Combination of tauroursodeoxycholic acid, co-enzyme Q10 and creatine demonstrates additive neuroprotective effects in in-vitro models of Parkinson’s disease by Alexander Shtilbans, Alexander Shtilbans, Wolfgang E. Reintsch, Valerio E. C. Piscopo, Andrea I. Krahn, Thomas M. Durcan

“…We have identified a triple combination of these supplements that showed an additive protective effect across all these endpoints. Indeed, the agents in that combination could address the majority of the known pathways leading to neurodegeneration, such as accumulation of misfolded α-synuclein, mitochondrial dysfunction, reactive oxygen species, and neuroinflammation. …”
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Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects by Wen‐Hui Liu, Hui‐Min Hu, Chen Li, Qing Shi, Yi‐Fan Li, Peng Mao, Bi‐Fa Fan

“…Data from observational studies indicates that dysfunction of brain resting‐state functional networks is present in a wide range of peripheral neuropathic pain (pNP). …”
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Protective effects of dill fruit against acute acetic acid‐induced ulcerative colitis by reducing inflammation and oxidative stress in rats by Chirine Brinsi, Yassin Khadraoui, Mariem Mhimdi, Slimen Selmi, Houcem Sammari, Saber Jedidi, Houcine Selmi, Hichem Sebai

“…Abstract Nutritherapy is the art of using nutrients as a means of preventing or correcting dysfunction in the body. We aimed to evaluate the protective effect of dill fruit aqueous extract (DFAE) against acetic acid‐induced ulcerative colitis. …”
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The Effect of Digital Addiction Training on University Students’ Digital Addiction, Sleep Quality, and Orexin-A Levels: Randomized Controlled Trial by Zehra İncedal Sonkaya, Burak Yazgan

“…Conclusion Digital addiction training has been shown to be an effective program in reducing students’ levels of overuse, non-restraint, emotional state, dependence, and overall digital addiction. …”
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The Effect of Virtual Reality Training on Anticipatory Postural Adjustments in Patients with Chronic Nonspecific Low Back Pain: A Preliminary Study by Zhicheng Li, Qiuhua Yu, Haizhen Luo, Wenzhao Liang, Xin Li, Le Ge, Siyun Zhang, Le Li, Chuhuai Wang

“…The visual analogue scale (VAS) and Oswestry dysfunction index (ODI) scores were also recorded. Results. …”
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Effects of angiotensin receptor–neprilysin inhibition on myocardial energy metabolism and prognosis in patients with acute myocardial infarction complicated by heart failure by Caiming Cheng, Caiming Cheng, Caiming Cheng, Yu Nie, Yu Nie, Di Chen, Di Chen, Yan Yang, Yan Yang, Shunji Liang, Qin Yu

“…ObjectiveThis study aims to evaluate the effects of angiotensin receptor–neprilysin inhibitor (ARNI) on myocardial energy metabolism and prognosis in patients with acute myocardial infarction (AMI) complicated by heart failure (HF).MethodsA retrospective analysis was conducted on data from 244 inpatients admitted to our center, who were diagnosed with AMI complicated by HF. …”
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Multi-omics reveal the effects and regulatory mechanism of dietary echinocystic acid supplementation on abdominal fat and liver steatosis in broiler chickens by Lianggui Xiao, Jiazhe Liu, Liangshan Qin, Shan Deng, Guodong Mo, Dandan Zhang, Ben Huang

“…The accumulation of abdominal fat and the metabolic dysfunction-associated fatty liver disease (MAFLD) are prevalent problems in the poultry industry, and seriously compromise broiler health and reduce economic benefits. …”
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The effect of neuromuscular blocking reversal agents on perioperative neurocognitive function after general anaesthesia: a systematic review and meta-analysis by Hao Wang, Xinghua Lv, Lin Wu, Fangli Ma, Ling Wang, Yongqi Wang, Xiaoxia Wang, Yulan Li

“…Abstract Background Perioperative neurocognitive dysfunction (PND) is influenced by various perioperative factors. …”
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Limosilactobacillus reuteri DS0384 promotes intestinal epithelial maturation via the postbiotic effect in human intestinal organoids and infant mice by Hana Lee, Kwang Bo Jung, Ohman Kwon, Ye Seul Son, Eunho Choi, Won Dong Yu, Naeun Son, Jun Hyoung Jeon, Hana Jo, Haneol Yang, Yeong Rak Son, Chan-Seok Yun, Hyun-Soo Cho, Sang Kyu Kim, Dae-Soo Kim, Doo-Sang Park, Mi-Young Son

“…Moreover, NCG exerted a protective effect on experimental colitis in mice. These results suggest that DS0384 is a useful agent for probiotic applications and therapeutic treatment for disorders of early gut development and for preventing intestinal barrier dysfunction.…”
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New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson’s disease by Silvana-Yanina Romero-Zerbo, Nadia Valverde, Silvia Claros, Pablo Zamorano-Gonzalez, Federica Boraldi, Francesco-Demetrio Lofaro, Estrella Lara, Jose Pavia, Maria Garcia-Fernandez, Belen Gago, Elisa Martin-Montañez

