Complex immunotoxic effects of T-2 Toxin on the murine spleen and thymus: Oxidative damage, inflammasomes, apoptosis, and immunosuppression by Mingyan Chen, Yanfang Zhang, Yangbo Zhao, Kewei Cao, Ruiyan Niu, Dongguang Guo, Zilong Sun

“…The key mechanisms identified include oxidative stress, activation of the NLRP3 inflammasome, apoptosis, and mitochondrial dysfunction. These findings reveal critical pathways through which T-2 impairs immune system functionality and provide a basis for developing targeted therapeutic strategies to mitigate its immunotoxic effects.…”
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EFFECT OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES ON CYTOSKELETON STRUCTURE AND MIGRATION ACTIVITY OF HUMAN ENDOTHELIAL CELLS by E. A. Starikova, J. T. Mammedova, L. A. Burova, A. V. Sokolov, V. B. Vasilyev, I. S. Freidlin

“…There is a growing body of data about the cytopathic effect of bacterial arginine deiminase on human endothelial cells, but the precise mechanisms of endothelial dysfunction caused by the activity of the enzyme remain poorly understood. …”
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Effect of Stress-WIN, a novel polyherbal formulation, on DOCA-salt-induced hypertensive Wistar rats by Amit Ranjan, Anirban Roy, Poonam Pal, Somesh Agarwal, Amaresh Kumar Singh, Vinod Tiwari, Shreyans Kumar Jain, Hitesh Harsukhbhai Chandpa, Ankita Yadav, Sanjeev Kumar

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The Effectiveness of Acceptance and Commitment-Based Therapy on the Immune Function and Activity Limitations in Patients With Irritable Bowel Syndrome by Sepideh Shakernejad, Javad Khalatbari, Majid-Mahmoud Alilou

“…Introduction: Irritable bowel syndrome is the most common, costly, and disabling dysfunction of the gastrointestinal tract. Mental disorders can be one of the main factors in the onset, continuation, or exacerbation of gastrointestinal signs and symptoms in people with this syndrome. …”
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Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses by Haonan Zhao, Xiaojie Zheng, Guo Lin, Xiaomin Wang, Huiyuan Lu, Pengpeng Xie, Siqi Jia, Yiyang Shang, Yan Wang, Pengchu Bai, Xuan Zhang, Ning Tang, Xingshun Qi

“…Abstract Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden of disease. However, its effect on the risk of digestive diseases is unclear. …”
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Impacts of Early Weaning on Lamb Gut Health and Immune Function: Short-Term and Long-Term Effects by Chong Li, Yunfei Xu, Jiale Jia, Xiuxiu Weng, Yang Zhang, Jialin Peng, Xueming An, Guoxiu Wang

“…Early weaning exerts minimal lasting psychological stress but drives persistent gut dysfunction through transcriptome-mediated changes in metabolic and immune pathways, highlighting key genes such as <i>APOA4</i>, <i>NOS2</i>, and <i>COX1</i> as potential regulators of these effects.…”
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Effects of Injections of Monocytes, Platelet-Rich Plasma, and Hyaluronic Acid in Adults with Knee Osteoarthritis: An Observational Study by Rita Chiaramonte, Salvatore Caramma, Enrico Buccheri, Patrizia Finocchiaro, Umile Giuseppe Longo, Antonio Ammendolia, Alessandro de Sire, Michele Vecchio

“…<b>Results:</b> HA, PRP-HA, and PBMNCs demonstrated comparable effectiveness for improving the NRS score and all the other outcomes at 6 months. …”
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Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome by Silvia Maffei, Claudio De Felice, Pierpaolo Cannarile, Silvia Leoncini, Cinzia Signorini, Alessandra Pecorelli, Barbara Montomoli, Stefano Lunghetti, Lucia Ciccoli, Thierry Durand, Roberto Favilli, Joussef Hayek

