Pharmacological effects, molecular mechanisms and strategies to improve bioavailability of curcumin in the treatment of neurodegenerative diseases by Gang Wang, Gang Wang, Xueyuan Zhou, Xueyuan Zhou, Xiaoyan Pang, Xiaoyan Pang, Ke Ma, Ke Ma, Lu Li, Lu Li, Yuexin Song, Yuexin Song, Dongxia Hou, Dongxia Hou, Xiaohua Wang, Xiaohua Wang

“…Conventional administration methods often fail to achieve effective concentrations in vivo. Further clinical trials are also required to validate the therapeutic efficacy and potential adverse effects in human subjects. …”
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The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…The aim of the presented systematic review is to explore the existing knowledge regarding the effect of tocilizumab treatment on cAMR and to perform a meta-analysis of the available data. …”
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Effects of letrozole combined with clomiphene in the treatment of polycystic ovary syndrome: a meta-analysis by Baoying Du, Mengdi Ni, Ping Chen

“…Abstract Background PCOS is a common endocrine gynecological disorder, and its associated hormonal abnormalities and ovulatory dysfunction are leading causes of infertility. Ovulation induction is considered a fundamental treatment for PCOS patients. …”
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Anti-atherosclerotic effects and molecular targets of salvianolic acids from Salvia miltiorrhiza Bunge by Qingzhi Liang, Xiaoqin Liu, Xin Xu, Zhengtao Chen, Ting Luo, Yi Su, Hongyan Xie, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…Preclinical research has shown that the hydrophilic metabolites of S. miltiorrhiza Bunge represented by danshensu (DSS), salvianolic acid A (SAA), and salvianolic acid B (SAB) can reduce endothelial dysfunction, inhibit smooth muscle cell migration and proliferation, block platelet aggregation, have antithrombotic properties, and modulate vascular tone. …”
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Effectiveness of Interval Versus Continuous Training on Blood Pressure Among Hypertensive Postmenopausal Women by Preeti Saini, Nitesh Malhotra

“…The decline in estrogen levels during menopause contributes to increased oxidative stress, endothelial dysfunction, and heightened sympathetic activity, all of which can elevate blood pressure. …”
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Effect of Dietary Macronutrients on Postprandial Glucagon and Insulin Release in Obese and Normal-Weight Women by Tomasz Wikarek, Piotr Kocełak, Aleksander J. Owczarek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz

“…The aim of the study was to assess the effect of dietary macronutrients on circulating glucagon and insulin levels in obese and normal-weight women. …”
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Impact of COVID-19-associated Dysautonomia Phenotypes on the Effectiveness of Venovenous Extracorporeal Membrane Oxygenation by G. E. Savkov, S. S. Petrikov, N. V. Rybalko, L. T. Khamidova, O. Yu. Markatyuk, D. A. Lebedev, K. V. Kiselev, Yu. N. Vrabiy, N. E. Altshuler, K. A. Popugaev

“…The purpose of the presented work is to study the effect of different COVID-19-DA phenotypes on the performance parameters and effectiveness of VV ECMO, gas exchange and hemodynamics in patients with COVID-19.   …”
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Cerebral metabolic rate of oxygen is correlated to treatment effect of electroconvulsive therapy in patients with depression by Christoffer Cramer Lundsgaard, André Beyer Mathiassen, Henrik Bo Wiberg Larsson, Poul Videbech, Krzysztof Gbyl, Mark Bitsch Vestergaard

“…The effect was driven by both higher A-V.O2 and increased CBF. …”
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Inhaled nitric oxide: are expectations justified? by I. A. Kozlov

“…In cardiac surgery, numerous studies have reported the positive effect of iNO on pulmonary hypertension and the elimination of dysfunction and/or insufficiency of the right ventricle. …”
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Assessing the nitric oxide efficacy in bilateral lung transplantation by A. M. Talyzin, S. V. Zhuravel, M. Sh. Khubutiya, E. A. Tarabrin, N. K. Kuznetsova

“…There is evidence of the effectiveness of using inhaled nitric oxide in order to prevent such injury.Objective. …”
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Rhizoma Atractylodis Macrocephalae reduces HFD-induced MAFLD in mice through activated AMPK-mediated inhibition of fatty acid synthesis by Ke Zheng, Ruishuo Zhang, Yijing Xin, Yuge Zhou, Jiacheng Lin, Weifan Huang, Fang Wang, Liu Yang, Xuehua Sun, Xiaoni Kong

