Renal failure in patients with hematological malignancies (literature review) by E. G. Gromova

“…Dysfunction of the natural detoxification organs remains a significant problem in patients with hematological malignancies. …”
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Premature ventricular complexes: new possibilities of diagnostics and management by D. A. Kuzhel, E. A. Savchenko

“…On the other hand, asymptomatic, frequent PVC can lead to the development of left ventricular (LV) systolic dysfunction, which can be reversible with effective therapy. …”
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Brain Morphology in Mass Murderers: An In-Depth Exploration by Ana Starčević, Aleksandra Ilić

“…Reduced activity and structural abnormalities in the PFC and amygdala impair emotional regulation, empathy, and impulse control, while dysfunction in the OFC contributes to poor decision-making and risk assessment. …”
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Meta-analysis of calcineurin inhibitor vs.cyclophosphamide in the treatment of idiopathic membranous nephropathy by XIE Guang-liang, ZHU Lin, HAO Jing, YU Qing

“…Objective To objectively evaluate the efficacy and safety of calcineurin inhibitors,including tacrolimus and cyclosporine A(CsA),vs.cyclophosphamide(CTX) in treating idiopathic membranous nephropathy(IMN).Methods By methods of Cochrane systematic review,databases including Chinese Journal full-text Database,Weipu Database,Wanfang Database,PubMed,MEDLINE,and Cochrane Library were searched till October of 2014,and manual retrieval was employed meanwhile.Homogeneous data that met the inclusion criteria were analyzed by RevMan 5.0 software.Results Twelve randomized controlled trials(RCT) meeting the inclusion criteria were enrolled.The total remission rate and complete remission rate were higher(P<0.05),and the incidence rate of hepatic dysfunction,leukocytopenia and infection was lower in tacrolimus group than in CTX group(P<0.05),but there was no statistically significant difference in the incidence rate of glucose intolerance and gastrointestinal syndrome between the two groups(P>0.05).Between CsA group and CTX group,no statistically significant difference was found regarding to the total remission rate and complete remission rate(P>0.05),while the incidence rate of hepatic dysfunction,leukocytopenia,and gastrointestinal syndrome was lower in CsA group than in CTX group(P<0.05).Conclusions Calcineurin inhibitor can significantly increase the total remission rate and complete remission rate in IMN patients,tacrolimus is more effective than CTX,and CsA has similar effectiveness with CTX Moreover,calcineurin inhibitor has less incidence rate of adverse effects than CTX.However,large scale,multicentered,well-designed randomized controlled trials should be adopted to further confirm the conclusions.…”
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Complex lupus management: when multiple organs demand precision by Hirushi S. Jayasekera, Ayman Askari, Sourabh Chand

“…Mycophenolate mofetil (MMF), effective for lupus nephritis, was excluded because of its potential to worsen pancytopenia.8 Azathioprine, suitable for mild renal involvement, was ruled out because of liver dysfunction.9 Cyclophosphamide, typically used for severe SLE, was contraindicated because of its haematological and hepatic toxicity.3 Tacrolimus was considered for renal SLE, given the biopsy Class of I, but was unsuitable for non-renal lupus without MMF.10 Belimumab, an FDA-approved agent with steroid-sparing effects and a favourable safety profile, was considered but deemed challenging because of its slower onset of action and approval barriers.7 Hydroxychloroquine (300 mg daily) and corticosteroids (40 mg prednisolone) were ultimately chosen as the safest and most effective initial therapy. …”
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FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury by Yao Yan, Yao Yan, Yao Yan, Xinyu Ran, Xinyu Ran, Zihan Zhou, Zihan Zhou, Yuting Gu, Yuting Gu, Yuting Gu, Rendu Wang, Rendu Wang, Chuanqi Qiu, Chuanqi Qiu, Yinuo Sun, Yinuo Sun, Jifeng Wang, Jifeng Wang, Jian Xiao, Jian Xiao, Jian Xiao, Yingfeng Lu, Yingfeng Lu, Jian Wang, Jian Wang, Jian Wang

“…These models were used to investigate the effects of fibroblast growth factor 21 (FGF21) on PNI, both in vitro and in vivo, and to explore the potential mechanisms linking injury-induced ferroptosis and mitochondrial dysfunction.Results Our findings reveal that PNI triggers abnormal accumulation of lipid reactive oxygen species (ROS) and inactivates mitochondrial respiratory chain complex III, leading to mitochondrial dysfunction. …”
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eNOS activation by HDL is impaired in genetic CETP deficiency. by Monica Gomaraschi, Alice Ossoli, Silvia Pozzi, Peter Nilsson, Angelo B Cefalù, Maurizio Averna, Jan Albert Kuivenhoven, G Kees Hovingh, Fabrizio Veglia, Guido Franceschini, Laura Calabresi

“…When compared at the same protein concentration, HDL and HDL3 from carriers proved to be as effective as control HDL and HDL3 in down-regulating cytokine-induced VCAM-1, while carrier HDL2 were more effective than control HDL2 in inhibiting VCAM-1 expression. …”
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Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Disorders: Narrative Review by Mahsa Koochaki, Bahare Mahmoudpour, Sina Sarlak, Amirreza Hendi

