A Prospective Clinical Study Evaluating the Efficacy of Intra-Articular Ozone Therapy for Internal Derangement of the Temporomandibular Joint by Venugopal Vaishnavi, Ashish Kumar Shetty, Rithesh Kenchapal Balakrishna

“…Background: Temporomandibular joint (TMJ) internal derangement (ID) is a prevalent disorder causing significant pain and dysfunction. Initial treatment typically involves conservative methods, with ozone gas injection emerging as a potential therapy. …”
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Comment protéger la santé des travailleurs dans un système qui ne repose pas sur les notions d’aptitude et d’inaptitude ? by Robert Plante, Luc Bherer, Michel Vézina

“…Individual medical activities are limited to cases where the relevance and effectiveness of preventive benefits have been demonstrated. …”
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Thrombocytopenia in Sepsis by Alireza Setarehaseman, Abbas Mohammadi, Robert W. Maitta

“…Future research should focus on elucidating the mechanisms underlying platelet dysfunction in sepsis and exploring novel therapeutic approaches to optimize platelet function and mitigate inflammation. …”
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Cardiotoxicity Assessment of EGFR Tyrosine Kinase Inhibitors Using Human iPS Cell‐Derived Cardiomyocytes and FDA Adverse Events Reporting System by Shota Yanagida, Hiroyuki Kawagishi, Mitsuo Saito, Hirofumi Hamano, Yoshito Zamami, Yasunari Kanda

“…Therefore, it is important to understand the risks of anti‐cancer drug‐induced cardiac contractile dysfunction in drug development. We have previously developed image‐based motion analysis using human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) to assess the effect of drugs on contractility. …”
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Research Progress on the Correlation Between Mitophagy and Vascular Cognitive Impairment by LIU Yan, DONG Xingang, WANG Xiaoyuan, QI Gege, REN Yiqin, ZHOU Lianpeng, LI Hui, ZHANG Suqing, LI Weifeng

“…Vascular cognitive impairment (VCI), caused by cerebrovascular dysfunction, severely impacts the quality of life in the elderly population, yet effective therapeutic approaches remain limited. …”
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Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment by Wenyuan Zhang, Dan Peng, Shiqi Cheng, Rui Ni, Meiyang Yang, Yongqing Cai, Jianhong Chen, Fang Liu, Yao Liu

“…Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflammation post-MI can lead to cardiac dysfunction, scarring, and ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. …”
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CURRENT APPROACHES TO THERAPY OF RETT’S SYNDROME (A REVIEW OF LITERATURE) by N. Yu. Borovikova, M. Yu. Bobylova

“…Carbamazepine is effective for focal seizures and in the absence of diffuse EEG changes. …”
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A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers by Laurel K. Berry, Ashok K. Pullikuth, Kristen L. Stearns, Yuezhu Wang, Calvin J. Wagner, Jeff W. Chou, Janelle P. Darby, Michael G. Kelly, Raghvendra Mall, Ming Leung, Julia Chifman, Lance D. Miller

“…These observations suggest that a molecular basis for effective immunity may exist within a subpopulation of HGSC. …”
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The use of flowmetry during coronary bypass surgery in patients with diffuse coronary bed lesion by G. G. Borshchev, R. V. Sidorov, D. S. Ulbashev

“…Performing the full volume of myocardial revascularization in such patients is not always possible due to the nature of the lesion of the coronary bed, and the risk of shunt dysfunction in the early postoperative period remains high. …”
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Cerebral markers of neuroinflammation and neurodegeneration in hypertensive disorders during pregnancy by E. S. Taskina, I. V. Kibalina, V. A. Mudrov, S. O. Davydov

“…However, etiology and mechanisms of development of central nervous system dysfunction in this disease remain relevant for studies. …”
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GYY4137 protects against type 2 diabetes mellitus-associated myocardial autophagy by suppressing FOXO1 signal pathway by Gaofeng Zhu, Xiaoyong Li, Qinyuan Gao, Yuanjun Wang, Jiajie Li, Zena Huang, Yan Lin

