cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats by Liu X, Guo H, Sayed MDSM, Lu Y, Yang T, Zhou D, Chen Z, Wang H, Wang C, Xu J

“…Xu Liu,1,2,* Haibiao Guo,1,* Mohammad Daud SOM Sayed,3,4,* Yang Lu,3,4,* Ting Yang,5,* Dongsheng Zhou,6 Zhongming Chen,6 Haitao Wang,1 Chuang Wang,3,4 Jiangping Xu1 1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 2Department of Pharmacy, General Hospital of Chinese People’s Armed Police Forces, Beijing, 3Ningbo Key Laboratory of Behavioral Neuroscience, 4Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang, 5Department of Pediatrics, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 6Department of Geriatric Psychiatry, Ningbo Kangning Hospital, Ningbo, Zhejiang, People’s Republic of China *These authors contributed equally to this work Objectives: GEBR-7b, a potential phosphodiesterase 4D inhibitor, has been shown to have memory-enhancing effects in rodents. However, it is still unknown whether GEBR-7b also has the antidepressant-like effects in rats. …”
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Effects of VR task-oriented training combined with rTMS on balance function and brain plasticity in stroke patients: a randomized controlled trial study protocol by Yuanyuan Liu, Ruizhu Lin, Xinbao Tian, Junyi Wang, Ying Tao, Ning Zhu

“…Abstract Background Balance dysfunction affects 70% of stroke patients. Emerging neurophysiological approaches, such as virtual reality therapy (VRT) and repetitive transcranial magnetic stimulation (rTMS), have been proven by clinical studies that the balance function of stroke patients can be improved when applied alone, but there are relatively few studies on the combined treatment of balance dysfunction after stroke. …”
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A supercritical oil extract of Schisandra chinensis seeds ameliorates Huntington’s disease-like symptoms and neuropathology: the potential role of anti-oxidant and anti-inflammator... by Hyo-Sung Jo, Hyo-Sung Jo, Youn-Woo Lee, So-Ri Son, Dae Sik Jang, Tae Woo Kwon, Tae Woo Kwon, Yujeong Ha, Yujeong Ha, Sang-Kwan Moon, Min Soo Kim, Min Soo Kim, Ik-Hyun Cho, Ik-Hyun Cho, Ik-Hyun Cho, Ik-Hyun Cho

“…The purpose of this study was to determine neuroprotective effects of SOSC by supercritical fluid extraction against 3-nitropropionic acid (3-NPA)-induced HD-like symptoms and neuropathology in an experimental mouse model.MethodsSOSC (75, 150, and 300 mg/kg/day) was orally pre-administration once daily at 1 hour before 3-NPA intoxication.ResultsSOSC ameliorated movement dysfunction and lethality following 3-NPA intoxication in connection with reduction of lesion area, neurodegeneration/apoptosis, microglial migration/activation, and mRNA expression of pro-inflammatory cytokines/enzymes in the striatum. …”
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Comparative effect of Chamomile flower (Matricaria chamomilla L.) andPassion flower (Passiflora incarnata L.) powder tea in patients suffering from primary insomnia by Zartasha Khalid, Sana Noreen, Patrick Maduabuchi Aja, Abdul Rehman, Ayesha Sadiqa

“…This study explores the effect of chamomile and passionflower on sleep quality, stress, melatonin production, and liver function in individuals with primary insomnia. …”
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Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets by Ivan I. Dedov, Vsevolod A. Tkachuk, Nikolai B. Gusev, Vladimir P. Shirinsky, Aleksandr V. Vorotnikov, Tatiana N. Kochegura, Aleksander Y. Mayorov, Marina V. Shestakova

“…Hyperglycemia is a distant consequence of IR in which damaging effect of oxidative and carbonyl stress is realized and diagnosis of T2DM is stipulated. …”
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Effect of Respiratory Muscle Stretch Gymnastic on Peak Expiratory Flow Rate, Exercise Capacity, Rate of Perceived Exertion, Pain, and Posture in Computer Workers: An Interventional... by Jil Chokshi, Ayesha Mulla, Falak Oza, Nidhi Mevada

“…Very few studies have been conducted to see the RMSG effect on computer workers. Hence, this study aimed to determine the effect of RMSG on peak expiratory flow rate (PEFR), exercise capacity (EC), rate of perceived exertion (RPE), pain, and posture. …”
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Anti-inflammatory and renoprotective effects of difelikefalin, a kappa opioid receptor agonist, in a rat model of renal ischemia–reperfusion-induced acute kidney injury by Hiroto Takeuchi, Satoshi Tatemichi, Yuji Okuhara

“…Abstract Background This study evaluated the effects of difelikefalin, a kappa opioid receptor (KOR) agonist, on the inflammatory response and renal dysfunction in a rat model of acute kidney injury induced by renal ischemia–reperfusion injury, comparing it with other KOR agonists. …”
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Evaluation of the effect of phellodendrin application on rats creating an experimental model of non-compression lumbar disc herniation on the NF-κB-related inflammatory signaling p... by Panlin Tan, Jianbing Mei, Dong Wang

“…Abstract Objective To explore the therapeutic effects of phellodendrine on non-compression lumbar disc herniation (NCLDH). …”
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Antioxidant activity and protective effect of phyto‐active compounds of Crataegus azarolus berries decoction extract against acetic acid‐induced hepatorenal injuries in male rats... by Houcem Sammari, Anouar Abidi, Saber Jedidi, Nourhen Dhawefi, Hichem Sebai

