First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect by Iraida Caballero Aguirrechu, Braulio Mestre Fernández, Jorge Luis Soriano García, Nora Lim Alonso, Andrés Soto García, Vilma Fleites Calvo, Daines Mariño de la Puente, Geidy Vega Carvajal, Jenny Carolina Ávila Pérez, Ivis Mendoza Hernández, Elena García López, Alicia Tarinas Reyes, Gisela García-Pérez, Claudia Díaz Borges, Nuris Ledón Naranjo, Sum Lai Lozada Chang, Yanelda García Vega, Alexis Alvárez Lobaina, Mabel Alvárez Cardona, Patricia Lorenzo-Luaces Alvárez, Tania Crombet Ramos, Tania Carmenate Portilla, Kalet León Monzón

“…Dose escalation did not continue, as a greater clinical and pharmacodynamic effect was observed at intermediate doses. One patient developed a possibly related serious event consisting on ventricular dysfunction and pneumonitis. …”
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Protective effect of Col003 on the blood-brain barrier after cerebral ischemia-reperfusion injury in rats by XIE Yuliang, ZHOU Kejian, DENG Mengyu, XIE Xiaoyun, LIANG Tingting, LI Haoying, LIU Jingli

“…Conclusion Col003 can improve BBB injury after cerebral ischemia-reperfusion, and has a protective effect on BBB. Its protective effect on BBB may be achieved by inhibiting EndMT.…”
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Effects of modified lipoproteins on human trophoblast cells: a role in pre-eclampsia in pregnancies complicated by diabetes by Rebecca Helen McLeese, Jiawu Zhao, Dongxu Fu, Jeremy Y Yu, Derek P Brazil, Timothy J Lyons

“…The trophoblast culture model has potential for evaluating novel therapies targeting barrier dysfunction.…”
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Combined effects of aerobic exercise with ketogenic mediterranean and hypocaloric balanced diets on adolescents with polycystic ovarian syndrome by Reham Hamoda, Nada Elkady, Afaf Botla, Amir Gabr, Efrem Kentiba, Shaimaa Hamed

“…A treatment effect favored KMD + exercise for overall outcomes (p=0.030, η²=0.253). …”
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Comparative effect of ARNI and ACEI/ARB on left ventricular diastolic function in patients with hypertensive heart disease by YANG Hao, HE Yi, WANG Fangjuan

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Effects of high stocking density on the growth performance, intestinal health and bile salts composition of broiler chickens by Yuanyang Dong, Yuqi Zheng, Haoyu Liu, Yaru Wang, Jiaqing Cui, Yuan Wu, Lei Yan, Zhiqiang Miao, Miaomiao Han, Chenxuan Huang, Peifeng Li, Yuan Su, Yiru Shen, Junzhen Zhang, Jianmin Yuan, Bingkun Zhang, Jianhui Li

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Males and females respond differently to treatment during isolated kidney perfusion: combined effects of glucocorticoid and estradiol by Marina Vidal-dos-Santos, Marina Vidal-dos-Santos, Roberto Armstrong-Jr, Roberto Armstrong-Jr, Mayara Munhoz de Assis Ramos, Mayara Munhoz de Assis Ramos, Lucas Ferreira da Anunciação, Fernanda Yamamoto Ricardo-da-Silva, Cristiano de Jesus Correia, Petra J. Ottens, Luiz Felipe Pinho Moreira, Henri G. D. Leuvenink, Ana Cristina Breithaupt-Faloppa

“…After brain death (BD), hormonal dysfunction can compromise graft quality. Hormonal treatment of donors has shown positive outcomes, and treatment during ex vivo perfusion may be advantageous. …”
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Stabilising Collective Agreements in Continental Europe by Alexandre de le Court

“…After-effects can be regulated by specific legislative provisions. …”
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Inherent potential of mitochondria-targeted interventions for chronic neurodegenerative diseases by Min Zhou, Min Zheng, Siyao Liang, Maomao Li, Jiarui Ma, Shiyu Zhang, Xinyao Song, Yonglin Hu, Yuhong Lyu, Xingkun Ou, Changwu Yue

“…Recent studies have shown that enhancing mitochondrial function can mitigate the effects of these diseases. This paper comprehensively reviews the relationship between mitochondrial dysfunction and chronic neurodegenerative diseases, aiming to uncover the potential use of targeted mitochondrial interventions as viable therapeutic options. …”
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Contextual Emotions in Organizations: A Latent Profile Analysis of Their Co-Occurrence and Their Effects on Employee Well-Being by Laura Petitta, Lixin Jiang, Valerio Ghezzi

