Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice by Wenyi Chen, Xinyi Chen, Feiqiong Gao, Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Guanghua Ma, Jintao Gong, Qian Li, Yunhua Chen, Lee Wei Lim, Ilia Stambler, Georgina M. Ellison-Hughes, Brun Ulfhake, Robert Chunhua Zhao, Hongcui Cao

“…Functional assays, miRNA array, and CUT & Tag analyses reveal that EVs-derived hsa-miR-7977 targets NFKBIZ, repressing IκBζ translation to reduce IL-17A and its downstream targets involved in Th17 differentiation, IL-17 signaling, and bile secretion pathways. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Beyond their structural roles, these microbes produce a diverse array of bioactive metabolites that interact with the host immune system. …”
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LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) by Melissa Soun-udom, Maria Rita Garcia, Andreia P. Oliveira, Paula B. Andrade, Srunya Vajrodaya, Sutsawat Duangsrisai, Nelson G.M. Gomes

“…Due to an array of medicinal properties being attributed to Gotu kola (Centella asiatica (L.) …”
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Integral approach to organelle profiling in human iPSC-derived cardiomyocytes enhances in vitro cardiac safety classification of known cardiotoxic compounds by Brigitta R. Szabo, Brigitta R. Szabo, Jeroen Stein, Anna Savchenko, Thomas Hutschalik, Thomas Hutschalik, Filip Van Nieuwerburgh, Tim Meese, Georgios Kosmidis, Paul G. A. Volders, Elena Matsa, Elena Matsa, Elena Matsa, Elena Matsa

“…Current preclinical hiPSC-CMs models focus on functional changes such as electrophysiological abnormalities, however other parameters, such as structural toxicity, remain less understood.MethodsThis study utilized hiPSC-CMs from three independent donors, cultured in serum-free conditions, and treated with a library of 17 small molecules with stratified cardiac side effects. High-content imaging (HCI) targeting ten subcellular organelles, combined with multi-electrode array data, was employed to profile drug responses. …”
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Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages by Corinne Quadalti, Corinne Quadalti, Marzia Moretti, Fabio Ferrazzi, Laura Calzà, Laura Calzà, Laura Calzà, Luciana Giardino, Luciana Giardino, Luciana Giardino, Vito Antonio Baldassarro, Vito Antonio Baldassarro

“…A high-throughput gene expression array-based analysis showed a prompt response of the in vitro testing platform to TBBPA treatment. …”
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Microvesicles from Human Immortalized Cell Lines of Endothelial Progenitor Cells and Mesenchymal Stem/Stromal Cells of Adipose Tissue Origin as Carriers of Bioactive Factors Facili... by Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Honorata Kraskiewicz, Agnieszka Szyposzynska, Elżbieta Wojdat, Aleksandra Klimczak

“…The isolated microvesicles were assessed for their effect on the proliferation and proangiogenic properties of cells involved in tissue repair. …”
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Velocity Structure Correlations between the Nebular, Molecular, and Atmospheric Gases in the Cores of Four Cool Core Clusters by Muzi Li, B.R. McNamara, Alison L. Coil, Marie-Joëlle Gingras, Fabrizio Brighenti, H.R. Russell, Prathamesh D. Tamhaneh, S. Peng Oh, Serena Perrotta

“…We explore substantial systematic biases, including projection effects, windowing, and smoothing effects, when comparing VSFs using different telescopes and instruments.…”
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In-beam γ ray spectroscopy of 94Ag by Pereira-López X., Bentley M.A., Wadsworth R., Ruotsalainen P., Lenzi S.M., Forsberg U., Auranen K., Blazhev A., Cederwall B., Grahn T., Greenlees P., Illana A., Jenkins D.G., Julin R., Jutila H., Juutinen S., Liu X., Llewelyn R., Luoma M., Moschner K., Müller-Gatermann C., Singh B.S. Nara, Nowacki F., Ojala J., Pakarinen J., Papadakis P., Rahkila P., Romero J., Sandzelius M., Sarén J., Tann H., Uthayakumaar S., Uusitalo J., Vega-Romero J.G., Vilhena J.M., Yajzey R., Zhang W., Zimba G.

