Stroke from Infection by Aurauma Chutinet, Chutibhorn Charnnarong, Nijasri C. Suwanwela

“…Further research is needed to establish effective prevention and treatment for infection-related strokes, especially in low- and middle-income countries. …”
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Opioid analgesics: Managing the predictable by A Barnes, G Heppenstall-Harris, A Dickman

“…Predictable adverse effects are wide ranging, and include bowel dysfunction, nausea, sedation, endocrinopathy and pruritis. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Recent evidence from animal studies has provided novel insights into old and new downstream effects of astrocyte and microglial dysfunction such as toxin clearance disruption and myeloid cell attraction to the central nervous system parenchyma. …”
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Unveiling the Systemic Impact of Congestion in Heart Failure: A Narrative Review of Multisystem Pathophysiology and Clinical Implications by Daniela Mocan, Radu Jipa, Daniel Alexandru Jipa, Radu Ioan Lala, Florin Claudiu Rasinar, Iulia Groza, Ronela Sabau, Damaris Sulea Bratu, Diana Federica Balta, Sergiu Teodor Cioban, Maria Puschita

“…Given its widespread impact, effective congestion management requires a shift from a cardiovascular-centered approach to a comprehensive, multidisciplinary strategy. …”
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Pathophysiology in Systemic Sclerosis: Current Insights and Future Perspectives by Suzan Al-Gburi, Pia Moinzadeh, Thomas Krieg

“…The disease progresses from microvascular dysfunction, manifesting as Raynaud’s phenomenon, to systemic fibrosis affecting multiple organs, including the lungs, gastrointestinal tract, heart, and kidneys. …”
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Acute COVID-19 and LongCOVID syndrome – molecular implications for therapeutic strategies - review by Krzysztof Piotr Michalak, Amelia Zofia Michalak, Alicja Brenk-Krakowska

“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been recognized not only for its acute effects but also for its ability to cause LongCOVID Syndrome (LCS), a condition characterized by persistent symptoms affecting multiple organ systems. …”
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Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. by Yasir Alhamdi, Daniel R Neill, Simon T Abrams, Hesham A Malak, Reham Yahya, Richard Barrett-Jolley, Guozheng Wang, Aras Kadioglu, Cheng-Hock Toh

“…Distinctively, these arise despite effective antibiotic therapy. Here, we describe a novel mechanism of myocardial injury, which is triggered and sustained by circulating pneumolysin (PLY). …”
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The Role of (Nuclear) Lipid Droplets in the Pathogenesis of Metabolic Syndrome by Natalia Todosenko, Kristina Yurova, Olga Khaziakhmatova, Maria Vulf, Vladimir Malashchenko, Aleksandra Komar, Ivan Kozlov, Igor Khlusov, Larisa Litvinova

“…Metabolic syndrome (MetS) is a widespread multi-component pathological condition characterized by meta-inflammation and cellular dysfunction. MetS and other metabolic diseases (metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular-kidney-metabolic syndrome (CKMS)) stem from the disorder of energy metabolism and changes in the structure and function of specialized organelles such as lipid droplets, endoplasmic reticula, mitochondria, and nuclei. …”
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The Influence of Allergic Biomarkers in Chronic Rhinosinusitis Patients Who Underwent Functional Endoscopic Sinus Surgery by Lin‐Hsin Tsuei, Rong‐San Jiang

“…Conclusion Our results show that allergy testing and serum IgE levels were not reliable tools for CRS severity or outcomes, while elevated serum and tissue eosinophils were associated with worse preoperative CRS severity, particularly in olfactory dysfunction. FESS provided effective improvements in olfactory outcomes in eosinophilic CRS patients. …”
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Pre-operative therapeutic eyelid hygiene in the prevention of complications following excimer laser vision correction by V. V. Kurenkov, A. V. Zhemchugova, E. G. Polunina, S. I. Abramov, A. A. Kozhuchov

“…Purpose: to assess the effectiveness of pre-operative therapeutic eyelid hygiene in the prevention and treatment of dry eye and meibomian glands dysfunction following excimer laser vision surgery.Methods: In enrolled 144 patients (288 eyes), ocular surface and meibomian glands functions were evaluated before and following refractive surgery (LASIK and REIK). …”
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Early structural cardiovascular disease, HIV, and tuberculosis in East Africa (ASANTE): cross-sectional study protocol for a multimodal cardiac imaging study in Nairobi, Kenya by John Kinuthia, Chris T Longenecker, Bernard Gitura, Bhavna Chohan, Carey Farquhar, Alfred Osoti, Priscilla Y Hsue, Saate S Shakil, Sidney Korir, Geoffrey Omondi, Boni Maxime Ale, Marian Morris, Norrisa Haynes

