronary microvascular dysfunction remains unclear. Here, we examined the contribution of LD biogenesis to oleic acid-induced lipotoxic effects in mouse cardiac ECs (MCECs). …”
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Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes by J. H. Musgrave, J.-C. Han, M.-L. Ward, N. Kang, A. J. Taberner, K. Tran

“…Conclusions Our key results point to potential mechanisms of clinical dysfunction in diabetic heart tissue. Lower active force production in diabetic trabeculae suggests that these patients are developing contractile dysfunction. …”
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