Aggressive Intravenous Hydration and a Defined Plant-Based Diet Safely and Effectively Treated Type 5 Cardiorenal Syndrome with Stage E Heart Failure-Related Cardiogenic Shock: A C... by Baxter Delworth Montgomery, Camille V. Owens, Rami Salim Najjar, Mawadda Saad

“…<b>Background and Clinical Significance</b>: Heart failure and kidney diseases often coexist and are difficult to clinically manage. Dysfunction in either organ exacerbates dysfunction in the other, potentially leading to cardiorenal syndrome (CRS). …”
Get full text

Effect of alfalfa supplementary change dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) ratio on rumen fermentation and microbial function in Gansu alpine fi... by Qian Chen, Yun-feng Cui, Zhao-xi Zhang, Fu-cheng Jiang, Xiang-yu Meng, Jin-jin Li, Da-yong Cui, Jian-lei Jia

“…Alfalfa is a good roughage supplementary for ruminants, which can improve grazing sheep bodyweight-loss and rumen microbial dysfunction during grass-withering period. This study evaluated the effects of alfalfa hay supplementary change dietary non-fibrous carbohydrate/neutral detergent fiber (NFC/NDF) ratios on rumen fermentation and microbial function of Gansu alpine fine wool sheep during extreme cold season. 120 ewes (3–4 yrs) with an average body weight of 28.71 ± 1.22 kg were allocated randomly into three treatments, and fed NFC/NDF of 1.92 (H group), 1.11 (M group), and 0.68 (L group), respectively. …”
Get full text

A Comparison of the Treatment Effects of a Risperidone Solution, an Equal Ratio of DHA/ARA, and a Larger Ratio of Omega-6 PUFA Added to Omega-3 PUFA: An Open-Label Clinical Trial by Kunio Yui, George Imataka

“…These findings demonstrate, firstly, that reduced inflammation through increased anti-inflammatory proteins such as Cp and IGF has clinical effects on the motivation–reward system and mannerisms in patients with ASD through the amelioration of dopamine D2, 5-HT2a, and 5-HT2b dysfunction.…”
Get full text

Neuroprotective Potential of <i>Stevia rebaudiana</i> and <i>Stachys sieboldii</i>: Effects on Oxidative Stress and Locomotor Activity in Male Rats Fed a High-Fat, High-Sucrose Die... by Yelena Pozdnyakova, Aigul Murzatayeva

“…A high-fat, high-sugar diet (HFHS) is known to exacerbate oxidative stress and behavioral dysfunctions, increasing susceptibility to cognitive decline. …”
Get full text

Effectiveness of Electrical Muscle Elongation and Proprioceptive Neuromuscular Facilitation Programs on Muscle Flexibility and Stiffness in Young Adults with Functional Hamstring D... by Carolina Jiménez-Sánchez, Rocío Fortún-Rabadán, Beatriz Carpallo-Porcar, Paula Cordova-Alegre, Luis Espejo-Antúnez, María Ortiz-Lucas

“…Background: Adequate hamstring flexibility is crucial for musculoskeletal health as increased muscle tone can lead to stretch-type injuries, muscle weakness, dysfunctional neuromuscular control, postural changes, and lower back pain. …”
Get full text

Protective Effects of Lotus Seedpod Extract on Hepatic Lipid and Glucose Metabolism via AMPK-Associated Mechanisms in a Mouse Model of Metabolic Syndrome and Oleic Acid-Induced Hep... by Hui-Hsuan Lin, Pei-Rong Yu, Chiao-Yun Tseng, Ming-Shih Lee, Jing-Hsien Chen

“…Metabolic syndrome (MetS) poses considerable toxicological risks due to its association with an increased likelihood of metabolic dysfunction-associated steatotic liver disease (MASLD), and is characterized by hypertension, hyperglycemia, dyslipidemia, and obesity. …”
Get full text

Effects of Three Sessions of Diaphragmatic Myofascial Release on Pain, Balance, and Quality of Life in Patients with Chronic Nonspecific Low Back Pain (A Regional Interdependence M... by soheil hejazi yekta, kazem malmir, Sara Fereydounnia, Khadijeh Otadi, Fatemeh Ehteshami

“…The diaphragm, a key respiratory muscle crucial for adjusting intra-abdominal pressure and maintaining lumbar spine stability, often exhibits dysfunction in chronic LBP. Improving diaphragm function may yield positive effects on chronic LBP. …”
Get full text

Effect of cortisol levels on working memory performance in elderly subjects with Alzheimer's disease Efeito dos níveis de cortisol no desempenho da memória operacional de idosos co... by Juliana Nery de Souza-Talarico, Paulo Caramelli, Ricardo Nitrini, Eliane Corrêa Chaves

Get full text

Effect of individualized versus conventional perioperative blood pressure management on postoperative major complications in high-risk patients undergoing noncardiac surgery: study... by Jaeyeon Chung, Chang-Hoon Koo, Jungchan Park, Hye-Bin Kim, Jinyoung Bae, Jae-Woo Ju, Soowon Lee, Ah Ran Oh, Hyo Sung Kim, Soo Jung Park, Yunseok Jeon, Karam Nam, for the Seoul PeRioperative OUTcome research-4 (SPROUT-4) Investigators

