Ameliorative Effects of <i>Prunella vulgaris</i> on Lower Urinary Tract Symptoms Induced by Benign Prostatic Hyperplasia in SD Rats via Nitric Oxide and Potassium Channels by Beno Ramesh Nirujan, Jeongsook Kim, Eun-Bok Baek, Kyungmi Kim, Nishani Jayanika Jayathilake, Youn Gil Kwak, Mi Ran Jang, Hyo Seong Ji, Hyo-Jung Kwun, Kyu Pil Lee

“…Current pharmacological treatments for LUTS and benign prostatic hyperplasia (BPH) are widely used in clinical practice; however, adverse effects associated with these drugs have been reported for sexual dysfunction and orthostatic hypotension. …”
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Nursing of a patient with septic shock (1例脓毒症休克患者的护理体会) by DONG Chao (董超), LI Jing (李静), LI Ning (李宁)

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Liver function effects of SGLT2 inhibitor and GLP‐1 receptor agonist combination treatment in patients with type 2 diabetes (post hoc analysis of RECAP study) by Daisuke Tsuriya, Kazuo Kobayashi, Kei Takeshita, Takuya Hashimoto, Moritsugu Kimura, Yoshimi Muta, Hisashi Yokomizo, Yuichi Takashi, Shunichiro Tsukamoto, Kouichi Tamura, Keizo Kanasaki, Daiji Kawanami, Masao Toyoda

“…ABSTRACT Aim The favor effect on liver disease by odium‐glucose cotransporter inhibitor (SGLT2i) and GLP‐1 receptor agonist (GLP1Ra) was reported; however, the effect of the combination treatment of these drugs was not well known. …”
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Results of an open multicenter non-interventional study of clinical efficacy and tolerability of etoricoxib in osteoarthritis and nonspecific back pain with additional evaluation o... by A. E. Karateev, E. Yu. Polishchuk, E. S. Filatova, V. N. Amirdzhanova, V. A. Nesterenko, A. S. Potapova, S. I. Glukhova, A. M. Lila, A. V. Sarapulova, A. A. Mukhin, O. S. Lyusina, L. A. Levasheva, E. V. Kryukova, D. K. Klein, N. V. Kichai, M. A. Kabalyk, N. E. Dobrokhotova, Yu. Yu. Grabovetskaya, L. A. Blagodareva, E. V. Zonova, S. M. Zwinger, P. P. Popov

“…The formation of chronic musculoskeletal pain (MSP) is a multifactorial process, in its pathogenesis mechanism of central sensitization (CS) plays an important role.Objective: to evaluate the effectiveness of etoricoxib at a dose of 60 mg per day in diseases accompanied by moderate/severe chronic MPS, with an additional analysis of the effect of this drug on the manifestations of CS.Patients and methods. …”
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Pirfenidone Prevents Myocarditis by Restoring Metabolic Hormone Levels in a Mouse MASH Model and its Effect on H9c2 Myoblast Viability under Glucolipotoxicity by Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Ángel O. Vázquez-Esqueda, Jonathan S. Rodríguez-Sanabria, Juan Armendáriz-Borunda, Jorge Gutiérrez-Cuevas

“…Introduction and Objectives: Obesity, global epidemic, can cause metabolic dysfunction-associated steatohepatitis (MASH) and cardiovascular diseases. …”
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Therapeutic Effects of Fire Needling Acupuncture on Pain Relief and Cartilage Protection in MIA-Induced Knee Osteoarthritis Rats: The Role of Macrophage Polarization in Synovium an... by Wei J, Yang X, Ge X, Zhao L, Liu X, Zhang J, Zhou J, Zhang C, Li W, Li Z, Lyu T, Wang Y, Yuan F, Liu L, Li B

“…Clinical studies indicate that fire needling acupuncture can alleviate joint stiffness, pain, and dysfunction in KOA. Previous research demonstrated its efficacy in reducing pain, mitigating cartilage damage, and regulating macrophage polarization, but its effects on subchondral bone remain unclear. …”
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A Critical and Semiotic Approach to the Wonderful, Horrible Life Cycle of the Kony 2012 Viral Video by Fernando Andacht

“…Their functionalist analysis of media effects posits a peculiar “narcotizing dysfunction” to account for the apathy produced in the audience despite the increasing intake of media information by the population. …”
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Effects of antagonistic network-targeted tDCS on brain co-activation patterns depends on the networks’ electric field: a simultaneous tDCS-fMRI study by Hechun Li, Hongru Shi, Sisi Jiang, Changyue Hou, Haonan Pei, Hanxi Wu, María Luisa Bringas Vega, Gang Yao, Dezhong Yao, Cheng Luo

“…Background: Brain networks should be ideal targets for non-invasive brain stimulation, as network dysfunction is a common feature of various neuropsychiatric disorders. …”
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Therapeutic outcomes of enzalutamide-docetaxel combination versus docetaxel monotherapy in post-sequential androgen receptor axis-targeted therapy failure metastatic castration-res... by Zhiyu Zhang, Yanhang Yu, Chuanao Zhang, Jianglei Zhang, Xuefeng Zhang, Jun Ouyang

