Symptom network between problematic smartphone use and poor sleep quality in adolescents with depression by Yongjie Zhou, Jian Gong, Jing Shao, Nan Yan, Linlin Meng, Kongliang He, Ying Shen, Qian Wei, Chunyan Zhang, Xuan Lei, Yuehua Cao, Yanni Wang

“…The symptom ‘Daytime dysfunction’ of PSQ was the most severely affected by PSU. …”
Get full text

Deciphering the complex links between inflammatory bowel diseases and NAFLD through advanced statistical and machine learning analysis by Deepak Kumar, Brijesh Bakariya, Chaman Verma, Zoltán Illés

“…Method:: One popular and effective approach is collecting serum biomarker samples. …”
Get full text

Assessment of left ventricle myocardial performance index (Tei index) by myocardial tissue Doppler imaging and its correlation with serum thyroid-stimulating hormone levels and ath... by Amratansh Varshney, Satyajit Singh, Amritava Ghosh, Surendra Kumar Naik, Abhishek Kumar, Chandraprakash Thakur, Muneshwar Kumar, Nupur Goyal, Nabodoy Majumder, Rounak Kumar, Muhammad Rihas Rasheed

“…Conclusion: Subclinical hypothyroid patients have significant subclinical cardiac dysfunction (as determined by the Tei index) and dyslipidemia. …”
Get full text

The correlation between RLS and motor or other non-motor symptoms of PD patients: an observational study by Junfeng Chen, Lan Li, Xiuhua Tian, Xiaoyan Guo

“…However, research into the effects of concurrent RLS on the function of the autonomic nervous system remains limited. …”
Get full text

Comparison of sepsis-associated acute kidney injury with different degrees and causes reveals patterns in mitochondrial metabolism and immune infiltration changes by Nan Yuan, Jianwen Chen, Feng Luo, Zhenyu Fang, Mengjie Huang, Jiaona Liu, Xiangmei Chen, Congjuan Luo

“…It remains primarily treated with supportive and nonspecific therapies because of the absence of effective diagnostic biomarkers and therapeutic targets. …”
Get full text

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF by Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella

“…Results DesAb-O was found to selectively detect synthetic Aβ42 oligomers both in vitro and in cultured cells, and to neutralise their associated neuronal dysfunction. DesAb-O can also identify Aβ42 oligomers present in the CSFs of AD patients with respect to healthy individuals, and completely prevent cell dysfunction induced by the administration of CSFs to neuronal cells. …”
Get full text

Comparative Analysis of Resmetirom vs. FGF21 Analogs vs. GLP-1 Agonists in MASLD and MASH: Network Meta-Analysis of Clinical Trials by Hazem Ayesh, Azizullah Beran, Sajida Suhail, Suhail Ayesh, Kevin Niswender

“…Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic-Dysfunction Associated Steatohepatitis (MASH) are linked to obesity, type 2 diabetes, and metabolic syndrome, increasing liver-related morbidity and cardiovascular risk. …”
Get full text

The technique of three-component regional blockade of the anterior neck region as a component of anesthesia during operations on the thyroid and parathyroid glands by A. A. Alekseev, A. G. Yavorovskiy, E. N. Prazdnikov, A. M. Ovechkin, D. V. Dospekhov, V. S. Vakhromkin, E. A. Sozonova, E. V. Batulina, A. A. Maksimova, E. N. Zolotova

“…The use of various regional blockades as a component of general anesthesia reduces the risk of postoperative complications such as intense pain syndrome, postoperative nausea and vomiting, and postoperative cognitive dysfunction. The study is devoted to the development and description of the technique of regional anesthesia of the anterior surface of the neck during operations on the thyroid and parathyroid glands under ultrasound navigation.The objective was to develop a safe and effective technique of regional anesthesia for operations on the thyroid and parathyroid glands under ultrasound navigation.Materials and methods. …”
Get full text

Efficacy of Functional Endoscopic Sinus Surgery and Impact of Chronic Lung Disease on its Outcome in Patients of Chronic Rhinosinusitis by Minakshmi Karmakar, V D Prasanna Kumar Vasamsetty, Bonapart Chowdhury

“…Conclusion The leading complaints within the symptom profile of patients with CRS are nasal obstruction with nasal discharge. FESS is highly effective treatment to relieve all major symptoms of CRS except smell dysfunction. …”
Get full text

Preclinical Evidence for the Benefits of Penile Rehabilitation Therapy following Nerve-Sparing Radical Prostatectomy by M. Albersen, S. Joniau, H. Claes, H. Van Poppel