“…Introduction: One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant and neuroprotective effects in some neurodegenerative diseases, including PD. …”
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Effect of ACE-inhibition on coronary microvascular function and symptoms in normotensive women with microvascular angina: A randomized placebo-controlled trial. by Marie Mide Michelsen, Anna Bay Rask, Elena Suhrs, Kristoffer Flintholm Raft, Nis Høst, Eva Prescott

“…To explore whether the ACE inhibitor ramipril has a direct effect on the microvasculature beyond the blood pressure (BP) lowering effect, we investigated whether ramipril improved coronary microvascular function in normotensive women with coronary microvascular dysfunction (CMD).…”
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Effect of Multi-Joint Functional Electrical Stimulation Combined with Conventional Rehabilitation Therapy on Lower Limb Motor Function of Patients with Stroke by LIU Jiapeng, WANG Weining, XU Dongyan, WANG Nianhong, WU Yi

“…ObjectiveTo investigate the effect of multi-joint functional electrical stimulation (FES) combined with conventional rehabilitation therapy on lower limb motor function of patients with stroke.MethodsA total of 35 patients with lower limb motor dysfunction after stroke were admitted to the Department of Rehabilitation Medicine in the Huashan Hospital, Fudan University from January to December 2023. …”
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Effect of traumatic brain injury on mild behavioral impairment domains prior to all‐cause dementia diagnosis and throughout disease progression by Michael J. C. Bray, Barry R. Bryant, Aaron I. Esagoff, Lisa N. Richey, Carla Rodriguez, Akshay Krieg, Gardner McCullough, Jerry Tsai, William Tobolowsky, Sahar Jahed, C. Munro Cullum, Christian LoBue, Zahinoor Ismail, Haijuan Yan, Constantine G. Lyketsos, Matthew E. Peters

“…This investigation sought to evaluate the effect of TBI on NPS related by the MBI construct in participants progressing from normal cognitive status to all‐cause dementia. …”
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Photobiomodulation Therapy Reduces Oxidative Stress and Inflammation to Alleviate the Cardiotoxic Effects of Doxorubicin in Human Stem Cell-Derived Ventricular Cardiomyocytes by Guilherme Rabelo Nasuk, Leonardo Paroche de Matos, Allan Luís Barboza Atum, Bruna Calixto de Jesus, Julio Gustavo Cardoso Batista, Gabriel Almeida da Silva, Antonio Henrique Martins, Maria Laura Alchorne Trivelin, Cinthya Cosme Gutierrez Duran, Ana Paula Ligeiro de Oliveira, Renato de Araújo Prates, Rodrigo Labat Marcos, Stella Regina Zamuner, Ovidiu Constantin Baltatu, José Antônio Silva

“…PBM also demonstrated gene reprogramming effects in ventricular cells, encompassing regulatory changes in <i>NPPA, NPPB,</i> and <i>MYH6</i>. …”
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Functional foods and bioactive compounds: a comprehensive review on their role in mitigating drug-induced liver injury by Jin-Wei Zhao, Wei-Yi Zhao, Meng Zhao, Lu Yu

“…They exert significant hepatoprotective effects by preventing mitochondrial dysfunction and oxidative stress, as well as inhibiting inflammation. …”
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Chronic Kidney Disease and Malignant Neoplasms: The Current State of the Problem by I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, Zh. A. Murkamilova, I. O. Kudaibergenova, F. A. Yusupov

“…The mechanisms of the negative effect on the renal tissue of anticancer drugs — cisplatin, ifosfamide, methotrexate and cyclophosphamide — are discussed. …”
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“The Dark Side of Musculoskeletal Care”: Why Do Ineffective Techniques Seem to Work? A Comprehensive Review of Complementary and Alternative Therapies by Lucas Mamud-Meroni, Germán E. Tarcaya, Andoni Carrasco-Uribarren, Giacomo Rossettini, Mar Flores-Cortes, Luis Ceballos-Laita

“…The integration of therapies with limited biological plausibility, whose effects may primarily rely on placebo effects, into healthcare systems raises important ethical dilemmas. …”
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Parenting stress and depressive symptoms in the family caregivers of children with genetic or rare diseases: The mediation effects of coping strategies and self-esteem by Chin-Chen Wen, Shao-Yin Chu

“…The serial multiple mediation pathway (parenting stress → low self-esteem → dysfunctional coping → depressive symptoms) was not significant, whereas the indirect effect of via dysfunctional coping alone had a significantly partial mediation effect. …”
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Inflammatory and metabolic markers mediate the association between urinary metals and non-alcoholic fatty liver disease in U.S. adults: a cross-sectional study by Shu-yue Li, Jia-jie Lv, Jia-jie Lv, Xi-tao Yang, Xi-tao Yang, Cheng-hao Yang, Cheng-hao Yang, Min-yi Yin, Min-yi Yin

“…Clinically, this highlights the importance of monitoring environmental metal exposure and addressing inflammation and metabolic dysfunction as potential intervention targets to reduce NAFLD risk.…”
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Inflammation and LPS-Binding Protein Enable the Stimulatory Effect of Endotoxin on Prolactin Secretion in the Ovine Anterior Pituitary: Ex Vivo Study by Dorota Tomaszewska-Zaremba, Karolina Haziak, Monika Tomczyk, Andrzej P. Herman

“…Identification of the neuroendocrine and immune interactions in the regulation of prolactin secretion could be helpful in developing newer and more effective treatments for dysfunctions connected with disorders in this hormone secretion.…”
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