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EFFECTIVENESS OF INDIVIDUALIZED APPROACH FOR PHYSIOTHERAPY OF CHRONIC SHOULDER PAIN AND PHYSICAL FUNCTIONING IN ELITE ATHLETES WITH PHYSICAL DISABILITIES by Martin Eremiev, Bobi Krumov, Irena Lyudmilova, Nadezhda Popova, Daniela Lubenova

“…Objective: Тo study the potential effectiveness of individual physiotherapy program for wheelchair athletes with shoulder girdle persistent pain and dysfunctions. …”
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Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets by Yoshiaki Yoshimura, Toru Iwahashi, Taisuke Kasuya, Toshiki Shimada, Katsuyuki Konishi, Atsushi Kamata, Mai Konishi, Arisa Kazui, Ryoya Shiode, Satoshi Miyamura, Kunihiro Oka, Seiji Okada, Hiroyuki Tanaka

“…Abstract Postoperative adhesion around nerves sometimes results in sensory and motor dysfunctions. To prevent these disorders, we have developed an electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), an active form of vitamin B12 with anti-inflammatory and neuroregenerative effects. …”
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Effects of domestic violence on menopausal symptoms, sexual function, and quality of life: a cross-sectional study by Laís Lima Ferreira, Charles Francisco Ferreira, Maria Celeste Osório Wender

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Comparative effects of transcatheter versus surgical pulmonary valve replacement: A systematic review and meta-analysis. by Bunchai Chongmelaxme, Kok Pim Kua, Chanokpol Amornvetchayakul, Nichapond Chawviriyathep, Thunyapat Kerdklinhom

“…This study aims to investigate the effects of TPVR among patients with pulmonary valve or right ventricular outflow tract dysfunctions.…”
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Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells by Patrik Milić, Mojca Justin Kjuder, Katerina Jazbec Gradišar, Urban Švajger, Primož Rožman

“…Abstract Background Aging is linked to various dysfunctions of the immune system, including the decline of its primary developmental source: the hematopoietic stem cell (HSC) niche. …”
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Essential roles of B cell subsets in the progression of MASLD and HCC by Nataliia Petriv, Huizhen Suo, Inga Hochnadel, Kai Timrott, Nina Bondarenko, Lavinia Neubert, Elena Reinhard, Nils Jedicke, Patrick Kaufhold, Carlos Alberto Guzmán, Ralf Lichtinghagen, Michael P. Manns, Heike Bantel, Tetyana Yevsa

“…Background & Aims: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant cause of HCC. …”
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Effect of electroacupuncture on anxiety in patients with obesity: a protocol for a randomised, blinded, sham-controlled trial by Fan Zhang, Qing Yu, Qi Shu, Qiumei Peng, Wenxiu Duan, Rong-Lin Cai

“…However, data on the effectiveness of EA for anxiety patients with obesity are lacking. …”
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Effect of experimental and clinical pain on the spatial distribution of muscle activity: a systematic review and meta-analysis by Guillermo Mendez-Rebolledo, Ignacio Orozco-Chavez, Joaquín Salazar-Méndez, Juan Morales-Verdugo, Eduardo Martinez-Valdes

“…IntroductionMusculoskeletal dysfunctions can significantly impair quality of life due to persistent pain and neuromuscular adaptations. …”
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The Protective Effect of Adiponectin-Transfected Endothelial Progenitor Cells on Cognitive Function in D-Galactose-Induced Aging Rats by Jing Huang, Botong Hou, Shuaimei Zhang, Meiyao Wang, Xuanzhen Lu, Qunfeng Wang, Yumin Liu

“…Aging is a multifactorial process involving the cumulative effects of inflammation, oxidative stress, and mitochondrial dynamics, which can produce complex structural and biochemical alterations to the nervous system and lead to dysfunction of microcirculation, blood-brain barrier (BBB), and other problems in the brain. …”
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Absence of Anterior Guidance and its Effects on Early Discal Changes in Temporomandibular Joint: A Cross-sectional Study by Lokesh Sai Karanam, Suresh Venugopalan

“…JVA can serve as an effective diagnostic tool for the early detection of TMJ dysfunction.…”
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