Systemic evaluation of the effects of monomeric GLP-1R-based agonists on MASLD and its complications by Yangke Cai, Siyuan Xie, Liyi Xu, Jiamin Chen, Jianting Cai

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide, yet efficient therapeutic approaches are lacking. …”
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Effectiveness, pharmacokinetics, and safety of triptorelin acetate microspheres in patients with locally advanced and metastatic prostate cancer by Guolan Wu, Feng Zhou, Haiping Wang, Kan Liu, Dexin Yu, Lianlian Fan, Yangyun Han, Xiaohong Ai, Youhan Cao, Xiaolin Wang, Sheng Wang, Chaohong He, Jitao Wu, Ji Wu, Youlei Wang, Yanqing Wang, Baiye Jin, Jianzhong Shentu

“…Prolonged QT interval on electrocardiogram, erectile dysfunction, and decreased libido each occurred in ⩽4% of the patients. …”
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HEIX1 Mutation Effects on Endoplasmic Reticulum Stress, Caspase Activation, and JNK2 Pathways by MA Dragh, ZS Al-Allak, ZZG Allami

“…Mutations in the HEIX1 gene disrupt these processes, triggering activation of the P-ERK and JNK signalling pathways, which lead to ER stress, mitochondrial dysfunction, and apoptosis. This study examines the molecular mechanisms underlying HEIX1 loss-of-function mutations in S2 cells, focusing on P-ERK and JNK pathway activation and their effects on cellular stress responses. …”
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Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery by G. Pacini, A. Tura, Y. Winhofer, A. Kautzky-Willer

“…Therefore, the diminished IE of fGDM seems to reflect an early abnormality of the general beta-cell dysfunction in the progression toward type 2 diabetes.…”
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Effectiveness of low dose thyroxine in patients with subclinical hypothyroidism and migraine; systematic review and meta-analysis by Alia Alokley, Maryam N. ALNasser, Razan Anwar Alabdulqader, Faisal Abdulhamid Aljohni, Duaa Hussain Alqadhib, Rose Khalid Aljuaid, Montather Akeel Alshik Ali, Shahad Shadi Hanbazazah, Abdullah Almaqhawi

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Comparative effectiveness of spirapril and enalapril in patients with coronary heart disease-caused chronic heart failure by S, Yu. Volkova, V. V. Ragozina, V. A. Balina, M. A. Pushnikova, V. A. Shchupletsova, S. V. Shalaev

“…During prospective 6-month follow-up, to compare spirapril and enalapril effectiveness in patients with coronary heart disease (CHD)-caused chronic heart failure (CHF). …”
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Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms by Yang Zhu, Lingyi Liao, Shihao Gao, Yong Tao, Hao Huang, Xiangqin Fang, Changyan Yuan, Changyue Gao

“…Abstract Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions, for which an effective treatment is currently unavailable. Repetitive transcranial magnetic stimulation (rTMS), a well‐established noninvasive brain stimulation method, is utilized in clinical settings to address various neuropsychiatric conditions, such as depression, neuropathic pain, and poststroke dysfunction. …”
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Current insights on the effects of medicinal plants in the management of obesity and infectious diseases: An update from 2020 by Ezichi Favour Ofoezie, Chinwendu Angela Ogbonna, Ezinne Tiffany George, Chioma Juliet Anunobi, Sandra C. Olisakwe, Simeon Babarinde, Chidera Godson Chukwuemeka, Uzochukwu Eric Ogbonna, Chibuzo Collette Amafili, Justina Onyinyechi Omaba, Henry Nnaemeka Ogbonna

“…Their ability to target multiple biological pathways simultaneously makes them effective in addressing the complex interplay between metabolic disorders and immune dysfunction.…”
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Effect of Acotiamide on Detrusor Underactivity Induced Through Bilateral Pelvic Nerve Crush Injury in Rats by Ei-ichiro Takaoka, Kenji Nagahama, Jun Kamei, Toru Sugihara, Satoshi Ando, Tetsuya Fujimura, Naoki Yoshimura

“…Purpose To investigate the effectiveness of acotiamide on lower urinary tract dysfunction by using a rat model of neurogenic underactive bladder induced through pelvic nerve crush (PNC) injury. …”
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Effects of ambulatory self-control on renal function and electrolyte metabolism in patients with severe heart failure by S. V. Berdnikov, V. I. Vishnevskyi, O. A. Berdnikova

