Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment by Ming Gao, Ming Gao, Jie Li, Jie Li, Xu Han, Beiyao Zhang, Jinting Chen, Jiadong Lang, Qiangqiang Zhang

“…Melatonin (MEL) is known for its antioxidant and anti-inflammation effects in neuroprotective aspects. Recent evidence has demonstrated that the gut microbiome plays a key role in DCI by modulating cognitive function through the gut–brain crosstalk. …”
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Pelvic vasectomy and its protective effects on rat testis function by Heng Yang, Yujun Chen, Xiaofeng Cheng, Jingxin Wu, Ruohui Huang, Biao Qian, Gongxian Wang

“…Therefore, this study aims to evaluate and compare the effects of two vasectomy techniques on reproductive system parameters in rats. …”
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Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier by Yang Liu, Qing Liu, Chengcheng Zhang, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

“…This study confirmed the different effects of A. muciniphila strains on gut barrier modulation and provided molecular and genetic targets for the screening of A. muciniphila strains with superior protection against gut barrier dysfunction.…”
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The Effects of Pediatric Acute Lymphoblastic Leukemia Treatment on Cardiac Repolarization by Diana R. Lazar, Simona Cainap, Florin Leontin Lazar, Dana Maniu, Cristina Blag, Madalina Bota, Marius C. Colceriu, Mihnea Zdrenghea

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Comparative analysis of cardioprotective effects of two renal denervation techniques by T. M. Ripp, S. E. Pekarskiy, A. E. Baev, T. R. Ryabova, E. I. Yaroslavskay, A. Yu. Falkovskaya, E. S. Sitkova, V. A. Lichikaki, I. V. Zubanova, M. A. Manukian, L. I. Gapon, V. F. Mordovin

“…To compare cardioprotective effects of two renal denervation (RD) techniques: main renal artery or its branches after bifurcation in patients with resistant hypertension (RH).Materials and methods. …”
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Autosomal dominant tubulointerstitial kidney disease-UMOD: a short review by Panpan Qiao, Zhaohui Wang, Jingyuan Xie

“…By synthesizing existing literature and addressing gaps in knowledge, this review seeks to enhance understanding of ADTKD-UMOD and promote effective clinical approaches to management and treatment.…”
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Comparing targeted thrust manipulation with general thrust manipulation in patients with low back pain. A general approach is as effective as a specific one. A randomised controlle... by Christopher J McCarthy, Louise Potter, Jackie A Oldham

“…The application of spinal manipulation has traditionally involved an element of targeting the technique to a level of the spine where the proposed movement dysfunction is sited. We evaluated the effects of a targeted manipulative thrust versus a thrust applied generally to the lumbar region.Methods A randomised controlled clinical trial in patients with low back pain following CONSORT (Consolidated Standards of Reporting Trials) guidelines. …”
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Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice by Yan‐Yan Zhu, Xin Dong, Hao Zhou, Ze‐Yan Li, Bo Wang, Ya‐Ping Song, Zhi‐Bing Liu, Xue Lu, Yi‐Hao Zhang, Yichao Huang, Hua Wang, De‐Xiang Xu

“…Abstract The global prevalence of Metabolic Dysfunction‐Associated Fatty Liver Disease (MAFLD) has a rising trend. …”
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Virtual reality navigation for the early detection of Alzheimer’s disease by Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike, Atsushi Kasai, Epifanio Bagarinao, Epifanio Bagarinao, Kazuya Kawabata, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Junichi Hata, Shinsuke Ishigaki, Junichiro Yoshimoto, Hiroshi Toyama, Takahiko Tokuda, Akihiko Takashima, Hirohisa Watanabe, Hirohisa Watanabe

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A novel free fatty acid receptor agonist improving metabolic health in Drosophila models by Kashi Brunetti, Elisabetta Catalani, Simona Del Quondam, Nicla Romano, Marcello Ceci, Giuditta Clerici, Marianna Gordin, Gianluca Bianchini, Laura Brandolini, Andrea Aramini, Davide Cervia

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The effect of hyperbaric oxygenation on cardiodynamics and oxidative stress in rats with sepsis by Jevtić Aleksandar, Živković Vladimir, Milinković Milica, Mijailović Željko, Draginić Nevena, Anđić Marijana, Milojević-Šamanović Anđela, Bolevich Sergey, Jakovljević Vladimir

“…Background/Aim. Dysfunctions at the cellular, tissue, and organ level, which can result in death, are caused by metabolic changes and affection on the regulation of gene transcription and micro- and macrocirculation. …”
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Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided perso... by Yukari Kobayashi, Kazuhiro Kakimi, Koji Nagaoka, Akihiro Hosoi, Masashi Fujita, Masataka Shirai, Kiyomi Taniguchi, Changbo Sun, Kazuhiro Maejima, Hidewaki Nakagawa, Sachiyo Nomura

“…Background Although immune checkpoint blockade is effective for several malignancies, a substantial number of patients remain refractory to treatment. …”
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Molecular Mechanisms Responsible for Mesenchymal Stem Cell-Dependent Attenuation of Tear Hyperosmolarity and Immune Cell-Driven Inflammation in the Eyes of Patients with Dry Eye Di... by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

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FDA’s approval of resmetirom (Rezdiffra): a breakthrough in MASH management by Muhammad Mazhar Azam, Sameen Mukhtar, Muhammad Haris, Fatima Laique, Suhaina Amir, Mubashir Mohiuddin, Bibek Giri

“…The FDA’s approval of resmetirom (Rezdiffra) marks a significant breakthrough in treating metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis, conditions linked to non-alcoholic fatty liver disease (NAFLD). …”
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Comparison of endothelial function in patients with Stage I-II arterial hypertension and stable angina, receiving various bradycardic agents and perindopril by L. L. Kirichenko, A. N. Golosova, S. V. Gatsura, A. P. Korolev, K. V. Ovsyannikov, P. V. Struchkov

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Endothelium protecting properties of taurin in chronic heart failure with type 2 diabetes by M. E. Stacenko, S. V. Turkina, N. N. Shilina, A. A. Vinnikova

“…To study the effects of taurin treatment as part of combination therapy for CHF with DM2, taking its influence on endothelial dysfunction.Material and methods. …”
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DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway by Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang, Fachun Zhou

“…TET2 knockdown exacerbated the dysfunction and apoptosis of HPMECs induced by LPS. …”
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Comprehensive treatment approaches for skeletal deformities in hypophosphatasia: a case study of ALPL gene variants by Qiongjie Jiao, Guixia Ma, Qian Ni

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Metabolic phenotypes in a Lyz2Cre recombinase mouse model by S. M. Niazur Rahman, Justin Hou Ming Yung, Allen Volchuk, Neil M. Goldenberg, Neil M. Goldenberg, Neil M. Goldenberg, Neil M. Goldenberg, Adria Giacca, Adria Giacca, Adria Giacca, Adria Giacca

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Macrophage NLRP3-dependent IL-1β production contributes to aortic fibrosis in heart failure with preserved ejection fraction by Chen Sheng, Lu Zhiqiang

“…Furthermore, we show that macrophage NLRP3 inflammasome inhibition improves aortic fibrosis and LV diastolic dysfunction. In conclusion, this study demonstrates the pivotal effect of macrophage NLRP3-dependent IL-1β production on aortic fibrosis and cardiac function in HFpEF, suggesting a potential target for HFpEF therapy.…”
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