Mitochondria and oxidative stress in epilepsy: advances in antioxidant therapy by Delphine Ji, Delphine Ji, Shanthini Mylvaganam, Prathyusha Ravi Chander, Mark Tarnopolsky, Keiran Murphy, Peter Carlen, Peter Carlen, Peter Carlen

“…Future directions include conducting clinical trials to evaluate these combination therapies, and to translate preclinical successes into effective clinical interventions. Targeting oxidative stress and mitochondrial dysfunction through combination antioxidant therapy represents a promising adjunctive strategy to modify disease progression and improve outcomes for individuals living with epilepsy.…”
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Multisystem Health Consequences of Prenatal Hyperandrogenism in Offspring by Dong Liu, Wenxi Chen, Qian Zhong

“…Further research is needed to develop effective interventions to mitigate these adverse effects.…”
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A green tea extract catechin EGCg: Therapeutic potential for pediatric cardiomyopathies by Junjun Quan, Dustin Gerber, Ang Li, Xupei Huang, Jie Tian

“…In this review, we will discuss the molecular mechanisms associated with the pathogenesis of diastolic dysfunction and summarize the pharmacological effects of EGCg on experimental animals and pediatric patients with cardiomyopathies and diastolic dysfunction.…”
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The Breathing IQ: an anthropometric index of diaphragmatic breathing efficiency by Belisa Vranich, Rachel Lee, John Zapanta, Brian Shoen, Helene Houghton, Crystal Ruelas, Mary Lisa Wahlfeldt, Robin Kerr, Andrei Pripotnev, Michaela Goorahoo, Jean-Berne Baptiste, Joanne Elliot

“…Breath hold (BH) improved from pre- to post-intervention, from 37.2 (18.7) to 66.0 (26.9), with a mean change 24.3 (15.3), which was highly significant (p < 0.001).ConclusionThe BIQ shows preliminary potential as an effective screening tool for mechanical breathing dysfunction.…”
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The potential of mitochondrial transfer as the modifying therapy for osteoarthritis by Yuanpei He, Xinge Wang, Xinge Wang, Boya Xu, Shichao Chen, Hongcai Li, Bei Chang, Chao Hu, Xiaorong Lan, Shiting Li, Guangwen Li

“…Recent research has begun to explore the potential of intercellular mitochondrial transfer as a therapeutic strategy for human diseases. Mitochondrial dysfunction represents a significant pathological alteration in osteoarthritis, and studies indicate that mitochondrial transfer may serve as an effective modulatory treatment approach for osteoarthritis. …”
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The Role and Pathogenesis of Tau Protein in Alzheimer’s Disease by Xiaoyue Hong, Linshu Huang, Fang Lei, Tian Li, Yi Luo, Mengliu Zeng, Zhuo Wang

“…An in-depth understanding of the pathogenesis and neuropathology of AD is essential for the development of effective treatments and early diagnosis techniques. …”
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Functional Disorders of the Biliary Tract and Cholelithiasis: Analysis of a Possible Relationship by Yu. O. Shulpekova, I. R. Popova, V. M. Nechaev

“…There is no doubt that the relevance of further study of the patterns of development of biliary dysfunctions and GI is obvious. The study of this problem will contribute to the development of effective preventive approaches, including in the field of nutraceuticals.…”
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Strength training promotes attenuation of fatty liver while improving insulin resistance and inflammatory biomarkers in obese rats induced by high-fat diet by S. Torezani-Sales, A.P.L. Damiani, A.R. Madureira, J.P. Cordeiro, G.H. Taufner, B.V. Nogueira, M.C. Dias, M.M. Sugizaki, A.S. Leopoldo, A.P. Lima-Leopoldo

“…Obesity is an independent risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation by Nadine Schrode, Trinisia Fortune, Aislinn M. Keane, Jesse F. Mangold, Benjamin Tweel, Kristin G. Beaumont, Talia H. Swartz