“…Introduction Persons living with HIV (PLWH) have an augmented risk of cardiovascular disease, including atherosclerosis and myocardial dysfunction, despite effective viral suppression with antiretroviral therapy. …”
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Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer’s Disease: A Review of Recent Evidence from Mechanistic Studies by Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez, Khalid M. Khan

“…Environmental exposure to these heavy metals induces a wide range of pathological processes that intersect with well-known mechanisms leading to AD, such as oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, autophagy dysfunction, and tau hyperphosphorylation. …”
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Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease by Irem Bayraktaroglu, Natalia Ortí-Casañ, Debby Van Dam, Peter P. De Deyn, Ulrich L. M. Eisel

“…By targeting peripheral immune dysfunction, we may advance our understanding of AD mechanisms and develop more effective therapeutic interventions to mitigate disease risk and progression.…”
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Heparan sulfate binding protein treatment ameliorates neuropathology and behavioral abnormalities in mucopolysaccharidosis IIIB mice by Serenella Anzilotti, Melania Scarcella, Mariangela Ciampa, Noemi Di Muraglia, Camilla Anastasio, Chiara Fiorentino, Federica Rossin, Luigi Avallone, Giuseppe Pignataro, Luigi Michele Pavone, Valeria De Pasquale

“…Currently, there is no effective treatment for MPS IIIB. We have recently developed a new therapeutic strategy based on the use of the HS-binding protein NK1, a spliced variant of hepatocyte growth factor. …”
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Investigating the Relationship Between Insulin-Like Growth Factor-I and Thyroid Hormones in Thyroid Disorder Patients by Aveen M. Asaad, Ismail S. Kakey

“…Incorporating IGF-I into routine thyroid evaluation may enhance early detection, risk stratification, and individualized management strategies, contributing to more precise and effective endocrine care. …”
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Atorvastatin for prevention of disease progression and hospitalisation in liver cirrhosis: protocol for a randomised, double-blind, placebo-controlled trial by Torben Hansen, Nina Kimer, Henning Grønbæk, Rikard Gøran Fred, Atul Shahaji Deshmukh, Mathias Mann, Flemming Bendtsen

“…Increasing evidence supports systemic inflammation and metabolic dysfunction in the hepatic stellate cell as key drivers of progression of cirrhosis. …”
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Risk factors and preventive role of vaccination in adult tetanus fatality: a systematic review of reported cases (1990-2024) and meta-analysis by Selin Kolsuz, Deniz Güllü, Koçer Dilan Karahan, Önder Ergönül

“…The analysis focused on risk factors such as autonomic dysfunction, opisthotonus, incubation time, diabetes mellitus, cardiovascular diseases, and dermatological conditions. …”
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Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model by Kazuhiro Tanabe, Qianqian Zheng, Xuguang Zhang, Naoki Tanaka, Chihiro Hayashi, Asaka Yokota, Rina Otsuka, Tomoko Katahira, Motoyuki Kohjima, Makoto Nakamuta

“…Abstract Diabetic cardiomyopathy (DCM) is a leading cause of mortality in patients with diabetes, highlighting the need to better understand its mechanisms for effective treatment. The primary pathogenic mechanism of DCM is mitochondrial dysfunction associated with increased oxidative stress; however, the exact reasons why diabetes triggers this condition remain unclear. …”
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Walking reduces the risk of dementia in patients with Parkinson’s disease: a longitudinal follow-up study by Cheng-Yu Wei, Ray-Chang Tzeng, Hsu-Chih Tai, Chun-Hsien Su, Pai-Yi Chiu

“…Background: Physical activity, particularly regular aerobic exercise, is effective in preventing dementia. However, such activities are less feasible for patients with Parkinson’s disease (PD) or other motor dysfunctions. …”
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The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Dou Shi, Mo Zhang, Yuhan Zhang, Yang Shi, Xing Liu, Xianxian Wu, Zhiwei Yang

“…Abdominal aortic aneurysm (AAA) is the most common aortic disease occurring below the renal arteries, caused by multiple etiologies. Currently, no effective drug treatment exists, and the specific pathogenesis remains unclear. …”
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