Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…Using multi-electrode array (MEA) analysis, we assessed the effects of EchA at concentrations ranging from 0.1 to 30 µM on electrophysiological parameters, including beat period, field potential amplitude, field potential duration, and spike slope. …”
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Aspalathin-rich unfermented Aspalathus linearsis extract mitigates vascular endothelial inflammation by inhibiting the TNF-α/Hexokinase 2/NF-κB signaling pathway by Ya-Pei Wang, Bi-Juan Wang, Hsin-Ying Lu, Christo J.F. Muller, Ying-Yu Kuo, Chieh Huo, Chih-Jen Lai, Shih-Han Huang, Elizabeth Joubert, Chih-Pin Chuu

“…Tube formation assay, transwell migration assay, wound healing assay and monolayer permeability assay were used to examine the inflammatory effects on vascular endothelial cells, while cytokine array, qRT-PCR, ELISA, reporter gene assay, fluorescent microscopy, western blot, IHC staining and Seahorse mitochondrial analyzer were used to dissect the molecular mechanisms lying underneath. …”
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CFET Beyond 3 nm: SRAM Reliability Under Design-Time and Run-Time Variability by Sufia Shahin, Swati Deshwal, Anirban Kar, Mahdi Benkhelifa, Yogesh S. Chauhan, Hussam Amrouch

“…This work investigates the reliability of complementary field-effect transistors (CFETs) by addressing both design-time variability arising from process variations and run-time variability due to temperature and aging effects. …”
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Oxygen saturation and acute mountain sickness during repeated altitude exposures simulating high-altitude working schedules by Nina F. Waldner, Sara E. Hartmann, Lara Muralt, Mona Lichtblau, Patrick R. Bader, Jean M. Rawling, Ivan Lopez, Silvia Ulrich, Marc J. Poulin, Konrad E. Bloch, Michael Furian

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Screening of cytokines in blood serum and lacrimal liquid in wet and atrophic forms of age-related macular degeneration by V. V. Neroev, N. V. Balatskaya, N. V. Neroeva, A. G. Karmokova, M. V. Ryabina, I. G. Kulikova

“…Our purpose was to study an array of 45 cytokines, in blood serum (BS) and lacrimal liquid (LL) of the patients with wet and atrophic AMD.The study included 70 people (85 eyes) with stage 3-4 AMD according to AREDS. …”
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Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer by Shuna Chen, Chao Han, Zihan Shi, Xin Guan, Liyuan Cheng, Liang Wang, Wei Zou, Jing Liu

“…T-cell compartments were identified by flow cytometry, and plasma cytokine levels were quantified using a cytometric bead array (CBA). Mitochondria in UMSCs were labeled with MitoTracker. …”
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Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway by Wenjing Zhou, Jiwei Wang, Qichao Qi, Zichao Feng, Bin Huang, Anjing Chen, Di Zhang, Wenjie Li, Qing Zhang, Rolf Bjerkvig, Xingang Li, Jian Wang

“…Here, we explored the effect of matrine on human glioblastoma multiforme (GBM) cells. …”
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Quantification of Phenolic Compounds by HPLC/DAD and Evaluation of the Antioxidant, Antileishmanial, and Cytotoxic Activities of Ethanolic Extracts from the Leaves and Bark of <i>S... by Natália Kelly Gomes de Carvalho, Débora Odília Duarte Leite, Aracélio Viana Colares, Fernando Almeida Souza, Kátia da Silva Calabrese, Gerson Javier Torres Salazar, Joice Barbosa do Nascimento, Mariana Pereira da Silva, Fabiola Fernandes Galvão Rodrigues, José Galberto Martins da Costa

“…Among the biological effects evaluated, EELSJ showed potent hydroxyl radical (•OH) scavenging activity, with IC₅₀ < 10 µg/mL, which potentially correlates with its phenolic acid and flavonoid content (0.7066 mg/g). …”
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Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation by Israel Ríos, Cristina Herrero, Mónica Torres-Torresano, Baltasar López-Navarro, María Teresa Schiaffino, Francisco Díaz Crespo, Alicia Nieto-Valle, Rafael Samaniego, Yolanda Sierra-Palomares, Eduardo Oliver, Fernando Revuelta-Salgado, Ricardo García-Luján, Paloma Sánchez-Mateos, Rafael Delgado, Amaya Puig-Kröger, Angel L Corbí

“…Monocyte-derived macrophages recruited into inflamed tissues can acquire an array of functional states depending on the extracellular environment. …”
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Identification of genetic locus with resistance to take-all in the wheat-Psathyrostachys huashanica Keng introgression line H148 by Sheng-sheng BAI, Han-bing ZHANG, Jing HAN, Jian-hui WU, Jia-chuang LI, Xing-xia GENG, Bo-ya LÜ, Song-feng XIE, De-jun HAN, Ji-xin ZHAO, Qun-hui YANG, Jun WU, Xin-hong CHEN

“…The mixed genetic model analysis showed that the take-all resistance was controlled by two major genes with additive, dominant and epistasis effects. Bulked segregant analysis combined with wheat axiom 660K genotyping array analysis showed the polymorphic SNPs with take-all resistance from P. huashanica alien introgression were mainly distributed on the chromosome 2A. …”
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Antiprotozoal Natural Products from Endophytic Fungi Associated with Cacao and Coffee by Cristopher A. Boya P., Candelario Rodriguez, Randy Mojica-Flores, Jean Carlo Urrutia, Víctor Cantilo-Diaz, Masiel Barrios-Jaén, Michelle G. Ng, Laura Pineda, Alejandro Llanes, Carmenza Spadafora, Luis C. Mejía, Marcelino Gutiérrez

