An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics by Shaobo Wang, Qiong Zhang, Hui Hui, Kriti Agrawal, Maile Ann Young Karris, Tariq M. Rana

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Empagliflozin as treatment in glycogen storage disease type IB patients by María Arbelo Rodríguez, Elena Márquez Mesa, Cristina Lorenzo González, Marina Gutiérrez Vilar, Loredana Arhip, Mónica Ruiz Pons, José Pablo Suárez Llanos

“…Background: Glycogen Storage Disease Ib (GSD Ib) is a disease that associates both neutropenia and neutrophil dysfunction, thereby causing recurrent infections and inflammatory bowel disease (IBD). …”
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Pathology of the peripheral circulation in chronic heart failure by A. T. Teplyakov, V. V. Kalyuzhin, E. V. Kalyuzhina, G. E. Chernogoryuk, M. I. Rachkovsky, I. D. Bespalova, N. N. Terentyeva, I. K. Livshits, M. A. Solovtsov, G. M. Chernjavskaja

“…Consistently examines the role of peripheral vascular remodeling and increased arterial stiffness, endothelial dysfunction of major and resistance arteries, as well as pathology of microcirculation. …”
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Anthocyanin attenuates disturbance of intestinal barrier in high fat-high cholesterol diet-challenged mice through regulating the response of T helper 17 cells by Qiannan Liu, Juan Pang, Yi Tang, Yiran You, Jiaxin Mi, Jinghe Xiao, Yu Chen, Wenhua Ling

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Association of daily step counts and step intensity with mortality among US adults: a cross–sectional study of NHANES 2005–2006 by Tianzhou Peng, Changhao Liu, Ti Yang, Leyi Liao, Qingping Li, Hanbiao Liang, Jiapeng Zhang, Chen Xie, Kai Wang, Chuanjiang Li

“…Abstract Background & aims We aimed to describe the dose–response relationship between daily step counts and intensity with respect to all–cause mortality among US adults diagnosed with metabolic dysfunction–associated steatotic liver disease (MASLD). …”
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Early Cardiovascular Events in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation by Nazanin Aghel, MD, MSc, Vincent Wang, BHSc, Darryl Leong, MD, PhD, Michelle Lui, PharmD, MSc, Livia Fu, BNSc, MN, RN(EC), Jasmine Kang, MD, Dina Khalaf, MD, Irwin Walker, MD, Christopher Hillis, MD, MSc, Brian Leber, MD, Harry Klimis, MD, PhD, Anne Holbrook, MD, PharmD, MSc, Catherine Demers, MD, MSc, Philip Joseph, MD, MSc, Kylie Lepic, MD, Alejandro Garcia-Horton, MD, Tobias Berg, MD, PhD, Jeffrey Howard Lipton, MD, PhD, Mylinh Duong, MD, MSc, Jane Turner, MD, Jinhui Ma, PhD

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Association between Metabolic Syndrome Score and Subclinical Atherosclerosis by Ming Yi, Xinyi Wang, Yan Li, Xuewen Li, Jin Si, Yinghua Zhang, Keling Xiao, Lijie Sun, Haoyu Zhang, Jinghao Sun, Zhaoli Liu, Jiaying Lin, Yuxin Xie, Bingyan Zhang, Jing Zhao, Xi Chu, Jing Li

“…Arterial stiffness was defined as baPWV ≥1400 cm/s, while endothelial dysfunction was described as bFMD >6%. Multiple logistic regression was performed to explore the effects of MetS and MetS score on arterial stiffness and endothelial dysfunction. …”
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Consistent improvements in liver histology across subgroups in a post hoc analysis of the SYNERGY-NASH trial with tirzepatide by Mark L. Hartman, Rohit Loomba, Eric J. Lawitz, Raj Vuppalanchi, Jérôme Boursier, Elisabetta Bugianesi, Masato Yoneda, Yuanyuan Tang, Bram Brouwers, Mathijs C. Bunck, Axel Haupt, Arun J. Sanyal

“…Background & Aims: In the SYNERGY-NASH trial for metabolic dysfunction-associated steatohepatitis (MASH) with stage 2 or 3 fibrosis, tirzepatide, an agonist of the glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, effectively resolved MASH without worsening fibrosis in up to 73% of patients. …”
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The fibrosis-4 index and its association with carotid atherosclerosis in type 2 diabetes: a cross-sectional study in China by Ying Miao, Yu Wang, Qin Wan, Nanwei Tong

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BLOOD PRESSURE AND ARTERIAL STIFFNESS DYNAMICS DEPENDING ON THE DURATION OF CPAP NIGHT SESSIONS IN PATIENTS WITH SEVERE OBSTRUCTIVE SLEEP APNEA by M. V. Gorbunova, S. L. Babak, T. V. Adasheva, A. G. Malyavin

