The modulating effect of circulating carbohydrate antigen 125 on ST2 and long-term recurrent morbidity burden by Elena Revuelta-López, Rafael de la Espriella, Gema Miñana, Enrique Santas, Sandra Villar, Juan Sanchis, Antoni Bayés-Genís, Julio Núñez

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Effects of Obeticholic Acid Treatment on Primary Human Hepatocytes in a Novel Tri-Culture Model System by Justin J. Odanga, Sharon M. Anderson, Edward L. LeCluyse, Sharon C. Presnell, Jingsong Chen, Jessica R. Weaver

“…Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing health concern worldwide. …”
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The Effects of Warm Acupuncture on the Expression of <i>AMPK</i> in High-Fat Diet-Induced MAFLD Rats by Yumi Lee, Donghee Choi, Junghye Park, Jae Gwan Kim, Taejin Choi, Daehwan Youn

“…This study investigated the effects of acupuncture and warm acupuncture on the expression and mechanism of the AMP-activated protein kinase (<i>AMPK</i>) signalling pathway associated with lipid accumulation in the liver tissue of rats with metabolic dysfunction-associated fatty liver disease (MAFLD) induced by a high-fat diet. …”
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The Effect of the AQP1 Gene Knockout on the Diversity, Composition and Function of Gut Microbiota in Mice with Heart Failure by Haotian Li, Yubo Li, Jianqin Yang, Yanjun Liu

“…Introduction: This study aims to elucidate the impact of AQP1 on cardiac function and the intestinal microbiota in mice with chronic heart failure and to further investigate the broad effects of AQP1 on the gut microbiota composition in these mice. …”
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Protective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis by Fugang Huang, Shuo Huang, Ke Sun, Yanhao Chen, Guanqun Xie, Jie Bao, Yongsheng Fan

“…At the central of this progression lies podocyte injury, a critical determinant of glomerular dysfunction. Compound K (CK), a bioactive metabolite derived from ginsenoside, has emerged as a compelling candidate for nephroprotective therapy. …”
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Effects of interval versus continuous exercise on cerebral vascular flow‐mediated dilatation in young healthy males by Harvey J. Walsh, Shotaro Saito, Narumi Kunimatsu, Marino Karaki, James P. Fisher, Shigehiko Ogoh

“…Abstract Aerobic exercise reduces the risk of cerebrovascular dysfunction. One proposed mechanism is exercise‐induced increases in cerebral shear stress (SS) improving cerebral endothelial function. …”
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Effects of Aerobic Exercise on Sleep Quality, Insomnia, and Inflammatory Markers: A Systematic Review and Meta-Analysis by Mariazel Rubio-Valles, Arnulfo Ramos-Jimenez

“…Poor sleep quality and insomnia are increasingly linked to chronic inflammation and obesity-related metabolic dysfunction. Aerobic exercise is a promising non-pharmacological approach for enhancing sleep quality and reducing systemic inflammation; Therefore, we aim to systematically evaluate and quantify the effects of aerobic exercise interventions on subjective sleep quality, insomnia severity, and circulating markers (IL-6 and TNF-α) in adults. …”
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Therapeutic effects of striatal dopaminergic modulation on idiopathic dystonia and OCD in humans: insights from the striosome hypothesis by Shinichi Matsumoto, Hideki Shimazu, Satoshi Goto, Satoshi Goto

“…Our findings indicate that dystonia and OCD may share a common striatal dysfunction due to altered D1R signaling in the striosomes. …”
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Quality of life as a criterion for assessing the effectiveness of rehabilitation programs in patients with painful external genital endometriosis by E. Begovich, B. Baigalmaa, A. G. Solopova, V. O. Bitsadze, J. Kh. Khizroeva, E. A. Son, Sh. Kh. Zobaid, G. K. Bykovshchenko

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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. …”
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Perinatal Effects of Combined Use of Heroin, Methadone, and Amphetamine during Pregnancy and Quantitative Measurement of Metabolites in Hair by Pen-Hua Su, Yan-Zin Chang, Chen Yang, Yan-Yan Ng, Jia-Yuh Chen, Su-Chin Chen