“…Results Of 271 found articles, only 8 were included in the study, of which 6 confirmed that the LLLT was effective in the treatment of TMDs. One article concluded that superluminous devices are more effective than LLLT and one article concluded that LLLT is not effective in treating TMDs. …”
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Corpus callosotomy for treatment of pediatric epilepsy: two clinical cases and a literature review by R. Matonytė, S. Ročka, J. Grikinienė

“…Children with uncontrolled seizures may develop speech, language, cognitive and behavioral dysfunction epileptic encephalopathies. Effective management of epilepsy in children not only improves condition of health, but also reduces social exclusion and helps integrate into educational activities. …”
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The incidence， characteristics， and risk factors of non-suicidal self-injury behavior in adolescent patients with mental disorders in Wenzhou City， Zhejiang Province by MA Chuchu, YE Xinwu, HUANG Haixiao

“…Multivariate logistic regression analysis showed that having a mother with a junior college education or above, experiencing campus violence, childhood abuse experiences, childhood family dysfunction, high academic pressure and an LRS score >11 points were risk factors for NSSI in adolescent patients with mental disorders (all P<0.05).ConclusionThe occurrence of NSSI in adolescent patients with mental disorders is closely related to factors such as having a mother with a junior college education or above, high academic pressure, exposure to campus violence, childhood abuse experiences, childhood family dysfunction, and an LRS score >11 points.…”
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Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic Targets by Amanda Farage Frade, Hélléa Guérin, Joao Paulo Silva Nunes, Luiz Felipe Souza e Silva, Vinicius Moraes de Paiva Roda, Rafael Pedro Madeira, Pauline Brochet, Pauline Andrieux, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto

“…Myocardial fibrosis, inflammation, and mitochondrial dysfunction are involved in heart failure and arrhythmia. …”
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Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients by Jian Ruan, Min Zhang, Zhao Han, Jie Chen, Jie Chen, Qingwei Ruan, Qingwei Ruan, Zhijun Bao, Zhijun Bao

“…In addition to having a sensory component, tinnitus disorder might also be involved in tinnitus-related distress, cognitive dysfunction, and/or autonomic arousal, resulting in different behavioral changes and functional disabilities. …”
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Neurobiology-based cognitive biotypes using multi-scale intrinsic connectivity networks in psychotic disorders by Pablo Andrés-Camazón, Covadonga M. Diaz-Caneja, Ram Ballem, Jiayu Chen, Vince D. Calhoun, Armin Iraji

“…Abstract Understanding neurobiology and developing effective interventions for cognitive dysfunction in psychotic disorders remain elusive. …”
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The Impact of Heritable Myopathies on Gastrointestinal Skeletal Muscle FunctionSummary by Aishwarya Iyer, Madeline Alizadeh, Jennifer Megan Mariano, Aikaterini Kontrogianni-Konstantopoulos, Jean-Pierre Raufman

“…Hence, distal GI tract skeletal muscle dysfunction may result in the leakage of flatus and fecal matter, whereas, in contrast, pelvic floor dysfunction may contribute to constipation. …”
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Statins: a tale of two pathways—cardiovascular savior, renal ineffectual by Jihyun Yang

“…Statins are effective in improving outcomes in the general population. …”
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From fat to facts: the potential of adipokine and insulin dosing in obese feline patients by Laura Cernat, Sorana Daina, Adrian Macri

“…Leptin resistance and compensatory hyperinsulinemia further reflect early metabolic dysfunction. These endocrine changes mirror those seen in humans and dogs, suggesting shared mechanisms across species. …”
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HIV, Inflammation, and Immunometabolism: A Model of the Inflammatory Theory of Disease by Eman Teer, Nyasha C. Mukonowenzou, M. Faadiel Essop

“…While acute inflammation is a short-lived, protective response, chronic inflammation is sustained over time and can lead to immune dysfunction, tissue damage, and disease progression. …”
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Outcomes Following In-Office Peroneal Needle Tendoscopy: A Retrospective Review by James J. Butler MB BCh BAO, Grace W. Randall BS, Taylor Wingo MD, Arianna Gianakos DO, John G. Kennedy MD, MCh, MMSc, FFSEM, FRCS (Orth)

“…Conclusion: This retrospective study found that IONT is an effective modality in the management of peroneal tendon dysfunction. …”
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Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment by Mohammed S. Alasmari, Faleh Alqahtani, Fawaz Alasmari, Abdullah Alsultan

“…It is extensively metabolized in the liver via the cytochrome P450 system and may accumulate markedly in patients with hepatic dysfunction, exposing them to toxicity. The aim of the current study is to utilize a physiologically-based pharmacokinetic modeling approach to evaluate the impact of hepatic impairment on the pharmacokinetic behavior of etrasimod and to appropriately select dosage regimens for patients with chronic liver disease; Methods: PK-Sim was used to develop the etrasimod PBPK model, which was verified using clinical data from healthy subjects and subsequently adapted to reflect the physiological changes associated with varying degrees of hepatic dysfunction; Results: Simulations indicated that hepatic clearance of etrasimod is clearly reduced in patients with Child–Pugh B and C liver impairment. …”
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Cross-sectional study of male sexual function in bariatric patients by Michał R. Janik, Ilona Bielecka, Andrzej Kwiatkowski, Piotr E. Janik, Thomas Drazba, Jan Bujok, Edward Stanowski, Krzysztof Paśnik

“…Bariatric surgery is an effective treatment for obese people. Male sexual function after bariatric surgery is not well known. …”
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