Study on the Combined Application of Occlusal Splint and Intra-Articular Injection of Hyaluronic Acid in the Treatment of Non-Reducible Anterior Disc Displacement of the Temporoman... by Bi K, Cheng G, Wu X, Lv Z

“…The clinical treatment effects, pain levels (Visual Analog Scale [VAS]), temporomandibular joint dysfunction (Friction Temporomandibular Joint Dysfunction Index [CMI]), mandibular movement function (maximum mouth opening [MMO], left lateral excursion [LLE], right lateral excursion [RLE], protrusive movement [PM]), clinical aesthetic indicators (condylar height, joint space width), and adverse reactions were compared between the two groups.Results: (1) Clinical Efficacy: The observation group had a higher total effective rate (90.32% vs 67.74%, P < 0.05). (2) Pain & Dysfunction: Both groups showed significant improvement in VAS and CMI scores over time, with the observation group exhibiting greater reductions (P < 0.05). (3) Mandibular Function & Aesthetic Indicators: The observation group had greater improvements in MMO, LLE, RLE, PM, condylar height, and joint space width (P < 0.05). (4) Adverse Reactions: No significant difference in adverse reaction rates (P > 0.05).Conclusion: The combination of intra-articular injection of HA with occlusal splint therapy can further improve the treatment outcomes for ADDWoR patients, alleviate pain, improve temporomandibular joint dysfunction and mandibular movement function, promote aesthetic recovery, and does not increase the risk of adverse reactions.Keywords: occlusal splint, intra-articular injection of HA, non-reducible anterior disc displacement of the temporomandibular joint, ADDWoR, treatment efficacy…”
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Diminazine protects against cardiac aging through the improvement of mitophagy and apoptosis in aging rats induced by D-galactose by Ensiyeh Velayati, Abdolrahman Sarihi, Mohammad Zarei, Alireza Komaki, Fatemeh Ramezani-Aliakbari

“…Abstract Background Mitochondrial dysfunction is a main feature of the aged heart. However, there is still no effective treatment against cardiac aging. …”
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Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP. by Junjie Gao, Fangli Wang, Weisong Wang, Zhiguo Su, Canghui Guo, Shuyi Cao

“…As one of the most serious microvascular complications of diabetes and a major cause of end stage renal disease, diabetic nephropathy (DN) is calling for effective treatment strategies. Here, we provide evidence that hyperglycemia can induce proliferation and decreasing apoptosis of mesangial cells (MCs) and subsequent renal dysfunction by up-regulating cellular FLICE-inhibitory protein (cFLIP). …”
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Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies by Claudia Reytor-González, Daniel Simancas-Racines, Martín Campuzano-Donoso, Janeth Castano Jimenez, Náthaly Mercedes Román-Galeano, Gerardo Sarno, Evelyn Frias-Toral

“…A multidisciplinary approach integrating dietary and lifestyle modifications is essential for effective metabolic dysfunction-associated steatotic liver disease management.…”
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Association of sildenafil use with age-related macular degeneration: a retrospective cohort study by Nicola Jaime Adderley, Krishnarajah Nirantharakumar, Anuradhaa Subramanian, Alastair K Denniston, Wen Hwa Lee, Ji Eun Diana Han, Jesse Coker

“…The study found no significant difference in AMD incidence between the sildenafil users and the non-users, with an adjusted hazard ratio (HR) of 0.99 (95% CI 0.84 to 1.16), after accounting for confounders such as age, ethnicity, Townsend deprivation quintile, body mass index category, and diagnosis of hypertension and type 2 diabetes.Conclusion The study results indicated no significant association between sildenafil use and AMD prevention in UK men with erectile dysfunction, suggesting sildenafil’s protective effect on AMD is likely insignificant.…”
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A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment: Evidence for erectile restoration and cavernous nerve regeneration by Eric Chung

“…Objective: The following article explores our evolving understandings of the role of regenerative technology as an effective penile rehabilitation tool in men with erectile dysfunction (ED) in the setting of prostate cancer (PCa) treatment and PCa survivorship. …”
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RG100204, A Novel Aquaporin-9 Inhibitor, Reduces Septic Cardiomyopathy and Multiple Organ Failure in Murine Sepsis by Shireen Mohammad, Caroline E. O’Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenäs, Patrizia Gena, Angela Tesse, Michael Rützler, Michael Rützler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann

“…Post-treatment of CLP-mice with RG100204 also attenuated the cardiac dysfunction (systolic and diastolic), the renal dysfunction caused by CLP-induced sepsis, but did not significantly reduce the liver injury or hypothermia. …”
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Evaluation of renal function in patients with human immunodeficiency virus by Ederson dos Santos Costa, Déborah Éllen Pinheiro de Oliveira, Francilene de Sousa Vieira, Gleciane Costa de Sousa, Maria Edileuza Soares Moura

