Enpp1 ameliorates MAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathway by Xiaohui Liu, Shuai Chen, Xing Liu, Xianxian Wu, Xiaoliang Jiang, Yuhan Li, Zhiwei Yang

“…Abstract Background Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the leading chronic liver disease globally, and there are no approved pharmacotherapies to treat this disease. …”
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Testosterone therapy for hypoactive sexual desire disorder in women by Jagoda Misiuk Misiuk, Karolina Kopeć, Aleksandra Bartoszek, Julia Adamiuk, Agnieszka Marut, Marta Biskup, Adriana Skuba, Katarzyna Załuska, Sylwia Nykiel, Agnieszka Świdniak

“…While the therapy is generally well-tolerated, common side effects include acne, hirsutism, and voice deepening. …”
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Statin use and risk of HCC in patients with MASLD and T2DM: an umbrella review and meta-analysis by Nazanin Hosseinkhan, Laily Najafi, Soodeh Jahangiri, Zahra Emami, Mohammad E. Khamseh

“…Abstract Background The effect of statin use on hepatocellular carcinoma (HCC) in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) or type two diabetes mellitus (T2DM) is still unclear. …”
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Exploring Glyoxalase Strategies for Managing Sugar-Induced Chronic Diseases by Alejandro Gugliucci

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A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice by Bining Zhao, Haowen Wu, Qiyang Yao, Wenpei Bai, Jihong Kang

“…The aim of the present study was to investigate the effect of KD on the reproductive phenotype of a letrozole-induced PCOS mouse model. …”
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Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression by T. N. Malishevskaya, T. N. Kiseleva, Yu. E. Filippova, M. S. Zaitsev, A. S. Vlasova, I. V. Nemtsova, K. V. Lugovkina

“…The mild degree of endothelial dysfunction (ED) predominantly was detected in patients of the 1st group (69 % of cases). …”
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Mucormycosis and Hearing: A Hospital-Based Study by Monalisa Jati, Ripu Daman Arora, Ruuzeno Koutsu, Nitin M. Nagarkar, Roshan Marandi, Kartik Agrawal

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The impact of ketamine on cognitive outcomes in geriatric anesthesia: a comprehensive review by Shuyong You, Shuyong You, Zhaohui Li

“…Postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) are frequent complications in elderly surgical patients, resulting in longer hospital stays, higher healthcare costs, and long-term cognitive impairment. …”
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Dual-responsive nanoscale ultrasound contrast agent as an oxidative stress amplifier for enhanced DNA damage in BRCA-proficient ovarian cancer by Jialu Zhang, Xiaoxuan Wang, Lu Guo, Shan Xiao, Dong Meng, Mengmeng Shang, Xiao Sun, Dandan Shi, Yading Zhao, Rui Liu, Shuting Huang, Xinyu Zeng, Jie Li

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Molecular mechanism of phytochemical compounds in mitigating hypertension by Putri Cahaya Situmorang, Syahputra Wibowo, Masitta Tanjung, Raden Jokokuncoroningrat Susilo, Ananda, Rizal Mukra, Alexander Patera Nugraha, Wida Akasah

“…The analysis focused on phytochemicals affecting vascular smooth muscle cells (VSMCs), oxidative stress (ROS/NO), the renin–angiotensin system (RAS), NF-κB signaling, endothelial dysfunction, and prostacyclin (PGI₂) pathways. Results: Numerous phytochemicals, including quercetin, resveratrol, apigenin, and ursolic acid, demonstrate antihypertensive effects by targeting key signaling cascades involved in vascular remodeling, inflammation, and oxidative stress. …”
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The P2X7 receptor in depression: Novel insights and therapeutic implications by Yue-ting Zhong, Chao Pi, Ying Zuo, Yan Wei, Wen Li, Yong-qiang Jiang, Lei Tao, Wen-wu Zheng, Jun Jiang, Yan Yang, Shi-feng Chu, Bin-yan Liu, Ke-zhi Liu, Yu-meng Wei, Ling Zhao

“…Current first-line antidepressant medications suffer from slow onset of action, limited effectiveness, and high side effects, necessitating the search for new therapeutic targets. …”
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The association between HPV vaccination and new-onset cardiovascular and cerebrovascular diseases: based on a retrospective study by Chiao-Yu Yang, Yu-Hsiang Shih, Chia-Chi Lung

