The Relationship Between Obesity, Bariatric Surgery, and Infertility: A Systematic Review by Charalampos Voros, Antonia Varthaliti, Kyriakos Bananis, Despoina Mavrogianni, Diamantis Athanasiou, Antonia Athanasiou, Aikaterini Athanasiou, Anthi-Maria Papahliou, Constantinos G. Zografos, Panagiota Kondili, Menelaos Darlas, Ioannis Papapanagiotou, Maria Anastasia Daskalaki, Marianna Theodora, Panagiotis Antsaklis, Georgios Daskalakis, Dimitrios Loutradis

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Comparison of the Long-Term Efficacy of Targeting the Subthalamic Nucleus Versus the Globus Pallidus Interna for Deep Brain Stimulation Treatment of Motor Dysfunction in Patients W... by Makenna Huhn, Matthew Prewett, Julien Rossignol, Gary L. Dunbar

“…A cardinal symptom of Parkinson’s disease (PD) is motor dysfunction, including bradykinesia and tremors, which is quantified in the Unified PD Rating Scale (UPDRS). …”
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The effectiveness of biapenem in the treatment of sepsis by I. V. Shlyk, A. A. Spiridonova, V. A. Panafidina

“…The objective was to evaluate the clinical effectiveness and safety of biapenem (Bianem–AF drug) in the treatment of severe forms of infection in ICU patients.Materials and methods. …”
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The safety profile of drug treatment of alzheimer's disease by V. А. Moroz

“…Analysis of the data has showed that the greatest limiting factor in the use of anticholinesterase drugs in the treatment is their direct dose-related side effects of dangerous dysfunction of the heart, nervous and respiratory systems, dyspepsia, which allows to use the recommended effective dose more than 3 months only in 50-58% of the patients with a minimum of efficiency. …”
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Dynamics of endothelial dysfunction, nephropathic and dyslipidemic disorders in patients with insufficient glycemic compensation of type 2 diabetes mellitus during 1 year of applic... by Pertseva N.O.

“…Antihypertensive treatment of patients with insufficient compensation of hyperglycemia using angiotensin II receptor antagonists significantly more effective than standard treatment rule tactics by the influence on development of endothelial dysfunction on the background of normalization of nephropathic and dyslipidemic disorders. …”
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Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice by Chaeeun Cho, Minje Ji, Eunhee Cho, Seon Yi, Jae Geun Kim, Sewon Lee

“…Abstract Exercise is an effective intervention to ameliorate metabolic diseases including obesity and insulin resistance, but the mechanisms involved in the metabolic amelioration have not yet been fully elucidated. …”
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A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signalin... by Wan-Yi Guo, Qi-Min Wu, Hao-Feng Zeng, Yu-Lian Chen, Jie Xu, Zhen-Yi Yu, Yong-Kang Shu, Xiao-Nan Yang, Chuan-Hai Zhang, Xi-Zi He, Jia-Ning Mi, Si Chen, Xiao-Man Chen, Jia-Qi Wu, He-Quan Yao, Liang Liu, Hu-Dan Pan

“…Bone destruction in rheumatoid arthritis (RA) leads to significant disability, yet effective treatments are limited. Sinomenine (Sino) demonstrates anti-arthritic and bone-protective effects but requires high doses. …”
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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

“…Ting Li,1,2,* Yuechu Zhao,3,* Zhi Cao,2,* Ying Shen,2 Jiaqi Chen,2 Xinran Huang,2 Zhuang Shao,2 Yi Zeng,2 Qi Chen,2 Xiaofei Yan,3 Xin Li,1,2 Yuelin Zhang,1,2 Bei Hu1,2 1School of Medicine, South China University of Technology, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuelin Zhang; Bei Hu, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 510080, People’s Republic of China, Tel +86-20-83827812-20974, Email zhangyuelin1999@163.com; qhubei@hotmail.comBackground: Exosomes sourced from mesenchymal stem cells (MSC-EXOs) have become a promising therapeutic tool for sepsis-induced myocardial dysfunction (SMD). Our previous study demonstrated that Apelin pretreatment enhanced the therapeutic benefit of MSCs in myocardial infarction by improving their paracrine effects. …”
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DRUG-INDUCED ENCEPHALOPATHY WITH IMPAIRED COGNITIVE FUNCTIONS DURING TOCILIZUMAB USE by P. A. Shesternya, S. V. Prokopenko, E. Yu. Mozheiko, O. D. Gritsenko, T. V. Tupaeva, E. M. Kurts