“…Aim. To investigate the effects of the ambulatory self-control treatment strategy on renal function, electrolyte metabolism, functional status, and the number of repeat hospitalisations in patients with chronic heart failure (CHF). …”
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Effect of neuroinflammation on the progression of Alzheimer’s disease and its significant ramifications for novel anti-inflammatory treatments by Pritam Kamila, Koyel Kar, Sailee Chowdhury, Priyanka Chakraborty, Ria Dutta, Sowmiya S, Ankul Singh S, Bhupendra Gopalbhai Prajapati

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Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement by Zrinka Safaric Oremus, Nikola Bradic, Ivan Gospic, Ivana Presecki, Sanja Sakan, Natasa Sojcic, Kresimir Oremus, Davor Baric, Vlatka Sotosek, Igor Rudez

“…This study aimed to investigate whether dexmedetomidine exerts a clinically relevant anti-inflammatory effect in patients undergoing open-heart surgery and to determine the optimal dose. …”
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Evaluating the effect of voxel size on the accuracy of 3D volumetric analysis measurements of brain tumors by Rithvik S. Ghankot, Manwi Singh, Shelby T. Desroches, Noemi Jester, Amit Mahajan, Samantha Lorr, Frank D. Buono, Daniel H. Wiznia, Daniel H. Wiznia, Michele H. Johnson, Steven M. Tommasini, Steven M. Tommasini

“…IntroductionNeurofibromatosis type 2 related Schwannomatosis (NF2-SWN) is a genetic disorder characterized by the growth of vestibular schwannomas (VS), which often leads to progressive hearing loss and vestibular dysfunction. Accurate volumetric assessment of VS tumors is crucial for effective monitoring and treatment planning. …”
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Effectiveness of virtual reality for functional disorders in cerebral palsy: an overview of systematic reviews and meta-analyses by Enhui Fang, Hui Guan, Binhong Du, Xuejun Ma, Lihong Ma

“…However, heterogeneity in outcome measures, CP subtypes, and VR protocols limited generalizability.ConclusionVR shows potential in improving motor dysfunction and ADL in CP. However, the included SRs/MAs typically exhibited low methodological and evidence quality. …”
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Differential Effects of Canonical Androgens and 11-Ketotestosterone on Reproductive Phenotypes and Folliculogenesis in Mouse Model of PCOS by Yi-Ru Tsai, Yen-Nung Liao, Cheng-Ju Tsai, Yu-Ang Lee, Shih-Min Hsia, Kuo-Chung Lan, Hong-Yo Kang

“…This study investigates the differential effects of these androgens on folliculogenesis, ovulation, and steroidogenesis using in vivo and in vitro models. …”
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Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities by Junli Jiang, Chunchun Tang, Juanjuan Ren, Chao Zhang, Liang Dong, Zhaoqiong Zhu

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Effect of invasive acupuncture on awakening quality after general anesthesia: systematic review and meta-analysis by Fan-dong Bu, Shang-kun Si, Shang-kun Si, Shang-kun Si, Dong-bin Zhang, Yong-liang Chi

“…BackgroundThe process of waking up from general anesthesia is still not well understood, and recovery issues such as delayed awakening, agitation, postoperative cognitive dysfunction, continue to be a challenge for anesthesiologists. …”
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Behavioral and neurochemical changes in mice induced by low-level lead exposure: Implications for ADHD and conduct disorders by Yeonghoon Son, Ye Ji Jeong, Hyun-Yong Kim, Soo-Ho Lee, Yoonsoo Choi, Hyung-Do Choi, Hae-June Lee

“…Lead (Pb) exposure in children and adolescents poses a significant public health risk due to its potential neurotoxic effects. While high-level Pb exposure is known to impair learning and cognition, the behavioral and molecular consequences of low-level Pb exposure during developmental periods remain poorly understood. …”
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Primary Effect of SERCA2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction by Lukas J. Motloch, Marine Cacheux, Kiyotake Ishikawa, Chaoqin Xie, Jun Hu, Jaume Aguero, Kenneth M. Fish, Roger J. Hajjar, Fadi G. Akar

“…We sought to uncover the electrophysiological effects of adeno‐associated virus serotype 1.SERCA2a GT following myocardial infarction (MI). …”
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MYOCARDIAL PERFUSION ASSESSMENT IN FORECASTING EFFECT OF CORONARY ANGIOPLASTY IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE by A. B. Mironkov, V. V. Chestukhin, F. A. Blyakhman, T. F. Shklyar, E. N. Ostroumov, Е. D. Kotina, S. A. Sakhovsky, E. T. Asoev, B. L. Mironkov

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