“…Background: HIV-1 infection, even with effective antiretroviral therapy (ART), is associated with chronic inflammation and immune dysfunction, contributing to long-term health complications. …”
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Cardioprotective Peptides from Dry-Cured Ham in Primary Endothelial Cells and Human Plasma: An Omics Approach by Clara Noguera-Navarro, Javier Stelling, Esteban Orenes-Piñero, Caterina Pipino, Francisco José Nicolás, Silvia Montoro-García

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Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine by Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen

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Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications by Linghong Kong, Hui Wang, Weiwei Jiang, Yun Chen, Zhuoling Du, Qiong Zhang, Jianyue Dong, Changchun Zeng, Hanping Liu

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Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes by Ying-Chieh Wu, Šárka Lehtonen, Kalevi Trontti, Riitta Kauppinen, Pinja Kettunen, Ville Leinonen, Markku Laakso, Johanna Kuusisto, Mikko Hiltunen, Iiris Hovatta, Kristine Freude, Hiramani Dhungana, Jari Koistinaho, Taisia Rolova

“…Conclusions Our findings indicate that the APPswe mutation in iPLCs mimics several aspects of CAA pathology in vitro, suggesting that our iPSC-based vascular cell model could serve as an effective platform for drug discovery aimed to ameliorate vascular dysfunction in AD.…”
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Formation of myofаscial pain syndrome and its correction in patients with tension headache by A.V. Vesnin, O.L. Tovazhnianska

“…This approach is effective for treating TH. …”
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Restless Legs Syndrome: A Comprehensive Review of Current Treatment Methods and the Disease's Impact on Quality of Life by Natalie Papachristoforou, Natalia Tekiela, Daria Michałka, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Emilia Bąk, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

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The effect of acromegaly on thyroid disease by Caiyan Mo, Liyong Zhong

“…Long-term stimulation of thyroid follicular epithelium by high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with acromegaly can lead to thyroid dysfunction, goiter, thyroid nodules, and even thyroid cancer and thyroid-associated ophthalmopathy (TAO). …”
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Effect of Diet on HDL in Obesity by Tiziana Bacchetti, Camilla Morresi, Oriana Simonetti, Gianna Ferretti

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Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. by Awab Ahmad, MD, Timothy R. Harris, MD, Aaron Williams, MD, Alexandra DeBose-Scarlett, MD, Rubayet Kamal, BS, Enock Atta Adjei, MD, Hasan K. Siddiqi, MD, Chen Chia Wang, Mark Petrovic, Clifton D. Keck, Shelley R. Scholl, RN, Ashish S. Shah, MD, Swaroop Bommareddi, MD, Brian Lima, MD MBA, John M. Trahanas, MD

“…Donor and recipient baseline characteristics, distance traveled and ischemic time, and recipient outcomes were collected. Primary graft dysfunction (PGD) was determined based on 2014 ISHLT guidelines. …”
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Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management—a review by Jhan Sebastian Saavedra Torres, Francisco Javier Tamayo-Giraldo, Alejandro Bejarano-Zuleta, Alejandro Bejarano-Zuleta, H. A. Nati-Castillo, Diego A. Quintero, M. J. Ospina-Mejía, Camila Salazar-Santoliva, Isaac Suárez-Sangucho, Esteban Ortiz-Prado, Juan S. Izquierdo-Condoy

“…Sepsis-induced organ dysfunction impacts multiple systems, including the brain, heart, and kidneys. …”
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Effects of Statins on Cardiorenal Syndrome by Shusuke Yagi, Ken-ichi Aihara, Yasumasa Ikeda, Masashi Akaike, Masataka Sata, Toshio Matsumoto

“…Statins, HMG-CoA reductase inhibitors, have not only cholesterol-lowering effects but also pleiotropic effects on cardiovascular systems, including anti-inflammatory and antioxidant effects and improvement of nitric oxide bioavailability. …”
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