Effects of DPP4 Inhibitors as Neuroprotective Drug on Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review by Yuting Yuan, Yue Zhang, Min Lei, Xiying Guo, Xiaosong Yang, Changhan Ouyang, Chao Liu, Qingjie Chen

“…DPP4 inhibitors are effective drugs for the treatment of type 2 diabetes mellitus. …”
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Longitudinal Effects of Transcranial Direct Current Stimulation on Daily Rejection-Related Emotions in Borderline Personality Disorder: An Ecological Momentary Assessment Study Pro... by Chiara De Panfilis, Alessandro Lisco, Kevin B. Meehan, Maria Lidia Gerra, Emanuele Preti, Paolo Riva, Leonor Josefina Romero Lauro

“…Background: Borderline Personality Disorder (BPD) is a debilitating mental health condition characterized by emotional dysregulation and interpersonal dysfunction, with perceived social rejection exacerbating these issues. …”
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The Effects of High-Intensity Interval Training (HIIT) on Sleep Quality in Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Kittibhum Kawinchotpaisan, Charnsiri Segsarnviriya, Phawit Norchai

“…Method: This study aimed to examine the effects of HIIT on sleep quality in obese patients through a systematic review and meta-analysis of studies published in five databases: PubMed, Scopus, Ovid, The Cochrane Library, and Google Scholar. …”
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Effectiveness of electrical stimulation with conservative treatment for lower urinary tract symptoms in Parkinson's disease: A three-armed randomized controlled trial protocol by Dorien Bennink, Rob A. de Bie, Henk W. Elzevier, Dagmar H. Hepp, Gommert A. van Koeveringe, Anton A. van der Plas, Hein Putter, Maxime T.M. Kummeling, Heidi F.A. Moossdorff-Steinhauser

“…Conservative treatments, such as bladder training, pelvic floor muscle exercises (PFME) with biofeedback and electrical stimulation, have been shown safe and effective in the general population, with minimal side effects. …”
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Is the Meibopatch Heated Pad Useful in Treating Patients with Meibomian Gland-Related Dry Eye Disease? – Assessing Tolerability, Acceptance, and Effectiveness by Bakhiet TE, Ansari AS, Williams GS, Awad MH, Thomas A

“…However, its long-term acceptance and efficacy among patients with posterior blepharitis, a condition closely linked with Meibomian gland dysfunction (MGD), has yet to be demonstrated.Methods: Patients with symptomatic non-responsive blepharitis were enrolled during clinic visits and asked to self-administer Meibopatch treatment for four weeks. …”
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Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study by Sndos Z. Fattiny, Manal Abdulaziz Binobead, Abu ElGasim A. Yagoub, Ghedeir M. Alshammari, Ali Saleh, Mohammed Abdo Yahya

“…Research has shown that rhoifolin (ROF) can effectively treat metabolic illnesses. This study examines the impact of ROF on glucose and lipid metabolism in a rat model of Type 2 Diabetes Mellitus (T2DM) and investigates its underlying mechanisms.MethodsT2DM was induced in adult male Wistar rats by administering a high-fat diet (HFD) along with a low dose of streptozotocin (STZ) (35 mg/kg, i. p.). …”
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Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial by Azam Ildarabadi, Marzieh Vahid-Dastjerdi, Mina Ghorbanpour, Ahmad Mousavi, Mehrnoush Meshkani, Mirsaeed Yekaninejad, Ahmad Saedisomeolia

“…This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS. …”
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The effect of osteopathic manipulative treatment on lenght of stay and pain relief in pediatric appendectomy: a pilot non-randomized time-controlled clinical trial by Roberto Lo Piccolo, Roberto Lo Piccolo, Michele Maria Cantagalli, Tommaso Ferroni, Florinda Fracchiolla, Antonino Morabito, Antonino Morabito

“…Osteopathic manipulative treatment (OMT) may improve recovery by addressing fascial restrictions and visceral dysfunction. This pilot study investigates OMT's effect on postoperative pain and hospital length of stay in pediatric patients undergoing appendectomy.MethodsThis non-randomized, time-controlled clinical trial was conducted at Meyer Pediatric Hospital (Florence, Italy) with 43 patients aged 5–17 undergoing laparoscopic appendectomy. …”
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Protective effect of phenolic-rich extract of Anona muricata Linn leaf on renal oxidative stress and inflammation in streptozotocin-induced diabetes in diabetic rats by Benjamin Olusola Omiyale, Bidemi Emmanuel Ekundayo, Makhosazana Siduduzile Mathenjwa-Goqo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye

“…Diabetic nephropathy is one of the most pronounced complications that develops as a result of diabetes and it is a highly ranked caused of end-stage renal dysfunction. Anona muricata has been traditionally considered to be beneficial in treatment of diabetic complications. …”
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Effect of acute kidney injury care bundle on kidney outcomes in cardiac patients receiving critical care: a systematic review and meta-analysis by Fatma Refaat Ahmed, Nabeel Al-Yateem, Seyed Aria Nejadghaderi, Rawia Gamil, Mohannad Eid AbuRuz

“…However, given the inclusion of non-cardiac patients in some studies, the observed effect may not be solely attributable to cardiac surgery cases. …”
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The effects of masseter muscle morphology on three-dimensional occlusion and temporomandibular joint in adult patients with skeletal class II malocclusion: a CBCT study by Yiyang Shen, Xin Li, Xiaoyan Feng, Chenxing Zhang, Yufeng Shang, Jun Lin

