Valve-in-valve transcatheter aortic valve replacement on a self-expandable nitinol frame due to degeneration of primary bioprosthetic valve cusps. Clinical case of a high-risk surg... by L. S. Kokov, V. V. Sokolov, M. V. Parkhomenko, R. Sh. Muslimov, M. V. Bulanova, N. M. Bikbova

“…The minimally invasive valve-in-valve transcatheter aortic valve replacement used to correct the dysfunction of a bioprosthetic AV that was previously implanted during an open surgery was shown to be safe and effective and can be considered as one of the options for repeat valve replacement.…”
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Pathological mechanisms and treatment progression of Alzheimer’s disease by Jingjing Zhang, Guoqing Kong, Jinyue Yang, Lin Pang, Xiubin Li

“…Our analysis underscores the importance of multimodal interventions targeting multiple pathological processes simultaneously, combined with early detection methods, to effectively combat this devastating disease. This review aims to provide researchers and clinicians with an updated framework for understanding AD pathogenesis and developing more effective treatment paradigms.…”
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Revisiting Russell's viper (Daboia russelii) bite in Sri Lanka: is abdominal pain an early feature of systemic envenoming? by Senanayake A M Kularatne, Anjana Silva, Kosala Weerakoon, Kalana Maduwage, Chamara Walathara, Ranjith Paranagama, Suresh Mendis

“…The clinical profile of Russell's viper bite includes local swelling, coagulopathy, renal dysfunction and neuromuscular paralysis, based on which the syndromic diagnostic tools have been developed. …”
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Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis by Bethany Y. A. Hollingworth, Patrick N. Pallier, Stuart I. Jenkins, Ruoli Chen

“…Promoting such endogenous protective signalling pathways could be an effective therapy for MS patients.…”
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Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology by Laiba Husain

“…As populations worldwide experience unprecedented demographic shifts towards advanced age, understanding the molecular mechanisms that link ageing to cancer initiation, progression, and therapeutic response has become essential for developing effective precision medicine approaches. Main body This review examines the fundamental molecular pathways through which ageing influences cancer biology, including telomere dysfunction, cellular senescence, DNA damage accumulation, and epigenetic alterations. …”
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GLCCI1 alleviates GRP78-initiated endoplasmic reticulum stress-induced apoptosis of retinal ganglion cells in diabetic retinopathy by upregulating and interacting with HSP90AB1 by Jiayou Liu, Hongdan Yu, Shengxue Yu, Mengren Liu, Xinyuan Chen, Yufei Wang, Jing Li, Caixing Shi, Wenqiang Liu, Zhongfu Zuo, Xuezheng Liu

“…GLCCI1 overexpression mitigated the apoptosis of RGCs and the swelling of endoplasmic reticulum and mitochondria under hyperglycemia, and downregulated ERS-induced apoptosis related markers (GRP78, CHOP and cleaved CASP3), whereas GLCCI1 knockdown has the opposite effect. In vivo, GLCCI1 overexpression not only prevents structural lesions but also protects against microvascular dysfunctions in the retinas of DR mice. …”
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Misoprostol in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Gastrointestinal Mucosal Injury by Naurang M Agrawal

“…Furthermore, misoprostol did not adversely affect anti-inflammatory and analgesic efficacy of aspirin in rheumatoid arthritis. ln one prevention study, misoprostol co-administered with therapeutic doses of NSAIDs, was found co be safe and effective in preventing NSAID-induced gastric ulcers in osteoarthritic patients. …”
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Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants by Ugwu Okechukwu Paul-Chima, Anyanwu Chinyere Nkemjika, Ugwu Melvin Nnaemeka, Hope Onohuean

“…The therapeutic power of plant signaling pathways is harnessed to develop sustainable, inclusive, and effective diabetes management strategies.…”
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Overview of Research Progress on White Matter Fiber Bundle Defect Diseases of ADHD, ASD, and OCD by Yang Xilu

“…The paper also discusses the research progress of drug therapy and behavioral therapy as the main treatment methods, emphasizes the importance of early intervention, and proposes the importance of cross disease research (the research of different disorders together to find commonalities that could lead to more targeted and effective treatments for all of them) to promote the development of more precise and effective intervention strategies. …”
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INFLUENCE OF ARTIFICIAL LUNG VENTILATION ON REAL ENERGY EXPENDITURE VALUE OF SURGICAL INTENSIVE CARE UNIT PATIENTS by I. V. Polyakov, K. N. Zolotukhin, I. N. Leyderman

