Sexual Motivation (Desire): Problems with Current Preclinical and Clinical Evaluations of Treatment Effects and a Solution by Anders Ågmo

“…A possible reason for this may be that both the preclinical and clinical evaluation of treatment effects have been inadequate. The present literature review shows that the intensity of sexual approach behaviors in non-human animals appears to be predictive of clinical effect whereas the traditional studies of copulatory behaviors and associated motor patterns have questionable predictive power regarding effects on human sexual desire. …”
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Non-cancer effects after proton beam therapy for pediatric tumors- a narrative review by Anna Zając-Grabiec, Beata Biesaga, Beata Biesaga, Monika Krzyżowska, Katarzyna Drosik-Rutowicz, Justyna Miszczyk

“…Moreover, pediatric patients undergoing PBT may also experience a range of non-cancer late effects, including brainstem injury, cognitive dysfunctions, and side effects from endocrine or cardiovascular systems. …”
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Heterogeneity and mediating effect in beliefs and attitudes about sleep of cadres: a latent profile analysis by CHEN Zihao, YAO Ailun, FAN Xinwei, LIU Cuiling, SUN Qian, LI Guangming

“…Objective To categorize civil servants’ sleep beliefs and their effects on sleep quality to inform tailored interventions. …”
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Pretext of the adoption of the 2024 Common European Asylum System reform and an early take on the potential effect by Novaković Marko

“…Despite these concerns, the German federal government, led by Chancellor Olaf Scholz, defends the reform as a necessary compromise to address the dysfunctionality of the current system. The analysis also explores the challenges in implementing the CEAS reforms in countries with restrictive asylum practices, such as Italy. …”
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Blood–brain barrier disruption and neuroinflammation in the hippocampus of a cardiac arrest porcine model: Single-cell RNA sequencing analysis by Tangxing Jiang, Yaning Li, Hehui Liu, Yijun Sun, Huidan Zhang, Qirui Zhang, Shuyao Tang, Xu Niu, Han Du, Yinxia Yu, Hongwei Yue, Yunyun Guo, Yuguo Chen, Feng Xu

“…Additionally, we revealed the post-cardiac arrest dysfunction of oligodendrocytes and the differentiation of oligodendrocyte precursor cells into oligodendrocytes. …”
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Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus. by Oskar Kövamees, Alexey Shemyakin, John Pernow

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Experimental modeling of sudden death pathological mechanisms in Na+ channel blocker treatment by V. M. Moroz, T. N. Lipnitsky

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Research progress on the effects and mechanisms of different cell types on osteoclast differentiation in bone metabolism in rheumatoid arthritis by Yingjun Wei, Xingwen Xie, Xingwen Xie, Dingpeng Li, Dingpeng Li, Xuan Hou, Ling Ren, Kangwei Wan

“…One of the main pathological features is irreversible damage and dysfunction of bone and joints, and the core pathological link is osteoclast-mediated imbalance of bone metabolism. …”
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The relationship between trait anxiety and sleep quality in college students: an exploratory analysis of physical activity as a moderator by Liyang Zhong, Xiaochen Ma, Sen Li, Ling Yu

“…PA level significantly moderated the relationships between trait anxiety and four dimensions of sleep: sleep quality, sleep latency, sleep efficiency, and daytime dysfunction. Stronger buffering effects were observed under conditions of high intensity, long duration, and high frequency of PA.ConclusionHigh-intensity, long-duration, and high-frequency physical activity may help alleviate anxiety-related sleep disturbances in college students, exhibiting a clear dose–response effect. …”
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Potential Effects of Exercise-Induced Alterations in the Gut Microbiome and Its Metabolites on Cerebrovascular Health and Alzheimer's Disease by Da-Hui Sim, Dong-Hyun Lee, Jun-Hee Lee, Kwang-Seok Hong