“…However, the multifaceted biological effects of IL-6 determine the probability of unexpected ARs. …”
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Silencing PinX1 enhances radiosensitivity and antitumor-immunity of radiotherapy in non-small cell lung cancer by Jieping Qiu, Ying Xia, Yawei Bao, Jingjing Cheng, Lei Liu, Dong Qian

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Acupuncture for patients with mild cognitive impairment: a randomized, patient–assessor-blinded, sham-controlled pilot study by Yujin Choi, Pyung-Wha Kim, In-Chul Jung, Ae-Ran Kim, Hyo-Ju Park, Ojin Kwon, Jun-Hwan Lee, Joo-Hee Kim

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Microcirculatory bed in former smokers with arterial hypertension by N. V. Korneeva, B. Z. Sirotin

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Sex- and ALDH2-dependent differences in alcohol metabolism and psychomotor performance: a study in Han Chinese adults after binge drinking by Yi Ye, Yidie Lin, Takeshi Haseba, Fan Chen, Fanlai Cui, Xiaoqin Yi, Weihao Fan, Gangqin Li

“…However, the influence of sex and ALDH2 polymorphism on psychomotor dysfunction has not yet been investigated.Methods One-hundred and three participants, genotyped for ALDH2 rs671, were administered a dose of 1.0 g/kg of white spirits. …”
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Establishment of a dexamethasone-induced zebrafish skeletal muscle atrophy model and exploration of its mechanisms by Chen-Chen Sun, Ye-Jun Li, Dan-Ting Zhu, Zhang-Lin Chen, Jiang-Ling Xiao, Xiang-Tao Chen, Lan Zheng, Xi-Yang Peng, Chang-Fa Tang

“…Background: Skeletal muscle atrophy is one of the main side effects of high-dose or continuous use of glucocorticoids (such as dexamethasone). …”
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Individual Approach to the Treatment of Complicated Forms of Blepharitis: from Theory to Practice by E. A. Drozdova, E. V. Mikhailova

“…The second case is devoted to the features of the posterior blepharitis clinical course with meibomian gland dysfunction, complicated by multiple chalazions. The article explains in detail the stages of prescribing various medications, including eyelid hygiene, antibacterial, anti-inflammatory therapy and artificial tears, discusses possible side effects of the therapy and ways to restore the eye surface.Conclusion. …”
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CircFndc3b Mediates Exercise‐Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice by Yun Zhao, Xiaofei He, Xiaofeng Yang, Zhongqiu Hong, Yin Xu, Jinghui Xu, Haiqing Zheng, Liying Zhang, Zejie Zuo, Xiquan Hu

“…These results suggest that circFndc3b mediates exercise‐induced anti‐pyroptotic effects via the ENO1/Klf2 axis, and a circFndc3b/ENO1/FUS positive feedback loop may potentiate exercise's neuroprotective effects. …”
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ATRIAL FIBRILLATION AND ARTERIAL HYPERTENSION: GENDER DIFFERENCES OF VENTRICULOATRIAL REMODELING WITH PRESERVED EJECTION FRACTION by Zh. D. Kobalava, E. V. Kokhan, G. K. Kiyakbaev, A. A. Shavarov

“…Explanation for it can be provided by a higher prevalence of left ventricular diastolic dysfunction in women, which is strongly related with central aortic pressures. …”
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Bauhinia coccinea extract prevents memory loss induced by scopolamine through activation of antiapoptotic and antioxidant pathways in mice by Eunjin Sohn, Bu-Yeo Kim, Yu Jin Kim, Joo-Hwan Kim, Soo-Jin Jeong

“…Abstract Alzheimer’s disease (AD) is characterized by oxidative stress-mediated memory dysfunction and neuronal cell death. This study investigated the effects of an ethanol extract from Bauhinia coccinea (EEBC) on memory impairment and neuronal damage in a memory deficit mouse model. …”
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THE LEFT VENTRICLE DIASTOLIC FUNCTION IN PATIENTS WITH HYPERTENSION UNDER THE USE OF DIFFERENT DRUG GROUPS by A. V. Budnevskij, E. S. Ovsjannikov, L. E. Kulikova

“…The objective: To assess the prevalence of diastolic dysfunction in patients with hypertension and preserved left ventricular ejection fraction under pharmacological correction (monotherapy) with angiotensin converting enzyme inhibitors, angiotensin II receptor blockers and β-blockers. …”
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Dimethyl-2-oxoglutarate but not antioxidants prevents glucose hypometabolism induced neural cell death: implications in the pathogenesis and therapy of Alzheimer's disease by Aman Chauhan, Karanpreet Bhutani, Aritri Bir, Ajay Singh, Sankha Shubhra Chakrabarti, Adesh K. Saini, Sasanka Chakrabarti, Arindam Ghosh

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