Enhanced allergic Eustachian tube response in surfactant protein D knockout mice induced by ovalbumin by Xuan Yu, Hejie Li, Wei Tang, Xi Lian, Wenting Yu, Ting Li, Shimin Zong, Hongjun Xiao

“…Background: Allergic reactions have been widely recognized as closely associated with the development of Eustachian tube dysfunction (ETD). However, the precise pathophysiological mechanisms remain unclear, and effective models to elucidate the role of allergic responses in ETD are lacking. …”
Get full text

A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes by Manyun Chen, Yilei Peng, Yuhui Hu, Zhiqiang Kang, Ting Chen, Yulong Zhang, Xiaoping Chen, Qing Li, Zuyi Yuan, Yue Wu, Heng Xu, Gan Zhou, Tao Liu, Honghao Zhou, Chunsu Yuan, Weihua Huang, Wei Zhang

Get full text

Combined Esculentin-2CHa Fusion Protein-Coated Au Nanoparticles for Effective Against Non-Alcoholic Fatty Liver Disease in Mice Model by Amatya R, Joseph A, Roh GS, Moon C, Benmokadem Y, Kim D, Min KA, Shin MC

“…Reeju Amatya,1 Amala Joseph,1 Gu Seob Roh,2 Cheol Moon,3 Yassmine Benmokadem,4 Doyeon Kim,4 Kyoung Ah Min,4 Meong Cheol Shin1 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongnam, 52828, Republic of Korea; 2Department of Anatomy and Convergence Medical Science, Metabolic Dysfunction Liver Disease Research Center, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju, Gyeongnam, 52727, Republic of Korea; 3College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam, 57922, Republic of Korea; 4College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae, Gyeongnam, 50834, Republic of KoreaCorrespondence: Meong Cheol Shin, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongnam, 52828, Republic of Korea, Tel +1 82 55 772 2421, Fax +1 82 55 772 2429, Email shinmc@gnu.ac.kr Kyoung Ah Min, College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje University, Gimhae, Gyeongnam, 50834, Republic of Korea, Tel +1 82 55 320 3459, Fax +1 82 55 320 3940, Email minkahh@inje.ac.krIntroduction: Extensive research has focused on identifying effective treatments for NAFLD, with numerous bioactive peptide candidates showing significant promise. …”
Get full text

Cyanidin-3-<i>O</i>-Glucoside Mitigates Amyloid-Beta (1–42)-Induced Apoptosis in SH-SY5Y Cells by Regulating Ca²⁺ Homeostasis and Inhibiting Mitochondrial Dysfunction by Chao Ma, Yu Nie, Donglei Zhang, Lulu Ran, Su Xu, Xun Ran, Junya Huang, Lingshuai Meng

Get full text

Assessing the Use of BotulinumtoxinA for Hyperactive Urinary Tract Dysfunction a Decade after Approval: A Single-Blind Study to Evaluate the Reduction in Pain in OnabotulinumtoxinA... by Heinrich Schulte-Baukloh, Catarina Weiss, Thorsten Schlomm, Sarah Weinberger, Hendrik Borgmann, Dirk Höppner, Kathrin Haberecht, Jörg Neymeyer

Get full text

Integrated medical and nursing ward rounds in a patient with gastrointestinal dysfunction after gastric cancer surgery (1例胃癌术后胃肠功能紊乱患者的医护一体化查房)... by ZHAO Yan (赵燕), LIU Shuhong (刘书红), TANG Ling (唐玲), LI Ye (李野), E Haiyan (鄂海燕)

“…To summarize the application effect of integrated medical and nursing ward rounds in a patient with gastrointestinal dysfunction after gastric cancer surgery. …”
Get full text

DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradat... by Shigang Qiao, Guofang Mao, Hua Li, Zhimin Ma, Lei Hong, Huiling Zhang, Chen Wang, Jianzhong An

“…Chronic Western diet consumption elevated plasma glucose and insulin and caused obesity, diastolic dysfunction, and β-cell dysfunction. DPP-4 inhibition with SIT resulted in reduction in body weight, fasting glucose, and plasma insulin, and improved cardiac diastolic dysfunction. …”
Get full text

Differentiation and correlation of regional uptake heterogeneity with cardiac dysfunction in biopsy-proven transthyretin amyloid cardiomyopathy using quantitative single-photon emi... by Masakazu Tsujimoto, Hideki Kawai, Shingo Tanahashi, Masayoshi Sarai, Yasuki Asada, Hideo Izawa