“…Fungal endophytes associated with plants are known to produce a wide array of bioactive secondary metabolites, including antiprotozoal compounds. …”
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Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells by Karen A. Cavassani, Rebecca J. Meza, David M. Habiel, Jie‐Fu Chen, Alexander Montes, Manisha Tripathi, Gislâine A. Martins, Timothy R. Crother, Sungyong You, Cory M. Hogaboam, Neil Bhowmick, Edwin M. Posadas

“…We then identified the proteome profile of these monocytes using proteome array and ELISA. Results Conditioned media from circulating monocytes in patients with metastatic prostate cancer (PCa‐M) increased invasion of epithelial PCa cells in vitro. …”
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Impact of prior exposures on biomarkers of blast during military tactical training by Zhaoyu Wang, Zhaoyu Wang, Shengnan Sun, Shengnan Sun, Qingkun Liu, Qingkun Liu, Alis Askar Kranfli, Jeffrey Nemes, Molly Sullan, Molly Sullan, Andrew Hoisington, Andrew Hoisington, Andrew Hoisington, Lisa A. Brenner, Lisa A. Brenner, Maciej Skotak, Christina R. LaValle, Yongchao Ge, Walter Carr, Fatemeh Haghighi, Fatemeh Haghighi

“…IntroductionBlast injuries and subclinical effects are of significant concern among those Service Members (SMs) participating in military operations and tactical trainings. …”
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Comprehensive plasma metabolomics analysis of berberine treatment in ulcerative colitis rats by LC-MS/MS by Baodong Feng, Baodong Feng, Linqi Su, Linqi Su, Yang Yang, Renyan Liu, Renyan Liu, Yu Zhang, Yu Zhang, Lingyi Xin, Lingyi Xin, Li Wang, Li Wang, Zhiming Yang, Xuemei Wei, Qinhua Chen, Qinhua Chen

“…This approach, characterized by its short analysis time of 20 min per sample, excellent reproducibility, and straightforward data processing, allowed for the comprehensive detection of a wide array of metabolites, including amino acids, lipids, and organic acids, many of which are implicated in the pathophysiology of UC.ResultsOur results showed that berberine modulated the metabolic disturbances of 33 compounds in the plasma of UC rats, primarily including amino acids, pyrimidines, organic phosphoric acids, fatty acyls, and organonitrogen compounds. …”
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Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation by Shimrit Oz, Tal Keren-Raifman, Tom Sharon, Suraj Subramaniam, Tamara Pallien, Moshe Katz, Vladimir Tsemakhovich, Anastasiia Sholokh, Baraa Watad, Debi Ranjan Tripathy, Giorgia Sasson, Orna Chomsky-Hecht, Leonid Vysochek, Maike Schulz-Christian, Claudia Fecher-Trost, Kerstin Zühlke, Daniela Bertinetti, Friedrich W. Herberg, Veit Flockerzi, Joel A. Hirsch, Enno Klussmann, Sharon Weiss, Nathan Dascal

“…We propose that these tripartite interactions, if present in vivo, may participate in organizing the multimolecular signaling complex and fine-tuning the βAR effect in cardiomyocytes.…”
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Extracellular vesicles derived from salivary gland stem cells cultured on microwell scaffolds loaded with WNT3A promote the recovery of salivary gland function damaged by radiation... by Jae-Min Cho, Sujeong Ahn, Yeo-Jun Yoon, Sunyoung Park, Hyeon Song Lee, Seungyeon Hwang, Ye Jin Jeong, Yongpyo Hong, Sunyoung Seo, Dohyun Kim, Hyo-Il Jung, Won-Gun Koh, Jae-Yol Lim

“…We developed a WNT3A-releasing double-layered microwell scaffold by integrating WNT3A-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers with a polycaprolactone (PCL)-based microwell array. This 3D platform promotes salivary gland epithelial stem cell (sgEpSC) spheroid formation and sustained biochemical stimulation. …”
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Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. by Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium

“…To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. …”
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Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population by Yinghao Yao, Xingyong Li, Lan Wu, Jia Zhang, Yuanyuan Gui, Xiangyi Yu, Yang Zhou, Xuefei Li, Xinyu Liu, Shilai Xing, Gang An, Zhenlin Du, Hui Liu, Shasha Li, Xiaoguang Yu, Myopia Associated Genetics Intervention and Consortiums, Hua Chen, Jianzhong Su, Shihao Chen

“…Additionally, a significant correlation of allelic effects was observed for suggestive SNPs between the largest multi-ethnic meta-genome-wide association study (GWAS) and our study. …”
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Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like... by Ludovica Barone, Martina Cucchiara, Maria Teresa Palano, Barbara Bassani, Matteo Gallazzi, Federica Rossi, Mario Raspanti, Piero Antonio Zecca, Gianluca De Antoni, Christina Pagiatakis, Roberto Papait, Giovanni Bernardini, Antonino Bruno, Rosalba Gornati

“…CMs were characterized by a secretome protein array, then used for in vivo and in vitro experiments. …”
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Integrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decocti... by Wenbin Huang, Xiaoju Liu, Xingjia Li, Ruixiang Zhang, Guofang Chen, Guofang Chen, Xiaodong Mao, Shuhang Xu, Chao Liu, Chao Liu

“…ObjectiveTo explore the pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction (HYD) in treating hyperthyroidism via an analysis integrating network pharmacology, molecular docking, and non-targeted serum metabolomics.MethodsTherapeutic targets of hyperthyroidism were searched through multi-array analyses in the Gene Expression Omnibus (GEO) database. …”
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