“…Subgroup analyses further supported the protective effect of HPV vaccination across different demographics. …”
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HYPERTENSION AND DIABETES MELLITUS TYPE 2 by M. E. Statsenko, M. V. Derevyanchenko

“…Aim. To study the effect of long-term combined antihypertensive therapy with lisinopril plus amlodipine on the parameters of central aortic pressure (CAD) and visceral obesity in patients with arterial hypertension (HT) combined with type 2 diabetes mellitus (DM).Material and methods. 30 patients with stage III of HT and DM type 2 aged 40-65 years were included into the study. …”
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Interventions by Cardiovascular Drugs Against Aircraft Noise-Induced Cardiovascular Oxidative Stress and Damage by Marin Kuntić, Ivana Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Dilja Krueger-Burg, Huige Li, Sebastian Steven, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber

“…Here, we investigated the protective effects of cardiovascular drug interventions against aircraft noise-mediated cardiovascular complications such as elevated oxidative stress or endothelial dysfunction. …”
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Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy by N. N. Koloskova, E. A. Nikitina, V. M. Zakharevich, I. I. Muminov, V. S. Cvan, V. N. Poptsov, R. L. Ahmadzai, D. A. Izotov, A. O. Shevchenko

“…However, nephrotoxicity of CNIs has been  largely responsible for the progressive development of renal dysfunction and  reduces long-term patient survival. …”
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Petroleum Jelly Versus Tea Tree Oil and Tea Tree Facial Wash Lid Scrub in Patients with Blepharitis Associated with Above-normal Demodex Count by Karen Angela L. Tiuseco, MD, Ruben Lim Bon Siong, MD, Johann Michael Reyes, MD, Eleonor B. Iguban, MD

“…Purpose: To determine the effectiveness of lid scrub with petroleum jelly versus lid scrub with tea tree oil and tea tree facial wash in patients with symptomatic blepharitis associated with above-normal Demodex counts Methods: Patients with symptomatic anterior blepharitis (AB), meibomian gland dysfunction (MGD), or mixed blepharitis (MB) were recruited into the study. …”
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Co-exposure of ferruginous components of subway particles with lipopolysaccharide impairs vascular function: A comparative study with ambient particulate matter by Oluwatoyin Hannah Owokoniran, Akiko Honda, Takamichi Ichinose, Raga Ishikawa, Megumi Nagao, Natsuko Miyasaka, Zaoshi Wang, Satsuki Takai, Issei Omori, Kerui Zhang, Wei Liu, Yuya Higaki, Takayuki Kameda, Tomonari Matsuda, Taku Fujiwara, Tomoaki Okuda, Hirohisa Takano

“…Several empirical studies have linked subway and ambient particle exposure to toxicity, pro-inflammatory responses, and vascular dysfunction. However, the health effects of pollutants generated from varying sources, particularly when combined with lipopolysaccharide (LPS), are still unexplored. …”
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Sexual Quality of Life in Postmenopausal Women: A Comparative Randomized Controlled Trial of Intravaginal PRP Therapy Versus Local Hormonal Treatments by Geanina Sacarin, Ahmed Abu-Awwad, Nitu Razvan, Marius Craina, Bogdan Hogea, Bogdan Sorop, Simona-Alina Abu-Awwad, Mircea Diaconu, Nicolae Ciprian Pilut, Madalina-Ianca Suba

“…<i>Background and Objectives</i>: Genitourinary syndrome of menopause (GSM) is a prevalent and distressing condition in postmenopausal women, often leading to sexual dysfunction characterized by vaginal dryness, pain, and reduced libido. …”
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Myocardial Viability: Evolving Insights and Challenges in Revascularization and Functional Recovery by Kristoffer Ken Ralota, Jamie Layland, Kyi Thar Han Win, Nay M. Htun

“…Myocardial viability—the potential ability of dysfunctional myocardium to recover contractile function after revascularization—remains an ongoing key area of research in managing ischemic cardiomyopathy. …”
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Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health by Eugenio Caradonna, Federico Abate, Elisabetta Schiano, Francesca Paparella, Fulvio Ferrara, Emilio Vanoli, Rossana Difruscolo, Vito Maria Goffredo, Bruno Amato, Carlo Setacci, Francesco Setacci, Ettore Novellino

“…Notably, TMAO-mediated pathways include endothelial dysfunction, inflammation via NLRP3 inflammasome activation, and cholesterol metabolism disruption, which collectively accelerate atherosclerosis and disease progression. …”
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