“…A subclinical myocardial biventricular dysfunction has been recently reported in RTT by our group and found to be associated with an enhanced oxidative stress (OS) status. …”
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Protective effects of Morus alba Linn leaf extract on streptozotocin-induced diabetic nephropathy in mice model by Ngoc Kim Nguyen, Ha Thu Thi Nguyen, Thanh Phuong Mai, Quang Vinh Trinh, Nghia Trong Duong, Phong Xuan Pham, Van Anh Thi Pham

“…Background: Diabetic nephropathy, a major microvascular complication of type 2 diabetes, arises from chronic hyperglycemia-induced renal dysfunction. Current therapies have limited efficacy in halting its progression. …”
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The landscape in telomere related gene prognostic signature for survival and medication treatment effectiveness prediction in hepatocellular carcinoma by Kai Zhou, Xingyu Liu, Mingda Wang, Jinjiang Duan, Xu Zhao, Hanjun Yin

“…The study analyzed the relationship between risk ratings and drug treatment effectiveness using data from the CellMiner database. …”
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Effect of Endolymphatic Hydrops on Sound Transmission in Live Guinea Pigs Measured with a Laser Doppler Vibrometer by Chen-Ru Ding, Xin-Da Xu, Xin-Wei Wang, Xian-Hao Jia, Xiang Cheng, Xiang Liu, Lin Yang, Bu-Sheng Tong, Fang-Lu Chi, Dong-Dong Ren

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Effects of left ventricular hypertrophy on prognosis of kidney in patients with chronic kidney disease of stages 3～4 by XIAO Xiao-fen, WANG Xiao-qin, HAN Si-ping

“…Objective To analyze the distribution of left ventricular hypertrophy（LVH） and its effect on renal progression in patients with chronic kidney disease（CKD） of stages 3⁴.Methods We collected the baseline data of 61 patients with CKD stages of 3⁴ who were followed up in Nephrology outpatient of Hubei Provincial Hospital of TCM from February 2012 to February 2016,and found out the distribution of LVH.By following up regularly,we recorded the outcome events including serum creatinine（SCr） double,estimated glomerular filtration rate（eGFR）<15 ml·min^-1·（1.73m²）^-1or 50%reduction,renal replacement therapy or death.And we divided 61 cases into renal function progression group and non-progression group,compared the data between two groups,and used COX risk regression model to analyze risk factors on prognosis of kidney.Results The average follow-up time was（34.70±9.54） months.One case dropped out,and 22 cases entered outcome events,including 12 cases with SCr doubles/50%reduction of eGFR or <15 ml·min^-1·（1.73 m²）^-1,8 cases undergoing maintain hemodialysis and two deaths.The prevelence of left ventricular dilatation,LVH and left ventricular diastolic dysfunction in CKD stages 3⁴ was 22.95%,37.70%,and60.66%respectively.The differences in systolic blood pressure,SCr,eGFR,interventricular septum thickness（IVST）,left ventricular end-diastolic diameter（LVEDd）,left ventricular mass（LVM）,left ventricular mass index（LVMI） and rate of left ventricular enlargement and LVH were significant between renal function progression group and non-progression group（P<0.05）.COX single factor regression analysis showed that systolic blood pressure（P = 0.013）,LVM（P = 0.003）,LVMI（P =0.001）,left ventricular enlargement（P<0.001） and LVH（P = 0.009） could endanger the patients of CKD of stages 3⁴ into the end point events.Multivariate COX proportional hazards regression analysis（enter method） showed risk factors associated with renal function progression in patients of CKD of stages 3⁴ were systolic blood pressure（b=1.075,HR=2.931,P = 0.025）,LVH（b=1.319,HR= 3.740,P = 0.048）.Conclusions LVH was common observed in patients with CKD of stages 3⁴.Early paying attentions to cardiac ultrasound,and timely intervening and controlling blood pressure and structural abnormality of left ventricle are necessary.…”
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Effects of transcranial electrical stimulation of the cerebellum, parietal cortex, anterior cingulate, and motor cortex on postural adaptation by Nastaran Bahadorani, Roya Khanmohammadi

