MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women by Ilaria Milani, Marianna Chinucci, Frida Leonetti, Danila Capoccia

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease influenced by genetic, lifestyle, and environmental factors. …”
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Restoration of autonomic balance and cortical and cerebral structures functions harmonization indicators by means of gamma-aminobutyric acid system modulation in patients with prim... by V. V. Batushkin, I. О. Lavrinchuk

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Cinnamaldehyde alleviates pulmonary hypertension by affecting vascular remodeling through the TLR4/NF-kB/HIF-1a pathway by Jinbo Zhang, Wenxin Zhang, Zhiyong Yang, Bingbing Fan, Chunhe Wang, Zhengkun Tian

“…TLR4/NF-kB/HIF-1a activation with RS09TFA inhibited CA’s effects. In vitro, CA mitigated hypoxia-induced HPAEC dysfunction, restoring VE-Cadherin and α-SMA expression, while RS09TFA blocked these effects.Conclusion CA alleviates PAH by inhibiting the TLR4/NF-kB/HIF-1a pathway and suppressing vascular remodeling, suggesting its potential as a therapeutic agent for PAH.…”
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The use of N-acetylcysteine to prevent further progression of preeclampsia by I Wayan Agung Indrawan, Leny Farida

“…The generation of free radicals in the placenta leads to endothelial dysfunction, which contributes greatly in preeclampsia. 2. …”
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Features of cerebral hemodynamics and vascular autoregulation in chronic cerebral ischemia by O.A. Kozyolkin, S.V. Yarkova

“…The studies demonstrate the effectiveness of L-arginine in treatment of chronic cerebrovascular disease. …”
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Evaluation of Thyroid Volume Normalisation in Female Patients with Hashimoto Thyroiditis: A 12-Month Comparative Study of Combined Supplements and Photobiomodulation Versus Supplem... by Venera Berisha-Muharremi, Bernard Tahirbegolli, Ruth Phypers, Reem Hanna

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IL-4 and IL-13 in Cardiovascular Disease: From Immune Modulation to Therapeutic Possibilities – A Narrative Review by Kılıç AT, Bora R, Toprak B

“…Ahmet Turhan Kılıç,1 Rıdvan Bora,2 Burak Toprak1 1Department of Cardiovascular Surgery, Mersin City Education and Research Hospital, Mersin, Turkey; 2Department of Cardiology, Tarsus State Hospital, Mersin, TurkeyCorrespondence: Burak Toprak, Department of Cardiovascular Surgery, Mersin City Education and Research Hospital, Kuzeykent District, 31131 Street No: 1, Floor: 6, Flat No: 11, Yenişehir, Mersin, 33120, Turkey, Email brk.tprk@gmail.comBackground: Interleukin-4 (IL-4) and Interleukin-13 (IL-13) are central regulators of the Th2 immune response and play pivotal roles in vascular inflammation, endothelial dysfunction, and cardiovascular remodeling. While their contributions to immune modulation are well known, their precise effects on the cardiovascular system remain an evolving field of study.Aim: This review aims to explore the mechanistic roles of IL-4 and IL-13 in endothelial dysfunction and the development of cardiovascular diseases, and to evaluate the therapeutic potential and risks associated with IL-4/IL-13 inhibitors.Methods: A narrative review approach was used. …”
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Damage and immunosuppression to Mytilus galloprovincialis hemocytes caused by chronic tris(chloropropyl)phosphate exposure by Ruixue Ma, Shubao Zhang, Quansheng Zhang, Huifeng Wu, Menghan Zhou, Yue Zhou, Yushun Yong, Junyi Wang, Lihao Guo, Jiatong Ma, Mingyu Zhong

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Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus by Xuemei Yin, Yinzi Sui, Zhengyan Chu, Suqing Han, Xiaodong Ge, Tingting Liu, Feng Zeng, Ligen Chen, Rong Shao, Wei Xu

“…The aim of this study was to analyze the regulatory effect of Suaeda salsa extract (SSE) on T2DM and its effect on the intestinal flora of mice.ResultsThe results showed that SSE could significantly improve the body weight, fasting blood glucose (FBG), area under the curve (AUC) of the oral glucose tolerance test (OGTT), glycosylated serum protein (GSP) and islet function index. …”
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A review of phosphodiesterase type 5 inhibitors by N. Schellack, A. Agoro