“…Results All metrics were significantly different between the ATTR-CM and non-amyloidosis groups. The rSUVH/Ao effectively differentiated patients with ATTR-CM from those with light-chain or non-amyloidosis. …”
Get full text

Dynamics of patient reported outcomes during the use various biological disease-modifying antirheumatic drugs for rheumatoid arthritis by A. E. Karateev, A. M. Lila, T. S. Panevin, A. S. Potapova, A. S. Semashko, A. O. Bobkova, V. N. Amirjanova, E. G. Zotkin

Get full text

Arterial hypertension in tuberculosis patients: clinical course and pharmaceutical control by N. Yu. Klimenko, N. V. Drobotya, A. A. Kastanayan, V. V. Kaltykova, E. Sh. Guseynova

“…To access arterial hypertension (AH) prevalence, pathogenesis, and effectiveness of fixed-dose perindopril and indapamide combination in tuberculosis (TB) patients. …”
Get full text

Modern aspects of angina treatment in arterial hypertension patients: emphasizing endothelial function role by L. L. Kirichenko, A. N. Golosova, S. V. Gatsura, A. P. Korolev, P. P. Struchkov, Zh. D. Dvoryanchikova

Get full text

Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders by Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie

Get full text

Prospective randomized study to evaluate and compare the post-procedural sexual function in patients undergoing semi-rigid ureterorenoscopy for distal ureteric stones in three diff... by Gajanan S. Bhat, Anuradha Shastry

Get full text

Use of Anabolic-Androgenic Steroids and Male Fertility: A Systematic Review and Meta-analysis by Prashant Motiram Mulawkar, Pankaj N. Maheshwari, Vineet Gauhar, Sumeet Gopal Agrawal, Taofiq Olayinka Mohammed, Abhishek Gajendra Singh, Gopal Ramdas Tak, Utsav Shailesh Shah, Deepali Parthsarthi Shukla, Deepali Mamankar

“…The erectile function improved with AAS use, but on withdrawal, there was decreased libido and erectile dysfunction. Most AAS users need additional medications to mitigate detrimental effects on fertility. …”
Get full text

Influence of Gender, Education Level, Alcohol Etiology, and Serum Sodium Levels on Delayed Neurocognitive Recovery in Patients Undergoing Living Donor Liver Transplant Surgery in E... by Deepak Mishra, Natasha Khullar Kumar, Ramneek Kaur, Vijay Vohra, Neerav Porwal, Ajit Bhardwaj

“…Background and Aims: Postoperative cognitive dysfunction has been known to be associated with liver transplantation. …”
Get full text

Expert Consensus on Transcranial Direct Current Stimulation Combined with Cognitive Training in the Treatment of Early Alzheimer's Disease by 白玉龙, 狄海波, 侯文生, 胡昔权, 李增勇, 刘颖, 吕泽平, 彭亮, 孙俊峰, 唐敏, 王永慧, 谢海群, 谢平, 许东升, 张丽君, 李伟

Get full text

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isola... by Yimiao Wang, Ze Wang, Yue Li, Min Cao, Shuying Zhang, Shixin Ding, Sijia Chen, Yuxi Jin, Yanli Zhang, Junying Gao, Ming Xiao

Get full text

Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model by Miri Park, Yu-Rim Chae, Hye-Bin Lee, Jang-Eun Lee, Jang-Eun Lee, Yu Ra Lee, Jinyoung Hur, Ho-Young Park, Ho-Young Park

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. …”
Get full text

Omega-3 Fatty Acids as an Adjunct Therapy in Sepsis: Insights and Implications: A Narrative Review by Swati, Madhvi Awasthi, Nameet Jerath

“…Sepsis arises from a disproportionate immune response to infection, leading to life-threatening organ dysfunction. This dysfunction is assessed using scoring systems like the Sequential Organ Failure Assessment (SOFA), where a score increase of two points or more signifies a high mortality risk in infected patients. …”
Get full text

Insulin resistance as a mediator of the association between obesity, high-intensity binge drinking, and liver enzyme abnormalities in young and middle-aged adults: a cross-sectiona... by Jiayi Zhu, Jiayi Zhu, Jiayi Zhu, Yinglong Duan, Ying Li, Yi Zhou, Zitong Lu, Nandan Chen, Juan Luo, Xingxing Wang, Xiaoqian Dong, Andy S. K. Cheng, Yuan Liu

Get full text