“…The fusion evaporation reaction 40Ca(58Ni,p3n)94 Ag has been used to study the odd-odd N=Z nucleus 94Ag at JYFL-ACCLAB using the MARA recoil separator and the JUROGAM 3 HPGe detector array. The recoil-β-tagging technique has allowed the observation of γ rays de-exciting states in 94Ag for the first time. …”
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Rapid identification of high-temperature Daqu Baijiu with the same aroma type by UV-VIS sensor of HBT combined with Zn2+ by Yanmei Zhu, Yuanyuan Su, Yipeng Cang, Hengye Chen, Wanjun Long, Wei Lan, Xue Jiang, Haiyan Fu

“…The accuracy of the data driven-soft independent modelling of class analogies (DD-SIMCA) model was between 90% and 100%, indicating that the array sensor had a good recognition effect on the adulteration of the same aroma type of Baijiu. …”
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Modulation of 8-Oxoguanine DNA Glycosylase 1 (OGG1) Alleviated Anemia Severity and Excessive Cytokines Release during Plasmodium berghei Malaria in Mice by Abdullahi Samaila, Rusliza Basir, Nur Aimi Liyana Abdul Aziz, Abdusalam Abdullah Alarabei, Mukhtar Lawal Gambo, Maizaton Atmadini Abdullah, Mohd Khairi Hussain, Norshariza Nordin, Roslaini Abd Majid

“…OGG1 activity in malaria mice was modulated using treatment with TH5487 and O8-OGG1 inhibitors. The effects of modulating OGG1 activity using OGG1 inhibitors on cytokine release and anemia during P. berghei malaria infection were assessed by cytometric bead array and measurement of total normal red blood cell count respectively. …”
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A diverse set of solubilized natural fibers drives structure-dependent metabolism and modulation of the human gut microbiota by Maria X. Maldonado-Gomez, Katharine M. Ng, Riley A. Drexler, Alexandria M. S. Conner, Cory G. Vierra, Nithya Krishnakumar, Hannah M. Gerber, Zachary R. Taylor, Jenna L. Treon, Megan Ellis, Jada K. A. Garcia, James P. Cerney, David G. Chapin, Robnet T. Kerns, Angela M. Marcobal, Steven M. Watkins, Matthew J. Amicucci

“…Studies have primarily focused on a limited range of fibers, rather than the diverse array of fibers representative of those commonly found in our diets. …”
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Harnessing plant growth-promoting bacteria to combat watermelon mosaic virus in squash by Shymaa R. Bashandy, Omima Abdelsater Mohamed, Osama A. Abdalla, A. Elfarash, Mohamed Hemida Abd-Alla

“…GC–MS analysis of the six bacterial strains revealed a diverse array of 73 chemical metabolites, including common compounds such as 9-Octadecenoic acid (Z), benzene derivatives, and cyclopentanones. …”
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<i>C11orf58</i> (Hero20) Gene Polymorphism: Contribution to Ischemic Stroke Risk and Interactions with Other Heat-Resistant Obscure Chaperones by Irina Shilenok, Ksenia Kobzeva, Vladislav Soldatov, Alexey Deykin, Olga Bushueva