“…PURPOSE This review aimed to explore the potential effects of exercise-induced alterations in the gut microbiome and its metabolites on cognitive function and cerebrovascular health, focusing on the prevention and treatment of cerebrovascular dysfunction and neurodegenerative diseases, such as Alzheimer's disease (AD). …”
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Protective effects of resveratrol in high fat diet– and metals (Al, Pb, As)-induced metabolic and cognitive impairments by Abida Zulfiqar, Saima Bashir, Touqeer Ahmed

“…Resveratrol treatment, particularly at 20 mg/kg, significantly restored cognitive performances by increasing time spent in the target quadrant (78.9 ± 2.0; p<0.001), improving spontaneous alternation performance (66.6 ± 2.3; p<0.001), and improved metabolic dysfunction. These findings suggest resveratrol's therapeutic pro-mise in mitigating the neurotoxic effects of high fat diet and metals. …”
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A systematic review of long-term cardiotoxic effects of treatment in survivors of childhood acute lymphoblastic leukemia by Paige Johnson, Ellie Whitney, Coleton Evans, Donald Beam

“…This systematic literature review focuses on the various long term cardiotoxic effects as a result of these treatments. The authors conducted a systematic review to identify studies that evaluated long-term cardiotoxic effects after anthracycline treatments among survivors of childhood ALL via PubMed search engine. …”
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Levofloxacin-induced visual hallucinations: A case report and review of the literature by Valentina Raffaelli, Giulia Cantoni, Gabriella Nucera, Pietro Marino

“…However, the true prevalence of levofloxacininduced neuropsychiatric adverse effects could be underestimated. Therefore, physicians and psychiatrists should consider neuropsychiatric adverse effects when prescribing levofloxacin or other fluoroquinolones.…”
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Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay by Caleb M. Embree, Debadrita Paul, Andreas Stephanou, Guramrit Singh

“…While some of this increase could be due to widespread pleiotropic effects of spliceosome dysfunction (e.g. reduced expression of NMD factors due to missplicing of their mRNAs), we identified that AQR, SF3B1, SF3B4, and CDC40 may have a more direct role in NMD. …”
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Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes by Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietiläinen

“…Mitochondrial dysfunction in white adipose tissue is strongly associated with obesity and its metabolic complications, which are important health challenges worldwide. …”
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Effects of bariatric surgery upon the sympathetic nervous system and hypothalamic-pituitary-adrenal axis in obese humans by Andreas Kraag Ziegler, Mette Christensen, Henrik Løvendahl Jørgensen, Mogens Fenger, Sara Fogh Myrup, Carsten Dirksen, Sten Madsbad

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Study the effect of hepcidin antimicrobial peptide gene polymorphism on fertility hormone in female with beta-thalassemia major by Heba Mohamed Hasan Alkatawe, Rayah Sulaiman Baban, Hind Shaker Al-Mamoori

“…Among these, reproductive dysfunction is a significant concern for affected females, often linked to iron overload from frequent blood transfusions. …”
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Metabolic reprogramming as the basis for sodium-glucose co-transporter type 2 inhibitors cardio- and nephroprotective effect by O N. Kurochkina, D. A. Korotkov, A. S. Sazhina, A N. Bogomolov

“…The described processes may serve as the basis for the cardioprotective and nephroprotective effects of SGLT2 inhibitors.…”
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Assessment of the Short-Term Effectiveness of Kinesiotaping and Trigger Points Release Used in Functional Disorders of the Masticatory Muscles by Danuta Lietz-Kijak, Łukasz Kopacz, Roman Ardan, Marta Grzegocka, Edward Kijak

“…The more beneficial outcomes of the therapy were observed after using the KT method, which increased the analgesic effect in dysfunctional patients.…”
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Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR‐II Hyperthermia Cancer Therapy by Fei Cun, Jie Chen, Hanxue Li, Yufang Kou, Meiyan Wang, Xiaomin Li, Hui Chen, Jilie Kong

“…This process can induce robust oxidative stress and oxygenation within the tumor, thereby activating the apoptosis pathway for tumor eradication by mitochondrial dysfunction, cell membrane disruption, HIF‐1α downregulation as well as caspase 3 activation, which pave the way for multimodal and effective cancer treatment.…”
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