“…Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clinically studied for treatment of postprostatectomy erectile dysfunction. Since these studies showed benefits of “penile rehabilitation therapy,” these effects have been studied in a preclinical setting. …”
Get full text

The Association Between Inflammatory Markers and Hypertension. A Call for Anti-Inflammatory Strategies? by Néstor H. García, Luis I. Juncos

“…One such target may be endothelial dysfunction. In effect, endothelial dysfunction not only may precede the elevation of blood pressure, but may also pave the way to conditions often associated with hypertension, such as diabetes, arteriosclerosis, microalbuminuria, congestive heart failure, and tissue hypertrophy. …”
Get full text

Delving into the Perception, Use, and Context of Duloxetine in Clinical Practice: An Analysis Based on the Experience of Healthcare Professionals by Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel Angel Alvarez-Mon, Miguel A. Ortega, Melchor Alvarez-Mon, Javier Quintero

“…Overall satisfaction was high, with 99% of psychiatrists reporting being either “satisfied” or “very satisfied” with its use. The side effect profile was generally viewed as manageable, with low perceived rates of weight gain, sedation, and sexual dysfunction. …”
Get full text

Dimensions of psychosis in delirious and catatonic trauma critically Ill patients by Ming-Ray Xu, Trey W. McGonigle, Jinyuan Liu, Robert S. Dittus, Stephan Heckers, Pratik P. Pandharipande, Shawniqua Williams Roberson, Mayur B. Patel, E. Wesley Ely, Jo Ellen Wilson

Get full text

Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis. by Matthew D Christensen, Wen Dun, Penelope A Boyden, Mark E Anderson, Peter J Mohler, Thomas J Hund

“…Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Dysfunction in the CaMKII signaling pathway occurs in heart disease and is associated with increased susceptibility to life-threatening arrhythmia. …”
Get full text

Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…After nanofiber disassembly, the released 1-Pept converts into Pept under the catalysis of intracellular overexpressed trypsin, which then reassembles into denser Pept NFs, inducing a cascade of effects including disruption of the cytoskeleton, mitochondrial dysfunction, and activation of caspase-3. …”
Get full text

Epithelial and macrophage cell interaction in cervical cancer through single-cell RNA-sequencing and spatial analysis by Zhichao Wang, Long Cheng, Guanghui Li, Huiyan Cheng

“…Immunohistochemistry assessed marker expression in CC and normal tissues. Tumor immune dysfunction and exclusion (TIDE) scores differentiated high- and low-macrophage groups. …”
Get full text

Buddhist meditation for vascular function: a narrative review by Anjalee Thanuja Amarasekera, Dennis Chang

“…Background: High blood pressure represents an important risk factor for diseases related to cardiovascular system and is directly associated with high oxidative stress, inflammation and vascular endothelial dysfunction. Recently, there is promising data available to suggest that meditation-based low-cost and low-risk lifestyle modification strategies may provide beneficial effects on chronic inflammation, oxidative stress and maintenance of blood pressure, both in young and older adults. …”
Get full text

RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) by Elmas Rumeysa Yıldırım, Nuray Ulusoy Güzeldemirci

“…Alzheimer’s disease (AD) is a common neurodegenerative disorder which has a catastrophic effect on the brain. It significantly affects people’s daily life, especially the population over the age of 65, with problems such as neuron death, memory loss, cognitive disorders, and cholinergic dysfunction. …”
Get full text

Role of ketamine in treatment-resistant depression by Joanna Dmochowska, Marcin Ciechański, Joanna Cieszkowska, Julia Czerwik, Marta Czubala, Patrycja Felisiak, Wiktor Gąska, Karol Kanon, Edyta Witkowska

“…Ketamine, an NMDA antagonist, has shown rapid antidepressant effects, and research suggests glutamatergic dysfunction plays a role in TRD, highlighting the need for faster, more effective treatments.  …”
Get full text

Comparative analysis of mitochondrial and mesenchymal stem cell transplantation for angiogenesis and muscle regeneration by Mi Jin Kim, Jung Wook Hwang, Chang-Koo Yun, Ikhyun Lim, Kyunghoon Min, Yong-Soo Choi

“…Overall, PD-MSC-derived mitochondrial transplantation demonstrated proved more effective over MSC transplantation in reducing inflammation, restoring mitochondrial function, and supporting tissue recovery, highlighting its promise as an effective therapeutic approach for CLI and other ischemic conditions by directly addressing mitochondrial dysfunction and overcoming the limitations of conventional cell therapies.…”
Get full text