Clinical application of long-term indwelling cuffed tunneled catheter in chronic dialysis access by CHENG Wei, YE Li-ping, LI Zhong-sheng, GAO Lu, GU Jing, WU Mei-jun

“…Objective To explore the complications and their treatment in long-term indwelling cuffed tunneled catheter in chronic dialysis access.Dialysis effect and complications were observed and compared between patients with palindrome catheter group and those with non-palindrome catheter group.Methods We retrospectively reviewed 157 patients with long-term indwelling catheterization in deep vein for hemodialysis(HD) blood access from July 2008 to Aug.2014 in our center,and analyzed the complications due to the catheterization and their management.Forty-seven cases using Palindrom catheter and 36 cases using a common catheter in the last two years were selected.The average blood flow,urea clearance(Kt/v) and urea descent rate(URR) were observed.The incidence of dysfunction and infection was compared.Results The operation for central venous catheterization was successful in patients.There were 31 catheterization-unrelated deaths during the follow-up period,and 13 patients lost follow-up.The average indwelling period of the catheters was(19.6 ± 15.7) months(107 days to69 months) in the rest of 113 patients.The major complications during the catheterization included errhysis in 6 cases,palpitation in 2 cases,angled torsion of the catheter in 2 cases and difficult-ties of the guide wire to enter blood vessels in 2 cases.Complications in the blood access for hemodialysis period occurred in 39 cases,including dysfunction(16.81%),local infection(15.04%),out off cuff of the catheter(1.77%) and cracks in the head of the catheter(0.88%).There were 83 times of catheterization from August 2012 to August 2014.In palindrome catheter group(n = 47),dysfunction occurred in 16 cases(1.23 times/1 000 catheter-days),and infection 2 times(0.13 times/1 000 catheterdays),and none of the catheters were finally removed.In non-palindrome catheter group(n = 36),dysfunction occurred 47 times(6.33 times/1 000 catheter-days),and infection 9 times(1.16 times/1000 catheter-days).One case was converted to Palindrom tube after repeated infections.The infection rate in Palindrom catheter group was lower than that in control group.The average infection and dysfunction rate in Palindrom catheter group was lower than that in control group.The average blood flow,Kt/v,and URR indicators were better in Palindrom catheter than in control group.There was statistically significant difference between the two groups.Conclusions Sufficient preoperative preparation,proficient operative technology and good catheter maintenance are the key for catheter indwelling success,long-term use and reduction of the complications.Palindrome dialysis catheter is a better device for chronic HD patients than the ordinary catheter.…”
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Application of repetitive transcranial magnetic stimulation in lower limb rehabilitation after stroke by LI Yajie, XING Zheng, CHU Xiaolei, LI Qi

“…Repetitive transcranial magnetic stimulation (rTMS), as a non-invasive and painless neural regulation technique, has become a new supplementary method for improving limb dysfunction in stroke patients in recent years. It has been widely used to recover post-stroke motor dysfunction and has achieved good results. …”
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Inflammation and Arterial Stiffness as Drivers of Cardiovascular Risk in Kidney Disease by Lorenzo Lo Cicero, Paolo Lentini, Concetto Sessa, Niccolò Castellino, Ambra D'Anca, Irene Torrisi, Carmelita Marcantoni, Pietro Castellino, Domenico Santoro, Luca Zanoli

“…Key Messages: In this review, we explore mechanisms of vascular dysfunction in CKD, paying particular attention to inflammation, reporting current data in other models of mild and severe inflammation, and discussing the vascular effect of several drugs currently used in nephrology. …”
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BETA-BLOCKERS AND RENOPROTECTION: THE POTENTIAL OF CARVEDILOL by I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, F. A. Yusupov

“…Carvedilol with a pronounced vasodilating effect and a long half-life significantly reduces central arterial pressure that is also animportant renoprotective mechanism in the treatment of patients with renal dysfunction. …”
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Green jackfruit flour ameliorates MASH and development of HCC via the AMPK and MAPK signaling pathways in experimental model systems by Diwakar Suresh, Bharathwaaj Gunaseelan, Akshatha N. Srinivas, Amith Bharadwaj, James Joseph, Megha, Thomas Varughese, Suchitha Satish, Deepak Suvarna, Prasanna K. Santhekadur, Saravana Babu Chidambaram, Ajay Duseja, Divya P. Kumar

“…Given the paucity of approved therapeutic strategies for this lifestyle disorder, dietary interventions may prove effective. We evaluated the mechanisms of how green jackfruit flour (JF) ameliorates metabolic-dysfunction-associated steatohepatitis (MASH) and halts the progression to hepatocellular carcinoma (HCC). …”
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Exploration of Pathogenesis and Cutting-Edge Treatment Strategies of Sarcopenia: A Narrative Review by Gao Y, Liu D, Xiao Q, Huang S, Li L, Xie B, Zhou L, Qi Y, Liu Y

“…Notably, emerging evidence points to the pivotal role of mitochondrial dysfunction, altered myokine profiles, and neuromuscular junction degeneration in sarcopenia progression. …”
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Efficacy of DaXianXiong Decoction in Preventing the Progression of Acute Pancreatitis Severity: Protocol for a Randomized Controlled Trial by Dongsheng Ren, Judan Tan, Yuling Zhou, Zhenchun Luo

