Multi-Omics Analysis of Chronic Heat Stress-Induced Biological Effects, Liver Injury, and Heat Tolerance Mechanisms via Oxidative and Anti-Inflammatory Pathways in Early-Pregnancy... by Jie Chai, Zhenhao Wen, Li Chen, Qiang Pu, Taorun Luo, Xiaoqian Wu, Zihan Ma, Zonggang Luo, Jia Luo, Jingyong Wang

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PU.1 alleviates the inhibitory effects of cigarette smoke on endothelial progenitor cell function and lung-homing through Wnt/β-catenin and CXCL12/CXCR4 pathways by Xue He⁺, Yanan Cui⁺, Tiao Li, Lijuan Luo, Zihang Zeng, Yiming Ma, Yan Chen

“…Introduction Endothelial progenitor cells (EPCs) dysfunction is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). …”
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The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa,... by Adolfo Daniel Rodríguez-Carrizalez, José Alberto Castellanos-González, Esaú César Martínez-Romero, Guillermo Miller-Arrevillaga, Luis Miguel Román-Pintos, Fermín Paul Pacheco-Moisés, Alejandra Guillermina Miranda-Díaz

“…Objectives: To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial. …”
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The effects of poloxamer and sodium alginate mixture (Guardix-SG®) on range of motion after axillary lymph node dissection: A single-center, prospective, randomized, double-blind p... by Sae Byul Lee, Sung-Chan Gwark, Cheol Min Kang, Guiyun Sohn, Jisun Kim, Il Yong Chung, Jong Won Lee, Hee Jeong Kim, Beom Seok Ko, Sei-Hyun Ahn, Won Kim, Junghwa Do, Jae Yong Jeon, Jinsung Kim, Eunhae Um, Tae In Yoon, Sung-Ui Jung, Minkyu Han, Byung Ho Son

“…<h4>Purpose</h4>Restricted shoulder mobility is a major upper extremity dysfunction associated with lower quality of life and disability after breast cancer surgery. …”
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Effects of e-aid cognitive behavioural therapy for insomnia (eCBTI) to prevent the transition from episodic insomnia to persistent insomnia: study protocol for a randomised control... by Jihui Zhang, Yuan Yang, Xian Luo, Dhirendra Paudel, Shirley Xin Li

“…Patients will be randomly assigned to receive 1 week eCBTI via a Smartphone application, or to receive TAU. Treatment effects will be assessed at 1 week and 3 months after intervention. …”
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Effects of pressure garments of varying designs on upper extremity sensorimotor functions and quality of life after stroke: Study protocol for a multicenter, double-blind, prospect... by Zhenkun Xu, Siaw Chui Chai, Shin Ying Chu, Kuicheng Li

“…<h4>Rationale</h4>Stroke often results in extensive neurological damage, leading to a wide range of rehabilitation needs and challenges, with upper extremity dysfunction being particularly prevalent. Although pressure garments have been used in the rehabilitation of children with cerebral palsy to reduce muscle tone, their therapeutic effects have not been thoroughly investigated in the field of stroke.…”
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Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity by Beatrice Polini, Caterina Ricardi, Francesca Di Lupo, Massimiliano Runfola, Andrea Bacci, Simona Rapposelli, Ranieri Bizzarri, Marco Scalese, Federica Saponaro, Grazia Chiellini

“…Moreover, TG68 administration was observed to efficiently counteract HFD-altered central and peripheral expressions in mice with selected biomarkers of metabolic dysfunction, inflammation, and neurotoxicity, revealing promising neuroprotective effects. …”
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Effect of adjunctive intraoral balance appliance in the usual care of patients with chronic temporomandibular joint disorders using Korean medicine in South Korea: study protocol f... by Jae-Heung Cho, Hyungsuk Kim, Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Won-Seok Chung, Mi-yeon Song