“…Results: GYY4137 demonstrated a protective effect against cardiac dysfunction, fibrosis, and autophagy in cardiac tissues of T2DM mice. …”
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Pathobiochemical aspects of alcoholic cardiomyopathy. The role of hydrogen sulfide in the mechanism of cardiocytoprotection (a review) by N. I. Voloshchuk, K. V. Rudenko, O. R. Matiash, O. M. Denysiuk

“…Analysis of literature data about the mechanisms of alcohol-induced cardiotoxicity revealed trigger factors for myocardial damage. Negative effect of ethanol on the heart is realized through induction of oxidative-nitrosative stress, apoptosis, inflammation, fibrogenesis, hypoenergetic state and ion pump dysfunction, development of endothelial dysfunction, impaired ribosomal synthesis. …”
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A Marked Response to Immunosuppressive Intervention for Abruptly Occurring Cardiac Complications in a Case of Juvenile Systemic Sclerosis Overlapped with Dermatomyositis by Tsunehisa Nagamori, Yoichiro Yoshida, Hironori Takahashi, Hideharu Oka, Aya Kajihama, Koichi Nakau, Masaya Sugimoto, Masako Minami-Hori, Hiroshi Azuma

“…Cardiac investigations then showed pericardiac effusion and diastolic dysfunction due to significant biventricular hypertrophy causing heart failure. …”
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Implementation of pro- and anti-inflammatory mechanisms of sirtuin-1 in patients with chronic obstructive pulmonary disease and chronic coronary syndrome and their combination by Ya. V. Chobanu, T. O. Ilashchuk

“…One of the key pathogenetic aspects of chronic obstructive pulmonary disease (COPD) and chronic coronary syndrome (CCS) is endothelial dysfunction. Further study on this pathological process is relevant for a better understanding of the course and increasing the treatment effectiveness of these diseases. …”
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Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease by You-Yen Lin, De-Maw Chuang, Cheng-Yu Chi, Shih-Ya Hung

“…Parkinson's disease (PD) is a prevalent movement disorder characterized by mitochondrial dysfunction and dopaminergic neuronal loss in the substantia nigra of the midbrain. …”
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Research on the construction of corneal endothelium transplantation with acellular amniotic membrane as a scaffold by Ya-Nan Chen, Rui-Qin Guo, Bo-Yu Liang, Hong-Qin Ke, Meng-Jie Dong, Ming-Fang He, Ji Yang, Hai Liu

“…These findings provide experimental evidence for the potential clinical application of the HAAM in corneal endothelial transplantation, offering a promising therapeutic option for patients with corneal endothelial dysfunction. Further studies are warranted to explore the long-term efficacy and safety of the HAAM in preclinical and clinical settings.…”
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Metformin carbon dots enhance neurogenesis and neuroprotection in Alzheimer's disease: A potential nanomedicine approach by Jing Zhang, Xuehan Yang, Sushan Wang, Jianhua Dong, Meishuang Zhang, Ming Zhang, Li Chen

“…These results suggest that CMCDs can cognitive dysfunction in AD and promote the proliferation and neurogenesis of NSCs, as well as ameliorate neuronal injury. …”
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Clinical Value of Detecting Fecal Calprotectin by Using Colloidal Gold Assay in Screening or Diagnosing Crohn’s Disease by Wangdong Zhang, Yanyun Fan, Meijun Chen

“…Detecting FCP by using the colloidal gold semiquantitative assay can be effective in screening and adjunct diagnosing of CD.…”
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Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications by Mengru Liu, Siqi Liu, Zihan Lin, Xi Chen, Qian Jiao, Xixun Du, Hong Jiang

“…Given the limited efficacy of therapies targeting either autophagy dysfunction or oxidative stress, it is crucial to elucidate the intricate mechanisms governing their interplay in PD to develop more effective therapeutics. …”
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The relationship between polycystic ovary syndrome and gynecological cancers: neurotransmitter metabolism changes and immune regulation by Dongning Wu, Dongning Wu, Dongning Wu, Yue Zhang, Congying Wu, Bo An, Bo An, Xin Wang, Jinxia Ni, Min Chen

“…Moreover, PCOS is characterized by chronic low-grade inflammation, including dysregulated pro-inflammatory cytokine secretion, increased immune cell proliferation, and endothelial dysfunction. These factors contribute to cancer development, primarily through impaired immune metabolism, preventing effective tumor cell clearance and facilitating metastasis. …”
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