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OPTIMAL USE OF BETA-BLOCKERS IN CASE OF CHRONIC HEART FAILURE by N. A. Shostak, N. A. Demidova

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Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer by Chase Garcia, Ariana Banerjee, Claire Montgomery, Lauren Adcock, Izumi Maezawa, Jon Ramsey, Ana Cristina G. Grodzki, Kyoungmi Kim, Gino Cortopassi

“…Conversely, microglial dysfunction and inflammation are connected to cognitive decline and neurodegenerative diseases. …”
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Effects of acupuncture on the insulin signaling pathway and mitochondrial AMPK pathway in an animal model of type 2 diabetes mellitus: systematic evaluation and meta-analysis by Fang Luo, Zhijun Ma, Hanhan Chen, Zhuoxuan Li, Junjie Feng, Chengguo Su, Jun Zhu

“…Finally acupuncture had the following beneficial effects on the insulin signaling pathway and mitochondrial AMPK pathway: (1) insulin signaling pathway: Acupuncture can balance the phosphorylation levels of IRS-1 tyrosine 895 and IRS-1 serine/threonine 307 and promote the expression of all factors of the insulin signaling pathway, namely, IRS-1 mRNA, p-IRS-1, PI3K p85, PI3K mRNA, AKT, p-AKT, GLUT 4, and GLUT 4 mRNA—promoting glucose uptake, alleviating IR, and ameliorating impaired glucose metabolism. (2) Mitochondrial AMPK pathway: acupuncture significantly promoted AMPK, AMPK mRNA, p-AMPK, SIRT1, SIRT1 mRNA, PGC-1α, PGC-1α mRNA and NRF1, improved mitochondrial dysfunction, enhanced glucose metabolism, and alleviated T2DM symptoms. …”
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Effect of injecting adipose stem cells combined with platelet-rich fibrin releasate at Shenshu acupoint (BL23) on acute kidney injury in rabbits by Hsin-Ni Chuang, Wen Pei, Tzong-Fu Kuo, Yu-Hao Liu, Chia-Yih Wang, Yen-Wei Chang, Chi‐Hsuan Chuang, Chang-Huan Yang, Ming-Hsi Chuang, Ming-Hsi Chuang, Ming-Hsi Chuang, Ming-Hsi Chuang

“…The observed synergistic effect indicates that this approach holds potential as a novel therapeutic strategy for kidney injury. …”
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Effects of pulsatile flow on postoperative recovery in adult cardiac surgery with cardiopulmonary bypass: A systematic review and meta-analysis of randomized controlled trials by Weidong Yan, Tianlong Wang, Jing Wang, RuiNing Yang, Han Zhang, Mingru Zhang, Bingyang Ji

“…Data were analyzed using the random-effects model. Then, sensitive analysis and meta-regression were conducted. …”
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Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease by Sisi Wang, Ziyang Ding, Zhou Zhu, Xiaoru Zhong, Ashok Iyaswamy, Yaping Niu, Wei Zhang, Jichao Sun, Yulin Feng, Chuanbin Yang, Jigang Wang

“…Knockout of the TFEB gene effectively inhibited LA‐induced autophagy, suggesting that LA induced autophagy through TFEB activation. …”
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Effects of non-invasive brain stimulation over the supplementary motor area on motor function in Parkinson's disease: A systematic review and meta-analysis by Yawen Chen, Hanhong Jiang, Yixin Wei, Saiqing Ye, Jiaxin Jiang, Margaret K.Y. Mak, Marco Y.C. Pang, Qiang Gao, Meizhen Huang

“…Background: Motor dysfunction profoundly affects individuals with Parkinson's disease (PD). …”
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Protective Effects of the Ketogenic Diet on Cognitive Impairment Induced by Status Epilepticus in Rats: Modulation of Neuroinflammation Through the NF‐κB Signaling Pathway by Wandi Wang, Lingman Wang, Chunxue Jiang, Shengxuan Zhang, Chen Tan, Liqiong Peng, Ran Ding, Bing Tian, Xiaojie Song, Li Jiang

“…ABSTRACT Epilepsy is a chronic neurological disorder characterized by abnormal synchronized neuronal discharges, leading to cognitive dysfunction. The ketogenic diet (KD) has shown promise as an effective treatment for drug‐resistant epilepsy (DRE), reducing seizures and improving cognitive and behavioral outcomes in patients. …”
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Cardio–Renal and Systemic Effects of SGLT2i Dapagliflozin on Short-Term Anthracycline and HER-2-Blocking Agent Therapy-Induced Cardiotoxicity by Vincenzo Quagliariello, Annabella Di Mauro, Gerardo Ferrara, Francesca Bruzzese, Giuseppe Palma, Antonio Luciano, Maria Laura Canale, Irma Bisceglia, Martina Iovine, Christian Cadeddu Dessalvi, Carlo Maurea, Matteo Barbato, Alessandro Inno, Massimiliano Berretta, Andrea Paccone, Alfredo Mauriello, Celeste Fonderico, Anna Chiara Maratea, Nicola Maurea

“…Our findings demonstrate that dapagliflozin effectively mitigates early cardiac dysfunction and injury in a preclinical model of sequential doxorubicin and HER-2 inhibitor therapy.…”
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