“…Therapeutic agents targeting AMP-activated protein kinase (AMPK) activation have been suggested as potential treatments for metabolic disorders such as metabolic dysfunction-associated steatohepatitis (MASH). Rhizoma Atractylodis Macrocephalae (RAM) has been clinically used to treat obesity-related health problems, but its therapeutic effects on MAFLD and the underlying mechanism remain unclear. …”
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Evaluation of the protective role of resveratrol on LPS-induced septic intestinal barrier function via TLR4/MyD88/NF-κB signaling pathways by Zhongliang Shi, Yanna Jiao, Zhizhen Lai, Juan Liu, Bo Yang, Mahong Hu, Jianbiao Meng

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Effects of sleep deprivation on heart rate variability: a systematic review and meta-analysis by Suling Zhang, Xiaodan Niu, Jinke Ma, Jinke Ma, Xin Wei, Xin Wei, Jun Zhang, Jun Zhang, Weiping Du

“…Heart rate variability (HRV), an important indicator of ANS function, reflects fluctuations in sympathetic and parasympathetic activity and is commonly used to assess the autonomic effects of sleep deprivation. However, existing studies exhibit considerable heterogeneity due to inconsistencies in HRV measurement methods, variations in deprivation duration, and inadequate control of confounding factors.ObjectiveThis study aimed to comprehensively evaluate the impact of sleep deprivation on HRV through a systematic review and meta-analysis of randomized controlled trials (RCTs), to elucidate the potential mechanisms underlying sleep deprivation-induced cardiac autonomic dysfunction, and to provide insights for optimizing sleep-related interventions and preventing cardiovascular disease.MethodsA systematic search was conducted in PubMed, Embase, CNKI, Wanfang, and VIP databases for RCTs investigating the effects of sleep deprivation on HRV, covering the period from January 2010 to May 2024. …”
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Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke by Ran Meng, Zhengzhong Sun, Ruxue Chi, Yan Gu, Yuxiang Zhang, Jiaxing Wang

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Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case repor... by Yuya Ando, Suguru Mabuchi, Norikazu Mataki, Satoshi Nakayama, Arata Honda, Mari Kamiya, Shinsuke Yasuda, Hiroaki Takeo, Shigeaki Aono, Masayoshi Hashimoto, Kenichi Harada, Naoya Murashima

“…Future studies involving larger cohorts and detailed mechanistic analyses are necessary to confirm the systemic and hepatic effects of anti-centromere antibodies.…”
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Post-COVID-19 Pandemic Sequelae in Liver Diseases by Cristina Stasi

“…Therefore, the long-term effects of COVID-19 extensively include hepatic manifestations. …”
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Fixed-dose combinations in pharmacotherapy of chronic venous diseases by V. Yu. Bogachev, B. V. Boldin, K. V. Komov, O. V. Dzhenina

“…Some of these drugs are able to inhibit the vein-specific inflammation, improve the microcirculatory bed regulation, increase the vein tone and contractility and, as a result, have a positive effect on the clinical signs of chronic venous disease. …”
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Integrating network pharmacology and experimental validation to investigate the mechanism of Gualou Xiebai Banxia decoction against myocardial ischemia by Wanjun Zhu, Ping Shao, Ying Ren, Wenxuan Liu, Xiaorui Han, Kexin Zeng, Chunmei Dai, Feifei Liu

“…However, the molecular mechanisms underlying its effects remain unclear. This study integrated network pharmacology and experimental validation to investigate the efficacy and potential mechanisms of GXBD in MI treatment.MethodsNetwork pharmacology was used to predict the mechanism of action of GXBD in MI. …”
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Association between placental insufficiency and manifestations of preeclampsia by A. N. Strizhakov, Yu. V. Tezikov, I. S. Lipatov, D. V. Pechkurov

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Impact of hepatic steatosis on liver stiffness measurement by vibration-controlled transient elastography and its diagnostic performance for identifying liver fibrosis in patients... by Zhiyuan Chen, Ye Huang, Yan Zhang, Dongjing Zhou, Yu Yang, Shuping Zhang, Huanming Xiao, HaiXia Li, Yupin Liu

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