Genome-wide, chromosome-naïve compartmentalization of major developmental networks tailored by modular placement of human embryo-regulatory Long Terminal Repeats by Gennadi V. Glinsky

“…GRMs appear to operate along specific phenotypic avenues on the timescale of an individual’s life-span, exerting profound effects on patterns of transcription, protein–protein interaction, developmental phenotypes, physiological traits, and pathological conditions in Modern Humans. …”
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Homogeneous Aptasensor with Electrochemical and Electrochemiluminescence Dual Detection Channels Enabled by Nanochannel-Based Probe Enrichment and DNase I Cleavage for Tumor Biomar... by Jiong Gao, Shiyue Zhang, Fengna Xi

“…A vertically ordered mesoporous silica film (VMSF) with ultrasmall, uniform, and vertically aligned nanochannel arrays was rapidly grown on the inexpensive and disposable indium tin oxide (ITO) electrode, forming the detection interface. …”
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An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. by Yi-Hsiang Hsu, M Carola Zillikens, Scott G Wilson, Charles R Farber, Serkalem Demissie, Nicole Soranzo, Estelle N Bianchi, Elin Grundberg, Liming Liang, J Brent Richards, Karol Estrada, Yanhua Zhou, Atila van Nas, Miriam F Moffatt, Guangju Zhai, Albert Hofman, Joyce B van Meurs, Huibert A P Pols, Roger I Price, Olle Nilsson, Tomi Pastinen, L Adrienne Cupples, Aldons J Lusis, Eric E Schadt, Serge Ferrari, André G Uitterlinden, Fernando Rivadeneira, Timothy D Spector, David Karasik, Douglas P Kiel

“…Due to the modest genetic effect size and inadequate power, true association signals may not be revealed based on a stringent genome-wide significance threshold. …”
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Real-Time Landform Feature Detection and Segmentation Based on Heterogeneous MPSoCs for Lunar Robotic Exploration by Q. Fan, R. Duan, B. Wu, H. Zhou, S. Zhang, Y. Ma

“…The results suggest that such a system can be deployed in future lunar rovers and robots to enhance the effectiveness of exploration tasks.…”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…UPF consumption was defined applying the Nova food classification system (group 4), and DNA methylation was measured in blood with Illumina Infinium Methylation arrays. Associations were estimated within each cohort using robust linear regression models, adjusting for relevant covariates, followed by a meta-analysis of the resulting EWAS estimates. …”
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AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1 by Yang Ji, Huanzhen Chen, Lihua Pang, Changnong Chen, Sha Wang, Jing Chen, Lei Fang, Benrong Liu, Yongruo Cheng, Shiming Liu, Yun Zhong

“…Overexpression of miR-22-5p in HUVECs using lentiviral vectors recapitulated the inflammatory effects observed with AGE-Exos, whereas anti-miR-22-5p conferred protective effects. …”
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Lysin (K)-specific demethylase 1 inhibition enhances proteasome inhibitor response and overcomes drug resistance in multiple myeloma by Cecilia Bandini, Elisabetta Mereu, Tina Paradzik, Maria Labrador, Monica Maccagno, Michela Cumerlato, Federico Oreglia, Lorenzo Prever, Veronica Manicardi, Elisa Taiana, Domenica Ronchetti, Mattia D’Agostino, Francesca Gay, Alessandra Larocca, Lenka Besse, Giorgio Roberto Merlo, Emilio Hirsch, Alessia Ciarrocchi, Giorgio Inghirami, Antonino Neri, Roberto Piva

“…We exploited RNA-sequencing and Reverse-Phase Protein Arrays (RPPA) to investigate the molecular mechanisms of the synergy. …”
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Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…Tumor cells intrinsic mitochondria dynamics could pass effects on the extracellular microenvironment through mtDNA stress. …”
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Amino acid transporter LAT1 (SLC7A5) promotes metabolic rewiring in TNBC progression through the L-Trp/QPRT/NAD+ pathway by Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

“…Methods The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. …”
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Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover studyResearch in context by Ebenezer O. Chinedu-Eneh, Sharon Chiang, John P. Andrews, Ehsan Tadayon, Joline M. Fan, Paul A. Garcia, Ernesto Gonzalez-Giraldo, Manu Hegde, Patrick Hullett, Vikram R. Rao, Robert C. Knowlton, Edward F. Chang, Jonathan K. Kleen

“…Methods: In this experimental study we compared SOZ localisation between spontaneously captured seizures on higher-density depth and grid electrode arrays (4–5 mm inter-electrode spacing) vs. lower-density resampled versions of those same seizures (8–10 mm spacing). …”
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Machine learning-based new classification for immune infiltration of gliomas. by Feng Yuan, Yingshuai Wang, Lei Yuan, Lei Ye, Yangchun Hu, Hongwei Cheng, Yan Li

“…<h4>Methods</h4>We first performed unsupervised cluster analysis on the genes and arrays of 693 gliomas in CGGA database and 702 gliomas in TCGA database. …”
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Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes by Mona Rady, Albert Ashraf, Hesham Abdelaziz, Mohamed El-Azizi

“…A panel of 84 genes involved in T and B cell activation was analyzed to assess changes in expression using RT2 QPCR arrays. Additionally, we measured serum levels of the four IgG subclasses (IgG1, IgG2, IgG3, and IgG4) in CRC patients to explore possible alterations in humoral immunity. …”
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Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator by L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh

“…Methylation of ZFP57 was analysed by EPIC arrays, pyrosequencing and clonal analysis, and transcription assessed by PCR-based methods. …”
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EVALUATING CAUSES OF ROAD FAILURE ALONG KM 5, ADO-IKERE-EKITI ROAD, SOUTHWESTERN NIGERIA by Ajayi, C. A., Abdu-Raheem, Y. A., Talabi, A. O., Ilugbo S.O.

“…The EM survey electromagnetic fields were transmitted into the ground at varying frequencies to generate an output of frequency effect in percentage which is interpreted as apparent resistivity. …”
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Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma by John Lee, Dean Lee, Patrick Soon-Shiong, Yaya Chu, Gaurav Nayyar, Nang Kham Su, Jeremy M Rosenblum, Jeffrey T Safrit, Matthew Barth, Mitchell S Cairo

“…Gene expression changes were examined using real-time PCR arrays.Results N-820 significantly enhanced the expression of NK activating receptors (p&lt;0.001) and the proliferation of exPBNK cells with enhanced Ki67 expression and Stat5 phosphorylation (p&lt;0.001). …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Leucocyte DNA methylation was assessed using the Illumina EPIC and 450K arrays. Linear mixed-effects models were employed to identify significant associations between methylation sites and diabetes status, as well as with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homoeostasis model assessment of beta cell function (HOMA-B), and homoeostasis model assessment of insulin resistance (HOMA-IR). …”
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Possibilities and reserves of using electronic medical records data in health information systems on the example of assessing the causes of visits to outpatient clinics and death i... by I. V. Samorodskaya, R. N. Shepel, I. V. Klyuchnikov, M. M. Lukyanov, S. Yu. Martsevich, E. P. Kakorina, O. M. Drapkina

“…It also indicates the relevance of research analysis of HIS information in order to improve the stratification of the risk of adverse outcomes and increase the effectiveness of treatment and preventive care at the outpatient stage.…”
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