“…The PDE inhibitors are used in males to treat erectile dysfunction. However, sildenafil is also registered for use in the treatment of pulmonary hypertension. …”
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Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis by I. A. Koltsov, M. Yu. Martynov, A. N. Yasamanova, I. A. Shchukin, M. S. Fidler, A. N. Boyko

“…Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. …”
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RETRACTED ARTICLE: Intravenous lidocaine improves postoperative cognition in patients undergoing laparoscopic colorectal surgery: a randomized, double-blind, controlled study by Xian-xue Wang, Jing Dai, Qi Wang, Hui-wei Deng, Yun Liu, Gui-fan He, Hua-jing Guo, Ya-lan Li

“…Abstract Background The risk of postoperative cognitive dysfunction(POCD) in laparoscopic surgery should not be overlooked. …”
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The influence of hand position on scapular kinematics in push-ups: comparing athletes with chronic shoulder pain and healthy controls by Sajjad Abdollahi, Rahman Sheikhhoseini, Mohammad Salsali, Hashem Piri, Julie A. Hides

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Enalapril therapy and thrombotic and inflammatory abnormalities in essential arterial hypertension by O. M. Moiseeva, O. A. Berkovich, S. V. Villevalde, I. V. Emelyanov

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The critical role of Sirt1 in ischemic stroke by Ziyi Jia, Ke Xu, Ruobing Li, Siyu Yang, Long Chen, Qianwen Zhang, Shulin Li, Xiaowei Sun

“…It regulates inflammatory response, oxidative stress, mitochondrial dysfunction, autophagy, pro-death, and necrotic apoptosis. …”
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MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles by Linsey Peters, Leonida Rakateli, Rosanna Huchzermeier, Andrea Bonnin-Marquez, Sanne L Maas, Cheng Lin, Alexander Jans, Yana Geng, Alan Gorter, Marion Gijbels, Sander Rensen, Peter Olinga, Tim Hendrikx, Marcin Krawczyk, Malvina Brisbois, Joachim Jankowski, Kiril Bidzhekov, Christian Weber, Erik AL Biessen, Ronit Shiri-Sverdlov, Tom Houben, Yvonne Döring, Matthias Bartneck, Emiel van der Vorst

“…The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. …”
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Evaluation of Biochemical Oxidative Stress Indices in Male Wistar Rats Treated with Swinol Tablets by I. Enubuogidi, I. O. Okoro

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Reliability and Validity of the Pain Self-efficacy Questionnaire in Simplified Chinese Version by Zhongfei BAI, Mengjian QU, Enqi DING, Qinghe ZHAO, Weili XIA, Tian SHU, Jiani LU

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The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm by Zhiran Wang, Dmitrii Lebedev, Simeng Li, Sudharshan Rao, Kevin Wu, Lorcan Doyle, Kieran Wynne, Alfonso Blanco, Margaritha M. Mysior, Jeremy C. Simpson, Dimitri Scholz, Petra Wülfroth, Kai Zacharowski, Walter Kolch, Vadim Zhernovkov, Günther Eissner

“…IntroductionCoronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major health emergency since its emergence in late 2019. Endothelial dysfunction is a hallmark of COVID-19, leading to severe illness, i.e. coagulopathy, multi-organ failure. …”
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Content of Some Endothotelium-Dependent Vasoactive Substances in the Blood of Patients, Depending on the Liver Cirrhosis Severity and the Organism’s Redox System State by Abrahamovych M., Abrahamovych O., Fayura O., Tolopko S., Ferko M.

“…As a result, NO-dependent vasodilatation, increased endothelin-1 synthesis, activation of the renin-aldosterone system, whose effect is negligible, since the decreased sensitivity of the vascular receptors to the influence of endogenous vasoconstrictors, increase of the content of natriuretic peptide, due to the inhibition of renin and aldosterone secretion, as well as a direct effect on the smooth muscle cells of the vascular wall. …”
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