“…Conclusion: Indirect calorimetry method usage for the estimation of energy needs in surgical ICU patients is more effective than special equations method during first 7 days of critical illness and may be recommended for clinical practice implication.…”
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Efficacy of transcranial magnetic stimulation in persistent somatoform pain disorder (psychosomatic pain): A narrative review by Shailja Joshi, Preeti Mishra, Shobit Garg, Sangha Mitra Godi, Sai Krishna Tikka, Mohan Dhyani

“…Transcranial magnetic stimulation (TMS) has been proven as a safe and effective cortical stimulation technique to alleviate the symptoms in chronic pain conditions. …”
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Impact of Chess Based Intervention on Psychomotor and Executive Function in Patients Undergoing Chronic Hemodialysis in a Tertiary Care Center-A Pilot Study by Manish Lalwani, Bhavin Modasia, Mohammad Saad

“…However, no overt complications were reported; hence, ICIT was a safe and effective intervention. Conclusions: ICIT was found to be an effective and safe intervention for improving cognitive function in dialysis patients, with a predominant effect on EFs. …”
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Aspartate aminotransferase-to-platelet ratio index as a novel predictor of early mortality in heat stroke patients: a multi-centre retrospective study by Min Wang, Yun Li, Yuan Cao, Meng-Meng Yang, Fu-Jing Liu, Jie Jiao, Sheng-Yuan Wang, Bin Song, Lu Wang, Yi-Qi Wu, Hong-Jun Kang

“…Background The aspartate aminotransferase-to-platelet ratio index (APRI) is an effective non-invasive marker for chronic liver dysfunction. …”
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Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…However, there is still a lack of effective drugs for treating COPD. This study is intended to explore the function and molecular mechanism of ARHGAP18 and miR-613 in COPD pathogenesis.Methods: We initially identified the marker gene closely related to epithelial dysfunction in COPD by integrating bioinformatic analyses. …”
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Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis by Qi Zhang, Zhenmei Gao, Yunqing Deng, Xiangqing Xu, Wenyu Sun, Rui Liu, Tianao Zhang, Xilei Sun

“…It has been found that modulation of gut flora can be an effective intervention to improve cognitive dysfunction. …”
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Role of the functional status of the autonomic nervous system in the clinical course of purulent meningitis by D. A. Zadiraka, O. V. Ryabokon

“…The predominance of the autonomic dysfunction signs in the clinical picture was combined with the prolonged decreasing rating of humoral effects’ spectrum (p<0,04) against the background of other stably changed heart rate variability parameters. …”
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Efficacy and safety of therapies for acute ischemic stroke in China: a network meta-analysis of 13289 patients from 145 randomized controlled trials. by Bowen Yang, Jingpu Shi, Xin Chen, Bing Ma, Hao Sun

“…Edaravone + Kininogenase and Sodium ozagrel + Edaravone appeared the most effective treatments. And Sodium ozagrel, Sodium ozagrel + edaravone, Edaravone + Kininogenase can improve the nerve dysfunction.…”
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Review of modern phlebotrophic preparations based on flavonoids as perspective endothelioprotectors in the treatment of chronic diseases of the veins by A. V. Voronkov, O. Yu. Gamzeleva

“…In addition, the pharmacological  effects  of individual components of the MPFF and their synergism in the focus on the effect on endothelial dysfunction are also discussed.  …”
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Neurogenic Bladder by Peter T. Dorsher, Peter M. McIntosh

“…Congenital anomalies such as meningomyelocele and diseases/damage of the central, peripheral, or autonomic nervous systems may produce neurogenic bladder dysfunction, which untreated can result in progressive renal damage, adverse physical effects including decubiti and urinary tract infections, and psychological and social sequelae related to urinary incontinence. …”
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European territorial development and the place based approach: the budgetary dimension of Portugal 2020 by Filipe Eduardo MIRANDA FERREIRA, João Ricardo CATARINO

“…It is concluded that there is no correspondence between the place based formulation of the current territorial development policies cycle of the European Union for the period 2014-2020 and its effective implementation of Portugal 2020. This confirms the hypothesis that there is a dysfunction between theory and practice, not validating the advantages referenced in the scientific literature about the place based policies.…”
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