CD56 on intratumoral NK cells: orchestrating NK cell-mediated anti-tumor effects in bladder cancer by Zaineb Hassouneh, Onika D.V. Noel, Niannian Ji, Michelle E. Kim, Natalia Bowman, Robert S. Svatek, Emily Mace, Neelam Mukherjee

“…Prolonged exposure to bladder tumors led to CD56 loss in NK92 cells, suggesting tumor-induced NK92 cell dysfunction via CD56 reduction, consistent with our previous findings. …”
Get full text

Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease by Lan Weiss, Michele Carrer, Alyaa Shmara, Angela Martin, Hong Yin, Pallabi Pal, Cheng Cheng, Lac Ta, Victoria Boock, Yasamin Fazeli, Mindy Chang, Marvin Paguio, Jonathan Lee, Howard Yu, John Weiss, Tamar R Grossman, Nina Raben, Paymaan Jafar‐Nejad, Virginia Kimonis

Get full text

The SIRT1 activator SRT2104 exerts exercise mimetic effects and promotes Duchenne muscular dystrophy recovery by Matteo Giovarelli, Silvia Zecchini, Silvia Rosanna Casati, Laura Lociuro, Oriola Gjana, Luca Mollica, Elena Pisanu, Harcel Djaya Mbissam, Ornella Cappellari, Chiara De Santis, Alessandro Arcari, Anne Bigot, Giuditta Clerici, Elisabetta Catalani, Simona Del Quondam, Annapaola Andolfo, Clarissa Braccia, Maria Grazia Cattaneo, Cristina Banfi, Dario Brunetti, Emanuele Mocciaro, Annamaria De Luca, Emilio Clementi, Davide Cervia, Cristiana Perrotta, Clara De Palma

“…Abstract Duchenne muscular dystrophy (DMD) is a devastating genetic disorder, whose management is still a major challenge, despite progress in genetic and pharmacological disease-modifying treatments have been made. Mitochondrial dysfunctions contribute to DMD, however, there are no effective mitochondrial therapies for DMD. …”
Get full text

Quercetin inhibits the cAMP/PKA/CREB/glycolysis axis to exert anti-acute lymphoblastic leukemia effects by Qiuling Ma, Qiuling Ma, Qiuling Ma, Wenqing Liu, Wenqing Liu, Yajing Su, Yajing Su, Jue Guo, Jue Guo, Man Zhang, Man Zhang, Jiayuan Guo, Jiayuan Guo, Mingxin Liu, Mingxin Liu, Wenbo Dong, Wenbo Dong, Mingwei Li, Mingwei Li, Bo Wang, Bo Wang

“…Quercetin (Que) demonstrates broad antitumor effects by inhibiting glycolysis and cell proliferation. …”
Get full text

Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study by Francesco De Francesco, Letizia Ferroni, Ilaria Zanolla, Lucia Sileo, Maria Pia Cavaleri, Mario Fordellone, Letizia Senesi, Anna Maria Monachino, Elena Tremoli, Ilenia Pia Cappucci, Eduardo Maria Sommella, Massimo Bonora, Alfredo Ronca, Ugo D’Amora, Noemi De Cesare, Luca Lovatti, Michele Riccio, Ali Mobasheri, Paolo Pinton, Barbara Zavan

“…Strength tests indicated marked improvements in pinch grip, with no adverse effects or disease progression observed radiographically. …”
Get full text

Effect of visceral obesity on main artery elasticity and vascular age in patients with hypertension, obesity, and type 2 diabetes by M. E. Statsenko, M. V. Derevyanchenko

“…Aim. To assess the effect of visceral obesity on main artery elasticity and vascular age in patients with hypertension (HTN), obesity, and type 2 diabetes (T2D).Material and methods. …”
Get full text

Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

“…Comparative analysis highlighted PDK1-Phospho and FOXO1/3/4-Phospho as pivotal phosphorylated proteins mediating ZXF’s cardioprotective effects. Western blot analysis confirmed that ZXF enhanced phosphorylation levels of PI3K, PDK1, AKT, and FOXO1 in the Dox-induced HF model.Conclusion: This study, employing network pharmacology, phospho-antibody array analysis, and experimental validation, demonstrates that ZXF ameliorates cardiac dysfunction and suppresses myocardial apoptosis in Dox-induced HF through modulation of the PI3K/PDK1/AKT/FOXO1 signaling pathway.Keywords: network pharmacology, phospho-antibody array, Zhenxin Formula, heart failure, PI3K/PDK1/AKT/FOXO1 signaling pathway…”
Get full text

Cardioprotective effect of Saussurea involucrata injection against Doxorubicin-induced cardiotoxicity by network pharmacology analysis and e... by Wang Ding, Jin Yu, Yang Mengyu, Xue Yajing, Zhang Xiaotong, Guo Yanli, Li Xinzhi, Ma Ketao

“…Despite its efficacy, Dox induces numerous adverse effects in humans with significant cardiotoxicity, posing a major limitation to its use. …”
Get full text

