Liver disease trends in the Asia-Pacific region for the next 50 years by Shuichiro Shiina, Javkhlan Maikhuu, Qing Deng, Terguunbileg Batsaikhan, Lariza Marie Canseco, Maki Tobari, Hitoshi Maruyama, Hiroaki Nagamatsu, Diana Alcantara-Payawal, Rino Gani, Yi-Hsiang Huang, Tawesak Tanwandee, Giovanni Galati, Yoon Jun Kim

“…First, it highlights the alarming rise of metabolic dysfunction-associated fatty liver disease and metabolic dysfunction-associated steatohepatitis, diseases driven by modern lifestyle factors and inherent metabolic susceptibilities. …”
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Amniotic mesenchymal stem cells attenuate diabetic cardiomyopathy by inhibiting pyroptosis via modulation of the TLR4/NF-κb/NLRP3 pathway by Xuan Zhou, Shaoliang Xing, Lina Zhang, Jungu Lu, Deming Li, Yating Wang, Yuhang Ma, Weiqin Chang, Manman Su

“…Diabetic cardiomyopathy (DCM) is a specific type of cardiac dysfunction in diabetic patients, currently has no effective therapies. …”
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Inhibition of microglia priming by NLRP3 reduces the impact of early life stress and mild TBI by Fabiola Placeres-Uray, Aditi S. Gorthy, Maria Dominguez Torres, Coleen M. Atkins

“…We hypothesized that ELS mediates prolonged cognitive dysfunction after mTBI by exacerbating the NRLP3 inflammasome signaling pathway, and that these effects could be reversed by inhibiting NLRP3. …”
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Successful peritoneal dialysis using a percutaneous tube for peritoneal drainage in an extremely low birth weight infant: a case report by Satoshi Yokoyama, Takayuki Nukada, Yuka Ikeda, Shigeto Hara, Akira Yoshida

“…On DOL 75, extubation was conducted without circulatory dysfunction. The patient was discharged on DOL 224. …”
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Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21 by Eun Kyung Kim, Seung Hoon Lee, Joo Yeon Jhun, Jae Kyeong Byun, Jeong Hee Jeong, Seon-Young Lee, Jae Kyung Kim, Jong Young Choi, Mi-La Cho

“…We hypothesized that metformin, an effective pharmacological treatment for type 2 diabetes, would inhibit white adipogenesis, fatty liver, and metabolic dysfunction. …”
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Usefulness of the Córdoba Equation for Estimating Body Fat When Determining the Level of Risk of Developing Diabetes Type 2 or Prediabetes by Marta Marina Arroyo, Ignacio Ramírez Gallegos, Hernán Paublini, Ángel Arturo López-González, Pedro J. Tárraga López, Cristina Martorell Sánchez, Tomás Sastre-Alzamora, José Ignacio Ramírez-Manent

“…<i>Conclusions:</i> Adipose tissue distribution, particularly visceral adiposity, is a central factor in metabolic dysfunction. ECORE-BF provides a cost-effective alternative for large-scale T2D and prediabetes risk assessment. …”
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Unraveling the deadly dance: endothelial cells and neutrophils in sepsis-induced acute lung injury/acute respiratory distress syndrome by Xiujuan Xu, Xiujuan Xu, Qi Zhang, Zheng Lv, Chuji Cheng, Junjing Zha, Huaqing Shu, Huaqing Shu, Hairong Xiao, Hairong Xiao, Hairong Xiao, Shangwen Pan, Shangwen Pan

“…Neutrophils are important regulators of inflammation, while endothelial dysfunction exacerbates vascular permeability and the inflammatory cascade. …”
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Knockdown of <i>POLG</i> Mimics the Neuronal Pathology of Polymerase-γ Spectrum Disorders in Human Neurons by Çağla Çakmak Durmaz, Felix Langerscheidt, Imra Mantey, Xinyu Xia, Hans Zempel

“…It also offers a simple, cost-effective and human (and, as such, disease-relevant) platform for investigating disease mechanisms, one with screening potential for therapeutic approaches for POLG-related mitochondrial dysfunction in human neurons.…”
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Association between finasteride with subjective memory deficits: a study from the NHANES and FAERS databases by Hao Zhang, Hongqi Ou, Panli Zhao, Xi Luo, Ping Zhang, Hua Huang