“…Finally, CAB‐DE might have a possible protective effect against AA‐oxidative stress and dysfunction in the rat liver and kidney, suggesting that Crataegus azarolus berries may be beneficial for people suffering from liver issues and nephropathy.…”
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Effectiveness, Tolerability and Safety of a Compound Based on D-chiro-inositol + Myo-inositol, Melatonin, Folic Acid, and Vitamin D in Patients with Menstrual Cycle Disorders by Silvia P. González, María del Mar Rubio, Helena Losa

“…These disorders often encompass ovulatory dysfunction, accompanied by analytical and clinical anomalies linked to hyperandrogenism, collectively defining polycystic ovary syndrome (PCOS). …”
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Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway by Xinqi Chen, Yang Chen, Catherine Stanton, R.Paul Ross, Jianxin Zhao, Bo Yang, Wei Chen

“…This study aimed to evaluate the effects of Bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. …”
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Targeted heart rate control using the funny current inhibitor ivabradine to reduce morbidity in patients undergoing noncardiac surgery: study protocol for a phase 2a, triple-blind,... by Bernardo Bollen Pinto, Benjamin Shelley, Priyanthi Dias, Salma Begum, Florence Ennahdi-Elidrissi, Tom E.F. Abbott, Russell Hewson, Akshaykumar Patel, Kamran Khan, Rupert M. Pearse, Gareth L. Ackland, Bernardo Bollen Pinto, Benjamin Shelley, Priyanthi Dias, Salma Begum, Florence Ennahdi-Elidrissi, Russell Hewson, Anna Wozniak, Shaun M. May, Mareena Joseph, Agustine Miguel Saavedra, Tim Martin, Onika Ottley, Ana Santos, Fatima Seidu, Stéphanie Mulin, Stéphane Luise, Isabelle Pichon, John Daniels, Béatrice Gil-Wey, Soraya Bicher, Gaël Rais, Christene Aitken, Elizabeth Boyd, Patricia Griffen, Charlene Hamilton, Kathryn Valdeavella, Rhiannon McAreavey, Phillip McCall, Alfie Lloyd, Jocelyn Barr, Julie Buckley, Anne Marie Tiah, Henrike Janssen, Lisa Kandala, Angela Fitzpatrick, Alexander Lysomirski, Ahmed Ahltobi, Ana Gutierrez del Arroyo, Tom E.F. Abbott, Akshaykumar Patel, Kamran Khan, Rupert M. Pearse, Gareth L. Ackland

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‘Shared efforts, brighter smiles’: a protocol for a randomised controlled study on the effectiveness of a parent-child orofacial myofunctional therapy programme post-adenoidectomy... by Meng Zhao, Jianhua Liu, Jianchun Zhao, Aimin Wang, Haowei Du, Zhaoxia Wei

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The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats by Li Peng, Jie Li, Yixing Xu, Yangtian Wang, Hong Du, Jiaqing Shao, Zhimin Liu

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Protective effects of C-Phycocyanin from Spirulina platensis against pancreatic inflammation, lymphocyte infiltration, impaired carbohydrate digestion, and glucose metabolism dysre... by Insaf Bahrini, Muna Alamoudi, Maha Alazami, Jawaher Alrashdi, Noureddine Alouche

“…This study aimed to evaluate the effects of C-phycocyanin (CPC), a natural food coloring extracted from Spirulina platensis (Sp), on pancreatic inflammation, digestive enzyme activity, and glucose metabolism in alloxan-induced diabetic male Wistar rats. …”
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Yellow mealworm (Tenebrio molitor) meal in diets of grass carp (Ctenopharyngodon idellus): Effects on growth performance, antioxidant capacity, immunity, intestinal morphology, and... by Linlin Yang, Minglang Cai, Lei Zhong, Yulong Yin, Yonghong Xie, Shouqi Xie, Yi Hu, Junzhi Zhang

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Effect of dry period immunization of Salmonella Dublin latent carriers with a commercial live culture vaccine on intrauterine transmission based on the presence of precolostral ant... by Rafael E. Castro-Vargas, Faith M. Cullens-Nobis, Rinosh Mani, Jennifer N. Roberts, Angel Abuelo

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Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study by Sijia Yang, Kun Liao, Lu Zhou, Shengbo Zhang, Jianchao Wu

“…For BRI, values below 3.55 exhibited a strong positive effect on grip strength (β = 3.60, 95% CIs: 2.81–4.39), with weakened but persistent positive effects above this threshold (β = 0.24, 95% CI: 0.10–0.39). …”
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Effect of opioid-free anaesthesia on postoperative delirium in elderly patients undergoing gastrointestinal surgery: study protocol for a single-centre, prospective, randomized con... by Yuehan Du, Mengjie Liu, Xiaoling Yang, Jianbo Wu, Xiaojun Gao, Qiuyue Liu, Lina Chen, Xiaxuan Sun, Min Zhang, Yongtao Sun

“…Although existing studies have preliminarily investigated the effects of opioid-free anaesthesia (OFA) on POD, high-quality evidence on these effects for elderly patients undergoing gastrointestinal surgery remains limited. …”
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Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation by Esther Rodríguez-Gallego, Marta Riera-Borrull, Anna Hernández-Aguilera, Roger Mariné-Casadó, Anna Rull, Raúl Beltrán-Debón, Fedra Luciano-Mateo, Javier A. Menendez, Alejandro Vazquez-Martin, Juan J. Sirvent, Vicente Martín-Paredero, Angel L. Corbí, Elena Sierra-Filardi, Gerard Aragonès, Anabel García-Heredia, Jordi Camps, Carlos Alonso-Villaverde, Jorge Joven

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