“…Objective: to study the dynamics of blood pressure, arterial stiffness and endothelial dysfunction in patients with severe obstructive sleep apnea with resistant hypertension, depending on the duration of auto-adjusting CPAP (A-Flex therapy). …”
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Anti-neuropathic effects of astaxanthin in a rat model of chronic constriction injury: passing through opioid/benzodiazepine receptors and relevance to its antioxidant and anti-inf... by Boshra Hashemi, Sajad Fakhri, Amir Kiani, Amir Kiani, Fatemeh Abbaszadeh, Shahram Miraghaee, Mohammad Mohammadi, Javier Echeverría

“…To check the experimental signs of neuropathic pain and motor dysfunction, hot plate, acetone drop, and open field tests were used at the same time points. …”
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White adipose tissue in type 2 diabetes and the effect of antidiabetic drugs by Yixuan Zhao, Rensong Yue

“…This review used PubMed to search WAT dysfunction in T2D and the effects of these changes on insulin resistance. …”
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Risk factors influencing curative effect of class Ⅳ lupus nephritis by ZHANG Yu-rong, QI Yuan-yuan, MA Xiao, MENG Rui-xia, YANG Yan, WANG Jing

“…Objective To investigate the clinical risk factors for unresponsive common approaches on the treatment of class IV lupus nephritis(LN).Methods The class IV LN patients were confirmed by renal biopsy,treated with glucocorticoid and common immunosuppressive agents and followed up for more than6 months.They were divided into two groups according to curative effect after treatment for 6months.The differences between the two groups were analyzed by means of demographic characteristics,clinical manifestations,laboratory tests,autoantibodies,pathologic indicators,treatment regimens and outcomes.The possible influencing risk factors on the classⅣ LN were analyzed by Kaplan-Meier,and the independent risk factors were analyzed by multivariate COX regression modeling.Results A total of 198 patients with complete data and regularly followed-up were enrolled.They were divided into two groups:50(25.25%)patients in non-response group and 148(74.75%)in response group.There was no significant difference between two groups in responsive rate under various common induction therapies.And then,the risk factors influencing the curative effects of class LN Ⅳ patients were further explored.Results showed that the nonresponse group had a higher rate of photosensitization,renal dysfunction,moderate proteinuria,the anti-RNP positive,renal glomerular sclerosis,CI,chronic interstitial lesions,interstitial cellular infiltration and NNV than in the response group(P<0.05).Kaplan-Meier results showed that a decreasing response happened in the group with a higher rate of renal dysfunction,chronic lesions and interstitial cellular infiltration(Log Rank P<0.05).Then multivariate COX regression model investigated that renal dysfunction was an independent risk factor for poor curative effect.Conclusions Under the treatment of common induction therapy,the classⅣ LN patients with baseline renal dysfunction have a terrible curative effect.In addition,it is possible that the baseline anti-RNP positivity,chronic interstitial lesions,interstitial cellular infiltration or NNV are the risk factors for unresponsive treatment.…”
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Beneficial Effects of Resveratrol on Testicular Functions: Focus on Its Antioxidant Properties by Adele Chimento, Arianna De Luca, Massimo Venditti, Francesca De Amicis, Vincenzo Pezzi

“…The mechanisms underlying male reproductive system dysfunction are not fully understood and the specific drugs use has not produced optimal results. …”
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Different effects of prolonged β-adrenergic stimulation on heart and cerebral artery by Eunji Shin, Kyung Soo Ko, Byoung Doo Rhee, Jin Han, Nari Kim

“…The aim of this review was to understand the effects of β-adrenergic stimulation on oxidative stress, structural remodeling, and functional alterations in the heart and cerebral artery. …”
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Effect of systemic inflammatory response in the development of encephalopathy in severe thermal injury. by O. Y. Sorokina, T. O. Buryak

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The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes by Eric J. Gonzalez, Abbey Peterson, Susan Malley, Mitchel Daniel, Daniel Lambert, Michael Kosofsky, Margaret A. Vizzard

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EFFECTS OF TRIMETAZIDINE ON THE TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE by Yu. N. Fedulaev, N. S. Pavlyuchenko, T. V. Pinchuk, S. Kh. Galachieva, A. A. Kozina, V. N. Ryzhenkov

“…Aim. To study effects of trimetazidine on the left ventricular diastolic dysfunction in patients with combination of ischemic heart disease (IHD) and arterial hypertension (HT). …”
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CardioRespiratory Effects of Wildfire Suppression (CREWS) study: an experimental overview by L. Madden Brewster, Drew Lichty, Natasha Broznitsky, Philip N. Ainslie

“…The primary aims of the CardioRespiratory Effects of Wildfire Suppression (CREWS) Study are to: 1) Examine the chronic effect(s) of wildfire suppression on selected aspects of vascular and respiratory health in BCWS WFFs, 2) Examine cardiorespiratory effect(s) of acute (e.g., cross-shift) wildfire suppression, and 3) Identify mechanisms contributing to the progression of wildfire-associated cardiorespiratory dysfunction in WFFs. …”
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Effect of Discharge Plan on Outcomes of Patients with Lumbar Disc Herniation Surgery by Mabrouka A. Abd- Ella, Tahany A. Elsenousy, Dalia A. Abdelatief, Samar F. Marzouk

“…Aim: This study aimed to evaluate the discharge plan's effect on patients' outcomes with lumbar disc herniation surgery. …”
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