Safety and Effectiveness of Pharmacologic Conversion of Atrial Fibrillation and Flutter: Results of Multicenter Trial. Part II: Assessment of Safety by N. Yu. Mironov, Yu. A. Yuricheva, V. V. Vlodzyanovskiy, S. F. Sokolov, Kh. M. Dzaurova, S. P. Golitsyn, Yu. V. Shubik, M. V. Berman, M. M. Medvedev, A. E. Rivin, D. S. Parkhomchuk, A. E. Barybin, D. А. Balandin, R. E. Batalov, D. V. Terekhov, I. V. Evstifeev, I. R. Kildeev, O. V. Pyataeva, S. A. Zenin

“…We aimed to assess safety and effectiveness of class III antiarrhythmic drug Refralon for conversion of atrial fibrillation (AFib) and flutter (AFl) in post-registration trial and to compare data of primary center (National medical research center in cardiology) with data of other hospitals.Material and Methods. …”
Get full text

Effects of Physical Exercise on the Body Composition and Functionality in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review by Daysa de Souza-Santos, Redha Taiar, José Alexandre Bachur, Luiza Torres-Nunes, Bruno Bessa Monteiro-Oliveira, Eliane de Oliveira Guedes-Aguiar, Ana Carolina Coelho-Oliveira, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda, Anelise Sonza, Adérito Seixas, Mario Bernardo-Filho, Danúbia da Cunha de Sá-Caputo

“…In addition, musculoskeletal dysfunction and negative changes in body composition, among other comorbidities associated with this disease, result in a low quality of life. …”
Get full text

Effect of electroacupuncture on the MMP-2/9 pathway mediated blood-brain barrier permeability in mice with Parkinson's disease by Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA

“…Conclusion: EA can effectively ameliorate the motor dysfunction of PD mice, reduce the damage of dopaminergic neurons, and play a neuroprotective role. …”
Get full text

Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…No significant interaction was observed between treatment effect and subphenotypes. Interpretation: Subphenotypes with the highest concentration of biomarkers of endothelial dysfunction and inflammation (inflammatory) or myocardial injury/fibrosis (cardiopathic) were associated with mortality independently from the SCAI shock stages. …”
Get full text

Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…However, due to the pathogenesis of endotoxin-induced long-term cognitive dysfunction is not fully clarified, there is still a lack of effective treatment. …”
Get full text

Effects of Digital Sleep Interventions on Sleep Among College Students and Young Adults: Systematic Review and Meta-Analysis by Yi-An Lu, Hui-Chen Lin, Pei-Shan Tsai

“…ConclusionsDigital sleep interventions are effective in improving sleep quality and reducing insomnia severity, with moderate effects on dysfunctional beliefs and attitudes about sleep, sleep hygiene, and sleep knowledge. …”
Get full text

Detrimental Effects of School Organizational Climate on Teacher Job Motivation in EFL Context of Iran: A Phenomenological Approach by Parisa Ashkani, Ehsan Namaziandost, Karamollah Javanmard

Get full text

Effect of Combined Regulatory Behavior Index (CRBI) on regulatory fatigue and behavioral adaptability (classical and reformulated) in the university context by Jesús de la Fuente, Ena Ubani, Evangelia Karagiannopoulou, Evangelia Karagiannopoulou, Douglas F. Kauffman

“…IntroductionRegulatory fatigue is a potential explanatory mechanism for dysfunctional regulatory behavior, which would lead to poorly adaptive behavior. …”
Get full text

Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile. by Ahmed M Nagy, Heba A Fahmy, Mohamed F Abdel-Hameed, Rehab F Taher, Alaa M Ali, Mohamed M Amin, Sherif M Afifi, Tuba Esatbeyoglu, Mohamed A Farag, Abdelsamed I Elshamy

“…<h4>Conclusions</h4>These results emphasize the potential therapeutic effect of E. heterophylla on DM related to male infertility and reproductive dysfunctions via its antioxidant/angiogenetic /anti-apoptotic effect.…”
Get full text

Effect of exercise-based counselling intervention for female school administrators with experience of work-family conflict: an exploratory study by Patricia Uzoamaka Agu, Daphney Mawila-Chauke, Moses Onyemaechi Ede, Saint Oliver R. Ngwoke

“…Based on these reasons, we studied the effects of an exercise-based counselling intervention on work-family conflict and occupational dysfunctional thinking in a sample of female educational administrators in light of these circumstances. …”
Get full text

Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy by I. A. Shynchukovskyi, O. H. Tereshchuk

“…The prevalence of temporomandibular joint (TMJ) osteoarthritis is 18–85 % of all TMJ dysfunctional conditions. Most patients are elderly, especially women. …”
Get full text

Subtle myocardial effects of rheumatic heart disease in children are revealed earlier with two-dimensional speckle tracking echocardiography by Hüseyin Ilgın Bal, İrem Türkyılmaz, Şeyma Kayalı, Ayhan Kılıç

Get full text