The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model by Yasin Bagheri, Mahshid Dehghan, Seyyedeh Mina Hejazian, Mohammadreza Ardalan, Sepideh Zununi Vahed, Bahram Niknafs

“…In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction. This study aimed to investigate the antioxidative effects of Edaravone on cardiac tissues following the induction of renal ischemia-reperfusion injury (IRI) in rats. …”
Get full text

Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats by Kadeq Novita Prajawanti, Yohanes Ardian Kapri Negara, Intan Febiola Arianing, Fittri Junitasari

“…Furthermore, the highest dose of T. erecta extract (75 mg/kg BW) effectively attenuated elevated TNF-α levels, demonstrating a significant anti-inflammatory effect. …”
Get full text

Еprosartan therapy effectiveness in arterial hypertension patients after stroke or transient ischemic attack by Yu. M. Pozdnyakov, A. M. Urinsky, R. L. Kuznetsov, S. V. Belonosova, I. B. Ryzhikova, I. D. Bondarenko, O. V. Patrikhalkina

“…Eprosartan is an effective antihypertensive agent for AH treatment, with cerebroprotective effects in S and TIA patients, that could be used as monotherapy or in combination with a diuretic.…”
Get full text

The subjective hip value: a retrospective validation study in primary total hip arthroplasty by Kevin Y. Heo, Andrew Fuqua, Jason Shah, Omar Syed, Joseph Song, Emilie C. Collins, Jesse Seilern Und Aspang, Ajay Premkumar, Jacob M. Wilson

“…Abstract Background The hip dysfunction and osteoarthritis outcome score for joint replacement (HOOS JR) has been widely used to assess patient hip function. …”
Get full text

Endoplasmic reticulum stress sensor protein PERK in hepatic stellate cells promotes the progression of hepatocellular carcinoma via p38δ MAPK/IL-1β axis by Makoto Morita, Yoshio Tokumoto, Takao Watanabe, Yusuke Imai, Atsushi Yukimoto, Toyoki Shimamoto, Ryo Yano, Yuki Okazaki, Yoshiko Nakamura, Osamu Yoshida, Teruki Miyake, Masashi Hirooka, Masanori Abe, Yoichi Hiasa

“…Abstract Palmitic acid (PA) absorption from the intestine is increased in metabolic dysfunction-associated steatohepatitis (MASH). It induces endoplasmic reticulum (ER) stress and interleukin-1 beta (IL-1β) production in hepatic stellate cells (HSCs). …”
Get full text

MicroRNA-669f-5p targeting deoxycytidinephosphate deaminase contributes to sevoflurane-induced cognitive impairments in aged mice via the TLR2/4–MyD88–NF-κB pathway by Yuanping Zhong, Chao Zhang, Yuan Li, Dongqin Chen, Chunchun Tang, Xue Zheng, Zhaoqiong Zhu

“…Background: Postoperative cognitive dysfunction (POCD) is a common complication associated with sevoflurane anaesthesia in the aged population. …”
Get full text

Clinical and functional state of the retina after adequately performed laser coagulation of peripheral vitreochorioretinal dystrophies by V. V. Neroev, G. Yu. Zakharova, T. D. Okhotsimskaya, I. V. Tsapenko, M. V. Zueva, M. A. Arakelyan, B. M. Magamadov

Get full text

Mechanistic role of the KRTAP5-AS1/miR-199b-5p/CYP19A1 axis in polycystic ovary syndrome pathogenesis by Ping Tao, Xiaohong Yan, Zhanxiang Wang

“…Functional studies demonstrated that miR-199b-5p overexpression combined with KRTAP5-AS1 knockdown inhibited proliferation, promoted apoptosis, and reduced estradiol production, while opposite manipulations reversed these effects. Conclusions Our findings reveal that KRTAP5-AS1 modulates granulosa cell dysfunction in PCOS through the miR-199b-5p/CYP19A1 axis, highlighting miR-199b-5p as a potential therapeutic target for PCOS-related ovarian dysfunction and endocrine abnormalities. …”
Get full text

Effects of the Infusion of 4% or 20% Human Serum Albumin on the Skeletal Muscle Microcirculation in Endotoxemic Rats. by Elisa Damiani, Can Ince, Fiorenza Orlando, Elisa Pierpaoli, Oscar Cirioni, Andrea Giacometti, Federico Mocchegiani, Paolo Pelaia, Mauro Provinciali, Abele Donati