“…Introduction Temporomandibular disorders (TMDs) are a group of conditions affecting the temporomandibular joint (TMJ), masticatory muscles and associated structures, often leading to pain, dysfunction and a significant impact on quality of life. …”
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BrainFit: improving executive and subjective cognitive functioning in late-life mood disorders - a double-blind randomized active-controlled study evaluating the effect of online c... by Mardien L. Oudega, Mardien L. Oudega, Mardien L. Oudega, Mardien L. Oudega, Margot J. Wagenmakers, Margot J. Wagenmakers, Margot J. Wagenmakers, Tanya Palsma, Adriaan W. Hoogendoorn, Adriaan W. Hoogendoorn, Chris Vriend, Chris Vriend, Chris Vriend, Odile A. van den Heuvel, Odile A. van den Heuvel, Odile A. van den Heuvel, Sigfried Schouws, Sigfried Schouws, Annemiek Dols, Annemiek Dols, Annemiek Dols

“…IntroductionUnipolar and bipolar mood disorders in older adults are accompanied by cognitive impairment, including executive dysfunction, with a severe impact on daily life. Up and till now, strategies to improve cognitive functioning in late-life mood disorders (LLMD) are sparse. …”
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Comparison of the effects of transcranial direct current stimulation combined with different rehabilitation interventions on motor function in people suffering from stroke-related... by Kaiqi Zheng, Liang Guo, Weidong Liang, Pengcheng Liu

“…Furthermore, MT + tDCS was the optimal tDCS-based rehabilitation approach for treating upper limb motor dysfunction, whereas AM+tDCS was the most effective strategy for addressing lower limb motor dysfunction in PSSS. …”
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Effect of transcutaneous auricular vagus nerve stimulation on postoperative liver function in patients undergoing partial hepatectomy: a study protocol for a prospective, double-bl... by Yuanyuan Wang, Yuanyuan Wang, Zhengxiu Sun, Zhengxiu Sun, Yongao Lin, Yongao Lin, Mingshu Tao, Mingshu Tao, Wenxin Zhao, Wenxin Zhao, Jinling Liu, Jinling Liu, Xiaoqin Guo, Xiaoqin Guo, Chuyu Hang, Chuyu Hang, Mingyuan Wang, Mingyuan Wang, Wen Tan, Wen Tan, Xingyu Xiong, Xingyu Xiong, Jun-Li Cao, Jun-Li Cao, He Liu, He Liu, He Liu, He Liu

“…This study is designed to evaluate the hepatoprotective effects of taVNS on liver function in patients undergoing elective partial hepatectomy under general anesthesia.Methods/designIn this single-center, prospective, double-blind, randomized controlled trial, 140 patients scheduled for partial hepatectomy will be randomly allocated in a 1:1 ratio to either the transcutaneous auricular active-taVNS or sham taVNS groups. …”
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Lysophosphatidylcholine Offsets the Protective Effects of Bone Marrow Mesenchymal Stem Cells on Inflammatory Response and Oxidative Stress Injury of Retinal Endothelial Cells via T... by Haijun Zhao, Yanhui He

“…HRMECs were further treated with 10-50 μg/ml LPC to investigate the effect of LPC on the dysfunction of HRMECs. Western blotting was conducted to evaluate levels of TLR4 and p-NF-κB proteins. …”
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Effects of chemotherapy on skeletal muscle mitochondrial oxidative capacity using near-infrared spectroscopy (NIRS): Protocol paper for an observational mixed model repeated measur... by Randolph Edward Hutchison, Shannon Smith, Chloe Caudell, Sara Biddle, William Larry Gluck, Jennifer L Trilk

“…However, less is understood regarding mitochondrial dysfunction in patients with cancer. Near infrared spectroscopy (NIRS) is a non-invasive and cost-effective approach to assessing mitochondrial function of skeletal muscle by measuring oxygenated and deoxygenated hemoglobin and calculating the resulting tissue saturation index. …”
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Ethyl Acetate Fraction of Chestnut Honey Attenuates Scopolamine-Induced Cognitive Impairment in Mice and Glutamate-Induced Neurotoxicity in HT22 Cells by Yun Hee Jeong, Wei Li, Hye Jin Yang, Se-Gun Kim, Hong Min Choi, Jang-Gi Choi, You-Chang Oh