“…Of these, 8.0% had renal dysfunction stage 2, and 3.3%, in stage 3. The variables, older age and prolonged exposure to antiretroviral therapy were statistically significant for altering renal function. …”
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Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. by Ellen Gerhardt, Simone Gräber, Eva M Szego, Nicoleta Moisoi, L Miguel Martins, Tiago F Outeiro, Pawel Kermer

“…Knockout of HtrA2 in mice also leads to mitochondrial dysfunction and to phenotypes that resemble those found in neurodegenerative disorders and, ultimately, lead to death of animals around postnatal day 30. …”
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Variations in platelet indices in patients with diabetes mellitus and hypertension: A case-control study from a tertiary hospital in North Bengal by Poulami Roy, Novonil Deb, Pratibha Rao Lahiri, Bidyut Krishna Goswami

“…Conclusion: The findings of this study suggest that PI can be used as a reliable and cost-effective tool for identifying platelet dysfunction and cardiovascular risk in individuals with DM and hypertension. …”
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Neuroinflammatory Mechanisms of Adult Sepsis-Associated Encephalopathy: Implications for Blood–Brain Barrier Disruption and Oxidative Stress by Hao Liu, Ting Zhang, Lixiao Zhang, Yanjun Zhong

“…Sepsis is a syndrome of life-threatening acute organ dysfunction caused by a dysregulated host response to infection. …”
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Acute lung injury: pathogenesis and treatment by Huanqi Liu, Junli Dong, Cailin Xu, Yang Ni, Zhenbang Ye, Zhenjun Sun, Honggang Fan, Yongping Chen

“…We also analyze the latest research advances in advanced nanomedicine for the treatment of ALI, and the application of this nanomedicine could provide new ideas for the development of effective ALI therapeutics in the future.…”
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From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders by Elisa Duranti, Chiara Villa

“…Muscle atrophy and mitochondrial dysfunction are also observed in AD, which may exacerbate cognitive decline due to systemic metabolic dysregulation. …”
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Evaluation of renal function in patients with human immunodeficiency virus by Ederson dos Santos Costa, Déborah Éllen Pinheiro de Oliveira, Francilene de Sousa Vieira, Gleciane Costa de Sousa, Maria Edileuza Soares Moura

“…Of these, 8.0% had renal dysfunction stage 2, and 3.3%, in stage 3. The variables, older age and prolonged exposure to antiretroviral therapy were statistically significant for altering renal function. …”
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Cardiorenal syndrome in patients with rheumatoid arthritis by Z. Yu. Mutovina, A. I. Zagrebneva, E. A. Galushko, A. V. Gordeev

“…In 2008, the term cardiorenal syndrome (CRS) was proposed by the Acute Dialysis Quality Initiative (ADQI) Group to denote pathological reciprocal conditions involving the heart and kidneys, which develop due to acute or chronic dysfunction of one of the organs, followed by acute or chronic dysfunction of the other one. …”
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Challenges of obtaining cultured corneal endothelial cells for regenerative purposes by D. S. Ostrovski, S. A. Borzenok, B. E. Malyugin, O. P. Antonova, M. Kh. Khubetsova, T. Z. Kerimov

“…Currently, the only effective standard treatment for corneal endothelial dysfunction is transplantation of donor cornea that contains a pool of healthy and functionally active cells. …”
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Long-term indapamide retard therapy in adolescents with Stage I arterial hypertension by I. V. Logacheva, E. A. Gunicheva

“…IR monotherapy had beneficial effects on HRV, due to moderate parasympathetic stimulation. …”
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The Triglyceride–Glucose Index, a Marker of Insulin Resistance, Is Associated with the Myocardial Performance Index in Asymptomatic Subjects by Necip Nas, Muzaffer Aslan, Semih Saglik, Hafize Uzun

“…Regression analysis was used to determine the effective parameters in subclinical left ventricular dysfunction (SCLVD). …”
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MOG associated autoimmune encephalomyelitis with active disease dynamic in imaging examinations and minimal clinical manifestation by E. Tilindytė, I. Muliuolis, R. Samaitienė

“…Progressive encephalopathy and multiple focal neurological symptoms are characteristic to this disease: irritability, disturbed consciousness, weakness, sensory disorders, bowel, bladder dysfunction, spasticity, hyperreflexia, positive Babinsky reflex, paresis, cerebral ataxia, cerebral neuropathy, and spinal cord dysfunction (transverse myelitis). …”
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Research on the influence of Siberian fir polyprenols on learning and memory of mice with an experimental model of Alzheimer's disease by Nikolay I. Suslov, Yulia S. Fedorova, Maxim L. Korobov

“…Gliatilin showed a similar effect. The authors believe that cholinergic receptors are involved in the development of the anti-amnestic effect. …”
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