“…There were no significant differences in myelosuppression, gastrointestinal issues, liver dysfunction, neurological symptoms, edema, rash, or high blood pressure between groups (P &gt; 0.05).ConclusionCombining enzalutamide with docetaxel is more effective than docetaxel alone for treating mCRPC after abiraterone and enzalutamide, providing better PSA-PFS and improved metastasis outcomes, along with better pain relief. …”
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…<h4>Conclusions</h4>ELO water raises arterial blood oxygen levels, appears to have a protective effect on hyperglycaemia-induced reduction in mitochondrial mass and mitochondrial dysfunction, and may be effective adjuvant therapy for type 2 diabetes.…”
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The Effects of Lipid Extracts from Microalgae <i>Chlorococcum amblystomatis</i> and <i>Nannochloropsis oceanica</i> on the Proteome of 3D-Cultured Fibroblasts Exposed to UVA Radiat... by Sinemyiz Atalay Ekiner, Agnieszka Gęgotek, Maria Rosário Domingues, Pedro Domingues, Elżbieta Skrzydlewska

“…<i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> exhibit significant potential for protecting skin cells from oxidative stress-induced metabolic dysfunctions, owing to their high bioactive lipid content. …”
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The effects of a single session of lumbar spinal manipulative therapy in terms of physical performance test symmetry in asymptomatic athletes: a single-blinded, randomised controll... by Bruno A P Alvarenga, Ricardo Fujikawa, Filipa João, Jerusa P R Lara, António P Veloso

“…Background and aim Musculoskeletal disorders in athletes, including spinal biomechanical dysfunctions, are believed to negatively influence symmetry. …”
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Effect of tirzepatide-induced weight loss on adipose tissue in obesity: rationale and design of the randomized placebo-controlled Tirzepatide Brown and Beige Adipose Tissue Activat... by Rok Herman, Mojca Jensterle, Simon Horvat, Luka Lezaic, Ziga Snoj, Igor Pusnik, Katja Goricar, Andrej Cör, Luka Pusnik, Vid Mlacnik, Lara Hanzelic, Andrej Janez

“…Abstract Background Obesity is a complex disease marked by excessive, dysfunctional adipose tissue accumulation. Recent research underscores the pivotal role of brown adipose tissue (BAT) in metabolic health and its potential as a therapeutic target for obesity management. …”
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Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and &amp;gamma;-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome by Zhang W, Wei L, Yu W, Cui X, Liu X, Wang Q, Wang S

“…This study evaluated the effect of JPZDD on glutamate (Glu) and &amp;gamma;-aminobutyric acid (GABA) and their receptors in a TS rat model.Materials and methods: Rats were divided into four groups (n=12 each). …”
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The Relation between Endothelial Monocyte-activating Polypeptide II and Polymorphism of Endothelin-1 Gene (G8002A) and Their Effect on Renal Function in Adolescent Patients with Be... by Dahlia N. Al-Saidi, Sumaya Saady, Zainab Walid Abdul Ameer

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The Corrective Effect of Fucoidan, a Sulfated Polysaccharide Extracted from Brown Algae Fucus evanescens, in the Formation of a Specific Immune Response Against Seasonal Influenza... by T. S. Zaporozhets, S. P. Kryzhanovsky, E. V. Persianova, T. A. Kuznetsova, T. P. Smolina, A. K. Gazha, N. M. Shevchenko, S. P. Ermakova, T. N. Zvyagintseva, N. N. Besednova

“…The article establishes the particularities of immune system dysfunction in the elderly during formation of a specific immune response to vaccination with a seasonal influenza vaccine depending on the level of seroconversion. …”
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Changes in Protease-Activated Receptor and Trypsin-1 Expression Are Involved in the Therapeutic Effect of Mg2+ Supplementation in Type 2 Diabetes-Induced Gastric Injury in Male Adu... by Nasrin Mehranfard, Hossein Rezazadeh, Nepton Soltani, Azadesadat Hosseini Dastgerdi, Mahtab Ghanbari Rad, Maedeh Ghasemi

“…Evidence suggests protease-activated receptors (PARs) are a link between inflammation and gastrointestinal dysfunction. Given that magnesium (Mg2+) deficiency is a highly prevalent condition in T2DM patients, we assessed the therapeutic role of Mg2+ on the factors involved in gastric inflammation in T2DM. …”
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Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy. by Yihua Wang, Qing Liao, Xue Mei, Han Xu, Lijun Luo, Rong Huang, Yue Tang, Chunyang Zhou

“…The traditional treatment primarily relies on statins; however, these drugs are often linked to side effects such as liver dysfunction and muscle impairment. …”
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Clinical effect of three-dimensional left ventricular mechanical dyssynchrony and cardiac sympathetic denervation in systolic heart failure risk-stratified by left ventricular ejec... by Takahiro Doi, Koki Morishita, Rintaro Furuoka, Kosuke Uruno, Ryosuke Hatano, Mirei Nabuchi, Ken Masuda, Kaoru Komuro, Hiroyuki Iwano, Daigo Nagahara, Satoshi Yuda, Akiyoshi Hashimoto, Tomoaki Nakata

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Effect of Curcumin on Docetaxel-Induced Apoptosis in the DU145 (Prostate) Cell Line Using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide Assay by Mohammad Shokrzadeh, Elahe Gharehkhani, Mahboube Rahmati Kukandeh, Mahsa Hosseini

“…This study aimed to determine the effect of curcumin on DTX-induced apoptosis in the DU145 (prostate) cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. …”
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