“…Thus, this study compared the effects of tDCS over these specific brain regions on postural adaptation. …”
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Effects of Mnemonic Strategy Training on Brain Activity and Cognitive Functioning of Left-Hemisphere Ischemic Stroke Patients by Alana X. Batista, Paulo R. Bazán, Adriana B. Conforto, Maria da Graça M. Martin, Sharon. S. Simon, Benjamin Hampstead, Eberval Gadelha Figueiredo, Eliane C. Miotto

“…Memory dysfunction is one of the main cognitive impairments caused by stroke, especially associative memory. …”
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Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity by Biran Zhu, Zequan Zhang, Ying Xie, Min Huang, Yu Chen, Yong Yang, Xiongjie Shi, Jian Han, Lihua Yang, Min Zhao

“…Collectively, these findings indicate that BPS impair the intestinal health, disrupt gut microbiome, and ultimately lead to reproductive dysfunction through the gut-blood-testicular axis.…”
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The effectiveness of antioxidant agents in delaying progression of diabetic nephropathy: A systematic review of randomized controlled trials by Ika Rahayu, Nur Arfian, Christina Yeni Kustanti, Mae Sri Hartati Wahyuningsih

“…Silymarin was found to be the most effective (-3.43 µmol/L; 6.02 to 0.83). Compared to silymarin and epigallocatechin gallate, vitamin E was more effective (at -35.4 ng/L; P < 0.001) in reducing inflammation by decreasing TNF-α levels. …”
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P-69 EFFECTS OF POPULATIONAL-RELEVANT DOSES OF CARBOXYMETHYLCELLULOSE AND POLYSORBATE 80 EMULSIFIERS ON MASLD-ASSOCIATED HEPATOCARCINOGENESIS by GABRIEL BACIL PRATA, Julia Noveti Oliveira, Heloiza Ferreira Alves, Guilherme Romualdo Ribeiro, Luis Fernando Barbisan

“…Thus, we assessed the effects of populational-based doses of CMC/P80 in a murine model of MASLD-associated hepatocarcinogenesis. …”
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Immune cells mediate the effect of plasma lipidomes on IgA nephropathy: a Mendelian randomization study by Quanxin Li, Ye Chen, Yahan Zhu, Xiaoyang Cui, Jichen Pan, Xiao Li, Xiaolin Liu

“…Furthermore, we quantified the proportional effect of immune cell-mediated lipidomes on IgAN using TSMR.Results This study identified significant causal relationships of 3 lipidomes on IgAN risk by examining 179 lipidome traits as exposures. …”
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Effects of Oral L-Carnitine on Liver Functions after Transarterial Chemoembolization in Intermediate-Stage HCC Patients by Abeer Hassan, Yasuhiro Tsuda, Akira Asai, Keisuke Yokohama, Ken Nakamura, Tetsuya Sujishi, Hideko Ohama, Yusuke Tsuchimoto, Shinya Fukunishi, Usama M. Abdelaal, Usama A. Arafa, Ali T. Hassan, Ali M. Kassem, Kazuhide Higuchi

“…Transarterial chemoembolization (TACE) is usually followed by hepatic dysfunction. We evaluated the effects of L-carnitine on post-TACE impaired liver functions. …”
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A Transcriptomics Approach to Unveil the Antioxidant Effects of Tryptophan on Oocyte Quality Under Oxidative Stress in Pigs by Zhekun Zhu, Yanlong Li, Xinyin Fan, Shuang Cai, Siyu Li, Yutian Wang, Xinyu Wang, Fengjuan Yang

“…This study investigates the effect of tryptophan treatment on aged pig oocytes, focusing on its potential to reduce oxidative stress and improve oocyte quality. …”
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