“…Chestnut honey has various benefits, such as antioxidative, anti-inflammatory, immunomodulatory, antibacterial, and antiviral effects. However, the effects of chestnut honey or the ethyl acetate fraction of chestnut honey (EACH) on neurodegenerative diseases and their related cognitive impairment and neurotoxicity have not yet been established. …”
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Risk of chronic kidney disease in type 2 diabetes determined by polymorphisms in NOS3, APOB, KCNJ11, TCF7L2 genes as compound effect of risk genotypes combination by Anna Viktorovna Zheleznyakova, Nadezhda Olegovna Lebedeva, Olga Konstantinovna Vikulova, Valery Vyacheslavovich Nosikov, Minara Shamkhalovna Shamkhalova, Marina Vladimirovna Shestakova

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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects by Maria Jure-Kunkel, Christina Yu, Nora Pencheva, Mark Fereshteh, Alexander Muik, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Brandon W Higgs, Jordan M Blum, Saskia M Burm, Vanessa M Spires, Angelica Sette, Sina Fellermeier-Kopf, Andrea Imle, Michela Capello, Kristin Strumane, Theo Plantinga, Craig J Thalhauser, Kristina B Nürmberger, Patricia Garrido Castro, Carol Costa Sa, Bruna de Andrade Pereira

“…The mechanism of action of the combination was investigated in the MC38 syngeneic model through immunohistochemistry, flow cytometry, and bulk RNA sequencing.Results The combination reinvigorated dysfunctional T cells in vitro, while also potentiating T-cell expansion, interleukin (IL)-2 and interferon gamma secretion and cytotoxic activity. …”
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Modulating Effects of L-Arginine and <i>Tribulus terrestris</i> Extract on Fipronil-Induced Interference in the Male Reproductive System of Rats: Antioxidant Potential, Androgen Re... by Doaa H. Elsayed, Ahmed A. Bakhashwain, Eman A. Ahmed, Hatim A. Al-Abbadi, Heba M. A. Abdelrazek, Menna Allah I. El-Menyawy, Wafaa K. Teleb, Noran M. Tawfik, Ibrahim E. Helal, Heba N. Gad EL-Hak

“…Histopathological studies of the testes and penis tissue, immunohistochemical expression of PCNA in testicular tissues, and biochemical analyses further confirmed the protective effects of TT and L-Arg. Collectively, these findings highlighted the potential of TT and L-Arg in counteracting FPN-induced reproductive impairments.…”
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Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multi... by Jie Liu, Jie Zhang, Wen Zhang, Ying Wang, Lu Zhang, Bing Zhang, Kun Wang, Weili Yan, Yan Bi, Zhou Zhang, Xiang Xu, Wenhui Zhu, Fangyi Li, Xiaoya Zhang, Xiaowei Zhu, Congcong Yu, Huijie Yang, Shihua Chen, Sijue Yang, Beibei Zhai, Tianyu Wu, Shengyi Zhao, Xuewei Tong, Yanjie Duan, Yining Chao, Jindan Wu, Xinhua Ye, Haiyan Cheng

“…Introduction Diabetes is a significant modifiable risk factor for cognitive dysfunction. There are currently no effective treatments that delay or reverse the progression of cognitive dysfunction. …”
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The effects of treadmill exercise and diet control on cognitive function in HFD-induced ApoE-/- mice based on the SIRT1-NF-κB/PGC-1α-BDNF signaling pathways by Xu Ting, Deng Wenjuan, Li Shufeng, Liu Yi, Shi Zhitong, Zhang Xiaoyue, Wang Ningping

“…[Objective] To investigate the effect and mechanism of treadmill exercise and diet control on cognitive dysfunction in apolipoprotein E knockout(ApoE-/-)mice model. …”
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Comparative estimation of the effectiveness of the Khorana, Vienna CATS, and TiC-Onco scores and the vWF/ADAMTS13 ratio in identifying a high risk of thrombotic complications in pa... by A. V. Vorobеv, A. G. Solopova, V. O. Bitsadze, M. M. Baeva, M. E. Sosnyagova, V. N. Galkin, D. O. Utkin, A. D. Makatsariya

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