“…BackgroundPostmarketing pharmacovigilance data have raised concerns regarding the potential cognitive effects associated with finasteride administration. …”
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Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Has the Time Come for Cardiologists to Be Hepatologists? by Mohamed H. Ahmed, Salma Barakat, Ahmed O. Almobarak

“…Importantly, the current evidence suggest that statins are safe and effective treatment for CVD in individuals with NAFLD.…”
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Pathophysiology, Treatment, and Prognosis of Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis/Renal Failure, and Organomegaly (TAFRO) Syndrome: A Review by Takuya Kakutani, Riko Kamada, Yotaro Tamai

“…Due to the lack of appropriate treatment, it often presents with multiple organ dysfunction and fatality. In this review, we summarized new findings on the pathogenesis of TAFRO syndrome and discussed current effective therapies and future treatment strategies.…”
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Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue by Cristina Antinozzi, Paolo Sgrò, Luigi Di Luigi

“…Phosphodiesterase type 5 inhibitors (PDE5i) have long been used as an effective therapeutic option for the treatment of erectile dysfunction (ED). …”
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Current status of surgical treatment for pediatric drug-resistant epilepsy by ZHANG Xiao-lei, DONG Sheng, GUO Jia-he, GUO Yi, YANG Xue-jun

“…Surgery is an effective treatment for DRE, especially for children who do not respond to medication. …”
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Biomimetic Nanomaterials for Osteoarthritis Treatment: Targeting Cartilage, Subchondral Bone, and Synovium by Xiaoshan Gong, Hao Tang, Jingjin Dai, Guoqiang Wang, Shiwu Dong

“…Eventually, the challenges and prospects for the clinical translation of biomimetic nanomaterials are further discussed, with the goal of accessing an effective approach for OA treatment.…”
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P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS

“…The resulting nuclear dysfunction sensitizes glioblastoma cells to oxidative stress triggered by Menadione, while having minimal effects on normal human astrocytes. …”
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A low-cost simulation model for priapism detumescence training by Sachin Garach, Hanlie Dreyer, Ahmed Adam, Abdullah Laher

“…Ischaemic priapism is a urological emergency requiring prompt intervention to prevent complications such as erectile dysfunction. Because of its low incidence, opportunities for hands-on training are limited, particularly in resource-constrained settings. …”
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The link between optic neuritis and multiple sclerosis. Literature review by A. Kubiliūtė, R. Liutkevičienė

“…Some diagnostic methods may not only help to understand the cause of vision loss, but also provide predictive value for the development of multiple sclerosis in the future. Unfortunately, no effective treatment to slow the progression of the disease has been approved yet. …”
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Systematic analysis and exploration of molecular mechanisms of psoriasis and metabolic comorbidities by LI Sijia, CAO Zhejia, ZHENG Siqi, CHENG Shuqiong, ZHONG Meizhen, ZHENG Yue, HUANG Xiaowen

“…Psoriasis is strongly associated with metabolic disorders. Effective management of metabolic dysfunction and individualized treatment strategies for different comorbidities are crucial for preventing disease progression and improving the overall health of psoriatic patients. …”
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Research progress of knee fibrosis after anterior cruciate ligament reconstruction by YangYang Liang, QingQing Zhang, YouFei Fan

“…Anterior cruciate ligament (ACL) injury is a common sports injury, and ACL reconstruction is an effective surgery for this trauma. Most cases gain good recovery after surgery, while some patients may experience knee stiffness, which is characterized by joint fibrosis, leading to reduced joint mobility, pain, and dysfunction. …”
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Risques climatiques et sécurité alimentaire et nutritionnelle au Niger : cartographie des impacts et des besoins de résilience by Bouda Maja Chardi Moussa, Torou bio Mohamadou, Oumarou diadie Halima, Balla Abdourahamane

“…They are grouped into four groups - V1, V2, V3 and V4 - serving as benchmarks or decision support tools for efficient and effective responses established in the form of classes of climate risk resilience needs.…”
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