Transformer-based multimodal precision intervention model for enhancing diaphragm function in elderly patients by Ma Xinli, Zhao Jie, Yan Ming, Zhang Yanping, Li Fan, Jia Jing, Ding Lu

“…Diaphragm dysfunction represents a significant complication in elderly patients undergoing mechanical ventilation, often resulting in extended intensive care stays, unsuccessful weaning attempts, and increased healthcare expenditures. …”
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The correlation between facial and eyelid demodicosis. Complex therapeutic approaches by D. Yu. Maychuk, M. M. Shokirova, T. A. Simonova, Z. G. Malysheva

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Physiologically Based Pharmacokinetic Modeling for Predicting Drug Levels After Bariatric Surgery: Vardenafil Exposure Before vs. After Gastric Sleeve/Bypass by Daniel Porat, Oleg Dukhno, Sandra Cvijić, Arik Dahan

“…Phosphodiesterase-5 inhibitor (PDE5i) drugs are the first-line treatment of erectile dysfunction, a condition associated with a higher BMI. …”
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Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metaboli... by Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta

“…Our data demonstrate for the first time that the mutation in the LRRK2-I1371V allele causes significant astrocytic dysfunction with respect to Nrf2-mediated antioxidant machinery, AT -generation, and glutamate metabolism, even with comparable astrocyte yields.…”
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SIRT1 prevents noise-induced hearing loss by enhancing cochlear mitochondrial function by Yuelian Luo, Haoyang Wu, Xin Min, Yi Chen, Wenting Deng, Minjun Chen, Chuxuan Yang, Hao Xiong

“…Abstract Exposure to traumatic noise triggers cochlear damage and consequently causes permanent sensorineural hearing loss. However, effective treatment strategies for noise-induced hearing loss (NIHL) are lacking. …”
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Relationship Between Noninvasive Doppler-Derived Coronary Flow Reserve Measured by Transthoracic Echocardiography and Angiography Thermodilution-Measured Coronary Flow Reserve and... by Milenko Čanković, Aleksandra Milovančev, Snežana Tadić, Maja Stefanović, Milovan Petrović, Mila Kovačević, Igor Tomas, Dragana Dabović, Vladimir Ivanović, Aleksandra Ilić, Anastazija Stojšić-Milosavljević, Snežana Stojšić, Nikola Komazec, Bojan Mihajlović, Igor Ivanov

“…<b>Background/Objectives</b>: Coronary microvascular dysfunction (CMD) is emerging as a critical factor in patients presenting with anginal symptoms without obstructive coronary artery disease (CAD). …”
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Long-term nifedipine CR therapy and arterial characteristics in hypertensive patients aged over 60 years by V. E. Oleynikov, I. B. Matrosova, E. E. Grishaeva, N. A. Borisova, E. I. Yastrebova

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Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination by M. V. Leonova

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An evaluation of wet and dry needling techniques for treating myofascial pain in trapezius muscle – A meta-analysis by P. Ramaswamy, C. H. Saikiran, M. Swathi, B. Mrudula Raj, Poluri Lakshmisasi

“…Introduction: Myofascial pain is a common sign of temporomandibular joint disorders and a significant cause of dysfunction in the general population. Although there are many ways to treat it, because of their ease of use and effectiveness in reducing pain, needling therapies, particularly those inside the masticatory muscles, have seen a recent surge in attention. …”
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WAYS OF PREVENTION SYNDROME OF INTRA-ABDOMINAL HYPERTENSION IN BARIATRIC SURGERY by M. I. Neimark, A. Yu. Elizariev, R. V. Kiselev

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Choosing optimal combination of neuro-humoral modulators in chronic heart failure: CHARM-Added study lessons by Yu. M. Lopatin

“…The article is focused on choosing optimal doses and combinations of neuro-humoral modulators in systolic left ventricular dysfunction and heart failure. The results of CHARM-Added, Val-HeFT, RALES, and EPHESUS studies are analyzed, as well as their effect on modern recommendations on chronic heart failure diagnostics and treatment.…”
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Low-dose polystyrene microplastics exposure increases susceptibility to obesity-induced MASLD via disrupting intestinal barrier integrity and gut microbiota homeostasis by Gang Wei, Kai Zhang, Feng-Jie Shen, Rong-Rong Xie, Feng-Wei Wang, Hua-Qi Guo, Lin Liu

“…Furthermore, low-dose MPs exposure exacerbated these effects in combination with HFD feeding, exhibiting a ‘double hit’ effect. …”
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AN ANGIOTENSIN-CONVERTING ENZYME INHIBITOR AND CALCIUM ANTAGONIST COMBINATION IN PHARMACOTHERAPY OF ARTERIAL HYPERTENSION by L. L. Kirichenko, S. V. Gatsura, A. N. Golosova, K. V. Ovsyannikov, O. V. Budik, A. V. Fedorov

“…The authors also present the latest evidence on the ACEI/AC combination effects on such vascular parameters as microcirculation and endothelial dysfunction.…”
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The system of anesthesiological support for coloproctological operations by G. A. Myshkov, M. V. Abritsova, N. R. Torchua

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Application of radiofrequency features in the diagnosis of severity of fatty liver disease by Zhixiang Wang, Xuebin Cao, Yiran Wang, Jiaqi Han, Jianguo Ma, Xiangdong Hu

“…Abstract Objective This study aims to explore the capability of raw radiofrequency (RF) information in the diagnosis of the severity of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), especially its effectiveness in differentiating patients with varying severity of fatty liver disease. …”
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Pentoxyphylline: possibilities to reduce manifestations of chronic heart failure with preserved left ventricular ejection fraction in elderly by V. B. Shatylo, L. A. Bodretska, I. S. Shapovalenko, H. P. Voinarovska, Zh. S. Butynets

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Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1 by Xinxin Li, Jinghua Cui, Zanbo Ding, Ziyan Tian, Yiming Kong, Linghai Li, Yang Liu, Wen Zhao, Xueying Chen, Han Guo, Zhengshuo Cui, Xinwei Li, Jing Yuan, Huina Zhang

“…This study aimed to investigate the effects of K.pn EVs on endothelial function and to elucidate the underlying mechanisms. …”
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Percutaneous transluminal coronary angioplasty in the right ventricle myocardial infarction treatment by Rafajlovski Saša I., Orozović Vjekoslav, Ristić-Anđelkov Anđelka, Rađen Goran

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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease by Mengjiao Xu, Peng Feng, Peng Feng, Jun Yan, Lei Li

“…However, in COPD, due to the persistent stimulation of harmful factors such as smoking and air pollution, mitochondrial quality control mechanisms often become deregulated, leading to mitochondrial dysfunction. Mitochondrial dysfunction plays a pivotal role in the pathogenesis of COPD, contributing toinflammatory response, oxidative stress, cellular senescence. …”
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Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations by Ignacio de la Mora-de la Mora, Itzhel García-Torres, Luis Antonio Flores-López, Gabriel López-Velázquez, Gloria Hernández-Alcántara, Saúl Gómez-Manzo, Sergio Enríquez-Flores

“…Triosephosphate isomerase (TPI) dysfunction is a critical factor in diverse pathological conditions. …”
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