“…<b>Methods</b>: 2204 Russian subjects (917 IS patients and 1287 controls) were genotyped for fifteen common SNPs in Hero20 gene <i>C11orf58</i> using probe-based PCR and the MassArray-4 system. <b>Results</b>: Six <i>C11orf58</i> SNPs were significantly associated with an increased risk of IS in the overall group (OG) and significantly modified by smoking (SMK) and low fruit/vegetable intake (LFVI): rs10766342 (effect allele (EA) A; P(_OG = 0.02; _SMK = 0.009; _LFVI = 0.04)), rs11024032 (EA T; P(_OG = 0.01; _SMK = 0.01; _LFVI = 0.036)), rs11826990 (EA G; P(_OG = 0.007; _SMK = 0.004; _LFVI = 0.03)), rs3203295 (EA C; P(_OG = 0.016; _SMK = 0.01; _LFVI = 0.04)), rs10832676 (EA G; P(_OG = 0.006; _SMK = 0.002; _LFVI = 0.01)), rs4757429 (EA T; P(_OG = 0.02; _SMK = 0.04; _LFVI = 0.04)). …”
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Ethyl acetate extract from red coralline macroalgae Mastophora rosea, rich in polyphenolic catechins, induces apoptosis and inhibits metastasis in melanoma cell line by Eka Sunarwidhi Prasedya, Putu Bella Aprillia Saraswati, Ni Wayan Riyani Martyasari, Andri Frediansyah, Munawar Khalil, Sri Widyastuti

“…The existing therapeutic approaches for skin cancer such as chemotherapy induce significant adverse effects. This highlights the need for further development of novel medicinal substances from natural sources which has less side effects implications. …”
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<i>APOC1</i> rs445925 and rs4420638 polymorphic variants as genetic predictors of occlusive peripheral arterial disease of lower extremities by S. N. Zhabin, V. A. Lazarenko, Yu. E. Azarova, E. Yu. Klesova, M. A. Bykanova, S. S. Chernousova, D. A. Bashkatov, M. I. Churnosov, M. A. Solodilova, A. V. Polonikov

“…The rs445925G/G×rs4420638A/A diplotype had a protective effect on the disease development (OR 0,26, 95% CI 0,20-0,35, P=1,3×10-20). …”
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Exploring methylation signatures for high de novo recurrence risk in hepatocellular carcinoma by Da-Won Kim, Jin Hyun Park, Suk Kyun Hong, Min-Hyeok Jung, Ji-One Pyeon, Jin-Young Lee, Kyung-Suk Suh, Nam-Joon Yi, YoungRok Choi, Kwang-Woong Lee, Young-Joon Kim

“…Using the Infinium Methylation EPIC array on 140 samples in the discovery cohort, we classified patients into low- and high-risk groups based on methylation profiles. …”
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Biomaterials nanoplatform-based tumor vaccines for immunotherapy by Zhilin Li, Hongbin Zhang, Qiyong Gong, Kui Luo

“…We then dived into an array of biomaterial-based nanoplatforms explored for tumor vaccine delivery, including lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, biomimetic nanoparticles, and hydrogels. …”
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Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease by Huimin Li, Xueyu Wen, Xinyi Gong, Yange Wu, Puxuan Zhao, Yun Zhang, Zhuomin Sha, Hao Chang, Xuepeng Chen

“…The resulting Mino‐DMN patch features an array of minocycline‐enriched gelatin MNs with a porous HA patch backing. …”
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Yiqi Huayu Jiedu Decoction reduces colorectal cancer liver metastasis by promoting N1 neutrophil chemotaxis by Hua-Jian Zhou, Bai-Xiang Mu, Meng-Chao Wen, Qi Zhao, Yuanxiang Li, Wen-Xuan Zhao, Hong-Ye Yin, Shuai Ren, Jin-Yong Zhou, Jin-Yong Zhou, Min Chen

“…Transcriptomics, proteomics, and multiplex cytokine array analyses were conducted to further verify the role of YHJD on CXCL1. …”
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Static phase gradient metasurface antenna enabling synergistic radiation-scattering function integration by Xin Wang, Qin Chen, Junlin Wang, Yifan Hou, Chengshuang Zhu, Yunsheng Guo, Yang Wang, Tao Zhou

“…According to the simulation and measurement results, the meta-plane antenna, after forming an array, can operate in the frequency band up to 8.5 GHz–10.6 GHz (22%), and the radiation gain in the frequency band can reach 20.1 dBi–21.4 dBi, which can effectively reduce the RCS in and out of the frequency band, as well as realize the functions of vortex wave generation and beam deflection, and, in short, the meta-plane antenna achieves the integration of radiation and scattering functions.…”
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