Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease by Sha Sha, Lina Ren, Xiaona Xing, Wanshu Guo, Yan Wang, Ying Li, Yunpeng Cao, Le Qu

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ROLE OF SUSTAINED-RELEASE CALCIUM ANTAGONIST (AMLODIPINE MALEATE) IN THE TREATMENT OF ESSENTIAL HYPERTENSION IN PATIENTS WITH ASTHMA by N. A. Karoli, A. A. Roshchina, A. P. Rebrov

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Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation by Yoonseok Kam, Lisa Winer, Natalia Romero

“…The results suggest that PFCA-induced mitochondrial dysfunction is a key mechanism of PFAS-mediated cellular damage, primarily driven by proton leak-mediated ETC uncoupling, leading to impaired mitochondrial energy production. …”
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Long-term exposure to air pollution and liver fibrosis in the elderly with MASLD by Yanqi Lan, Haixia Zhang, Ahua Wu, Jiankang Huang, Zhinan Guo, Youlan Chen

“…Abstract This study aimed to investigate the relationship between air pollutants (AP) and liver fibrosis in the older Chinese population with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Association of the polymorphism in the androgen receptor gene and endothelial function in men with type 2 diabetes by Irina Alekseevna Khripun, Sergey Vladislavovich Vorobyev, Michael Iosifovich Kogan

“…In recent years, actively studied the effect of androgen deficiency on the cardiovascular system, including endothelial function. …”
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Successful treatment with ivabradine in a β‐blocker‐refractory patient with acute decompensated heart failure with reduced ejection fraction by Tomoko Inoue, Keiji Matsunaga, Waki Kobayashi, Tetsuo Minamino

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Homozygous FANCM Variant c.5101C>T p.(Gln1701*) in a Patient With Early Onset Breast Cancer, Chemotherapy Toxicity, and Chromosome Fragility: A Case Report by Sonja Sulkava, Anna H. Hakonen, Rikke Christensen, Minna Pöyhönen, Heli Nevanlinna

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Creation and validation of a daily task reminder clock for people with dementia in a Pune dementia center by Aarti Rahul Gaikwad, Sheela Upendra

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Impact of polyethylene terephthalate and polylactic acid nanoplastics on cellular uptake and lipid metabolism in differentiated 3T3-L1 adipocytes by Yu-Tung Jhang, Ching-Hao Li, Chih-En Yeh, Yen-Ju Chan, Tsung-Min Yang, Carlos Jose Quiroz Reyes, Ching-Wei Lin, I-Lun Hsiao

“…This study first proved that NPl-induced lipolysis of adipocytes is dependent on the plastic type, which serves as a basis for future concerns about NPl effects on cardiovascular disease and non-alcoholic fatty liver disease driven by adipocyte dysfunction.…”
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GrpEL1 overexpression mitigates hippocampal neuron damage via mitochondrial unfolded protein response after experimental status epilepticus by Minjia Xie, Xin Wu, Xi Liu, Longyuan Li, Feng Gu, Xinyu Tao, Bingyi Song, Lei Bai, Di Li, Haitao Shen, Zongqi Wang, Wei Gao

“…Methods: The effects of GrpEL1 were assessed in vivo using a Lithium-pilocarpine rat model of SE and in vitro with glutamate-treated HT22 hippocampal cells. …”
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New AIE Emitters from the Unexpected Boron Tribromide/Boron Trichloride‐mediated Cyclization Reaction and Application for Fluorescence Imaging of Lipid Droplets by Yichen Hu, Xin Gao, Junlong Ma, Zhichun Shangguan, Liangliang Chen, Guanxin Zhang, Xi‐Sha Zhang, Cheng Li, Yanbang Li, Deqing Zhang