“…The concentration of HSA infused may influence these effects. We compared the microcirculatory effects of the infusion of 4% and 20% HSA in an experimental model of sepsis.…”
Get full text

Therapeutic Effects of Traditional Chinese Exercises on Musculoskeletal Pain: A Systematic Review and Meta-Analysis by Zhenrui Li, Jie Zhuang, Shiwen Zhang, Qingyi He, Rui Zhao, Tursen Alima, Lei Fang

“…Among them, the Yi Jin Jing exercise was superior to other exercises, while Wu Qin Xi showed no significant effects. Besides, traditional Chinese exercises had significant positive effects on the dysfunction and stiffness of the waist and knee joints. …”
Get full text

The effectiveness and safety of physical activity and exercise on women with endometriosis: A systematic review and meta-analysis. by Min Xie, Xuemei Qing, Hailong Huang, Linyun Zhang, Qin Tu, Hongying Guo, Jing Zhang

“…The random or fixed effects model was used to analyze the data in meta-analysis. …”
Get full text

A comprehensive overview of fixed-volume hemorrhage effects in New Zealand White rabbit models by Dwi Utari Rahmiati, Gunanti Gunanti, Deni Noviana, Raden Harry Soehartono, Eva Harlina

Get full text

The effects of digital CBT intervention on attentional bias and sleep quality of poor sleepers with insomnia symptoms by Yimei Wu, Jingwen Li, Hongying Liu, Junlong Luo, Wen He, Haijiang Li

“…Digital cognitive therapy for insomnia (dCBT-I) has been validated as effective in alleviating this cognitive dysfunction. …”
Get full text

Investigating the Effects of Olanzapine in Changes in Metabolic Syndrome in High-fat diet-induced Obese Mice by Khadiza Begum, Md Abdur Rahman Ripon, Tabassum Akter, Md Monirul Islam, Rahima Begum, Mohammad Salim Hossain

“…Objectives: This study explores the potential of chronic OLA exposure to modulate inflammatory pathways in a context of metabolic dysfunction using high-fat diet (HFD) induced obese mice (female).  …”
Get full text

Integrative metabolomics and proteomics reveal the effect and mechanism of Zi Qi decoction on alleviating liver fibrosis by Xiaoying Chen, Yifan Wang, Xiaoyun Dou, Jie Wan, Jingwen Zhou, Tianci Li, Jun Yu, Fang Ye

“…Abstract Liver fibrosis is a common progressive liver disease that can cause liver dysfunction and lead to serious complications. Zi Qi decoction (ZQ) is a traditional formulation that exerts pharmacological effects on the treatment of liver fibrosis. …”
Get full text

Integrating an Extended-Gate Field-Effect Transistor in Microfluidic Chips for Potentiometric Detection of Creatinine in Urine by Dhaniella Cristhina De Brito Oliveira, Fernando Henrique Marques Costa, Renato Massaroto Beraldo, José Alberto Fracassi da Silva, José Alexandre Diniz

“…Using a system based on field-effect transistors, we carried out creatinine quantification in synthetic urine. …”
Get full text

An In Vivo Study on Intoxicating Effects of Nerium oleander Water Based Extract on Multiorgans of Wistar Rat by Muddasir Hassan Abbasi, Sana Fatima, Muhammad Babar Khawar, Shah Jahan, Nadeem Sheikh

Get full text

Effect of a Supervised Peridialytic Exercise Program on Serum Asymmetric Dimethylarginine in Maintenance Hemodialysis Patients by Yaser A. Ammar, Ahmad Awad

“…Regular physical exercise effectively decreased serum ADMA in several patient cohorts, but this potential benefit has not been specifically explored among MHD patients. …”
Get full text

The Effect of Emodin-Assisted Early Enteral Nutrition on Severe Acute Pancreatitis and Secondary Hepatic Injury by Gang Wang, Bei Sun, Yue Gao, Qing Hui Meng, Hong Chi Jiang

“…However, whether the combined strategy is rational and more effective than either one alone remains unknown. …”
Get full text

Effect of juvenile social isolation on excitability of prefrontal pyramidal cells with different subcortical axonal projections by Yosuke Nishihata, Hiroki Yoshino, Hiroki Yoshino, Yoichi Ogawa, Taketoshi Sugimura, Kazuya Okamura, Sohei Kimoto, Kazuhiko Yamamuro, Kazuhiko Yamamuro, Manabu Makinodan, Yasuhiko Saito, Toshifumi Kishimoto

Get full text