“…However, the effectiveness of this conventional management remains unproven in prospective randomized trials. …”
Get full text

Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs): A Pan-Steatotic Liver Disease Treatment? by Lampros Chrysavgis, Niki-Gerasimoula Mourelatou, Evangelos Cholongitas

“…Concurrently, the use of GLP-1 RAs in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has been associated with a clinically meaningful reduction in all-cause mortality, major cardiovascular events, and progression to metabolic dysfunction-associated steatohepatitis (MASH). …”
Get full text

PHARMACOECONOMIC ASSESSMENT OF INTERMITTENT AND CONTINUOUS RENAL REPLACEMENT THERAPY by Yu. S. Polushin, D. V. Sokolov, D. Yu. Belousov, A. E. Cheberda

“…The subject of this study is to investigate of pharmaco-economic results reflecting direct medical and indirect non-medical costs when using these technologies versus the maximum effective use of funds while treating patients with severe renal dysfunctions. …”
Get full text

The positive effects of high-frequency right dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation on memory, correlated with increases in brain metabolites d... by Qiao J, Jin G, Lei L, Wang L, Du Y, Wang X

“…Conclusion: High-frequency right DLPFC rTMS was associated with improvement in memory dysfunction, which is correlated with levels of hippocampal brain metabolites detected by 1H-MRS in recently detoxified alcohol-dependent patients. …”
Get full text

In Vitro Protective Effects of a Standardized Extract of <i>Opuntia ficus-indica</i> (L.) Mill. Cladodes and <i>Olea europaea</i> L. Leaves Against Indomethacin-Induced Intestinal... by Federica Lina Salamone, Maria Sofia Molonia, Claudia Muscarà, Antonella Saija, Francesco Cimino, Antonio Speciale

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce serious adverse effects in gastrointestinal (GI) mucosa, increasing intestinal permeability and leading to mitochondrial dysfunction, oxidative stress, apoptosis and inflammation. …”
Get full text

Mechanism of the effect of Piper crocatum extract on wound healing of Wistar rats post-excision mammary tumor based on IL-10 level, TGF-β1 expression, VEGF expression, Collagen den... by Nike Sari Oktavia, Arifa Mustika, Afif Nurul Hidayati

“…Patients with breast malignant tumors, exhibit immune system dysfunction while T cells play a major role in the inflammatory process of wound healing. …”
Get full text

Effects of opioid-free anesthesia combined with iliofascial nerve block on perioperative neurocognitive deficits in elderly patients undergoing hip fracture surgery: study protocol... by Tong Zhi, Shirong Wei, Jiao Kuang, Sitong Zhou, Danhong Yu, Tesheng Gao, Long Lei, Chengfei Xu, Liang Cheng, Qinghe Zhou, Ming Yao, Huadong Ni

“…Despite growing awareness of its clinical significance, current evidence regarding effective neuroprotective anesthetic strategies remains inconclusive. …”
Get full text

Effects of Spirulina (Arthrospira) platensis supplementation on intestinal permeability, oxidative stress markers, quality of life, and disease severity in patients with constipati... by Saeede Jafari Nasab, Awat Feizi, Parisa Hajihashemi, Mohammad-Hassan Entezari, Manoj Sharma, Peyman Adibi, Mohammad Bagherniya

“…Recent findings indicated that intestinal barrier dysfunction, hyperpermeability, oxidative stress, and inflammation play a role in IBS pathogenesis. …”
Get full text

Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…Secondary outcomes include visual acuity at different time points, vision-related quality of life, endothelial cell morphology and cost-effectiveness.Results The study outcomes will be analysed using mixed effects linear regression models, taking into account the treatment arms and relevant covariates. …”
Get full text

Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…This study proposed a synthesis method for ultra-small-diameter lentinan Se nanoparticles (LNT-UsSeNPs) with significantly superior reactive oxygen species (ROS) scavenging capabilities compared to conventional lentinan Se nanoparticles (LNT-SeNPs). These compounds effectively protected PC-12 cells from oxidative stress-induced cytotoxicity, alleviated mitochondrial dysfunction, reduced apoptosis. …”
Get full text

Effect of cognitive impairment assessment on the incidence of hypoglycemia in hospitalized elderly patients with type 2 diabetes mellitus (认知障碍评估对老年2型糖尿病患者低血糖发生率的影响)... by LIU Yunxia (刘云霞)

“…Objective To investigate the effect of cognitive impairment assessment on the incidence of hypoglycemia in elderly patients with type 2 diabetes. …”
Get full text

Effect of advanced glycation end products formed methylglyoxal, a food-borne dicarbonyl precursor, on the exacerbation of diabetic kidney disease by NOX4/Nrf2/NLRP3 inflammasome si... by Hee-Weon Lee, Min Ji Gu, Donghwan Kim, Eun Hee Han, Yoonsook Kim, Sang Keun Ha

Get full text