“…ABSTRACT The aberrant behavior of lipid droplets (LDs) is often indicative of cellular dysfunction, which may contribute to the development of a range of diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and atherosclerosis (AS). …”
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Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase by Cristina Algieri, Chiara Bernardini, Antonia Cugliari, Silvia Granata, Fabiana Trombetti, Patrycja Anna Glogowski, Micaela Fabbri, Giampaolo Morciano, Gaia Pedriali, Paolo Pinton, Salvatore Nesci

“…Melatonin is evaluated as a potential molecular therapy to counteract mitochondrial dysfunction caused by hypoxia/reoxygenation (H/R) in aortic endothelial cells (pAECs). …”
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Vitamin D3 affects liver expression of pro-/anti-inflammatory cytokines and nitric oxide synthases in type 2 diabetes by Ihor Shymanskyi, Olha Lisakovska, Mykola Veliky, Olha Mezhenska, Vasyl Bilous, Andrii Siromolot, Anna Khomenko, Dmytro Labudzynskyi, Tetyana Horid’ko, Elvira Pasichna

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Elucidating Early Radiation-Induced Cardiotoxicity Markers in Preclinical Genetic Models Through Advanced Machine Learning and Cardiac MRI by Dayeong An, El-Sayed Ibrahim

“…These findings suggest that ML, combined with cardiac MRI, can effectively detect early preclinical changes in RIHD, particularly alterations in regional myocardial contractility, highlighting the potential of these techniques for early detection and monitoring of radiation-induced cardiac dysfunction.…”
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Bidirectional Association between Thyroid Function and Glycemic Status: A Cross-Sectional Study by Zeynep Kusku Kiraz, Evin Kocatürk, Ezgi Kar

“…Aim: Diabetes and thyroid dysfunctions have similar mechanisms, and they may be overlooked or undiagnosed. …”
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Features of correction of metabolic disorders in women with polycystic ovary syndrome by O.V. Bulavenko, D.G. Konkov, O.A. Taran, O.V. Furman, V.V. Klivak

“…Most symptoms of PCOS are associated with insulin resistance, type II diabetes, decreased levels of sex hormone-binding globulin, increased levels of alanine aminotransferase and aspartate aminotransferase, which may indicate liver dysfunction. The metabolic profile and function of the ovaries can be affected by any pathological changes in the levels of systemic metabolism and/or in peripheral organs, in particular the liver, which serves as the metabolic center of the body, mediating its effects through the liver-ovary axis. …”
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Sexual health in female and male cancer survivors – compared with age-matched cancer-free controls in Norway by Emilie Åsberg, Guro F. Giskeødegård, Jarle Karlsen, Cecile E. Kiserud, Guro Aune, Marianne Nilsen, Randi J. Reidunsdatter

“…Background and purpose: Sexual dysfunction is a common late effect of cancer reducing quality of life. …”
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Potential of primary drug prevention of cardiotoxicity in the context of anticancer therapy by Yu. A. Vasyuk, E. Y. Shupenina, E. O. Novosel, D. A. Vyzhigin, A. G. Nosova, L. G. Zhukova, D. A. Filonenko, E. I. Khatkova

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Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention by Bassim El‐Sabawi, Kahraman Tanriverdi, Priya Gajjar, Matthew Nayor, Joshua M. Landman, Jennifer E. Below, Madeleine Haff, Michelle Long, Mark Ezpeleta, Jane E. Freedman, Krista Varady, Ravi Shah, Andrew S. Perry

“…Background Weight reduction through lifestyle, activity, and dietary interventions are the mainstay of initial therapy for metabolic dysfunction associated steatotic liver disease. Data on the relative effectiveness and metabolic pathways linking weight loss and decreased hepatic steatosis are lacking. …”
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Therapeutic potential of miR-133a-transfected bone marrow mesenchymal stem cell transplantation in improving cardiac function post-myocardial infarction by Yanglanduo Cao, Xiaohan Chen, Biao Cheng, Xuefei Tao, Wei Zhang, Yong Shi, Jie Gao, Minghuan Fu

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