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Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction by Tian X, Wang Q, Guo R, Xu L, Chen Q, Hou Y

“…In contrast, fluoxetine normalized the autonomic nervous system but did not reduce the expression of GRK2 nor improved cardiac performance.Conclusion: This study suggests that paroxetine is effective for improving cardiac function in patients with AMID and such effect correlates with GRK2 reduction. …”
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Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery by Roberto Visentin, Katrine Brodersen, Bjørn Richelsen, Niels Møller, Chiara Dalla Man, Andreas Kristian Pedersen, Jan Abrahamsen, Jens Juul Holst, Michael Festersen Nielsen

“…Background. β-cell dysfunction and insulin resistance are the main mechanisms causing glucose intolerance in type 2 diabetes (T2D). …”
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Effects of intranasal neural stem cells transplantation on olfactory epithelium regeneration in an anosmia-induced mouse model by Burak Hazir, Alper Ceylan, Emin Ümit Bagriacik, Duygu Dayanir, Milat Araz, Banu Tijen Ceylan, Nihan Oruklu, Muammer Melih Sahin

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Prognostic and immune modulatory effects of ammonia-induced cell death in head and neck squamous cell carcinoma by Qian Chengqun, Wang Xijun, Fan Yangyang, Yang Xiaoqin, Cheng Min, Xu Jun

“…However, the prognostic relevance and immunological effects of ammonia-induced cell death (ACD) in HNSC remain insufficiently studied. …”
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Effect of vitamin D levels on the hormonal and metabolic status in patients with metabolic syndrome and chronic kidney disease by O. A. Osipova, E. V. Gosteva, N. I. Zhernakova, O. N. Belousova, Yu. V. Tatarintseva, А. N. Khachaturov

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Effect of SGLT2 inhibitors on the course of chronic heart failure in patients with type 2 diabetes mellitus by A. N. Payudis, O. A. Efremova, L.  A. Kamyshnikova, Iu. S. Pavlova, O. V. Dudchenko, I. I. Khamnagadaev, T.  P. Golivets

“…Diabetes mellitus plays a significant role in the formation and is one of the significant risk factors for the development of chronic heart failure (CHF) through its glucose toxic effect, the effect on hyperlipidemia and blood coagulation, impaired autonomic regulation of the heart and a number of other mechanisms. …”
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The Effects of Disease-Modifying Antirheumatic Drugs on Cardiovascular Risk in Inflammatory Joint Diseases: Current Evidence and Uncertainties by Garmish O, Smiyan S, Hladkykh F, Koshak B, Komorovsky R

“…Karazin National University, Kharkiv, UkraineCorrespondence: Roman Komorovsky, Ivan Horbachevsky Ternopil National Medical University, 1, Maidan Voli, Ternopil, 46001, Ukraine, Email komorovsky@tdmu.edu.uaAbstract: Patients with inflammatory joint diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have an elevated risk of cardiovascular complications due to systemic inflammation, immune-mediated endothelial dysfunction, and associated metabolic changes. Disease-modifying antirheumatic drugs (DMARDs) influence cardiovascular risk through their effects on inflammation, lipid metabolism, and endothelial function. …”
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Vasoprotective effects of lysophosphatidic acid inhibit vascular injury caused by SARS-CoV-2 infection by Fumitaka Muramatsu, Naoi Hosoe, Tatsuya Suzuki, Teppei Shimamura, Yumiko Hayashi, Kazuhiro Takara, Lamri Lynda, Anna Shimizu, Weizhen Jia, Yoshimi Noda, Nobuyuki Takakura, Toru Okamoto, Hiroyasu Kidoya

“…The activation of LPA signaling in vascular endothelial cells may be an effective therapeutic approach for mitigating vascular injury in COVID-19.…”
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Effect of Marital Relationship Enhancement EducationBased on the Approach of Religious Teachings on Sexual, Spiritual and Mental Health by Hajar Pasha, Zohreh Khalajinia, Mohammad Hadi Yadollahpour, Hemmat Gholinia

“…Background and Objectives: The aim of this study was to evaluate the effect of marital relationship enhancement education based on the approach of religious teachings on different dimensions of sexual, spiritual, and mental health in married women. …”
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