Sleep disorders in patients with multiple sclerosis by Ebrahim Kouchaki, Sahar Bayat, Fatemeh Sadat Asgarian

“…Conclusions The final model demonstrated an effective relationship between the Sleepiness and variables of education level, drugs used in MS, Insomnia Severity, and morning dysfunction in the presence of other variables.…”
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Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628. by Frank Y Ma, Yingjie Han, David J Nikolic-Paterson, Peter Kolkhof, Greg H Tesch

“…<h4>Background/aim</h4>Steroidal mineralocorticoid receptor antagonists (MRAs) are effective in the treatment of kidney disease; however, the side effect of hyperkalaemia, particularly in the context of renal impairment, is a major limitation to their clinical use. …”
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Exploring the Role of GLP-1 Receptor Agonists in Alzheimer’s Disease: A Review of Preclinical and Clinical Evidence by Lívia C. R. Teixeira, Marcelo R. Luizon, Karina B. Gomes

“…Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including dulaglutide, liraglutide, semaglutide, and exenatide, are effective treatments for type 2 diabetes mellitus (T2DM) and obesity. …”
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Clinical application of internal jugular vein cuffed-tunneled catheters:Report of 240 cases by XIAO Feng-lin, WANG Sheng-yuan, ZHANG Zhi-yong, YU Yong-wu, LI Ming-xu

“…Objective To contrast the catheterization and application of internal jugular vein cuffed-tunneled catheters in hemodialysis(HD) patients at different ages,and to evaluate the safety and effectiveness of the application of internal jugular vein cuffed-tunneled catheters in elderly patients. …”
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Disseminated intravascular coagulation by Satoshi Gando, Marcel Levi, Cheng-Hock Toh

“…Conversely, these pathogenic pathways and DIC synergistically contribute to organ dysfunction, leading to poor prognoses. Effective DIC management requires treating the underlying condition, along with substitution therapies and, in some cases, antifibrinolytics. …”
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The results of orthotopic heart transplantation using the bicaval technique by B. M. Todurov, H. I. Kovtun, O. A. Loskutov, S. R. Maruniak, D. O. Loskutov, A. Yu. Melnyk

“…Heart transplantation is the most effective method of treatment for terminal heart failure. …”
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Prognosis of Severe Covid-19 patients after treatment with Therapeutic Plasma Exchange (TPE) by Maliha Khalid, Faheem Feroze, Saad Bin Qamar, Naseem Abbas, Saeed Farooq, Aisha Siddiqui

“… OBJECTIVE: To demonstrate the effective role of plasmapheresis in the treatment of Cytokine Release Syndrome associated with severe Covid 19 pneumonia. …”
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Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization by Hiroshi Yamaguchi, Hikari Sugawa, Himeno Takahashi, Ryoji Nagai

“…While hundreds of 2SC-modified proteins have been identified and are associated with the dysfunction of proteins, the underlying molecular mechanisms remain poorly understood. …”
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Evaluation of trans burr hole ultrasonography usefulness in a resource-limited setting by V. de P. Djientcheu, A.K. Njamnshi, P. Ongolo-Zogo, T. Mvogo, F. Bello, A. Essomba

“…Trans burr hole US was effective in diagnosing or in excluding postoperative complications. …”
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The pathophysiological spectrum of maternal complications of pregnancy-induced hypertension: Review Article by Adedeji Okikiade, Chidinma Kanu, Oluwadamilare Iyapo, Ololade Omitogun

“…Conclusion: HDP poses a serious threat to maternal and fetal health, with potential long-term consequences. Effective management requires early diagnosis, close monitoring, and postpartum follow-up. …”
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Cigarette Smoke Contributes to the Progression of MASLD: From the Molecular Mechanisms to Therapy by Jiatong Xu, Yifan Li, Zixuan Feng, Hongping Chen

“…Recently, the term NAFLD has been changed to metabolic dysfunction-associated steatotic liver disease (MASLD), and NASH has been renamed metabolic dysfunction-associated steatohepatitis (MASH). …”
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Requirements and Value Elicitation for a High-Fidelity Pelvic Floor Simulator for Physiotherapists: Mixed Methods Study by Yael Zekaria, Antonia Tzemanaki, Jonathan Rossiter

“…Pelvic simulators exist and are a valuable supplement to the medical curriculum, yet none demonstrate pelvic floor muscle (PFM) function or dysfunction. To design effective simulators, an assessment of end-user requirements is essential. …”
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Connexin hemichannels and early atrophic signaling in muscle during sepsis by Elisa Balboa, Fujiko Saavedra, Luis A. Cea, Aníbal A. Vargas, Tomás Regueira, Juan C. Sáez

“…Sepsis pathogenesis is complex, and effective treatments are limited, leading to high mortality rates between 20% and 55%. …”
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Obesity-induced adipocytes promote diabetes mellitus by regulating β islet cell function through exosome miR-138-5p by Shihong Fan, Nengjuan Li

“…Unfortunately, there remains a need for more effective clinical treatments for DM. Obesity is closely associated with islet dysfunction, but these inside mechanisms remain unclear. …”
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Simulated synapse loss induces depression-like behaviors in deep reinforcement learning by Eric Chalmers, Santina Duarte, Xena Al-Hejji, Daniel Devoe, Aaron Gruber, Robert J. McDonald

“…These results support a conceptual model of MDD as a reduction of brain connectivity (and thus information-processing capacity) rather than an imbalance in monoamines—though the computational model suggests a possible explanation for the dysfunction of dopamine systems in MDD. Reversing the spine-loss effect in our computational MDD model can lead to rescue of rewarding behavior under some conditions. …”
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Viruses and the Brain—A Relationship Prone to Trouble by Matylda Barbara Mielcarska, Barry T. Rouse

“…Consequences may manifest as acute disease, such as encephalitis, meningitis, or result in long-term effects, such as neuromuscular dysfunction, as occurs in poliomyelitis. …”
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Therapeutic Role of Heterocyclic Compounds in Neurodegenerative Diseases: Insights from Alzheimer’s and Parkinson’s Diseases by Nidhi Puranik, Minseok Song

“…There is no effective protective medicine or therapy available even with the availability of numerous medications. …”
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Psilocybin-assisted psychotherapy as a potential treatment for eating disorders: a narrative review of preliminary evidence by Elena Koning, Elisa Brietzke

“…Moreover, there are few effective treatment options and long-term remission of ED symptoms is difficult to achieve. …”
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Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1... by Valentina Tedeschi, Valeria Nele, Valeria Valsecchi, Serenella Anzilotti, Antonio Vinciguerra, Laura Zucaro, Maria Josè Sisalli, Chiara Cassiano, Nunzia De Iesu, Giuseppe Pignataro, Lorella Maria Teresa Canzoniero, Anna Pannaccione, Giuseppe De Rosa, Agnese Secondo

“…Of note F1 prevented gliosis and autophagy dysfunction in ALS mice by restoring PI(3,5)P2 level.Our novel self-assembling lipidic formulation for PI(3,5)P2 delivery exerts a neuroprotective effect in preclinical models of ALS mainly regulating dysfunctional autophagy through TRPML1 activity stabilization.…”
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Révéler et démasquer by François-Xavier Nérard

“…These texts point, most of the time, personal responsability to explain the dysfunction, denunciation thus being made very often denouncement. …”
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