ACE inhibitors in arterial hypertension management: zofenopril – class-specific effects and extra benefits by V. S. Zadionchenko, T. V. Adasheva, M. V. Matsievich

“…The mechanisms of ACE inhibitors’ effects on oxidative stress, endothelial dysfunction, insulin and glucose metabolism are discussed. …”
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Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease by Jie Jin, Huajing Zhang, Qianying Lu, Linqiang Tian, Sanqiao Yao, Feng Lai, Yangfan Liang, Chuanchuan Liu, Yujia Lu, Sijia Tian, Yanmei Zhao, Wenjie Ren

“…Traumatic brain injury and Alzheimer’s disease share pathological similarities, including neuronal loss, amyloid-β deposition, tau hyperphosphorylation, blood–brain barrier dysfunction, neuroinflammation, and cognitive deficits. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…It is becoming clearer that HFpEF has a lot of different causes, which makes it challenging to find effective treatments. Currently, there are no proven treatments for people with deteriorating HF or HFpEF. …”
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The Effect Of Demographic Factors And Comorbidities On Ejection Fraction Outcome In Acute Myocardial Infarction Patients by Kausar Malik, Faiza Batool, Shazia Siddiq, Lubna Meraj

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A Coupled Model of the Cardiovascular and Immune Systems to Analyze the Effects of COVID-19 Infection by Camila Ribeiro Passos, Alexandre Altamir Moreira, Ruy Freitas Reis, Rodrigo Weber dos Santos, Marcelo Lobosco, Bernardo Martins Rocha

“…These findings highlight the model’s capacity to distinguish differential cardiac dysfunction across clinical outcomes and its potential to enhance our understanding of COVID-19 pathophysiology.…”
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Analysis of Clinical Characteristics and the Effect of Symptomatic Supportive Treatment for Severe Neonatal Enterovirus Infection by Xuan Z, Wang T, Li N, Tang Z

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Acute Effects of Cannabis Inhalation on Arterial Stiffness, Vascular Endothelial Function, and Cardiac Function by Christian P. Cheung, Alexandra M. Coates, Ryleigh E. Baker, Jamie F. Burr

“…Although evidence links chronic use to an increased risk of disease and adverse cardiovascular events, few studies have investigated the acute effects of cannabis inhalation on subclinical dysfunction. …”
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Effect of ranolazine on cardiac remodeling and pulmonary artery pressure in patients with acute pulmonary embolism by В.Й. Целуйко, М.В. Курінна, Є.І. Кіношенко

“…The development of right ventricular (RV) dysfunction is the most significant predictor of in-hospital mortality and one of the most important factors affecting the short- and long-term prognosis of pulmonary embolism (PE). …”
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Assessing the Effects of Pesticides on Aquacultured Fish and Ecosystems: A Comprehensive Environmental Health Review by Emily Burch, Mohamed Ali Hussein, Manar Zaki, Lereen T. Kamal, Ghada Zaki, Tamer Shoeib, Mahmoud Dawood, Hani Sewilam, Anwar Abdelnaser

“…Pesticide exposure has been linked to severe health impacts in humans, such as non-communicable diseases, reproductive issues, cognitive dysfunction, and cancer. The current review comprehensively emphasizes the harmful effects of pesticides on fish and human health, urging the establishment of environmental monitoring programs and biomonitoring studies. …”
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Toxic Effects of Excess Vitamins A, B6, and Folic Acid on the Nervous System by Yu Sun, Xiaofeng Yu, Yiliang Teng, Yanping Sun

“…The purpose of this paper is to review the toxic effects of excessive vitamin intake on the nervous system, focusing on vitamin A and some of the B vitamins. …”
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The effects of melatonin and catalase supplements on the survival of α-Synuclein-expressing saccharomyces cerevisiae cells. by Laura Houghton

“…This causes cellular dysfunction and ultimately, cell death. As such, research on this protein is both critical and ongoing. …”
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Organoprotecive effects of angiotensin II receptor blockers in patients with type 2 diabetes mellitus by Ivona Yanovna Yarek-Martynova, Minara Shamkhalovna Shamkhalova

“…The currently available data suggest advantages of iACE and ARB as preparations for the treatmentof cardiovascular diseases such as ability of iACE to improve clinical picture and outcome of therapy of cardiac insufficiency, left ventricle dysfunction,and myocardial infarction. Large-scale prospective studies demonstrated effectiveness of these agents in the treatment of CHD, stroke, diabetes, renalpathology and revealed their additional advantages attributable to inhibition of angiotensin II secretion other than those related to reduction of AP.These studies gave evidence of a more pronounced decrease in the frequency of cardiovascular events under effect of ARB in high-risk patients. …”
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Ubiquitin-specific protease 38 exacerbates diabetic cardiomyopathy via post-translational modification of ACAD11 by Zheng Xiao, Yucheng Pan, Hong Meng, Zongze Qu, Liang Guo, Bin Kong, Wei Shuai, He Huang