“…The secondary outcomes will include the effect of the gastrointestinal dysfunction treatment. …”
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Sexual function, depression, and quality of life in patients with irritable bowel syndrome by Amir Keshavarzi, Seyed Saman Talebi, Mohammad Ahmadpanah, Alireza Soltanian, Saman Torkashvand

“…Other factors such as physiological symptoms, medication side effects, and psychological stressors also contribute to causing sexual dysfunction in these IBS patients.…”
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Standardization of TSH and FT4 to gestational age in early pregnancy and associations with clinical outcomes by Joris A J Osinga, Layal Chaker, Sjoerd van den Berg, Vincent W V Jaddoe, Eric A P Steegers, Henning Tiemeier, Robin P Peeters, Tim Korevaar

“…While the goal of treating gestational thyroid dysfunction is to prevent thyroid hormone-mediated adverse events, it remains unclear which method of standardizing to gestational age, if any, is most effective in identifying individuals at higher risk of adverse pregnancy events. …”
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Role of Bicarbonate-Sulphate-Alkaline-Earthy Mineral Water, Bentonite Clay Mud and Manual Somatic Stimulation in the Treatment of Osteoarthritis by Giovanni Barassi, Michelina Delli Bergoli, Maurizio Panunzio, Loris Prosperi, Celeste Marinucci, Giuseppe Luigi Matera, Piero Galasso, Pier Enrico Gallenga

“…It can be seriously disabling, so identifying effective therapies is fundamental for its management. …”
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The enlarged perivascular spaces in the hippocampus is associated with memory function in patients with type 2 diabetes mellitus by Peichun Pan, Dongsheng Zhang, Jing Li, Min Tang, Xuejiao Yan, Xin Zhang, Man Wang, Xiaoyan Lei, Xiaoling Zhang, Jie Gao

“…Abstract Early detection of cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM) is important for preventive measures due to the lack of effective treatments. …”
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Efficacy of a Graftless Salter Osteotomy in Developmental Dysplasia of the Hip by Andrew G. Kim, BA, Carter E. Hall, BS, Sulagna Sarkar, MS, Christopher J. DeFrancesco, MD, Wudbhav N. Sankar, MD

“…The graftless Salter osteotomy is a safe and effective alternative to the traditional Salter osteotomy without the risk of iliac wing deformities and potential abductor dysfunction. …”
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A Retrospective Cohort Study of Chinese Herbal Medicine Reducing the Risk of Readmission of Rheumatoid Arthritis Complicated with Sjogren's Syndrome by CHEN Xiaolu, LIU Jian

“…Results The incidence of liver dysfunction, chronic renal dysfunction, autoimmune hepatitis, the levelof rheumatoid factor (RF), and positive rates of anti-SS-A antibody (SSA) and anti-SS-B antibody (SSB) were higher in the RA+SS group than in the RA group, and the number of recurrent hospitalizations was higher in the RA group (P<0.05). …”
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Simple ECG-based score and clinical parameters to predict right ventricular dilation in patients with repaired tetralogy of fallot by Chodchanok Vijarnsorn, Prakul Chanthong, Paweena Chungsomprasong, Supaluck Kanjanauthai, Ploy Thammasate, Thita Pacharapakornpong, Kritvikrom Durongpisitkul, Jarupim Soongswang, Pornphairin Satawichairut, Watcharachai Kangvanskol, Karnkawin Patharateeranart

“…Receiver operating characteristic curves identified optimal cut-offs for predicting RV dysfunction and dilation. Logistic regression was used to determine predictors of RV dysfunction and dilation.Results QRSd showed moderate positive correlations with RV end-diastolic (EDVi) and end-systolic (ESVi) volume indices and negative correlations with RV ejection fraction (EF) and global radial strain. …”
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Extracorporeal cardiopulmonary resuscitation successfully used in a two-hour cardiac arrest caused by fulminant myocarditis: a case report by Qinxue Hu, Xing Liu, Chengli Wen, Songtao Mei, Xianying Lei, Tao Xu

“…This critical situation was effectively addressed through the utilization of extracorporeal cardiopulmonary resuscitation (ECPR). …”
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Critical Review of Diagnostic Methods Used in Chronic Pancreatic Disease by Ivan T Beck

“…Thus screening tests are not cost-effective - if they are negative, they do not exclude pancreatic disease; and if positive, they have to be confirmed by more specific tests. …”
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The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery by Zhangyi Yi, Xiaoying Wang, Ge Yin, Yu Sun

“…We argue that some intrinsic properties of the BLB can be strategically utilized for effective inner ear drug delivery.…”
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Towards Subject-Specific Strength Training Design through Predictive Use of Musculoskeletal Models by Michael Plüss, Florian Schellenberg, William R. Taylor, Silvio Lorenzetti

“…Lower extremity dysfunction is often associated with hip muscle strength deficiencies. …”
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Melatonin and cardiovascular disease: from mechanisms of action to potential clinical use (literature review) by O. M. Drapkina, A. V. Kontsevaya, A. V. Budnevsky, E. S. Ovsyannikov, E. S. Drobysheva, V. I. Bolotskih, A. V. Makeeva, M. V. Lushchik

“…For a long time, melatonin was perceived as a substance that is effective in the treatment of circadian cycle impairments. …”
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Update on schizophrenia and bipolar disorder: focus on cariprazine by Roberts RJ, Findlay LJ, El-Mallakh PL, El-Mallakh R

“…It is unclear if cariprazine is effective in depression associated with unipolar or bipolar illness. …”
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