Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches by Wei He, Panli Tang, Hongbin Lv

“…Additionally, mitochondrial dysfunction, retinal cell apoptosis, inflammation, and lipid peroxidation are key pathological processes associated with oxidative stress in DR. …”
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Development of an eco-friendly UPLC method for simultaneous quantification of six selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors in pharmaceutical formul... by Heba Abdel-Hafeez Mohamed, Mohamed Badawi NourEldin, Asmaa Ahmed El-Zaher, Sally Tarek Mahmoud

“…A face-centered composite design was utilized to systematically optimize critical parameters, resulting in effective separation using a reversed-phase C18 column, an acetate buffer (pH 3), and a mobile phase composed of buffer and methanol (72.5:27.5, v/v) at a flow rate of 0.5 mL/min. …”
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An angiotensin-converting enzyme inhibitor in the combination treatment of rheumatoid arthritis by E. B. Komarova, B. A. Rebrov, A. K. Knyazeva

“…Angiotensin-converting enzyme (ACE) inhibitors have anti-inflammatory and antiproliferative properties and can affect the processes of angiogenesis, by reducing the effects of angiotensin II (ATII). The use of ACE inhibitors in the combination therapy of rheumatoid arthritis (RA) can be also effective for monitoring disease activity and for reducing a cardiovascular risk.Objective: to evaluate the efficacy of an ACE inhibitor in the combination therapy of RA.Patients and methods. …”
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Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility by Rui Feng, Dexin Cheng, Wei Zhang, Jiayun Zhang, Sixiang Chen, Yan Xia

“…Obesity is a major contributor to male infertility, not only exacerbating infertility but also impairing the effectiveness of both surgical interventions and medical treatments. …”
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Use of plasmapheresis and intravenous immunoglobulins in pregnant women with antiphospholipid syndrome by E. S. Orlova, S. V. Chepanov, M. S. Zainulina, S. A. Selkov

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Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review by César Galván, Rafael Durán, Cristian Matos, Cristiana Indolfi, Angela Klain

“…<b>Results:</b> Analysis reveals significant immune dysfunction in allergic children, affecting both innate and adaptive immunity components. …”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

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Healthcare professionals’ experiences of discussing sexual function with menopausal women using a vaginal pessaryAJOG Global Reports at a Glance by Monica Quinlan, BSc, MSc, Victor Olagundoye, MBBS, MMedSci, MSc, MRCOG

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Tissue myocardial Doppler echocardiography in the assessment of right ventricular function among patients with pulmonary hypertension of various aetiology by Yu. A. Andreeva, M. A. Saidova, T. V. Martynyuk, V. P. Masenko, I. E. Chazova

“…Although at standard EchoCG, there was no clear evidence of diastolic RV dysfunction, TMD revealed diastolic RB dysfunction in all PH patients. …”
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The respiratory exercise significance in the olfaction restoration in the postcovid period by V. N. Nikolenko, M. V. Sankova, M. V. Zoller, M. V. Oganesyan, V. G. Zilov, D. A. Garkavy, A. E. Strizhkov

“…Using Nadi Shodhana breathing exercise course can significantly reduce the olfactory dysfunction level in this patient category. It was showen that the pranayama technique is more effective in people under 40 years of age. …”
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Identification of Pre-Heart Failure in Early Stages: The Role of Six Stages of Heart Failure by Monika Jankajova, Ram B. Singh, Krasimira Hristova, Galal Elkilany, Ghizal Fatima, Jaipaul Singh, Jan Fedacko

“…Despite increased availability of effective drug therapy for treatment of heart failure (HF), the morbidity and mortality in chronic heart failure (CHF) are unacceptably high. …”
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Intravenous Levosimendan versus Inhalational Milrinone in the Management of Pulmonary Hypertension during Adult Cardiac Surgery: A Randomized Clinical Trial by Panagiotis Ftikos, Georgios Gkantinas, Vlasios Karageorgos, Anna Smirli, Nektarios Kogerakis, Evangelos Leontiadis, Konstantinos Petsios, Theofani Antoniou, Kassiani Theodoraki

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Mesenchymal stromal cell secretome reduces lung injury and thrombo-inflammation induced by SARS-CoV-2 spike protein by Anna Pezzotta, Alessandra Bovio, Barbara Imberti, Monica Locatelli, Daniela Corna, Domenico Cerullo, Sara Gastoldi, Ariela Benigni, Giuseppe Remuzzi, Marina Morigi, Luca Perico

“…This was associated with reduced vascular dysfunction, in terms of restored thrombomodulin levels and decreased von Willebrand (vWF) expression. …”
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Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer’s disease model via inhibition of neuronal ferroptosis by Parisa Faraji, Elham Parandavar, Hartmut Kuhn, Mehran Habibi-Rezaei, Astrid Borchert, Elham Zahedi, Shahin Ahmadian

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Hepatoprotective Effect of Kaempferol—A Review by Przemysław Niziński, Anna Krajewska, Tomasz Oniszczuk, Beata Polak, Anna Oniszczuk

“…Currently, available pharmacotherapy for liver dysfunction has limited efficacy. Kaempferol, a naturally occurring flavonoid, has demonstrated significant hepatoprotective effects in preclinical models. …”
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A Novel Flavonoid Derivative of Icariside II (YS-10) Improves Erectile Dysfunction in a Diabetic Rat Model by Inhibiting Ferroptosis via Activation of the Nrf2/HO-1/GPX4 Pathway by Liu Y, Liu GN, Zha YR, Pan CL, Xu YD, Li HW, Zang YY, Wang WQ, Yao JJ, Sun JT, Yang Y, Wei ZT

“…These findings support its potential as a promising candidate for diabetes-related erectile dysfunction therapy.Keywords: diabetes mellitus, erectile dysfunction, ferroptosis, YS-10, ICA II, Nrf2, GPX4…”
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Molecular subtype of recurrent implantation failure reveals distinct endometrial etiology of female infertility by Jing Yang, Lingtao Yang, Ying Zhou, Fengyang Cao, Hongkun Fang, Huan Ma, Jun Ren, Chunyu Huang, Lianghui Diao, Qiyuan Li, Qionghua Chen

“…While embryo-related factors have been extensively investigated, the contribution of endometrial dysfunction to RIF remains poorly characterized. This study aimed to determine whether biologically distinct molecular subtypes of endometrial dysfunction exist in RIF and whether such subtypes could guide more personalized and effective treatment strategies. …”
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Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway by Huafang Jia, Mengru Liu, Hong Jiang, Zhen Qiao, Kaiyue Ren, Xixun Du, Xi Chen, Qian Jiao, Fengyuan Che

“…These findings suggest that EPS has great potential to become a therapeutic for PD as a clinically effective and safe medicine.…”
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The Effect of Oxygen-Ozone Treatment on Posture by Marcela DRAGOMIR

“…The lack of allergic reactions and side effects of oxygen-ozone therapy recommends it in the treatment of musculoskeletal disorders, caused by vertebral static disorders. …”
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Pleiotropic effects of antihypertensive therapy variants by S. V. Malchikova, E. I. Tarlovskaya

“…Aim. То compare the effects of different two-component antihypertensive therapy (AHT) variants on endothelial dysfunction (ED) and albuminuria (AU) in patients with arterial hypertension (AH).Material and methods. …”
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