“…Cardiomyocyte-specific USP38 overexpression aggravated cardiac dysfunction, cardiac inflammation and myocardial fibrosis, mitochondrial dysfunction, and increased vulnerability to ventricular arrhythmia in diabetic mice. …”
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Global burden trends and forecasts for MAFLD in adolescents and young adults from 1990 to 2021 by Shiying Ruan, Liyuan Huang, Jie Song, Zusong Yi, Weipeng Sun, Fankun Zhou, Chang Feng, Guihua Du, Jie Xie, Yuanan Lu, Guangqin Fan

“…Abstract Metabolic-dysfunction associated fatty liver disease (MAFLD) is a widespread chronic liver condition that has been steadily increasing among adolescents and young adults in recent years, posing a major global public health concern. …”
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The Development of a Non-Invasive Screening Method Based on Serum microRNAs to Quantify the Percentage of Liver Steatosis by Polina Soluyanova, Guillermo Quintás, Álvaro Pérez-Rubio, Iván Rienda, Erika Moro, Marcel van Herwijnen, Marcha Verheijen, Florian Caiment, Judith Pérez-Rojas, Ramón Trullenque-Juan, Eugenia Pareja, Ramiro Jover

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is often asymptomatic and underdiagnosed; consequently, there is a demand for simple, non-invasive diagnostic tools. …”
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The therapeutic effects and mechanisms of glucagon-like peptide-1 receptor agonists in neurocognitive disorders by Junchen Si, Kai Yu, Jiheng Hao, Jiyue Wang, Liyong Zhang

“…It can lead to multifaceted pathological alterations including neuroinflammation, neuronal apoptosis, blood–brain barrier disruption, synaptic plasticity deficits, and mitochondrial dysfunction. The glucagon-like peptide-1 receptor (GLP-1R), ubiquitously expressed across multiple organ systems, exerts neuroprotective effects by maintaining intracellular homeostasis and mitigating neuronal damage triggered by oxidative stress, inflammatory cascades, apoptotic signaling, and ischemic insults. …”
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Hu-lu-su-pian ameliorates hepatic steatosis by regulating CIDEA expression in AKT-driven MASLD mice by Rumeng Ren, Rumeng Ren, Qi Wang, Qi Wang, Dongjie Deng, Dongjie Deng, Aoao Guo, Aoao Guo, Xin Chen, Xin Chen, Yan Meng, Yan Meng, Ying Fang, Ying Fang, Guohua Zheng, Guohua Zheng, Zhong Xu, Zhong Xu, Man Li, Junjie Hu, Junjie Hu

“…However, the molecular mechanism by which HLSP affects metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. …”
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COMPARATIVE EFFECTIVENESS OF THE COMBINATIONS OF DIURETICS AND DIHYDROPYRIDINE AND NONDIHYDROPYRIDINE CALCIUM ANTAGONISTS IN PATIENTS WITH ARTERIAL HYPERTENSION by B. G. Iskenderov, E. V. Gridneva, O. N. Sisina, L. F. Burmistrova, S. V. Saushkina

“…In Group 1, combined therapy was more effective among patients with Type I left ventricular diastolic dysfunction (LVDD), non-dipper circadian BP profile, and hyperkinetic circulation type. …”
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Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease by Andy W. C. Man, Ning Xia, Huige Li

“…Healthy PVAT exerts anticontractile and anti-inflammatory effects, contributing to vascular protection. However, during obesity, PVAT becomes proinflammatory and profibrotic, exacerbating vascular dysfunction. …”
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Single-cell RNA sequencing reveals the effects of hederasaponin C in the treatment of diabetic nephropathy by Jing Liu, Qian Zhang, Wentong Zhao, Jinan Guo, Yin Kwan Wong, Chunting Zhang, Weijin Qiu, Piao Luo, Junhui Chen, Junmao Li, Xiaoran Li, Hongwei Gao, Shilin Yang, Yulin Feng, Jigang Wang

“…Hederasaponin C (PB5), a natural product, has been reported to exhibit significant therapeutic effects in various diseases; however, the possible effects and mechanism underlying PB5 in reducing diabetic renal complications have not been comprehensively reported. …”
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